International Journal of

Respiratory and Pulmonary MedicineISSN: 2378-3516

Early Online

 Open Access DOI:10.23937/2378-3516/1410132

Rheumatoid Arthritis Associated Interstitial Lung Disease in KwaZulu-Natal, South Africa: A Retrospective 5-Year Review

Hosam Ghammo, Mohammed Mitha, Catherine Connolly and Kennedy Nyamande

Article Type: Research Article | First Published: May 25, 2020

The demographic distribution, symptom profile and treatment outcomes in Rheumatoid arthritis associated interstitial lung disease (RA-ILD) has not been well described in South Africa due to a paucity of data. The aim of the study was to determine the demographic profile of the disease, symptom and radiological presentation, as well as treatments used and their outcomes at Inkosi Albert Luthuli Central Hospital (IALCH), a specialised public government hospital treating the majority of patients wi...

 Open Access DOI:10.23937/2378-3516/1410120

Acute Liver Injury: Due to a Rare Case Accompanied by Cardiac and Pulmonary Complications

Fatih Zengin, Vafa Suleymanova, Mehmet Rasih Sonsoz and Mustafa Erelel

Article Type: Case Report | First Published: September 30, 2019

One of the most important causes of acute hepatitis is vascular pathologies of the liver. There are several well-recognized forms of vascular injury to the liver, including Budd-Chiari syndrome, ischemic hepatitis, hepatic infarction and passive congestion due to hemodynamic instability. We present a case of acute liver injury accompanied by hemodynamic and respiratory pathologies. A 53-year-old lady was admitted to the emergency department with complaints of abdominal pain, nausea, vomiting for...

 Open Access DOI:10.23937/2378-3516/1410119

Effectiveness and Safety of Tunneled Pleural Catheter Placement in Patients with Malignant Pleural Effusions

Francisco Leon-Roman, Beatriz Pintado-Cort, Diana Chiluiza-Reyes, Edwin Mercedes- Noboa, Carmen Rodriguez-Calle, Diurbis Velasco-Alvarez, Andrea Perez-Figuera, Esther Barbero-Herranz, Paola Arrieta-Narvaez, Carlos Almonacid-Sanchez, Andres Quezada-Loaiza, Beatriz Prieto-Gonzalez and Deisy Barrios-Barreto

Article Type: Review article | First Published: September 26, 2019

Malignant pleural effusion (PE) is a frequent complication that worsens the quality of life and prognosis of patients with end-stage oncologic disease. Preceded only by parapneumonic PE, malignancy is one of the most common causes of pleural exudates and lung cancer accounts for as much as 37% of these cases. We used the modified scale of the Medical Research Council (mMRC) to assess for degree of dyspnea, the scale of the Eastern Cooperative Oncology Group (ECOG) to measure the functional capac...

 Open Access DOI:10.23937/2378-3516/1410118

Posterior Vitreous Detachment Prevalence in Patients with Chronic Obstructive Pulmonary Disease

Hatice Daldal, Musa Yigit and Yavuz Bardak

Article Type: Original Article | First Published: August 31, 2019

142 eyes of 71 consecutive patients with COPD who are applied to ophthalmology clinic were included in the retrospective study from January 2012 to August 2013. Trauma, ophthalmologic surgery history, diabetic retinopathy, uveitis, chorioretinitis, retinitis pigmentosa, retinal detachment and tears in the anamnesis and ophthalmologic examination were excluded from study. The visual acuity of the patients was assessed using Snellen chart. Intraocular pressure was measured with applanation tonomet...

 Open Access DOI:10.23937/2378-3516/1410117

Management of Obstructive Bronchial Fibrolipoma Bronchoscopically

Sinem Nedime Sokucu, Cengiz Ozdemir, Ozlem Kahya, Seda Tural Onur and Levent Dalar

Article Type: Case Report | First Published: August 29, 2019

Lipomas are unsual tumors endobroncially and they make 0.1 - 0.5% of lung tumors. Diagnosis is often misleading due to these non-specific symptoms and the appearance of the mass on imaging studies. Biopsy is the key feature for the diagnosis. The treatment for endobronchial lipoma is surgical or endoscopic resection. Early treatment may prevent distal lung damage. A patient with a mass lesion as a coincidental finding after chest trauma diagnosed as endobronchial fibrolipomatosis. Endobronchial ...

