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ClinMed International Library

The ClinMed International Library is a repository and an open access publisher for medical research that covers a wide range of areas in Clinical Medicine. ClinMed serves as a global platform for medical practitioners and research scholars to foster their learning and professional acumen through an extensive portfolio of research articles and publications that can be accessed without any restrictions.

Dedicated to clinical medical research, we now publish over 70 quality peer-reviewed journals making all the articles freely accessible. The manuscripts submitted to ClinMed will be processed through standard parameters and international peer review systems. This has enabled us to establish new milestones in the global research arena in terms of cogency and integrity, and to disseminate highly credible and accredited research content for researchers, scholars, and practitioners across the globe.

We ensure that all researchers and authors publishing their papers with us retain copyrights, licensed under Creative Commons Attribution License that permits the unrestricted use and re-use of the content with proper citation.

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All articles are fully peer reviewed, free to access and can be downloaded from our ClinMed archive.

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 Open Access DOI:10.23937/2378-3656/1410291

Phase Change Biological Switch: A New Hypothesis on the Mechanism of Cancer Formation

G Di Donna, MD, PhD and R. Di Muro, MD

Article Type: Research Article | First Published: November 25, 2019

The Authors hypothesize that, when in the presence of a chronic inflammatory process, the organism, while attempting to solve it, goes through a mechanism that the Authors define as Phase Change Biological Switch: the cell line regression, which differentiated in that organ with the purpose of reprogramming to overcome the chronic inflammatory process, but regression involves loss of connections with the surrounding tissues and provokes the cancerous degeneration....

 Open Access DOI:10.23937/2469-5807/1510104

Bone Marrow Necrosis and Fat Embolism in a Patient with Sickle Cell Crisis, a Fatal Complication

Gagandeep Kaur, Oluwaseyi Olayinka and Gunjan Gupta

Article Type: Case Report | First Published: November 22, 2019

Sickle cell disease is a group of inherited disorder due to substitution of valine for glutamic acid at position 6 of beta globin chain of hemoglobin leading to sickling of red blood cells. It is most common in African ancestry. The sickled RBC’s can cause vaso-occlusive crisis leading to dreadful complications. We report a case of a 56-year-old female with past medical history of sickle cell disease, atrial fibrillation and prior history of stroke. She presented to the emergency department with chief complaint of left leg pain. After few hours the pain moved to the lower and upper back. Acc...

 Open Access DOI:10.23937/2378-2951/1410162

Progressive First Degree AV Block Indicates the Need for Permanent Pacing

Han B Xiao, Waleed Arshad, Arvinder Kurbaan and Timothy J Bowker

Article Type: Research Article | First Published: November 27, 2019

First-degree AV block, though considered benign, has been reported to be associated with an increased risk for atrial fibrillation, permanent pacing, heart failure and allcause mortality. It is possible that the extent of PR prolongation indicates the severity of adverse outcome. This study investigated whether the length of PR and its change with heart rate can predict the need for permanent pacing. We retrospectively studied 21 patients with a PR over 270 ms. Nine patients underwent permanent pacing for symptomatic bradycardia or complete AV block and 12 did not. Two or more PR intervals and...

 Open Access DOI:10.23937/2378-2951/1410161

Spontaneous Hemopericardium as an Adverse Effect of Rivaroxaban Administration

Asif Surani, MD, Beatriz Martinez Quintero, MD, David Brual, MD, Hadi Elias, MD, Fahad Uddin Ahmed, MD and Matthew Peters, MD

Article Type: Case Report | First Published: November 25, 2019

Rivaroxaban is a direct oral anticoagulant with a favorable safety profile when compared to warfarin in respect to bleeding. During post-marketing surveillance, intracranial and retroperitoneal bleedings have been reported; however, hemopericardium has not been frequently described. In this case series, we present three cases of spontaneous hemopericardium where rivaroxaban was thought to be the causative agent. Predisposing factors for rivaroxaban induced hemopericardium might include impaired kidney function, concomitant use of antiplatelet agents, herbal supplements, and CYP3A4 metabolizers...

 Open Access DOI:10.23937/2643-4466/1710021

Peripheral Neuropathy as Initial Manifestation of Churg- Strauss Syndrome

Antonio Villa, MD

Article Type: Case Report | First Published: November 23, 2019

Peripheral neuropathies are well-known complications of primary systemic vasculitides. Antineutrophil cytoplasmic antibody (ANCA)-associated small vessel systemic vasculitides and medium-sized vessel vasculitis are known to frequently damage the peripheral nervous system. A 47-year-old man had a fifteen day history of pain in his lower and upper limbs associated to paresthesias and hypostenia. His medical history revealed no history of asthma, but in the last year some episodes of obstructive- congestive rhinitis were described....

