International Journal of Respiratory and Pulmonary Medicine is an open access and bimonthly journal which globalizes the awareness of this medicinal and clinical information freely without any subscription for the online users. We process and accept all types of articles including original papers, reviews, short commentaries, case reports and many more. The board for the journal includes specialists, pharmacologists, scientists, practioners, and professors. Published articles undergo a detailed peer-reviewed process by professionals with the same backgrounds. We truly welcome kind suggestions from the readers which are within the scope of the journal.

The journal mainly focuses on human pulmonary and respiratory health. Focus topics include the lungs, respiration (oxygen and carbon dioxide exchange), respiratory diseases, epidemiology, treatments, recent advances and therapeutic interventions. Tobacco usage, family history, obesity, HIV/AIDS, diet, and chemical exposures that are the major risk factors for respiratory diseases constitute a significant portion of the scope of the journal. Through open access, published work is freely available, and upon acceptance and formatting, becomes immediately available to other professionals.

 
Journal Information

Title: International Journal of Respiratory and Pulmonary Medicine

ISSN: 2378-3516

Editor-in-chief: Haibin Wang, Shufeng Zhou, Jian Fu

NLM title abbreviation: Int J Respir Pulm Med

ISO abbreviation: Int J Respir Pulm Med

Other titles: IJRPM

Category: General Medicine

Country of publication: USA

Language: English

DOI: 10.23937/2378-3516

Publication format (s): Electronic and print

Publication policy: Open Access; COPE guide

Peer review: Double blind

Review speed: 3 weeks

Fast-track review: 10 days

Publication type(s): Periodicals

Publisher: ClinMed International Library

Contact email: contact@clinmedjournals.org

 
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 Open Access DOI:10.23937/2378-3516/1410087

Supine Sleep during Polysomnography and the Diagnosis of Obstructive Sleep Apnea

Dandan A, Dettenmeier P, Chang J and Espiritu JRD

Article Type: Original Article | First Published: August 23, 2018

Since the supine position worsens obstructive sleep apnea (OSA) by promoting upper airway collapse, patients may avoid supine sleep in order to mitigate its effects. However, the avoidance of supine sleep during polysomnography (PSG) may result in a missed diagnosis of OSA. This study aims to examine the association between the presence/absence of supine sleep and the diagnosis of OSA during PSG....
 

 Open Access DOI:10.23937/2378-3516/1410086

An Incidental Case of Pulmonary Amyloidosis

Fatih Uzer and Hulya Dirol

Article Type: Case Report | First Published: August 23, 2018

Amyloidosis is characterized by extra-cellular deposition of an insoluble fibrillary protein, amyloid in organs and tissues. It is classified as either primary or secondary based on the presence of concomitant diseases, ranging from chronic infection or inflammation to malignancy and as limited or systemic based on the extent of organ invasion. The clinical and radiological manifestations of amyloidosis are varrious and often nonspecific, making ...
 

 Open Access DOI:10.23937/2378-3516/1410085

The Effect of Atorvastatin on Right Ventricular Function in Chronic Obstructive Pulmonary Disease: A Randomized Controlled Trial

Hoorak Poorzand, Fariba Rezaeetalab, Masoud Sadeghipour Marvy, Aida Javanbakht, Monavar Afzalaghaei and Majid Jalalyazdi

Article Type: Research Article | First Published: August 17, 2018

Inflammation has an important role in chronic obstructive pulmonary diseases (COPD) and statins are believed to have anti-inflammatory effects beyond low-density lipoprotein cholesterol reduction. This study aimed to assess the effect of statin on the function of the right ventricle and inflammatory markers in COPD patients....
 

 Open Access DOI:10.23937/2378-3516/1410084

Visual HRCT Score to Determine Severity and Prognosis of Idiopathic Pulmonary Fibrosis

Ricardo Peris Sanchez, Estrella Fernandez-Fabrellas, Gustavo Juan Samper, Maria Luisa Domingo Montanana and Lidia Navarro Vilar

Article Type: Original Article | First Published: August 16, 2018

High-resolution computed tomography (HRCT) is an essential technique for the diagnosis and follow-up of idiopathic pulmonary fibrosis (IPF), but it is not routinely used to evaluate severity. A semi-quantitative HRCT score was developed to determine its relation with physiologic variables, to assess severity and fibrosis progression, and to establish prognostic factors....
 

 Open Access DOI:10.23937/2378-3516/1410083

A Case of Primary Pulmonary Artery Intimal Sarcoma

Chiyo Yano, Masaki Tominaga, Keisuke Miwa, Yoshiko Naito, Yuki Sakazaki, Takuma Koga, Masaki Okamoto, Tomotaka Kawayama, Tomoaki Hoshino, Reiji Muto, Koichi Ohshima and Masanori Hisaoka

Article Type: Case Report | First Published: July 26, 2018

A 28-year-old Japanese woman complained of right chest pain, fever, and cough. Chest radiography revealed consolidation in her right lower lobe with a pleural effusion. She was diagnosed with pneumonia and treated with antibiotics, but her condition did not improve. She was referred to our hospital for evaluation. Contrast-enhanced computed tomography (CT) demonstrated a large saddle filling defect extending into the right pulmonary artery as wel...
 

 Open Access DOI:10.23937/2378-3516/1410082

An Asymptomatic Haemorrhagic Pleural Effusion Mimicking Extra-Pulmonary Tuberculosis in a Young Woman with Thoracic Endometriosis Syndrome: A Case Report

Vipula R Bataduwaarachchi, Jayani Jayawardhana, Champa Weerasinghe, Aflah Sadikeen, Roshana Constantine and Kirthi Gunasekara

Article Type: Case Report | First Published: July 14, 2018

A young woman presented with an asymptomatic recurrent right sided pleural effusion. Pleural fluid full report showed neutrophilic and haemorrhagic effusion. Adenosine deaminase level in the pleural fluid was elevated and the Mantoux test was positive. Microbiological diagnosis was negative, and she was started on anti-tuberculous therapy on clinical grounds for extrapulmonary tuberculosis. Diagnostic Thoracoscopy revealed characteristic appearan...
 

 Open Access DOI:10.23937/2378-3516/1410081

Tuberculosis Diagnosis in Private Independent Laboratories in Kampala- Uganda Implications for TB Control in the City

D Lukoye, D Okello, S Namatovu, A SSebagereka, K Mutesasira, Mabumba Eldad, M Nandala and P Suarez

Article Type: Research Article | First Published: July 13, 2018

Tuberculosis remains the greatest killer globally. Uganda, one of the highest TB burden countries has a rapidly growing private medical sector. Although a large proportion of patients first seek care from the private sector, there is very little if any literature about participation of private independent laboratories in diagnosis of TB. We aimed at assessing this and the extent to which diagnosed TB patients are linked to care....
 

 Open Access DOI:10.23937/2378-3516/1410080

Respiratory Disorders in Aluminum Extrusion Workers

Ammar Awad Elshiekh Elmajzoup, Abdel Rouf Ahmed Abbas Elbadawi and Faiz Abel Wahab Mohammed

Article Type: Original Article | First Published: June 14, 2018

The present study determined the prevalence of work-induced respiratory symptoms among Sudanese extrusion workers in an aluminum (Al) extrusion plant where the health effects of exposure duration, S-Al, and U-Al concentrations were evaluated. A total of 109 workers were enrolled in our study. Ambient Al fumes was estimated using a flame atomic absorption spectrophotometer (Varian, Spectr AA-250)....
 

 Open Access DOI:10.23937/2378-3516/1410079

Fibrosing Mediastinitis: A Review of Epidemiology, Diagnosis and Management

Abraham O Kuranga, Andrea M Eubank and Mark R Bowling

Article Type: Review Article | First Published: May 14, 2018

Fibrosing Mediastinitis (FM) is a rare but increasingly recognized complication that has been mainly associated with chronic pulmonary histoplasmosis, granulomatous diseases, infections and autoimmune processes. Symptoms vary depending on compromised structures, mainly structures within the mediastinum. This review will focus on the etiology, clinical presentation and management of fibrosing mediastinitis based on multiple case series published t...
 