 Open Access DOI:10.23937/2378-3516/1410116

Diagnostic Yield of Fiberoptic Bronchoscopy for the Evaluation of Chronic Cough in Patients with Normal Chest X-Ray

Zainab Syed, Ro- Jay Reid and Roberto Solis

Article Type: Research Article | First Published: July 25, 2019

Approximately 30 million annual clinic visits are attributed to cough in the United States. Moreover, evaluation and management of persistent cough in pulmonary clinics account for roughly 40% of patient volume. The most common etiologies are: Upper airway cough syndrome (UACS), asthma, non-asthmatic eosinophilic bronchitis (NAEB) and gastro-esophageal reflux disease (GERD) - all of which are treatable. However, despite avoidance of triggers and medical therapy, there remains an elusive diagnosi...

 Open Access DOI:10.23937/2378-3516/1410115

A Case of Pregnancy in a Patient with Idiopathic Fibrosing Mediastinitis

Jeffrey Miller and Jean Elwing

Article Type: Case Report | First Published: July 11, 2019

We report a case of a 36-years-old female with known Fibrosing Mediastinitis (FM) suspected from prior Histoplamosis infection who presented for medical induction of first pregnancy. The case centers on the outpatient and peripartum management of pregnant patients in the setting of FM with consideration given to method of delivery and anesthetic options during delivery....

 Open Access DOI:10.23937/2378-3516/1410114

Unilateral Pleural Effusion, Secondary to Germinal Teratoma: A Case Report

Ramirez-Galindo Maria del Rayo, Isis Areli Lopez-Garcia, Marlenne Perales-Garcia and Fernando Vazquez-Alaniz

Article Type: Case Report | First Published: June 17, 2019

Pleural Effusion is a common medical problem with more than 50 recognized causes including disease local to the pleura or underlying lung, systemic conditions, organ dysfunction, and drugs. The majority of malignant PEf is caused by metastatic disease: Most commonly lung cancer in men and breast cancer in women. However, few germinal teratomas have been reported as the main cause of unilateral PEf....

 Open Access DOI:10.23937/2378-3516/1410113

From Triumph to Tribulation: A Granulomatous Polyangiitis Case Report

Albert Iruthiaraj Lourdesamy Anthony, Zainal Abidin Ibrahim and Li-Cher Loh

Article Type: Case Report | First Published: June 14, 2019

We report the case of a 62-years-old woman with symptoms of cough and significant loss of weight with radiological findings to support a left lower lobe lung mass. The patient was initially suspected to have metastatic lung malignancy until biopsy results suggested necrotizing granulomatous inflammation. A diagnosis of limited GPA was made when the cytoplasmic antineutrophil cytoplasmic antibodies, (c-ANCA) and antiproteinase-3 antibodies (anti-PR3) was elevated. The patient was treated with com...

 Open Access DOI:10.23937/2378-3516/1410112

Allergic Bronchopulmonary Aspergillosis Mimicking Lung Cancer: A Case Report

S Guerrini, M D'Ascanio and A Ricci

Article Type: Case Report | First Published: June 14, 2019

Allergic bronchopulmonary aspergillosis (ABPA) is an immunologically mediated lung disease caused by principally spores of Aspergillus fumigatus especially in asthmatic patients. Various set of diagnostic criteria has been advocated in different studies without a prevailing definition Treatment is based mainly on oral corticosteroids with the possible addition of antifungal agents....

 Open Access DOI:10.23937/2378-3516/1410111

Primary Ciliary Dyskinesia (PCD) Registry in Alberta, Canada: Initial Results

Ronly Har-Even Cohn and Israel Amirav

Article Type: Review Article | First Published: June 13, 2019

Primary Ciliary Dyskinesia (PCD) is a rare, genetically heterogeneous and multi-organ disorder, caused by impaired structure and/or function of motile cilia. Impaired ciliary function results in recurrent upper and lower respiratory tract infections (due to ineffective clearance of mucous secretions and inhaled particles). Clinical manifestations of PCD are diverse and include recurrent and chronic infections in the lung, ear, nasal and sinus and involvement of other systems such as cardiovascul...

