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International Journal of Respiratory and Pulmonary Medicine is an open access and bimonthly journal which globalizes the awareness of this medicinal and clinical information freely without any subscription for the online users. We process and accept all types of articles including original papers, reviews, short commentaries, case reports and many more. The board for the journal includes specialists, pharmacologists, scientists, practioners, and professors. Published articles undergo a detailed peer-reviewed process by professionals with the same backgrounds. We truly welcome kind suggestions from the readers which are within the scope of the journal.

The journal mainly focuses on human pulmonary and respiratory health. Focus topics include the lungs, respiration (oxygen and carbon dioxide exchange), respiratory diseases, epidemiology, treatments, recent advances and therapeutic interventions. Tobacco usage, family history, obesity, HIV/AIDS, diet, and chemical exposures that are the major risk factors for respiratory diseases constitute a significant portion of the scope of the journal. Through open access, published work is freely available, and upon acceptance and formatting, becomes immediately available to other professionals.


Articles

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The 2005 guidelines recommended classification of patients based on their risk of infection by resistant bacterial pathogens. The now abandoned HCAP entity included any patient hospitalized in an acute care hospital for two or more days within 90 days of the infection; residing in a nursing home or long-term care facility; .. read more


10.23937/2378-3516/1410063

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We analyzed an emergency department (ED) performance improvement (PI) database from an airway registry that was developed to monitor the care of patients undergoing endotracheal intubation in prehospital settings or in the study site ED. PI initiatives included implementation of electronic health record (EHR) documentation templates for ETT placement/confirmation, an online .. read more


10.23937/2378-3516/1410062

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A descriptive, cross-sectional research study, framed in the study Prevalence of Metabolic Syndrome in Maracaibo city conformed by 2,212 adults of both genders; based on the medical information the individuals were classified in smokers, non-smokers and former smokers. Quantitative variables were expressed as medians and qualitative variables as absolute and relative .. read more


10.23937/2378-3516/1410061

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A 63-year-old Japanese male suffering from interstitial pneumonia underwent computed tomography (CT) guided tumor localization using a hook wire and a suture system for a small pulmonary nodule suspected of being lung carcinoma. He underwent subsequent video-assisted thoracoscopic surgery. The cut suture connecting to the metal head of the hook wire .. read more


10.23937/2378-3516/1410060

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Background: Polymyositis (PM) and dermatomyositis (DM) often have interstitial lung disease (ILD) and progression of ILD is important cause of death. Objectives: This study is conducted to clarify the important clinical, radiological factors of PM/DM ILD patients. Methods: We reviewed medical records, pulmonary function test (PFT), chest high-resolution computed tomography (HRCT) .. read more


10.23937/2378-3516/1410059

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Background: Patients with thoracic empyema occasionally require chest tubes for drainage. Several studies have reported that smaller chest tubes are effective and cause fewer complications. The aim of this study was to investigate the outcomes of patients with empyema who underwent drainage using a smaller-size chest tube. Methods: We retrospectively reviewed .. read more


10.23937/2378-3516/1410058

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A native Japanese woman in her 60's complained of hemosputum and had an irregular nodular shadow in her chest radiograph. The nodule was surgically removed, and the histopathological findings of the pulmonary lesion showed a necrotizing granuloma with central irregular geographic necrosis associated with parasite eggs. The results of the enzyme-linked .. read more


10.23937/2378-3516/1410057

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Sarcoidosis is a systemic granulomatous disorder of unknown causes. Haematological manifestations in sarcoidosis are uncommon and may include haemolytic anemia, leukopenia, eosinophilia and peripheral lymphopenia, but severe thrombocytopenia is rare. Causes of thrombocytopenia in sarcoidosis were identified a few mechanisms. There are no current guidelines concerning the treatment of thrombocytopenia in .. read more


10.23937/2378-3516/1410056

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Purpose: Bariatric surgery is an established treatment of morbid obesity and effectively controls symptoms of OSAHS. The aim of this study was to evaluate impact of bariatric surgery on OSAHS. Methods: Validated Epworth Sleepiness Score (ESS) and STOP-Bang questionnaires were used to assess the impact of bariatric surgery on OSAHS in .. read more