 Open Access DOI:10.23937/2378-3516/1410078

Different Perspective in Managing Airway Obstruction Secondary to Giant Tracheal Pyogenic Granuloma

YT Liew, KN Lorna Ting, AB Zulkiflee and N Prepageran

Article Type: Case Report | First Published: April 26, 2018

Pyogenic granuloma, or lobular capillary haemangioma is common in skin and mucosal surface such as oral cavity. It hardly occurs in tracheal mucosal, and even more rare to cause life threatening tracheal obstruction. Surgical excision is the mainstay of treatment with multidisciplinary support....
 

 Open Access DOI:10.23937/2378-3516/1410077

A Review of the Benefits, Challenges and the Future for Interfaces for Long Term Non-Invasive Ventilation in Children

Nicki Barker, Matt Willox and Heather Elphick

Article Type: Review Article | First Published: March 23, 2018

Long Term Non-Invasive Ventilation (NIV) is increasingly common and is benefitting children with a wider range of conditions. It improves quality of life and life expectancy and reduces hospital admissions and length of stay. Children are at risk however of adverse effects caused by NIV interfaces such as skin injury, facial flattening and eye problems....
 

 Open Access DOI:10.23937/2378-3516/1410076

Case Report of Lipoid Pneumonia: An Unusual Etiology of a Lung Cavity

Sravanthi Nandavaram and Dragos Manta

Article Type: Case Report | First Published: March 17, 2018

Lipoid pneumonia is an uncommon non-infectious condition that results from the accumulation of lipids of animal, vegetable or mineral origin, in the lungs. Most often it is a result of aspiration from altered swallowing or cough mechanism. Children with palatal abnormalities debilitated older adults or adults with neurological or gastrointestinal disorders are commonly affected....
 

 Open Access DOI:10.23937/2378-3516/1410075

Infections in Invasive Pleural Procedures: A Single Centre Experience

Anna Duffy and Avinash Aujayeb

Article Type: Review Article | First Published: November 24, 2017

We are an established pleural centre offering medical thoracoscopy and indwelling pleural catheters. Our infection rates with prophylactic antibiotics were lower than the national average and given the era of antibiotic stewardship and lack of evidence to support the administration, we stopped giving them....
 

 Open Access DOI:10.23937/2378-3516/1410074

Antiplatelet Exposure and Bleeding Events in Patients Undergoing EBUS-TBNA

Kevin Swiatek, Rachel Guthrie, John O Elliott and Kim Jordan

Article Type: Research Article | First Published: August 11, 2017

Periprocedural management of aspirin and clopidogrel, antiplatelet agents, for Endobronchial Ultrasound with Transbronchial Needle Aspiration (EBUS-TBNA) remains unclear. Discontinuation of antiplatelet therapy has been questioned given the low risk of hemorrhagic complications reported with this procedure....
 

 Open Access DOI:10.23937/2378-3516/1410073

Pulmonary Complications of Sickle Cell Disease in the Pregnant Patient

Kevin G Lazo, Joanna B Eldredge, Anne Press and Bushra A Mina

Article Type: Review Article | First Published: July 14, 2017

Respiratory complaints are common symptoms in pregnancy, and it is important to delineate whether the causative factor is cardiac, pulmonary, or physiologic in origin. The pathophysiology of Sickle Cell Disease (SCD) can further complicate the differential diagnosis....
 

 Open Access DOI:10.23937/2378-3516/1410072

Impact of Adopting 2014 Guidance for Palivizumab Prophylaxis for Children Previously Considered at High Risk for Severe Respiratory Syncytial Virus Disease

Rachel D Quick, Kathryn Merkel, Don K Murphey, Marisol Fernandez and Sarmistha B Hauger

Article Type: Original Article | First Published: June 22, 2017

This is a report of pediatric patients hospitalized with Respiratory Syncytial Virus Infection (RSV) during the season prior to, and 2 seasons following the 2014 palivizumab prophylaxis guidance release. The primary aim was to determine the effect of the 2014 guidance on children no longer considered eligible for prophylaxis....
 

 Open Access DOI:10.23937/2378-3516/1410071

Crimean-Congo Hemorrhagic Fever: What Do We Know about Pulmonary Injury? A Compilation of Evidence

Francisco X Leon-Roman Ismael Carrillo-Martin, Gema Fernandez-Plana and Salvador Diaz-Lobato

Article Type: Case Report | First Published: June 12, 2017

Crimean-Congo Haemorrhagic Fever (CCHF) is a lethal vector-borne viral infection produced by a Nairo virus, a genus of the Bunyan viridae family. Crimean-Congo Haemorrhagic Fever Virus (CCHFV) is a single-stranded RNA virus with three segments (large, medium, and small), two envelope proteins (Gn and Gc) and an RNA-dependent RNA polymerase....
 

 Open Access DOI:10.23937/2378-3516/1410070

The Hepatic Hydrothorax

Aujayeb A and Miller J

Article Type: Case Report | First Published: May 12, 2017

A 74-year-old with burnt out autoimmune hepatitis, portal hypertension with thrombocytopenia, oesophageal varices and previous hepatic encephalopathy has presented with a recurrence of a left sided pleural effusion. She was very breathless at rest and therapeutic aspiration of 1.1 litres of straw coloured fluid has good symptomatic benefit....
 

 Open Access DOI:10.23937/2378-3516/1410069

Pleural Lipoma

Pankaj Mathur, Vinod Namana, Sushilkumar S Gupta, Barbara Berger and Elliott Bondi

Article Type: Clinical Image | First Published: April 13, 2017

A 31-year-old male presented with complaints of a mild non-productive cough for 2 months. He had no history of smoking, fever, chills, rigors, weight loss, dyspnea, chest pain and hemoptysis. There was no history of exposure to occupational hazards or medications use. He was hemodynamically stable and had no significant findings on physical examination....
 

 Open Access DOI:10.23937/2378-3516/1410068

A Rare Case of Simultaneously Occurring Pulmonary Fungal Infections

William Li, Bhaskara Madhira and Michael Kosters

Article Type: Case Report | First Published: March 09, 2017

Endemic infections produce a spectrum of illness ranging from being subclinical to severe progressive disseminated diseases with Immuno compromised individuals being increased risk. In those with an apparently non-improving infection, a simultaneously occurring second infectious source should be considered....
 

 Open Access DOI:10.23937/2378-3516/1410067

A Single Center Review of Pleural Fluid Samples

C Walker, J Mackenzie, J Aust, J Port, D Cooper, S Parker, S Bourke, J Miller, M Weatherhead and A Aujayeb

Article Type: Research Article | First Published: February 20, 2017

All pleural aspirations done between January 1st 2014 and December 31st 2015 were analyzed for fluid biochemistry, microbe, cytology and final diagnoses (n = 264). Light's criteria were applied wherever possible. The fluid biochemistry, microbiology and cytology results were assimilated from the local electronic results system. The patient diagnosis was taken from clinic letters electronically uploaded to another system called SingleView. Local g...
 

 Open Access DOI:10.23937/2378-3516/1410066

Seromucinous Hamartoma Presenting as an Obstructive Endobronchial Mass

Guang-Qian Xiao and Sapna Patel

Article Type: Case Report | First Published: February 10, 2017

Seromucinous hamartoma is an extremely rare entity that has been described in the sinonasal cavity and nasopharynx. We here present a case of seromucinous hamartoma manifesting as an obstructive endobronchial mass in a 65-year-old male and active smoker, who presented with dyspnea upon prolonged exertion and atelectasis....
 

