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International Journal of Stem cell Research & Therapy is an open access, peer reviewed journal that initiates reviews and publishes articles from original research field, clinical studies and other article types in all areas of stem cells. IJSCRT will be authoritatively launched in June, 2014 are distributed as quarterly journal, on frequent processing, while frequencies steadily secure the journal as bi-monthly to monthly. IJSCRT is the major forum for translational research into stem cell therapies.

A global companion looked into IJSCRT; it distributes amazing open access examining articles with an exceptional attention on essential, translational and clinical exploration into undeveloped cell therapeutics and regenerative helps, including creature models and clinical trials. The journal additionally gives audits, perspectives, editorials and reports. Journal covers all parts of science including fundamental, clinical and translational research on heredity, organic chemistry, and physiology of different sorts of stem cells including embryonic, grown-up and actuated immature microorganisms. IJSCRT likewise distributes survey articles, specialized reports and treatise on moral issues.


Articles

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Adult stem cells hold tremendous potential for regenerative medicine. Harnessing their therapeutic benefits requires that we gain fundamental understanding of the mechanisms by which stem cells function and divide in vivo. This is hampered by the fact that stem cells often reside in compartments that remain difficult to access using imaging .. read more

December 10, 2016

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Central odontogenic fibroma (COF) is an uncommon benign tumor of the jaw, which clinically presents as a slow-growing neoplasm with cortical bony expansion. It has been postulated that COF might be derived from the inactive-like small nests or islands of odontogenic epithelium. However, the pathophysiology of this rare benign tumor remains .. read more

December 07, 2016

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Regeneration and repair is the ultimate goal of therapeutics in trauma of the central nervous system (CNS). Stroke and spinal cord injury (SCI) are two highly prevalent CNS disorders that remain incurable, despite numerous research studies and the clinical need for effective treatments. Neural engineering is a diverse biomedical field that .. read more

October 28, 2016

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A decade has passed since Shinya Yamanaka published his landmarking publication on how to produce pluripotent stem-cell-like cells and the term induced pluripotent stem cells, iPS cells, was coined. This past decade has been a decade devoted to pluripotent cells, scrutinizing molecular mechanisms in cell identity, and optimizing derivation methods, culture .. read more

August 17, 2016

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Macrophages and dendritic cells play a central role in the immune system. Here, we identify CD44(+) vascular wall-resident multipotent stem cells (VW-MPSCs) as progenitors for macrophages and dendritic cell-like cells. Using human internal thoracic artery (hITA) tissue specimens we performed ex vivo sprouting assays followed by immunohistochemistry. .. read more

August 13, 2016

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During the late 60's, the experiments with brain lesions in rats, suggested the possibility of neurogenesis in the adult brain. Three decades later, the conceptual link between adult neurogenesis and stem cells was proposed. We now know that the adult mammalian brain may have the ability to regenerate through adult neural .. read more

July 28, 2016

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The gastrointestinal epithelium is one of the tissues with highest self-renewing rates under steady-state conditions, and it thereby constitutes an excellent model to better understand how tissues maintain homeostasis. In the past decade, intense research in this field has allowed identifying stem cells responsible for this task and has contributed to .. read more

June 30, 2016

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Organisms are subjected during their lifespan to many environmental stresses such as starvation, temperature variations, chemicals, pathogens, injuries... In order to overcome the incoming stress and to yield an adapted answer, organisms have developed throughout evolution robust and conserved mechanisms such as immune response and tissue regeneration helping at maintaining their .. read more

June 30, 2016

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Osteoarthritis (OA) is predicted to be the fourth leading cause of disability in the world by the year 2020. OA results in damage to cartilage tissue and underlying subchondral bone. Current therapeutic options for osteoarthritis (OA) are limited due to the unique nature of cartilage tissue. Alternatively, mesenchymal stem cells (MSCs) .. read more

June 30, 2016

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Mesenchymal stem cells (MSCs) are multi-faceted cells capable of tissue regeneration, wound healing, and immunosuppression. Their immunosuppressive actions extend to most innate and adaptive immune cells, including TH17 cells, which have recently been discovered to be important pathogenic cells in a variety of disease settings, including many autoimmune diseases. As various .. read more

June 26, 2016

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All major metabolic and synthesis functions of liver are significantly perturbed in case of critical injury. Though liver regenerates by itself following acute injury, this process is impaired in case of chronic injury. In both cases, unless liver is allowed to regenerate by proving appropriate support, either internally or externally, depending .. read more