 Open Access DOI:10.23937/2474-3658/1510100

Host-Related Predictors of Persistence of Hepatitis C Virus Infection

Engy Mohamed El-Ghitany and Azza Galal Farghaly

Article Type: Research Article | First Published: November 16, 2019

Spontaneous clearance occurs in varying proportions in individuals infected by hepatitis C virus (HCV). However, the factors associated with this clearance are debatable. Their recognition may lead to a better understanding of HCV natural history and eventually improve associated prediction and management models. Aim: This study was conducted to determine the host-related factors associated with persistence of HCV infection. Among 1059 HCV-antibody-positive individuals who denied receiving HCV antiviral treatment, 257 (24.3%) spontaneously cleared the virus. Patient groups with persistent infe...

 Open Access DOI:10.23937/2474-3658/1510098

Statistical Behavior of Hospital Admissions for Respiratory Diseases by Probability Distribution Functions

Amaury de Souza, Flavio Aristone, Widinei A Fernandes, Zaccheus Olaofe, Marcel Carvalho Abreu, Jose Francisco de Oliveira Junio, Guilherme Cavazzana and Cícero Manoel dos Santos

Article Type: Research Article | First Published: November 04, 2019

Climate change has a high impact on health and morbidity/ mortality in respiratory system diseases and remains poorly investigated in probability distribution modeling. The objective of this study was to analyze the adjustments of Burr (Bu), Inv Gausian 3P (IG3P), Lognormal (LN), Pert (Pe), Rayleigh 2P (Ra 2P) and Weibull 3P (W3P) distributions of the historical series of hospitalizations for respiratory diseases (total hospital admissions) for the period from 2004 to 2018, in Campo Grande, MS. For the data series, the shape and scale parameters of the distributions were determined to verify t...

 Open Access DOI:10.23937/2378-3648/1410047

Cytogenetics of Chrysichthys nigrodigitatus as Bioindicator of Environmental Pollution from Two Polluted Lagoons, South- Western Nigeria

Bassey OB, Chukwu LO and Alimba GC

Article Type: Research Article | First Published: November 14, 2019

Pollution of aquatic ecosystems from anthropogenic activities has heightened in recent times and this has elicited national and international concern on the impacts on aquatic biota. This study investigated the genotoxic effects in C. nigrodigitatus from two polluted lagoons. Micronuclei (MN) test, as an index of chromosomal damage, is widely applied in field studies. The peripheral erythrocytes from C. nigrodigitatus were subjected to MN analysis and physicochemical parameters were evaluated following APHA standardized protocol. There were significant (p < 0.05) seasonal variations in water t...

 Open Access DOI:10.23937/2469-584X/1510071

Risk Factors for Mucosal Ulceration in Gastric Gastrointestinal Stromal Tumors (GIST)

Eran Ariam, Anton Bermont, Yehuda Herskovitz, Shay Matalon, Bard Vyacheslav, Reut Yaakobi, Daana Baseem, Fadi Younis, Asia Zubkov, Efrat Broide, Benjamin Avidan, Steven F Moss and Haim Shirin

Article Type: Case Report | First Published: November 18, 2019

Gastrointestinal stromal tumors (GIST) are the most common subepithelial tumors in the gastrointestinal (GI) tract and they are usually located in the stomach. To date, only a few studies have investigated the risk factors for GIST ulceration and bleeding and there have been no prior publications focused on role of Helicobacter pylori in GIST ulceration. The aim of current study was to investigate the risk factors of mucosal ulceration in gastric GISTs. A retrospective study was conducted of 130 patients with a histological diagnosis of gastric GIST, recruited from four medical centers in Isra...

 Open Access DOI:10.23937/2474-1353/1510107

Assessment of Reproductive and Sexual Health Literacy of Women in Armenia

Mariam Barseghyan, MD, MS, Hayk Barseghyan, PhD, Gardenia E Nahigian, BA, Eric J Vilain, MD, PhD, Elena Sagayan, MD and Michael S Wilkes, MD, MPH, PhD

Article Type: Research Article | First Published: November 07, 2019

Study consisted of 173 female participants (medical personnel and general respondents) from villages of Armavir and Lori Marz in the Northern Armenia who completed confidential self-filled and validated surveys in Armenian. Questions covered demographics and addressed risk factors, symptoms, and modes of prevention of STIs and cervical cancer as well as contraceptive choices of women. Respondents’ answers were tabulated, and common themes identified. Comparison was made between general population and health care workers level of knowledge on specific topic. Both general population and medica...

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