 Open Access DOI:10.23937/2378-3516/1410065

Effects of Chest Physical Therapy in Patients with Non-Tuberculous Mycobacteria

Basavaraj Ashwin, Segal Leopoldo, Samuels Jonathan, Feintuch Jeremy, Feintuch Joshua, Alter Kevin, Moffson Daniella, Scott Adrienne, Addrizzo-Harris Doreen, Liu Mengling and Kamelhar David

Article Type: Original Research | First Published: January 21, 2017

Antibiotic therapy against non-tuberculous mycobacteria (NTM) is prolonged and can be associated with toxicity. We sought to evaluate whether chest physical therapy (PT) was associated with clinical improvement in patients with NTM not receiving anti-mycobacterial pharmacotherapy. A retrospective review of 77 subjects that were followed from June 2006 to September 2014 was performed. Baseline time point was defined as the first positive sputum cu...
 

 Open Access DOI:10.23937/2378-3516/1410064

Inhaler Technology

Gumani D, Newmarch William, Puopolo Angelica and Casserly Brian

Article Type: Review Article | First Published: December 12, 2016

Inhalers are a commonly used device to deliver medication to individuals with airway disease. With correct use, inhalers are very effective at providing quick and effective symptomatic relief within the lung, avoiding high levels of systemic exposure. These pharmacokinetic characteristics widen the therapeutic index, thus allowing for maximal therapeutic benefit with minimal adverse effects. However, this theoretical advantage is somewhat attenua...
 

 Open Access DOI:10.23937/2378-3516/1410063

New Guidelines, Less Guidance, and the End of an Era: Healthcare -Associated Pneumonia in 2016

Jeena Jacob and Matthew Crotty

Article Type: Editorial | First Published: November 28, 2016

The 2005 guidelines recommended classification of patients based on their risk of infection by resistant bacterial pathogens. The now abandoned HCAP entity included any patient hospitalized in an acute care hospital for two or more days within 90 days of the infection; residing in a nursing home or long-term care facility; exposed to recent intravenous antibiotic-therapy, chemotherapy, or wound care within the past 30 days of the current infectio...
 

 Open Access DOI:10.23937/2378-3516/1410062

Relationship between Documented Confirmation of Endotracheal Tube Position and Mortality in the Emergency Department

Michael P Phelan, Jonathan M Glauser, Fredric M Hustey, Motunrayo Mobolaji-Lawal and Stephen W Meldon

Article Type: Original Research | First Published: November 21, 2016

We analyzed an emergency department (ED) performance improvement (PI) database from an airway registry that was developed to monitor the care of patients undergoing endotracheal intubation in prehospital settings or in the study site ED. PI initiatives included implementation of electronic health record (EHR) documentation templates for ETT placement/confirmation, an online educational module, and performance feedback....
 

 Open Access DOI:10.23937/2378-3516/1410061

Smoking Habit in Adult Population from Maracaibo City, Venezuela

Valmore Bermudez, Edgar Miquilena, Juan Salazar, Robys Gonzalez, Luis Carlos Olivar, Maria Jose Calvo, Roberto Anez, Jose R Rivas-Rios and Joselyn Rojas

Article Type: Research Article | First Published: November 06, 2016

A descriptive, cross-sectional research study, framed in the study Prevalence of Metabolic Syndrome in Maracaibo city conformed by 2,212 adults of both genders; based on the medical information the individuals were classified in smokers, non-smokers and former smokers. Quantitative variables were expressed as medians and qualitative variables as absolute and relative frequencies, using χ2 for significance and Z test for difference of proport...
 

 Open Access DOI:10.23937/2378-3516/1410060

Possible Complication of Marking Hook Wire Entry into the Systemic Circulation during Video-Assisted Thoracoscopic Surgery

Hiromasa Arai, Michihiko Tajiri, Kohei Ando, Koji Okudela, Tae Iwasawa and Munetaka Masuda

Article Type: Case Report | First Published: October 17, 2016

A 63-year-old Japanese male suffering from interstitial pneumonia underwent computed tomography (CT) guided tumor localization using a hook wire and a suture system for a small pulmonary nodule suspected of being lung carcinoma. He underwent subsequent video-assisted thoracoscopic surgery. The cut suture connecting to the metal head of the hook wire in the lung parenchyma was visible at the beginning of the procedure. During the surgery, the sutu...
 

 Open Access DOI:10.23937/2378-3516/1410059

Clinical and Radiological Predictor of Polymyositis and Dermatomyositis Associated Interstitial Lung Disease

Tomoo Kishaba, Hiroaki Nagano, Yuichiro Nei, Shin Yamashiro and Harumi Ito

Article Type: Original Article | First Published: October 03, 2016

Background: Polymyositis (PM) and dermatomyositis (DM) often have interstitial lung disease (ILD) and progression of ILD is important cause of death. Objectives: This study is conducted to clarify the important clinical, radiological factors of PM/DM ILD patients. Methods: We reviewed medical records, pulmonary function test (PFT), chest high-resolution computed tomography (HRCT) findings from January 1, 2001 to December 31, 2014 retrospectively ...
 

 Open Access DOI:10.23937/2378-3516/1410058

Drainage using Chest Tubes Smaller than 20 French is Suitable for Patients with Thoracic Empyema

Ryo Matsunuma, Kazumasa Kase, Nobuhiro Asai, Satoshi Watanabe, Yuko Waseda, Norihiro Kaneko, Masahiro Aoshima, Masaki Fujimura and Kazuo Kasahara

Article Type: Original Article | First Published: October 01, 2016

Background: Patients with thoracic empyema occasionally require chest tubes for drainage. Several studies have reported that smaller chest tubes are effective and cause fewer complications. The aim of this study was to investigate the outcomes of patients with empyema who underwent drainage using a smaller-size chest tube. Methods: We retrospectively reviewed all patients at 2 institutions with thoracic empyema. We performed both univariate and m...
 

 Open Access DOI:10.23937/2378-3516/1410057

Cross-Antigenicity of Paragonimus Westermani Egg Yolk Cells with Antibody against Surfactant Protein-D (SP-D) in Pulmonary Necrotizing Granuloma in a Native Japanese Woman

Yuji Ohtsuki, Shinji Fujioka, Masashi Uomoto, Yasuki Hachisuka, Masataka Korenaga, Atsushi Kurabayashi, Ichiro Murakami and Mutsuo Furihata

Article Type: Case Report | First Published: September 19, 2016

A native Japanese woman in her 60's complained of hemosputum and had an irregular nodular shadow in her chest radiograph. The nodule was surgically removed, and the histopathological findings of the pulmonary lesion showed a necrotizing granuloma with central irregular geographic necrosis associated with parasite eggs. The results of the enzyme-linked immunosorbent assay of her serum confirmed Paragonimus westermani (Pw) infection as the cause, o...
 

 Open Access DOI:10.23937/2378-3516/1410056

Sarcoidosis Presenting with Severe Thrombocytopenia

Yusuf Kayar, Nuket Bayram Kayar, Nurcan Unver and Iskender Ekinci

Article Type: Case Report | First Published: September 02, 2016

Sarcoidosis is a systemic granulomatous disorder of unknown causes. Haematological manifestations in sarcoidosis are uncommon and may include haemolytic anemia, leukopenia, eosinophilia and peripheral lymphopenia, but severe thrombocytopenia is rare. Causes of thrombocytopenia in sarcoidosis were identified a few mechanisms. There are no current guidelines concerning the treatment of thrombocytopenia in sarcoidosis. However, in emergency situatio...
 

 Open Access DOI:10.23937/2378-3516/1410055

Impact of Bariatric Surgery on Obstructive Sleep Apnoea in Morbidly Obese Patients; Single Centre Experience and a Literature Review

Muhammad Ali Karim, Muhammad Josheel Naveed, Amir Hussein and Abdulmajid Ali

Article Type: Original Article | First Published: September 01, 2016

Purpose: Bariatric surgery is an established treatment of morbid obesity and effectively controls symptoms of OSAHS. The aim of this study was to evaluate impact of bariatric surgery on OSAHS. Methods: Validated Epworth Sleepiness Score (ESS) and STOP-Bang questionnaires were used to assess the impact of bariatric surgery on OSAHS in morbidly obese patient's undergone bariatric surgery from May 2008 to December 2011. Change in ESS, STOP-Bang scor...
 