May 28, 2016

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Acute myeloblastic leukemia (AML) is characterized by the accumulation of immature myeloid cells, which lose their ability to differentiate into normal mature cells. The initial observations of the possibility of treatment with agents which induce terminal differentiation of myeloid leukemic cells were made by Leo Sachs and co-workers for more than .. read more

May 28, 2016

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The retina is a complex, light sensitive tissue layer on the inner surface of the eye, which functions to translate light stimuli into nerve impulses which travel to the brain via the optic nerve. Retinal diseases such as glaucoma, macular degeneration and retinitis pigmentosa can lead to significant vision problems and .. read more

May 28, 2016

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Normal human hematopoietic stem and progenitor cells (HPC) lose expression of MLH1, an important mismatch repair (MMR) pathway gene, with age. Loss of MMR leads to replication dependent mutational events and microsatellite instability observed in secondary acute myelogenous leukemia and other hematologic malignancies. Epigenetic CpG methylation upstream of the MLH1 promoter .. read more

May 24, 2016

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Mesenchymal stromal cells (MSC) are adult multipotent cells capable of differentiating into a number of different cell lineages, which can be isolated from bone marrow, adipose tissue, umbilical cord, amniotic membrane and other tissues, expanded in culture and, subsequently, administered by systemic or local routes into injured animals or ill patients. .. read more

March 31, 2016

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Mesenchymal stem cell (MSC) have the ability to self-renew and differentiate into various cell type, and they are the most widely used cell type in stem cell therapies. Designing a new MSC drug is an intricate process, considering the versatile nature of cells and the susceptibility to manufacturing processes. As the .. read more

March 31, 2016

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Novel methods are needed for this condition, and cells appear to have potential to improve fistula healing. Mesenchymal stromal cells (MSCs) have been used in several clinical trials, including phase-III studies. After an analysis of the published papers we can conclude that MSCs have evident anti-inflammatory and immune-regulatory properties, MSCs are .. read more

March 31, 2016

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Stem cell based therapy directed towards improving the long-term therapeutic outcome of heart disease in many regards remains in its infancy. Although strategies with bone marrow derived stem cells have been prevalent in clinical trials, other stem cell resources are less explored. The ability to use reprogrammed somatic cells for patient-optimized .. read more

March 30, 2016

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The regeneration of bone is a complex physiological process involved in fracture healing as well as defects created by trauma, infection, tumor resection, congenital abnormalities, and impaired or insufficient regeneration. Various bone regeneration and repair strategies exist to augment surgical reconstructive procedures, including use of alloplastic and allogenic materials, distraction osteogenesis, .. read more

February 26, 2016

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Cell surface markers for isolating proliferative human dental pulp stromal cells are currently lacking. Other tissues containing mesenchymal stromal cells have been studied in greater depth and candidate markers for cell isolation identified, one such marker being CD271. Previous reports suggest CD271 as a marker for isolating dental pulp stromal cells .. read more

February 08, 2016

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Cancer stem cells (CSCs) are self-renewing cancer cells in tumors that are suggested to be responsible for tumor initiation, progression and relapse. The molecular mechanisms of CSCs biology could provide some novel managements for cancer treatment. Sirtuins, as a family of class III deacetylases, are recently found to play essential roles .. read more

February 08, 2016

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Beta cell replacement, to supply the body with cells producing insulin, is considered as one of the most important alternative approaches to the treatment of diabetes. Transplantation of human islets and the resulting progressive improvement of clinical results confirm the approach as a positive trend in this field. Recent progress in .. read more

February 04, 2016

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The ability to target cancer cells using genetically enhanced immune effector cells armed with a chimeric antigen receptor (CAR) capable of recognising tumour associated antigen is a novel approach to the treatment of cancer. Remarkable success in early phase clinical trials has demonstrated a potent anti-cancer effect of T cells modified .. read more

February 04, 2016

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An attempt will be made to provide a short conceptual review to integrate, from an evolutionary perspective, how the emergence of gap junctional intercellular communication helped to bring about multi-cellularity and new adaptive phenotypes. This new fundamental biological function of the metazoans was needed to provide homeostatic control of new cellular .. read more

January 29, 2015

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Hypophosphatasia (HPP) is due to mutations in ALPL gene which encodes the tissue non-specific alkaline phosphatase isozyme (TNSALP). Defective/inactive TNSALP causes an increased concentration of inorganic pyrophosphate (PPi) in bone matrix that impairs bone mineralization. The accumulation of extracellular PPi observed in HPP causes impairment in bone mineralization process and leads .. read more