10.23937/2378-3516/1410055

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Myocardial infarction is usually recognized as the final stage of coronary artery stenosis or occlusion in response to coronary atherosclerosis and thrombosis involving dysfunction and activation of resident vascular cells as well as the release of t-PA. As a member of family proteins for deacetylation of core histones in eukaryotic cells, .. read more


10.23937/2378-3516/1410054

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Several echocardiographic parameters study right ventricular (RV) function, which has a prognostic impact on pulmonary hypertension (PH). Our goal was to evaluate the correlation between known prognostic markers and standard, as well as advanced echocardiographic parameters, including Tissue Doppler (TDI), strain imaging and three-dimensional (3D) echocardiography. .. read more


10.23937/2378-3516/1410053

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Henoch-Schonlein purpura (HSP) is a systemic vasculitis that affects small-sized vessels, characterized by non-thrombocytopenic purpura, along with other clinical manifestations such as arthritis, abdominal pain, gastrointestinal bleeding and renal disease. Although the presence of subclinical alterations of pulmonary function has been noticed, the appearance of diffuse alveolar hemorrhage (DAH) is a .. read more


10.23937/2378-3516/1410052

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We conducted a one-year prospective observational study of adult post-surgical patients admitted to the surgical intensive care unit and mechanically ventilated for more than 24 hours. Forced cough peak expiratory flow (FCPEF) was assessed by using a digital peak flow meter placed in-line with the endotracheal before extubation after passing previously .. read more


10.23937/2378-3516/1410051

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A 63-year-old man known to have human immune-deficiency viral (HIV) infection was referred for evaluation following three episodes of left upper lobe pneumonia. He was well controlled on his anti-retroviral medications. Physical exam showed left upper lobe wheezing. No evidence of obstruction could be seen on chest X-ray or computed tomography .. read more


10.23937/2378-3516/1410050

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Objective quantitative evaluation for the extent of fibrosis has been introduced using CT densitometry in patients with interstitial lung diseases, however, there have been no definitive attenuation cut-off values to evaluate the extent of ground-glass opacity and fibrosis separately. This study was conducted to investigate the relationships between quantitative CT measurements .. read more


10.23937/2378-3516/1410049

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Objective: Chronic obstructive pulmonary disease (COPD) poses a substantial burden of illness in the Asia-Pacific region, as it does worldwide. However large-scale and community-based epidemiology studies of COPD in Taiwan are limited. This paper conducted a population-based study to investigate the prevalence of COPD in southwestern Taiwan. Methods: Data were conducted .. read more


10.23937/2378-3516/1410048

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Objective: To assess the value of interleukin-6 (IL-6), interleukin-8 (IL-8) and C-reactive protein (CRP) in predicting the outcome of acute respiratory failure (ARF) on top of COPD. Patients and methods: Serum samples were collected from 33 COPD patients presented with ARF for IL-6, IL-8, and CRP analysis on admission, after 72 .. read more


10.23937/2378-3516/1410047

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Echinococcosis or hydatid cyst disease is among the oldest diseases known to man. Common presentations include involvement of liver and lungs. Hydatid cyst in diaphragm without hepatic involvement is rare and less than 100 cases are reported in literature. We are describing a case of a young female who presented with .. read more


10.23937/2378-3516/1410046

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This case report presents an acute and chronic inflammation process at the same time and resulted in death following exposure to chlorine gas. A 65-years-old woman died shortly after cleaning her bathroom with a mixture of various chemicals including bleach and an acid containing product. She was declared dead when she .. read more


10.23937/2378-3516/1410045

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A prevalent cohort of Medicare beneficiaries aged 65+ with COPD (chronic bronchitis, emphysema, bronchiectasis, chronic airway obstruction) was constructed from a 5% sample of Medicare beneficiaries. Existence of depression/anxiety was identified via healthcare services or prescription drug claims. Baseline characteristics were assessed (1/1/2006-6/31/2006) and patients followed from first depression/anxiety claim until .. read more


10.23937/2378-3516/1410044

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Neutrophil to lymphocyte ratio(NLR) and platalet to lymphocyte ratio (PLR) are recently defined novel inflammatory markers which are readily available. Their prognostic signifigance has been shown for a number of inflammatory diseases. A recent study evaluated the role of NLR in patients with chronic obstructive pulmonary disease(COPD). Thus, we aimed to .. read more