 Open Access DOI:10.23937/2378-3516/1410054

The Role of Histone Deacetylase Inhibitors in Myocardial Infarction

Ping Zeng and Jian Yang

Article Type: Review Article | First Published: August 25, 2016

Myocardial infarction is usually recognized as the final stage of coronary artery stenosis or occlusion in response to coronary atherosclerosis and thrombosis involving dysfunction and activation of resident vascular cells as well as the release of t-PA. As a member of family proteins for deacetylation of core histones in eukaryotic cells, Histone deacetylases are implicated in various biological processes....
 

 Open Access DOI:10.23937/2378-3516/1410053

Role of Tissue Doppler, Strain and 3D Echocardiographic Parameters in Pulmonary Hypertension

Marta Afonso Nogueira, Luisa Moura Branco, Ana Agapito, Ana Galrinho, Alexandra Borba, Ruben Ramos, Duarte Cacela and Rui Cruz Ferreira

Article Type: Original Article | First Published: August 23, 2016

Several echocardiographic parameters study right ventricular (RV) function, which has a prognostic impact on pulmonary hypertension (PH). Our goal was to evaluate the correlation between known prognostic markers and standard, as well as advanced echocardiographic parameters, including Tissue Doppler (TDI), strain imaging and three-dimensional (3D) echocardiography....
 

 Open Access DOI:10.23937/2378-3516/1410052

Diffuse Alveolar Hemorrhage as a Initial Manifestation of Henoch-Schonlein Purpura in Adults

Carmen Carrasco Cubero and Chamizo Carmona

Article Type: Case Report | First Published: August 22, 2016

Henoch-Schonlein purpura (HSP) is a systemic vasculitis that affects small-sized vessels, characterized by non-thrombocytopenic purpura, along with other clinical manifestations such as arthritis, abdominal pain, gastrointestinal bleeding and renal disease. Although the presence of subclinical alterations of pulmonary function has been noticed, the appearance of diffuse alveolar hemorrhage (DAH) is a rather an unusual symptom. We report a case of...
 

 Open Access DOI:10.23937/2378-3516/1410051

Extubation Outcome using Cough Expiratory Flow in Surgical Patients: An Observational Study

Ming-Shian Lu, Tsung-Ming Yang, Cheng-Chih Chang, Chien-Chao Lin, Yao-Kuang Huang and Ying-Huang Tsai

Article Type: Original Article | First Published: August 16, 2016

We conducted a one-year prospective observational study of adult post-surgical patients admitted to the surgical intensive care unit and mechanically ventilated for more than 24 hours. Forced cough peak expiratory flow (FCPEF) was assessed by using a digital peak flow meter placed in-line with the endotracheal before extubation after passing previously a spontaneous breathing trial....
 

 Open Access DOI:10.23937/2378-3516/1410050

An Unusual Case of Recurrent Post-Obstructive Pneumonia from Spontaneous Granulation Tissue Formation

Georges Al-Helou, Sripooja Satya, Brian Senisi, Robert Maximos and Jalil Ahari

Article Type: Case Report | First Published: July 11, 2016

A 63-year-old man known to have human immune-deficiency viral (HIV) infection was referred for evaluation following three episodes of left upper lobe pneumonia. He was well controlled on his anti-retroviral medications. Physical exam showed left upper lobe wheezing. No evidence of obstruction could be seen on chest X-ray or computed tomography (CT). Bronchoscopy was done and showed an obstructing lesion that was biopsied then ablated. It was foun...
 

 Open Access DOI:10.23937/2378-3516/1410049

Objective Quantitative CT Evaluation using Different Attenuation Ranges in Patients with Pulmonary Fibrosis: Correlations with Visual Scores

Shin Matsuoka, Tsuneo Yamashiro, Shoichiro Matsushita, Atsuko Fujikawa, Kunihiro Yagihashi and Yasuo Nakajima

Article Type: Original Article | First Published: June 30, 2016

Objective quantitative evaluation for the extent of fibrosis has been introduced using CT densitometry in patients with interstitial lung diseases, however, there have been no definitive attenuation cut-off values to evaluate the extent of ground-glass opacity and fibrosis separately. This study was conducted to investigate the relationships between quantitative CT measurements using different attenuation ranges and visual CT scores, and to deter...
 

 Open Access DOI:10.23937/2378-3516/1410048

Prevalence of Chronic Obstructive Pulmonary Disease in Southwestern Taiwan: A Population-Based Study

Su-Lun Hwang, Yu-Ching Lin, Su-Er Guo, Miao-Ching Chi, Chiang-Ting Chou and Chieh-Mo Lin

Article Type: Original Research Article | First Published: May 23, 2016

Objective: Chronic obstructive pulmonary disease (COPD) poses a substantial burden of illness in the Asia-Pacific region, as it does worldwide. However large-scale and community-based epidemiology studies of COPD in Taiwan are limited. This paper conducted a population-based study to investigate the prevalence of COPD in southwestern Taiwan. Methods: Data were conducted using a subset of medical claims data from the National Health Insurance Rese...
 

 Open Access DOI:10.23937/2378-3516/1410047

Outcome Predictors of Severe Acute Exacerbation of Chronic Obstructive Pulmonary Disease: Role of Inflammatory Biomarkers

Hanaa Shafiek, Nashwa Abd-elwahab, Manal Baddour, Akram Degady, Mohamed El-hoffy and Yehia Khalil

Article Type: Original Research Article | First Published: May 09, 2016

Objective: To assess the value of interleukin-6 (IL-6), interleukin-8 (IL-8) and C-reactive protein (CRP) in predicting the outcome of acute respiratory failure (ARF) on top of COPD. Patients and methods: Serum samples were collected from 33 COPD patients presented with ARF for IL-6, IL-8, and CRP analysis on admission, after 72 hours and after 14 days. Sputum samples were taken for microbiological evaluation. ...
 

 Open Access DOI:10.23937/2378-3516/1410046

Left Hemi-Diaphragmatic Hydatid Cyst - A Rare Presentation and Diagnostic Challenge

Haris Hakeem, Ghulam Fareed, Muhammad Irfan and Saulat Fatmi

Article Type: Case Report | First Published: April 22, 2016

Echinococcosis or hydatid cyst disease is among the oldest diseases known to man. Common presentations include involvement of liver and lungs. Hydatid cyst in diaphragm without hepatic involvement is rare and less than 100 cases are reported in literature. We are describing a case of a young female who presented with cough anddyspnea secondary to large cysts that appeared to involve the right lung and spleen on initial imaging studies. Peroperati...
 

 Open Access DOI:10.23937/2378-3516/1410045

A Case Report: What is the Real Cause of Death from Acute Chlorine Exposure in an Asthmatic Patient?

Toprak S and Kalkan EA

Article Type: Case Report | First Published: April 21, 2016

This case report presents an acute and chronic inflammation process at the same time and resulted in death following exposure to chlorine gas. A 65-years-old woman died shortly after cleaning her bathroom with a mixture of various chemicals including bleach and an acid containing product. She was declared dead when she arrives to hospital. She is a non-smoker and has no significant medical history other than asthma. Toxicological analysis showed ...
 

 Open Access DOI:10.23937/2378-3516/1410044

Prevalence of Depression/Anxiety among Medicare Beneficiaries with Chronic Obstructive Pulmonary Disease and Association with Acute Exacerbations

Christopher M. Blanchette, Melissa Roberts, Hans Petersen and Anne Fuhlbrigge

Article Type: Original Research | First Published: April 19, 2016

A prevalent cohort of Medicare beneficiaries aged 65+ with COPD (chronic bronchitis, emphysema, bronchiectasis, chronic airway obstruction) was constructed from a 5% sample of Medicare beneficiaries. Existence of depression/anxiety was identified via healthcare services or prescription drug claims. Baseline characteristics were assessed (1/1/2006-6/31/2006) and patients followed from first depression/anxiety claim until 12/31/2007 for all-cause a...
 