January 29, 2015

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Mesenchymal stem cells (MSCs) can be isolated from different adult tissues and can be differentiated along stromal lineages (i.e. osteoblasts, adipocytes, and chondrocytes). Recent data in the literature provided evidence that MSCs can also be differentiated in vitro into additional cell types, such as endothelial cells. In our studies we showed .. read more

January 13, 2015

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Implants of mammary glands from a single mammary fat pad in a H253 transgenic female mouse heterozygous for a lacZ-labeled X chromosome were analyzed at various time points following transplantation into the epithelium-cleared mammary fat pads of immune-compromised mice. The results show that the lacZ-marked X chromosome, demonstrated by nuclear-associated X-gal .. read more

January 03, 2015

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Preliminary studies based on stem cells were initially applied to the clinical setting of acute myocardial infarction (AMI) with the purpose of delivering a cardioprotective effect. The field has then rapidly expanded to embrace chronic heart failure as a cardiorestorative therapy. For the easiness of collection as hematologic tissue, Bone Marrow .. read more

January 03, 2015

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Reprogramming healthy somatic cells into disease-relevant cell types through cellular reprogramming has been intensively investigated. The discovery of reprogramming methods holds the promise of generating desired cells for disease modeling, drug screening studies and treatment of numerous diseases. Recently studies also focus on different disease cell reprogramming, including cancer cell reprogramming. .. read more

December 24, 2015

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Stem cell-based therapies in alleviating symptoms or reversing the progression of neurodegenerative diseases and nerve injuries have been investigated extensively. In this review, we first summarize our current understanding of the ontogeny of neural stem cells (NSCs) and their mobilization in vivo. We then focus on the cellular reprogramming in generation .. read more

December 21, 2015

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Mesenchymal stem cells (MSCs) are a multipotent cell population acquired most prominently from bone marrow with the capacity to differentiate into osteoblasts, chondrocytes, adipocytes, and others. MSCs demonstrate the capacity to home to sites of injury and contribute to tissue repair. Sphingosine 1-phosphate (S1P) is a biologically active sphingolipid impacting proliferation, .. read more

December 02, 2015

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Mesenchymal stem cells (MSCs) are adult stromal cells with multi-lineage differentiation potential and immunomodulatory properties. They can be isolated relatively easily from several tissues, including bone marrow and adipose tissue and can be expanded ex vivo to yield the large numbers required for a therapeutic dose. As such, MSCs are considered .. read more

November 27, 2015

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Human induced pluripotent stem cell (hiPSC) technology has widely been used for modeling of various genetic diseases. In the disease-modeling iPSC studies, it is necessary to generate hiPSC lines from peripheral tissues of multiple patients and of multiple age- and sex-matched control individuals in order to minimize the differences in genetic .. read more

October 22, 2015

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Several preclinical studies have shown potential immune-modulatory properties of mesenchymal stem cells (MSC) in type 1 diabetes leading to phase I/II clinical trials. Immune-modulatory properties of MSC have been mainly ascribed to their secretome. The extracellular vesicles (EV) have emerged as paracrine mediators of MSC actions. In fact, MSC-derived EV have .. read more

September 28, 2015

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Diabetes mellitus is a disease characterized by progressive destruction of the beta cells in the pancreatic islets of Langerhans. The current primary treatment is changing the life style and insulin injection. However, this therapy cannot provide sustained physiological glycemic control. Pancreas or islet cell transplantation would be the preferred treatment options. .. read more

July 02, 2015

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The oral cavity has proven to be an important reservoir of stem cells with the advantage of being a non-invasive source. These cells potential for maxillo-facial bone regeneration has been well documented throughout the last five years. This article aims at reviewing and discussing the different types of dental stem cells .. read more

June 02, 2015

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Regenerative endodontics is described as biologically based procedures designed to replace damaged structures, including dentin and root structures, as well as cells of the pulp-dentin complex, and is considered as an optimal approach for treating the immature permanent tooth with a necrotic pulp. .. read more

April 19, 2015

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Co-culture techniques associating both dermal firoblasts and epidermal keratinocytes have shown to have better clinical outcome than keratinocyte culture alone for the treatment of severe burns. Since fat grafting has been shown to improve scar remodelling, new techniques such as cell-therapy-assisted surgical reconstruction with isolated and expanded autologous adipose-derived stem cells .. read more