10.23937/2378-3516/1410043

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Increasing evidence in the literature indicates that respiratory allergies are often a hidden contributory factor in vocal dysfunction. Although the precise allergic pathophysiological process within the vocal folds is not yet determined, modern understanding suggests that allergic changes in the lining of the larynx are an integral part of a systemic .. read more


10.23937/2378-3516/1410042

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Mr. M was a 74-year-old male Korean War veteran who presented to the hospital with an acute exacerbation of his Chronic Obstructive Pulmonary Disease (COPD). The patient had a 50 pack-year history of smoking and continued to smoke one-and-a-half packs of cigarettes per day. He was frail with barrel chest and .. read more


10.23937/2378-3516/1410041

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Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has many potential complications though most occur infrequently. We encountered a case in which the EBUS needle broke during TBNA. The patient was a 65 year old man who underwent EBUS-TBNA for right paratracheal lymphadenopathy. During the procedure, the TBNA needle was found to be .. read more


10.23937/2378-3516/1410040

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The prevalence and mortality of chronic obstructive pulmonary disease (COPD) is expected to increase, not only in Japan but also worldwide. The prevalence of COPD is estimated to be 8.6% in Japan; however, it is reported that many COPD patients remain undiagnosed and untreated. Because COPD is a treatable and preventable .. read more


10.23937/2378-3516/1410039

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Scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDS) supplies information that is complementary to those data traditionally obtained using inductively coupled plasma-mass spectrometry for analysis of inorganic tobacco and tobacco smoke constituents. The SEM-EDS approach was used to identify select inorganic constituents of mainstream cigarette smoke "tar". The nature of .. read more


10.23937/2378-3516/1410038

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Pompe disease is a rare and progressive lysosomal storage disorder, of autosomal recessive inheritance. Disease onset and progression range from early infantile onset which is fatal and rapidly progressive to the late onset formthatis slowly progressive, but leads to severe respiratory dysfunction and significant morbidity. Besides, scoliosis and other spine deformities .. read more


10.23937/2378-3516/1410037

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Endobronchial lipomas, usually found in the obese and in smokers, can cause patients significant distress with chronic cough, chest pain, dyspnea, and increased infection risk. Here we present a case of a 61 year-old obese, never-smoker gentleman who initially presented with chronic productive cough, hemoptysis, chills and night sweats; and was .. read more


10.23937/2378-3516/1410036

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The use of electronic nicotine delivery systems such as electronic cigarettes has increased considerably in recent years among youth and adults. While the majority of adult electronic cigarette users are current conventional cigarette smokers, an increasing number of adolescents who have not previously smoked are using use electronic cigarettes. Despite these .. read more


10.23937/2378-3516/1410035

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Biliothorax and pleurobiliary fistula are rare complications secondary to biliary tree diseases. We report the case of a patient with left massive pleural effusion secondary to biliothorax without fistula or ascites. To our knowledge, this is the first case to be described with left side biliothorax. .. read more


10.23937/2378-3516/1410034

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The prevalence of allergic disease has risen significantly during recent years. A major component of the susceptibility to allergic disease is determined in prenatal life, when the placenta plays a central role in fetal growth and development. In this study, we aimed to identify the patterns of gene expression in the .. read more


10.23937/2378-3516/1410033

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Iatrogenic tracheal rupture following intubation is a rare, but potentially lethal complication. Usually patients present with the classical symptoms of mediastinal subcutaneous emphysema and respiratory distress. However, the timing or the onset of these symptoms is quite variable and differs between patients. .. read more


10.23937/2378-3516/1410032

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Pulmonary arterial hypertension (PAH) is a devastating disease with significantly reduced survival. To date, no tested therapies have demonstrated an ability to reverse or cure the disease. The etiology of PAH is heterogeneous and incompletely understood. Genetics plays an important role in idiopathic and heritable PAH. Many germline gene mutations have .. read more


10.23937/2378-3516/1410031

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A 21-year-old Guatemalan male presented with six months of headaches and neck pain. MRI of the cervical spine demonstrated multiple inflammatory processes, both within the paraspinal soft tissue as well as within the bone itself, including the appearance of total destruction of C1. Microbiologic confirmation of Mycobacterium tuberculosis was made by .. read more