 Open Access DOI:10.23937/2378-3516/1410043

Platelet to Lymphocyte Ratio as a Novel Prognostic Marker in Male Patients with Chronic Obstructive Pulmonary Disease

Sezgi Sahin Duyar, Yalcin Solak, Dilek Tekis, Jale Karakaya, Ferit Kuscu and Asuman Erarslan

Article Type: Original Article | First Published: March 31, 2016

Neutrophil to lymphocyte ratio(NLR) and platalet to lymphocyte ratio (PLR) are recently defined novel inflammatory markers which are readily available. Their prognostic signifigance has been shown for a number of inflammatory diseases. A recent study evaluated the role of NLR in patients with chronic obstructive pulmonary disease(COPD). Thus, we aimed to investigate the relations between NLR, PLR and severity of COPD in male patients who had stab...
 

 Open Access DOI:10.23937/2378-3516/1410042

Respiratory Allergy as a Contributory Factor in the Development of Vocal Fold Nodules

Anica Jokic, Gordana Mumovic, Maja Buljcik-Cupic and Olga Popov-Dragin

Article Type: Review Article | First Published: March 17, 2016

Increasing evidence in the literature indicates that respiratory allergies are often a hidden contributory factor in vocal dysfunction. Although the precise allergic pathophysiological process within the vocal folds is not yet determined, modern understanding suggests that allergic changes in the lining of the larynx are an integral part of a systemic respiratory allergic reaction....
 

 Open Access DOI:10.23937/2378-3516/1410041

Palliation of Refractory Dyspnea in a Patient with End Stage COPD (Chronic Obstructive Pulmonary Disease)

Sidra Anwar and Amy Case

Article Type: Review Article | First Published: March 15, 2016

Mr. M was a 74-year-old male Korean War veteran who presented to the hospital with an acute exacerbation of his Chronic Obstructive Pulmonary Disease (COPD). The patient had a 50 pack-year history of smoking and continued to smoke one-and-a-half packs of cigarettes per day. He was frail with barrel chest and pursed lip breathing, tachypnea, and dyspneic at rest. He was on Albuterol, Ipratropium bromide, and Fluticasone propionate, in addition to ...
 

 Open Access DOI:10.23937/2378-3516/1410040

A Case Report of Endobronchial Ultrasound Needle Fracture

Som N Chalise, Craig Brown and Mark R Bowling

Article Type: Case Report | First Published: February 22, 2016

Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has many potential complications though most occur infrequently. We encountered a case in which the EBUS needle broke during TBNA. The patient was a 65 year old man who underwent EBUS-TBNA for right paratracheal lymphadenopathy. During the procedure, the TBNA needle was found to be broken. We were able to completely recover it without any complications to the patient or ...
 

 Open Access DOI:10.23937/2378-3516/1410038

Clinical features of Coronary Artery Disease Patients with Chronic Obstructive Pulmonary Disease in Japan

Hirofumi Matsuoka, Sachie Kume, Sayaka Inoue, Nao Oda, Yusuke Matsumoto, Koji Tamai, Nobuhiko Okada, Akiko Otsuka, Yasuko Koma, Kenji Kaihotsu, Harukazu Yoshimatsu, Masanori Iwahashi, Toru Miyajima and Yujiro Suzuki

Article Type: Original Research | First Published: February 08, 2016

The prevalence and mortality of chronic obstructive pulmonary disease (COPD) is expected to increase, not only in Japan but also worldwide. The prevalence of COPD is estimated to be 8.6% in Japan; however, it is reported that many COPD patients remain undiagnosed and untreated. Because COPD is a treatable and preventable disease, early diagnosis and management are important....
 

 Open Access DOI:10.23937/2378-3516/1410039

Electron Microscopic Analysis of Silicate and Calcium Particles in Cigarette Smoke Tar

R Steven Pappas, Mary M Halstead and Clifford H Watson

Article Type: Research Article | First Published: February 11, 2016

Scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDS) supplies information that is complementary to those data traditionally obtained using inductively coupled plasma-mass spectrometry for analysis of inorganic tobacco and tobacco smoke constituents. The SEM-EDS approach was used to identify select inorganic constituents of mainstream cigarette smoke "tar". The nature of SEM-EDS instrumentation makes it an ideal choice ...
 

 Open Access DOI:10.23937/2378-3516/1410037

Debilitating Disease in a Daring Child with Determined Parents - Impact on Survival

Marie Christy Sharafine Stephen, Eswaran Venkata Raman, Gnanam Aram and Anitha Kumar

Article Type: Case Report | First Published: February 02, 2016

Pompe disease is a rare and progressive lysosomal storage disorder, of autosomal recessive inheritance. Disease onset and progression range from early infantile onset which is fatal and rapidly progressive to the late onset formthatis slowly progressive, but leads to severe respiratory dysfunction and significant morbidity. Besides, scoliosis and other spine deformities cause substantial workload on the already compromised ventilation. This has a...
 

 Open Access DOI:10.23937/2378-3516/1410036

Endobronchial Lipoma in a Never-Smoker

Li Wang, Meenakshi Bansal and Guang-Qian Xiao

Article Type: Case Report | First Published: December 22, 2015

Endobronchial lipomas, usually found in the obese and in smokers, can cause patients significant distress with chronic cough, chest pain, dyspnea, and increased infection risk. Here we present a case of a 61 year-old obese, never-smoker gentleman who initially presented with chronic productive cough, hemoptysis, chills and night sweats; and was later found to have a right upper lobe lung parenchymal lesion. Biopsy demonstrated a picture consisten...
 

 Open Access DOI:10.23937/2378-3516/1410035

Important Considerations for Providers Regarding the Use of Electronic Cigarettes

Lucinda England, Joseph G. Lisko and R. Steven Pappas

Article Type: Editorial | First Published: November 01, 2015

The use of electronic nicotine delivery systems such as electronic cigarettes has increased considerably in recent years among youth and adults. While the majority of adult electronic cigarette users are current conventional cigarette smokers, an increasing number of adolescents who have not previously smoked are using use electronic cigarettes. Despite these trends, many health care providers report feeling uninformed about the health risks asso...
 

 Open Access DOI:10.23937/2378-3516/1410034

An Unusual Case of Left-Sided Massive Biliothorax

Maria Jose Soler-Sempere, Nuria Vicente-Ibarra and Laura Heredia-Oliva

Article Type: Case Report | First Published: October 31, 2015

Biliothorax and pleurobiliary fistula are rare complications secondary to biliary tree diseases. We report the case of a patient with left massive pleural effusion secondary to biliothorax without fistula or ascites. To our knowledge, this is the first case to be described with left side biliothorax....
 

 Open Access DOI:10.23937/2378-3516/1410033

Distinct Sex-Specific Gene Expression Changes in the Placenta in Association with Childhood Allergy

Astrud R Tuck,Luke E Grzeskowiak, Annette Osei-Kumah, Zarqa Saif, Suzanne M Edwards, Andrew Tai, Susan L Prescott, MeriTulic, Richard Saffery and Vicki L Clifton

Article Type: Research Article | First Published: October 29, 2015

The prevalence of allergic disease has risen significantly during recent years. A major component of the susceptibility to allergic disease is determined in prenatal life, when the placenta plays a central role in fetal growth and development. In this study, we aimed to identify the patterns of gene expression in the placenta that may program early immune function to increase susceptibility to allergy....
 