April 06, 2015

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Synthesized polyethyleneglycol (PEG) hydrogels are appealing with regard to potential for cell therapy or as vehicles for drug delivery or even to regenerate tissue with similar hydrogel-like properties such as the nucleus pulposus of the intervertebral disc (IVD). .. read more

March 28, 2015

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Bone marrow is a major source of Mesenchymal Stem Cells (MSC), which are used in tissue engineering and other autologous stem cell therapies. Studies designed to use large canine models and translate the results to human practice must take into account the ex vivo and in vitro differences in the bone .. read more

January 19, 2015

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Pancreatic progenitors have been identified and isolated during embryonic development showing their potential to differentiate into insulin producing cells after transplantation. Subsequently, they have been proposed as an alternative to the treatment of Type I diabetes. However, fetal pancreata represent a limited donor supply and we proposed that ESC-derived pancreatic progenitors .. read more

December 31, 2014

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Biocompatible polymers have been successfully implemented to generate nanofibers for bone tissue engineering. This work focused on generating and functionalizing Poly-l-Lactic-coGlycolic Acid (PLGA) nanofiber scaffolds in the range of 700 nm using the electrospinning technique. Our specific objective is to design synthetic biodegradable scaffolds comprising electrospun nanofibers that will not only .. read more

December 15, 2014

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Embryonic stem cells (ES cells) have unique differentiation and self- renewal potential which makes them a potential candidate for cell therapy in degenerative disorders. However, the limitation of deriving ES cells from embryos and their immune-incompatibility hinder their clinical applications. Fortunately, by introduction of somatic cell reprogramming technology into induced pluripotent .. read more

December 14, 2014

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Glioblastoma (GBM) is the most common and deadly primary brain malignancy, with an annual incidence of over 10,000 new cases in the US and a median survival of 14-16 months. The current standard of care includes surgical resection followed by postoperative radiotherapy and treatment with the alkylating agent temozolamide. Sadly, prognosis .. read more

August 13, 2014

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All Volume and Issues


Contact our editorial office at: editor.stemcell@clinmedlib.org


Editor-in-Chief

Faris Farassati
Director of the Molecular Medicine
Associate Professor
Department of Medicine
University of Kansas Medical Center
USA


International Journal of Anesthetics and Anesthesiology (ISSN: 2377-4630)
International Journal of Blood Research and Disorders   (ISSN: 2469-5696)
International Journal of Brain Disorders and Treatment (ISSN: 2469-5866)
International Journal of Cancer and Clinical Research (ISSN: 2378-3419)
International Journal of Clinical Cardiology (ISSN: 2469-5696)
Journal of Clinical Gastroenterology and Treatment (ISSN: 2469-584X)
Clinical Medical Reviews and Case Reports (ISSN: 2378-3656)
Journal of Dermatology Research and Therapy (ISSN: 2469-5750)
International Journal of Diabetes and Clinical Research (ISSN: 2377-3634)
Journal of Family Medicine and Disease Prevention (ISSN: 2469-5793)
Journal of Genetics and Genome Research (ISSN: 2378-3648)
Journal of Geriatric Medicine and Gerontology (ISSN: 2469-5858)
International Journal of Immunology and Immunotherapy (ISSN: 2378-3672)
International Journal of Medical Nano Research (ISSN: 2378-3664)
International Journal of Neurology and Neurotherapy (ISSN: 2378-3001)
International Archives of Nursing and Health Care (ISSN: 2469-5823)
International Journal of Ophthalmology and Clinical Research (ISSN: 2378-346X)
International Journal of Oral and Dental Health (ISSN: 2469-5734)
International Journal of Pathology and Clinical Research (ISSN: 2469-5807)
International Journal of Pediatric Research (ISSN: 2469-5769)
International Journal of Respiratory and Pulmonary Medicine (ISSN: 2378-3516)
Journal of Rheumatic Diseases and Treatment (ISSN: 2469-5726)
International Journal of Sports and Exercise Medicine (ISSN: 2469-5718)
International Journal of Stem Cell Research & Therapy (ISSN: 2469-570X)
International Journal of Surgery Research and Practice (ISSN: 2378-3397)
Trauma Cases and Reviews (ISSN: 2469-5777)
International Archives of Urology and Complications (ISSN: 2469-5742)
International Journal of Virology and AIDS (ISSN: 2469-567X)
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