10.23937/2378-3516/1410030

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This study investigated whether Danish construction
workers had an increased prevalence of chronic obstructive
pulmonary disease (COPD) or affected lung function and if the
prevalence differed between types of jobs within construction. .. read more


10.23937/2378-3516/1410029

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Laryngocele is rare condition in which dilation of the laryngeal saccule that extends upward the false vocal cord, is filled with air, and is in communicating with the laryngeal lumen1. It can presents as neck mass or as cystic lesion in the neck. Awareness regarding this rare entity can help the .. read more


10.23937/2378-3516/1410028

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In patients with diabetes mellitus (DM), community-acquired pneumonia (CAP) is associated with significant morbidity and mortality. The primary objective of the study was to describe the clinical outcomes and risk factors for moderate-severe CAP in hospitalized patients with DM. Methods: We conducted a retrospective cohort study of 156 hospitalized patients with .. read more


10.23937/2378-3516/1410027

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ILI infections are infections of the human respiratory tract. They are caused by various viruses including corona viruses, adeno-viruses, influenza virus types A, B and C, among others (CDC- US, 2005). When these infections are circulating within the community, patients with ILI infections who have both cough and fever within 48 .. read more


10.23937/2378-3516/1410026

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The major obstacle in TB eradication is attributed to the dormant state of the TB bacilli, Mycobacterium tuberculosis and is characterized by asymptomatic, non-culturability and antibiotic resistant state of disease. Conventional antibiotic therapy is only applicable to the active form of the disease. These non-replicating cells can resume the growth in .. read more


10.23937/2378-3516/1410025

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Background: COPD is associated with significant morbidity, mortality, and hospital costs. The implementation of COPD 'discharge care bundles' has been proposed as having an impact on readmissions. We developed and implemented a discharge care bundle and the aim of this study was to evaluate its effects on utilization of hospital services .. read more


10.23937/2378-3516/1410024

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Background: The relationship between chronic rhinosinusitis (CRS) and airflow obstruction is still unclear. This cross-sectional study was conducted to investigate whether CRS is an independent risk factor for airflow obstruction in never-smokers without asthma. Methods: One hundred fifty-eight subjects aged ≥ 40 yr without asthma were divided into 4 groups: 22 .. read more


10.23937/2378-3516/1410023

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Malignant pleural effusion (MPE) is a common presenting feature of underlying malignancy and frequently results in debilitating symptoms. In chemosensitive malignancies, such as lymphoma, small cell lung or ovarian cancers, chemotherapy is often considered the fist line treatment, however if unsuccessful, pleural intervention to achieve fluid control is required. This may .. read more


10.23937/2378-3516/1410022

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Background: Pulmonary function tests are used routinely to evaluate patients with respiratory diseases and those who are at risk of developing respiratory diseases. Lung function prediction equations are generally developed for urban populations and whether these differ on rural population is not well studied. There is limited information on prediction equations .. read more


10.23937/2378-3516/1410021

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An obese 85 year-old woman was admitted to the hospital because of extreme dyspnoea after one week with fever and cough. She had been previously diagnosed with myelodysplastic syndrome, chronic renal failure with creatinine 2 mg/dl, glomerular fitrate 25 ml/min; and cirrhosis with moderate persistent ascites despite diuretic treatment and mild .. read more


10.23937/2378-3516/1410020

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Coccidioidomycosis is caused by inhalation of Coccidoides spores which is endemic in south western parts of USA and an uncommon cause of pneumonia in non-endemic areas. We report a young Hispanic man who lives in New York presenting with diabetic ketoacidosis and severe pulmonary Coccidioidomycosis. .. read more


10.23937/2378-3516/1410019

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Pathogenesis of primary spontaneous pneumothorax (PSP) is unclear and has been rarely reported in the literature. Thus, we measured expression of Krebs Vonden Lungen-6 (KL-6), firoblast growth factor-10 (FGF-10), and matrix metalloproteinase-9 (MMP-9) in PSP samples and evaluated their significance on the development and progress of the disease. .. read more


10.23937/2378-3516/1410018

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It is true that pulmonary medicine is already well served by several specialist journals, but it is also true that it remains difficult to publish the overwhelming amount of research articles in this rapidly growing field. This is particularly the case for the researchers from the developing countries, who contribute only .. read more