 Open Access DOI:10.23937/2378-3516/1410032

Iatrogenic Tracheal Rupture - The Role of a Thoracic Surgeon

Nikolaos Panagiotopoulos, Mohamed. A Gulamhussein, Davide Patrini, Rajeev Shukla, Martin Lees, Martin Hayward, Shyamsunder Kolvekar and David Lawrence

Article Type: Case Report | First Published: October 28, 2015

Iatrogenic tracheal rupture following intubation is a rare, but potentially lethal complication. Usually patients present with the classical symptoms of mediastinal subcutaneous emphysema and respiratory distress. However, the timing or the onset of these symptoms is quite variable and differs between patients....
 

 Open Access DOI:10.23937/2378-3516/1410031

Genetics and its Associated Pathways of Pulmonary Arterial Hypertension

Rui Fan, Daniel Penny and Yuxin Fan

Article Type: Review Article | First Published: October 23, 2015

Pulmonary arterial hypertension (PAH) is a devastating disease with significantly reduced survival. To date, no tested therapies have demonstrated an ability to reverse or cure the disease. The etiology of PAH is heterogeneous and incompletely understood. Genetics plays an important role in idiopathic and heritable PAH. Many germline gene mutations have been described as promoters of PAH and include mutations in the gene coding BMPR2, which has b...
 

 Open Access DOI:10.23937/2378-3516/1410030

A Pain in the Neck: A Pott's Disease Case Study

Caitlin Naureckas, Jonathan Movson and E Jane Carter

Article Type: Case Report | First Published: October 20, 2015

A 21-year-old Guatemalan male presented with six months of headaches and neck pain. MRI of the cervical spine demonstrated multiple inflammatory processes, both within the paraspinal soft tissue as well as within the bone itself, including the appearance of total destruction of C1. Microbiologic confirmation of Mycobacterium tuberculosis was made by fine needle aspiration. The patient was treated medically with appropriate anti-tuberculosis thera...
 

 Open Access DOI:10.23937/2378-3516/1410029

Respiratory Symptoms and Lung Function among Danish Construction Workers. A Cross-Sectional Study

Dorte Jessing Agerby Hanskov, Charlotte Brauer, Nina Breinegaard and Lilli Kirkeskov

Article Type: Original Research Article | First Published: October 2, 2015

This study investigated whether Danish construction workers had an increased prevalence of chronic obstructive pulmonary disease (COPD) or affected lung function and if the prevalence differed between types of jobs within construction....
 

 Open Access DOI:10.23937/2378-3516/1410028

Case Report: Laryngocele- A Rare Cause of OSAS and Respiratory Distress

Shlomo Merchavy and Nadav Bartal

Article Type: Case Report | First Published: September 16, 2015

Laryngocele is rare condition in which dilation of the laryngeal saccule that extends upward the false vocal cord, is filled with air, and is in communicating with the laryngeal lumen1. It can presents as neck mass or as cystic lesion in the neck. Awareness regarding this rare entity can help the physician in making the correct diagnosis....
 

 Open Access DOI:10.23937/2378-3516/1410027

Outcomes of Moderate-Severe Community-Acquired Pneumonia in Patients with Diabetes Mellitus: Impact of Systemic Steroids and Time to First Dose of Appropriate Antibiotic Therapy

Mazen S. Bader, Kassem Abouchehade, Annie A. Brooks, Yanqing Yi

Article Type: Research Article | First Published: September 10, 2015

In patients with diabetes mellitus (DM), community-acquired pneumonia (CAP) is associated with significant morbidity and mortality. The primary objective of the study was to describe the clinical outcomes and risk factors for moderate-severe CAP in hospitalized patients with DM. Methods: We conducted a retrospective cohort study of 156 hospitalized patients with DM and moderate-severe CAP at two tertiary medical centers....
 

 Open Access DOI:10.23937/2378-3516/1410026

A Study to Determine the Level of Knowledge, Attitudes and Practices on the Cause, Treatment, Prevention and Control of ILI Infections

Philip M Muthoka, Dismas Ongore and Mary Kinoti

Article Type: Research Article | First Published: September 07, 2015

ILI infections are infections of the human respiratory tract. They are caused by various viruses including corona viruses, adeno-viruses, influenza virus types A, B and C, among others (CDC- US, 2005). When these infections are circulating within the community, patients with ILI infections who have both cough and fever within 48 hours of symptom onset are likely to have influenza (A or B) infections. In Kenya, these infections cause significant m...
 

 Open Access DOI:10.23937/2378-3516/1410025

Differentially Expressed Proteins in Response to Resuscitation of NonCulturable Cells of Mycobacterium tuberculosis H37Rv: Potential New Drug Targets

Ravi Kr. Gupta, Bhavnesh Kumar, Deepa Bisht, Kiran Katoch, Kalyan Mitra and Ranjana Srivastava

Article Type: Case Report | First Published: August 03, 2015

The major obstacle in TB eradication is attributed to the dormant state of the TB bacilli, Mycobacterium tuberculosis and is characterized by asymptomatic, non-culturability and antibiotic resistant state of disease. Conventional antibiotic therapy is only applicable to the active form of the disease. These non-replicating cells can resume the growth in immunosuppression state and cause the symptomatic disease....
 

 Open Access DOI:10.23937/2378-3516/1410024

Discharge Care Bundle for Patients with Acute Exacerbations of COPD: Benefit more likely to be seen beyond 30 Days

Shorofsky M, Lebel M, Sedeno M, Zhi Li P and Bourbeau J

Article Type: Original Article | First Published: August 03, 2015

Background: COPD is associated with significant morbidity, mortality, and hospital costs. The implementation of COPD 'discharge care bundles' has been proposed as having an impact on readmissions. We developed and implemented a discharge care bundle and the aim of this study was to evaluate its effects on utilization of hospital services in a real life setting. Methods: We conducted a retrospective chart review study from 2007-2013 to evaluate ut...
 

 Open Access DOI:10.23937/2378-3516/1410023

Chronic Rhinosinusitis is Associated with Airflow Obstruction in Japanese Never-Smokers without Asthma

Keita Matsumoto, Tomotaka Kawayama, Takashi Kinoshita, Shuwa Minami, Kazuko Matsunaga, Masako Nagafuchi, Tomoaki Hoshino and Toru Rikimaru

Article Type: Original Article | First Published: July 22, 2015

Background: The relationship between chronic rhinosinusitis (CRS) and airflow obstruction is still unclear. This cross-sectional study was conducted to investigate whether CRS is an independent risk factor for airflow obstruction in never-smokers without asthma. Methods: One hundred fifty-eight subjects aged ≥ 40 yr without asthma were divided into 4 groups: 22 never-smokers with CRS, 27 smokers with CRS, 69 never-smokers without CRS, and 4...
 

 Open Access DOI:10.23937/2378-3516/1410022

Management of a Refractory Malignant Pleural Effusion in a Patient with Small Cell Lung Cancer: A Case Report

Maria M Wilczynska and Helen E Davies

Article Type: Case Report | First Published: July 20, 2015

Malignant pleural effusion (MPE) is a common presenting feature of underlying malignancy and frequently results in debilitating symptoms. In chemosensitive malignancies, such as lymphoma, small cell lung or ovarian cancers, chemotherapy is often considered the fist line treatment, however if unsuccessful, pleural intervention to achieve fluid control is required. This may include therapeutic thoracentesis, chest drain insertion, thoracoscopy, che...
 

 Open Access DOI:10.23937/2378-3516/1410021

Reference Values of Pulmonary Function Tests for Rural Canadians

Chandima P Karunanayake, James A Dosman, Louise Hagel, Donna C Rennie, Joshua A Lawson, Punam Pahwa and Saskatchewan Rural Health Study Group

Article Type: Original Research Article | First Published: June 22, 2015

Background: Pulmonary function tests are used routinely to evaluate patients with respiratory diseases and those who are at risk of developing respiratory diseases. Lung function prediction equations are generally developed for urban populations and whether these differ on rural population is not well studied. There is limited information on prediction equations for rural populations. Objective: The purpose of the present study was to derive pred...
 