 Open Access DOI:10.23937/2378-3516/1410110

Association of Pulmonary Function with Waist Circumference (WC) and Body Mass Index (BMI) among the Students of Management & Science University, Malaysia

Aniruddha Bhattacharjee, Aye Aye Myat, Shakunthala VT and Rajeev Sharma

Article Type: Research Article | First Published: June 10, 2019

Obesity is rapidly escalating in Malaysia in all age groups. Prevalence of obesity and overweight is increasing in adults and in children in both developed and developing countries. Obesity is a risk factor for many conditions including respiratory disorders regardless of BMI. However, studies investigating pulmonary functions in obese adolescents in Malaysia are few. Hence, the present study was aimed to investigate pulmonary function variables in the adolescent obese students of management and...

 Open Access DOI:10.23937/2378-3516/1410109

Seric Markers and Cell Profile in Blood and Sputum in Chronic Obstructive Pulmonary Disease Exacerbations (AECOPD)

Juliana Gjerazi, Eritjan Tashi, Irma Tashi and Jul Bushati

Article Type: Research Article | First Published: June 01, 2019

AECOPD have major implications on the quality of life, morbidity and mortality of COPD patients. In addition to their assessment on clinical presentation, which can be variable and difficult to predict, a large number of biomarkers are used. Inflammation increases during exacerbations of COPD and there are changes in systemic markers like CRP, IL 6 and PARC/CC18, as well as the cell structure in sputum and blood. The aim of this study was to investigate the diagnostic and prognostic value of pla...

 Open Access DOI:10.23937/2378-3516/1410108

Simulation Training on Mechanical Ventilation Using a High-Fidelity Ventilator Mannequin for Residents and Respiratory Therapists

Yasmin Leigh, Christian de Elia, Murali Krishna, La Tanya Taylor, Rachel Morales, Beth Kellogg and Frank Salvatore

Article Type: Research Article | First Published: June 01, 2019

Simulation-based education is thought to be more effective than traditional teaching and recent studies have described its benefits on physician performance in several clinical areas. Despite this, not many studies have researched the benefits of simulation training in teaching mechanical ventilation. With that said, this study was composed to assess the approach of mannequin simulation- based training as a method to provide an interactive learning experience for residents and respiratory therap...

 Open Access DOI:10.23937/2378-3516/1410107

An Investigation of Various Inspiratory Times and Inflation Pressures during Airway Pressure Release Ventilation

Tim W Gilmore, Robert E Walter, Patrick C Hardigan, Clifton F Frilot II and Guy M Nehrenz

Article Type: Original Research Article | First Published: May 16, 2019

There are few recommendations how best to apply certain modes of mechanical ventilation, and the application of Airway Pressure Release Ventilation (APRV) requires strategic implementation of specific inspiratory (I-time) and expiratory times (E-time) and particular mean airway pressures (MAWP), neither of which is standardized. We sought to identify whether an ideal I-time or MAWP could be identified to favor more positive clinical outcomes. A retrospective analysis of archived electronic healt...

 Open Access DOI:10.23937/2378-3516/1410106

The Bronchoscopy Role for Malignant Central Airway Obstruction

Francisco Leon-Roman, Alfonso Lopez-Frias Lopez-Jurado, Beatriz Pintado-Cort, Joaquin Asensio-Sanchez, Edwin Mercedes-Noboa, Beatriz Prieto-Gonzalez and Deisy Barrios-Barreto

Article Type: Clinical Case Report | First Published: April 26, 2019

We present the case of an active smoking 44-years-old woman (10 pack/years) diagnosed with lung adenocarcinoma T4N3M1a (stage IV) in the right upper lobe (RUL) in January 2017. She received four cycles of cisplatin-pemetrexed and radiosurgery of brain metastasis. The patient had a body mass index (BMI) of 28, with no other significant comorbidities. In July 2017, tumoral growth with secondary airway stenosis and invasion of the superior vena cava was evidenced. Given the progression of the disea...