10.23937/2378-3516/1410017

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Community-acquired pneumonia is defined as an acute infection of the pulmonary parenchyma in a patient who has acquired the infection in the community. CAP remains a common and potentially serious illness. It is associated with considerable morbidity, mortality and treatment cost, particularly in elderly patients. CAP causes problems like difficulty in .. read more


10.23937/2378-3516/1410016

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Primary mediastinal goiter is a rare entity. In most cases their finding is incidental. Excision is mandatory because of the risk of compression of vital structures within the chest. We report the case of a primary posterior mediastinal goiter that was resected through a cervical approach. .. read more


10.23937/2378-3516/1410015

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Objective: Obesity has many negative effects on lung functions. It is not yet clear whether body mass index (BMI) affects the success of noninvasive mechanical ventilation (NIMV). The aim of this study was to investigate the differences in NIMV strategies, on the basis of BMI, in patients with acute hypercapnic respiratory .. read more


10.23937/2378-3516/1410014

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Independent Lung Ventilation (ILV) has been used in the critical care setting as a rescue therapy for differential lung disease. The purpose of anatomic separation of the lungs is to prevent blood, purulent secretions, or other debris from one lung from contaminating the other lung. Physiologic separation of the lungs allows .. read more


10.23937/2378-3516/1410013

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After the pandemic influenza H1N1 2009, there are many lessons learned regarding the diagnosis and treatment of patients affected by this virus. However, there have also been a number of contingencies that have greater concern to the world population, mainly by new types as infectious outbreaks, as well as the report .. read more


10.23937/2378-3516/1410012

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A 25-year-old female patient presented with dry coughs of 20 days duration and fever for four days. Examination of respiratory system revealed no significant abnormality. Chest radiograph was normal. CT scan of the thorax revealed endobronchial opacity in the right main bronchus suggestive of a foreign body. Patient retrospectively recollected history .. read more


10.23937/2378-3516/1410011

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Background: International registries report an aging population suffering from PAH (Pulmonary Artery Hypertension) engendering diagnosis difficulties linked with growing cases of group 2 related to left heart failure with preserved Ejection Fraction (PH-HFpE). Pulmonary Capillary Wedge Pressure (PCWP) measurement by right heart catheterization remains a technical challenge for patient classification; many .. read more


10.23937/2378-3516/1410010

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Objectives: Cystic fibrosis (CF) is a complex genetic disorder of the lower and upper respiratory tract. The purpose of this study is to evaluate the effect of Halotherapy on sinusitis symptoms, dyspnea, pulmonary function tests, and quality of life in CF patients. Study design: This was a pilot open-label before-and-after-study. Settings: .. read more


10.23937/2378-3516/1410009

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838 patients referred 559 attended to and only 278 treated (33%); 55.4% males and 44.6% females; mean age of 46.4 years. The most important comorbidities were psychiatric (36.3%), cardiovascular (dyslipidemia 30.2%, hypertension 19.1%, diabetes 9.4%) and respiratory (chronic obstructive pulmonary disease (COPD), 15.1%; Obstructive Sleep Apnea Syndrome (OSAS), 11.9%; asthma, 7.6%). .. read more


10.23937/2378-3516/1410008

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Introduction: During acute lung inflammation, the lung microvasculature becomes hyperpermeable, resulting in immune cell infiltration and tissue edema. N-3 polyunsaturated fatty acids (PUFAs), when used as a supplement in parenteral nutrition, can attenuate Lipopolysaccharide (LPS)-induced lung injury. In this study, we examined the effects n-3 PUFAs on lung microvascular cell permeability. .. read more


10.23937/2378-3516/1410007

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The ductus arteriosus, an essential fetal structure, normally closes spontaneously soon after birth. It's persistence into late adulthood is considered rare; infective endarteritis complicating a patent ductus arteriosus (PDA) is an even rarer event. The clinical picture of an infected PDA could be subtle, and the diagnosis is frequently delayed. Symptoms .. read more


10.23937/2378-3516/1410006

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A variety of airway tumours are reported to manifest with symptoms similar to those of asthma and may cause delays in exact diagnosis because of the increase in size at a slow rate. Pulmonary endobronchial mesenchymoma is one of the slow growing tumours which is associated with symptoms or signs of .. read more