 Open Access DOI:10.23937/2378-3516/1410020

Spontaneous Bacterial Pleuritis from Respiratory Source and High Adenosine Deaminase Level

Alberto Garcia-Zamalloa, Mar Zabalo, Milagros Berruete and Elena Telleria

Article Type: Case Report | First Published: April 08, 2015

An obese 85 year-old woman was admitted to the hospital because of extreme dyspnoea after one week with fever and cough. She had been previously diagnosed with myelodysplastic syndrome, chronic renal failure with creatinine 2 mg/dl, glomerular fitrate 25 ml/min; and cirrhosis with moderate persistent ascites despite diuretic treatment and mild pleural effusion reaching a fit of the right hemithorax....
 

 Open Access DOI:10.23937/2378-3516/1410019

Unusual Case of Necrotizing Pneumonia

Rajapriya Manickam, Kabir Oladipo Olaniran and Raghu Loganathan

Article Type: Case Report | First Published: April 06, 2015

Coccidioidomycosis is caused by inhalation of Coccidoides spores which is endemic in south western parts of USA and an uncommon cause of pneumonia in non-endemic areas. We report a young Hispanic man who lives in New York presenting with diabetic ketoacidosis and severe pulmonary Coccidioidomycosis....
 

 Open Access DOI:10.23937/2378-3516/1410018

Preliminary Study of Expression of KL-6, FGF-10 and MMP-9 in the Primary Spontaneous Pneumothorax

Jinxin Cao, Jinbai Miao and Hui Li

Article Type: Research Article | First Published: April 03, 2015

Pathogenesis of primary spontaneous pneumothorax (PSP) is unclear and has been rarely reported in the literature. Thus, we measured expression of Krebs Vonden Lungen-6 (KL-6), firoblast growth factor-10 (FGF-10), and matrix metalloproteinase-9 (MMP-9) in PSP samples and evaluated their significance on the development and progress of the disease....
 

 Open Access DOI:10.23937/2378-3516/1410017

International Journal of Respiratory and Pulmonary Medicine - A New Place to Publish Basic and Clinical Lung Research

Haibin Wang

Article Type: Editorial | First Published: April 02, 2015

It is true that pulmonary medicine is already well served by several specialist journals, but it is also true that it remains difficult to publish the overwhelming amount of research articles in this rapidly growing field. This is particularly the case for the researchers from the developing countries, who contribute only a limited proportion to the total research output published in leading medical journals....
 

 Open Access DOI:10.23937/2378-3516/1410016

Community Acquired Pneumonia

Sonia Akter

Article Type: Review Article | First Published: March 21, 2015

Community-acquired pneumonia is defined as an acute infection of the pulmonary parenchyma in a patient who has acquired the infection in the community. CAP remains a common and potentially serious illness. It is associated with considerable morbidity, mortality and treatment cost, particularly in elderly patients. CAP causes problems like difficulty in breathing, fever, chest pains, and cough....
 

 Open Access DOI:10.23937/2378-3516/1410015

Primary Mediastinal Goiter Resected via Cervical Approach

Benito Vargas-Abrego, Pablo Alvarez-Maldonado, Rosa M Alcazar-Lopez, Francisco C Lorente-Ludlow and Carlos Nunez-Perez Redondo

Article Type: Case Report | First Published: February 24, 2015

Primary mediastinal goiter is a rare entity. In most cases their finding is incidental. Excision is mandatory because of the risk of compression of vital structures within the chest. We report the case of a primary posterior mediastinal goiter that was resected through a cervical approach....
 

 Open Access DOI:10.23937/2378-3516/1410014

Does the Body Mass Index Affect the Success of Noninvasive Mechanical Ventilation in Patients with Acute Hypercapnic Respiratory Failure?

Esmehan Akpinar, Serdar Akpinar and Nazire Ucar

Article Type: Research Article | First Published: February 15, 2015

Objective: Obesity has many negative effects on lung functions. It is not yet clear whether body mass index (BMI) affects the success of noninvasive mechanical ventilation (NIMV). The aim of this study was to investigate the differences in NIMV strategies, on the basis of BMI, in patients with acute hypercapnic respiratory failure and the effect of BMI on the success of NIMV. Methods: A total of 86 patients who had acute hypercapnic respiratory f...
 

 Open Access DOI:10.23937/2378-3516/1410013

The Use of Independent Lung Ventilation for Unilateral Pulmonary Hemorrhage

Ajit A. Sarnaik

Article Type: Case Report | First Published: February 08, 2015

Independent Lung Ventilation (ILV) has been used in the critical care setting as a rescue therapy for differential lung disease. The purpose of anatomic separation of the lungs is to prevent blood, purulent secretions, or other debris from one lung from contaminating the other lung. Physiologic separation of the lungs allows different ventilator strategies to be applied to each lung. We report the case of the successful use of ILV in a man with c...
 

 Open Access DOI:10.23937/2378-3516/1410012

New Treatment Strategies for Influenza

Luis del Carpio-Orantes

Article Type: Mini Review | First Published: January 28, 2015

After the pandemic influenza H1N1 2009, there are many lessons learned regarding the diagnosis and treatment of patients affected by this virus. However, there have also been a number of contingencies that have greater concern to the world population, mainly by new types as infectious outbreaks, as well as the report of virus mutations that confer resistance to common treatment widely used. For new outbreaks have resulted in a new calamity, after...
 

 Open Access DOI:10.23937/2378-3516/1410011

An Enlarging Airway Foreign Body

Vijay Hadda, Kavitha Venkatnarayan, Karan Madan, Anant Mohan and GC Khilnani

Article Type: Case Report | First Published: January 26, 2015

A 25-year-old female patient presented with dry coughs of 20 days duration and fever for four days. Examination of respiratory system revealed no significant abnormality. Chest radiograph was normal. CT scan of the thorax revealed endobronchial opacity in the right main bronchus suggestive of a foreign body. Patient retrospectively recollected history of betel nut aspiration just prior to onset of symptoms. Flexible bronchoscopy revealed a large ...
 

 Open Access DOI:10.23937/2378-3516/1410010

Pulmonary Capillary Wedge Pressure Measurement: A Challenge for Diagnosis of Pulmonary Arterial Hypertension

F. Zoreka, H. Bouvaist, E. Vautrin, S. Marliere, R. Guerbaai, J. Labarere, G. Vanzetto and C. Pison

Article Type: Research Article | First Published: January 11, 2015

Background: International registries report an aging population suffering from PAH (Pulmonary Artery Hypertension) engendering diagnosis difficulties linked with growing cases of group 2 related to left heart failure with preserved Ejection Fraction (PH-HFpE). Pulmonary Capillary Wedge Pressure (PCWP) measurement by right heart catheterization remains a technical challenge for patient classification; many centers still use digital PCWP given by c...
 

 Open Access DOI:10.23937/2378-3516/1410009

Halotherapy in Patients with Cystic Fibrosis: A Pilot Study

Morhaf AlAchkar, David E. Geller, Amanshe Perera Slaney and Daniel T Layish

Article Type: Research Article | First Published: January 04, 2015

Objectives: Cystic fibrosis (CF) is a complex genetic disorder of the lower and upper respiratory tract. The purpose of this study is to evaluate the effect of Halotherapy on sinusitis symptoms, dyspnea, pulmonary function tests, and quality of life in CF patients. Study design: This was a pilot open-label before-and-after-study. Settings: The study was performed at the Orlando Salt Room. Participants were from a single CF care center, and were e...
 