 Open Access DOI:10.23937/2378-3516/1410105

Determination of Epidermal Growth Factor Receptor (EGFR), KRAS and BRAF Mutation in Non Small Cell Lung Cancers Using Biofilm Chip Based Microarray Technology

Ozlem Ceren Gunizi, Gulay Ozbilim and Mualla Ozcan

Article Type: Research Article | First Published: April 26, 2019

Of the 96 patients included in the study, 58 were adenocarcinomas, 30 were squamous cell carcinomas (SCC), and 8 were large cell neuroendocrine carcinomas (LCNEC). While EGFR mutation was detected in 14 (24.1%) of the adenocarcinoma patients, KRAS mutation was detected in 12 (20.6%) patients. BRAF mutation was observed in 1 patient with adenocarcinoma (1.7%). KRAS mutation was observed in only 1 of the SCCs (3.3%). KRAS mutation was observed in 1 of the LCNECs (12.5%). EGFR mutation in adenocarc...

 Open Access DOI:10.23937/2378-3516/1410104

Forced Mid-Expiratory Flow Can Predict Ventilatory Limitation and Exercise Capacity

Mandeep Hundal, Christian Ghattas, Lori Lyn Price, Peter Lacamera and John Unterborn

Article Type: Original Research Article | First Published: April 03, 2019

Exercise limitation associated with most lung diseases is multifactorial and is due to complex interactions between impaired ventilatory, cardiovascular, and peripheral muscle responses. Cardiopulmonary exercise tests (CPETs) are often required to ascertain the primary cause of exercise limitation particularly in patients with multiple co-morbidities. CPETs are generally offered only at tertiary care medical centers. To evaluate if forced expiratory flow from 25% to 75% of vital capacity (FEF25-...

 Open Access DOI:10.23937/2378-3516/1410103

Prevalence and Associated Risk Factors of Chronic Bronchitis among Aboriginal Children and Adolescents in Canada - Results from 2012 Aboriginal Peoples Survey

Punam Pahwa, Khalid Amin, Chandima Karunanayake, Sylvia Abonyi and James Dosman

Article Type: ORIGINAL RESEARCH ARTICLE | First Published: February 25, 2019

There is limited knowledge about determinants of chronic bronchitis (CB) among Aboriginal children and adolescents in Canada. The objective of the study was to determine the prevalence and associated risk factors of chronic bronchitis in Aboriginal children (6-11 yrs.) and adolescents (12-19 yrs.). Canadian Aboriginal Peoples Survey (APS)-2012 data were analyzed. Logistic regression analysis with appropriate weight variable to estimate regression coefficient and the balanced repeated replicatio...

 Open Access DOI:10.23937/2378-3516/1410102

Tropical Pulmonary Eosinophilia: An Epidemiological and Clinical Review

Joanna V Santeliz

Article Type: Review Article | First Published: February 11, 2019

Pulmonary diseases associated with parasitic infections of the lung are unusual. However, the rise in immunosuppressive conditions such as HIV/AIDS, use of antineoplastic agents and post-transplant medications among others associated with the phenomenon of globalization which entails frequent traveling and migration, has raised their prevalence both in immunocompromised and immunocompetent individuals. Tropical pulmonary eosinophilia (TPE) is a neglected tropical disease of predominantly filaria...

 Open Access DOI:10.23937/2378-3516/1410101

Is A Body Shape Index (ABSI) Predictive of Lung Functions?

Mohsen Soltanifar, Chandima Karunanayake, Dinesh Khadka, Raina Henderson, Niels Konehnck, Sylvia Abonyi, James A Dosman, Punam Pahwa, Mark Fenton and the First Nations Lung Health Project and Saskatchewan Rural Health Research Teams

Article Type: Research Article | First Published: January 19, 2019

The available spirometric lung function equations in Canadian context have been limited to age and height as predictors and Caucasian ethnicity. The plausible equations with other individual predictors and First Nations populations are missing in the current literature. To set an initial investigation in terms of study sample size and simple reference spirometric equations on the association of the set of conventional predictors in companion with two new predictors BMI and ABSI with spirometric ...

Volume 6
Issue 1