10.23937/2378-3516/1410005

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Background: In patients with Pulmonary Hypertension (PH), the role of overnight oximetry as means to screen for Sleep Disordered Breathing (SDB) has not been well established. The aim of this study was to assess whether overnight oximetry was additive to a standard sleep questionnaire in the diagnosis of SDB. Methods: This .. read more


10.23937/2378-3516/1410004

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Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a known risk factor for pulmonary embolism (PE); however, neither the clinical nor the pulmonary function characteristics are well described in COPD patients admitted for PE. Methods: We conducted a retrospective cohort study of 395 patients admitted for acute PE in a tertiary hospital .. read more


10.23937/2378-3516/1410003

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Genome wide association studies (GWAS) have resulted in the identification of novel genetic loci associated with a variety of diseases and clinical phenotypes, including complex lung disease such as asthma and COPD. However, the translational utilization of these expensive datasets has been restricted by multiple reasons including limited methodology to understand .. read more


10.23937/2378-3516/1410002

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Sarcoidosis is a multisystem inflammatory disease of unknown etiology that is characterized by noncaseating granuloma. Its incidence is 11 cases per 100,000 population in whites and 34 cases per 100,000 population in African Americans. Sarcoidosis most often involves the lung and intrathoracic lymph nodes but can occur in any other organ .. read more


10.23937/2378-3516/1410001

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Editor-in-Chief

Jian Fu
Associate Professor
Department of Toxicology and Cancer Biology
University of Kentucky
Center for Research on Environmental Disease
College of Medicine
USA
Tel: 859-218-1029


Editor-in-Chief

Haibin Wang
Associate Professor
Division of Allergy and Inflammation and Immunology
Department of Medicine
Beth Israel Deaconess Medical Center
USA
Tel: 617-735-4111


Editor-in-Chief

Shufeng Zhou
Professor
Associate Vice President of Global Medical Development
Associate Dean of International Research
University of South Florida
Morsani College of Medicine
USA
Tel: 813-9746276


International Journal of Anesthetics and Anesthesiology (ISSN: 2377-4630)
International Journal of Blood Research and Disorders   (ISSN: 2469-5696)
International Journal of Brain Disorders and Treatment (ISSN: 2469-5866)
International Journal of Cancer and Clinical Research (ISSN: 2378-3419)
International Journal of Clinical Cardiology (ISSN: 2469-5696)
Journal of Clinical Gastroenterology and Treatment (ISSN: 2469-584X)
Clinical Medical Reviews and Case Reports (ISSN: 2378-3656)
Journal of Dermatology Research and Therapy (ISSN: 2469-5750)
International Journal of Diabetes and Clinical Research (ISSN: 2377-3634)
Journal of Family Medicine and Disease Prevention (ISSN: 2469-5793)
Journal of Genetics and Genome Research (ISSN: 2378-3648)
Journal of Geriatric Medicine and Gerontology (ISSN: 2469-5858)
International Journal of Immunology and Immunotherapy (ISSN: 2378-3672)
International Journal of Medical Nano Research (ISSN: 2378-3664)
International Journal of Neurology and Neurotherapy (ISSN: 2378-3001)
International Archives of Nursing and Health Care (ISSN: 2469-5823)
International Journal of Ophthalmology and Clinical Research (ISSN: 2378-346X)
International Journal of Oral and Dental Health (ISSN: 2469-5734)
International Journal of Pathology and Clinical Research (ISSN: 2469-5807)
International Journal of Pediatric Research (ISSN: 2469-5769)
International Journal of Respiratory and Pulmonary Medicine (ISSN: 2378-3516)
Journal of Rheumatic Diseases and Treatment (ISSN: 2469-5726)
International Journal of Sports and Exercise Medicine (ISSN: 2469-5718)
International Journal of Stem Cell Research & Therapy (ISSN: 2469-570X)
International Journal of Surgery Research and Practice (ISSN: 2378-3397)
Trauma Cases and Reviews (ISSN: 2469-5777)
International Archives of Urology and Complications (ISSN: 2469-5742)
International Journal of Virology and AIDS (ISSN: 2469-567X)
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