 Open Access DOI:10.23937/2378-3516/1410008

Continuous Abstinence Rates at 3, 6, 9 and 12 Months in a Smoking Cessation Unit at the Albacete University Hospital Over 2 Years

Callejas Gonzalez FJ, Genoves Crespo M, Cruz Ruiz J, Tornero Molina AI, Esquinas Lopez C, Bermejo Lopez P, Garcia Castillo S, Martinez Garcia AJ, Rodriguez Montes JA5 and Tarraga Lopez PJ

Article Type: Research Article | First Published: January 04, 2015

838 patients referred 559 attended to and only 278 treated (33%); 55.4% males and 44.6% females; mean age of 46.4 years. The most important comorbidities were psychiatric (36.3%), cardiovascular (dyslipidemia 30.2%, hypertension 19.1%, diabetes 9.4%) and respiratory (chronic obstructive pulmonary disease (COPD), 15.1%; Obstructive Sleep Apnea Syndrome (OSAS), 11.9%; asthma, 7.6%). Treatments included varenicline (VRN), 36.7%, nicotine replacement...
 

 Open Access DOI:10.23937/2378-3516/1410007

Eicosapentaenoic Acid Decreases Histamine Receptor 1 Expression on Lung Microvascular Endothelial Cells and Cell Permeability during LPS Stimulation

Takaaki Osako, Michiko Aoyama-Ishikawa, Hayato Yamashita, Makoto Usami, Atsunori Nakao and Joji Kotani

Article Type: Original Article | First Published: December 26, 2014

Introduction: During acute lung inflammation, the lung microvasculature becomes hyperpermeable, resulting in immune cell infiltration and tissue edema. N-3 polyunsaturated fatty acids (PUFAs), when used as a supplement in parenteral nutrition, can attenuate Lipopolysaccharide (LPS)-induced lung injury. In this study, we examined the effects n-3 PUFAs on lung microvascular cell permeability. Material and methods: Human lung microvascular endotheli...
 

 Open Access DOI:10.23937/2378-3516/1410006

Infective Endarteritis in a Patent Ductus Arteriosus

John Fani Srour

Article Type: Case Report | First Published: December 15, 2014

The ductus arteriosus, an essential fetal structure, normally closes spontaneously soon after birth. It's persistence into late adulthood is considered rare; infective endarteritis complicating a patent ductus arteriosus (PDA) is an even rarer event. The clinical picture of an infected PDA could be subtle, and the diagnosis is frequently delayed. Symptoms may well be attributed to community acquired pneumonia, pleurisy, or pulmonary infarction fr...
 

 Open Access DOI:10.23937/2378-3516/1410005

The Differential Diagnosis of Asthma: Endobronchial Pulmonary Mesenchymoma

Mehmet Unlu, Pinar Cimen, Nuran Katgi and Salih Zeki Guclu

Article Type: Case Report | First Published: December 06, 2014

A variety of airway tumours are reported to manifest with symptoms similar to those of asthma and may cause delays in exact diagnosis because of the increase in size at a slow rate. Pulmonary endobronchial mesenchymoma is one of the slow growing tumours which is associated with symptoms or signs of airway obstruction mimicking asthma. So, patients with chronic symptoms suggestive of asthma, poor response to asthma medications, and frequent exacer...
 

 Open Access DOI:10.23937/2378-3516/1410004

A Retrospective Analysis of Patients with Pulmonary Hypertension to Assess the Role of Overnight Oximetry in the Diagnosis of Sleep Disordered Breathing

Neal M Patel, Vichaya Arunthari, Michael Heckman and Charles D Burger

Article Type: Original Retrospective Study | First Published: October 10, 2014

Background: In patients with Pulmonary Hypertension (PH), the role of overnight oximetry as means to screen for Sleep Disordered Breathing (SDB) has not been well established. The aim of this study was to assess whether overnight oximetry was additive to a standard sleep questionnaire in the diagnosis of SDB. Methods: This retrospective study included 94 PH patients seen at Mayo Clinic Florida PH Center from 1992 to 2006. Analysis was performed o...
 

 Open Access DOI:10.23937/2378-3516/1410003

Functional Characteristics of COPD Patients Admitted for Acute Pulmonary Embolism

Rodriguez DA, Orozco-Levi M, Miranda F, Mayoral A, Clements JA, Martinez-Llorens J, Ventin C, Bruguera J, Gea J and Molina LL

Article Type: Research Article | First Published: September 10, 2014

Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a known risk factor for pulmonary embolism (PE); however, neither the clinical nor the pulmonary function characteristics are well described in COPD patients admitted for PE. Methods: We conducted a retrospective cohort study of 395 patients admitted for acute PE in a tertiary hospital setting. In COPD patients, clinical characteristics and pulmonary function were compared between the ...
 

 Open Access DOI:10.23937/2378-3516/1410002

A Novel Approach to Investigate Functional Exonic SNPs Associated with Lung Diseases at Post-Transcriptional Stage

Tong Zhou and Ting Wang

Article Type: Editorial | First Published: August 18, 2014

Genome wide association studies (GWAS) have resulted in the identification of novel genetic loci associated with a variety of diseases and clinical phenotypes, including complex lung disease such as asthma and COPD. However, the translational utilization of these expensive datasets has been restricted by multiple reasons including limited methodology to understand the exact molecular function of these single nucleotide polymorphisms (SNPs)....
 

 Open Access DOI:10.23937/2378-3516/1410001

Should Endobronchial Ultrasound be Performed in All Patients with Suspected Sarcoidosis?

Omar Assasa, Mohamed Omballi and Fayez Kheir

Article Type: Editorial | First Published: August 06, 2014

Sarcoidosis is a multisystem inflammatory disease of unknown etiology that is characterized by noncaseating granuloma. Its incidence is 11 cases per 100,000 population in whites and 34 cases per 100,000 population in African Americans. Sarcoidosis most often involves the lung and intrathoracic lymph nodes but can occur in any other organ system. The most common respiratory complaints are dyspnea, shortness of breath and wheezing. However, many pa...

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Sphingosine 1-Phosphate Receptor 2 Regulates the Migration,..
Pubmed ID:27275017 | PMC ID:PMC4888913
Mammary Epithelial Cell Lineage Analysis via the Lyon's Hypothesis..
Pubmed ID:27453956 | PMC ID:PMC4957014
Epigenetic Loss of MLH1 Expression in Normal Human Hematopoietic Stem Cell..
Pubmed ID:27570841 | PMC ID:PMC4996274
Long-Term Function, Pain and Medication Use Outcomes of Radiofrequency..
Pubmed ID:26005713 | PMC ID:PMC4440581
Caspase Cleaved Tau in Alzheimer's Disease: A Therapeutic Target..
Pubmed ID:25639474 | PMC ID:PMC4308811
Corpora Amylacea in Neurodegenerative Diseases: Cause or Effect?..
Pubmed ID:26550607 | PMC ID:PMC4634668
Differences in ME and CFS Symptomology in Patients with Normal and..
Pubmed ID:28713856 | PMC ID:PMC5510614
Gene-Specific Promoter Methylation Status in Hormone-Receptor-Positive..
Pubmed ID:26005715 | PMC ID:PMC4440485
A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1..
Pubmed ID:26688830 | PMC ID:PMC4682050
Overcoming Endocrine Resistance in Hormone-Receptor Positive Advanced..
Pubmed ID:26726315 | PMC ID:PMC4697745
Zinc Ionophore (Clioquinol) Inhibition of Human ZIP1-Deficient Prostate..
Pubmed ID:26878064 | PMC ID:PMC4751054
Electron Microscopic Analysis of Silicate and Calcium Particles..
Pubmed ID:27158665 | PMC ID:PMC4858188
Effects of chest physical therapy in patients with non-tuberculous mycobacteria
Pubmed ID:28804763 | PMC ID:PMC5552049
A Community-Based Exercise and Support Group Program Improves Quality..
Pubmed ID:26640827 | PMC ID:PMC4667740
Four Weeks of Balance Training Does Not Affect Ankle Joint Stiffness in Subjects..
Pubmed ID:27642647 | PMC ID:PMC5025258
Social Ecology and Diabetes Self-Management among Pacific Islanders..
Pubmed ID:28736764 | PMC ID:PMC4516390
Examining Characteristics of Hospitalizations in Heart Failure Patients: Results..
Pubmed ID:28736765 | PMC ID:PMC5517048