International Journal of

Respiratory and Pulmonary MedicineISSN: 2378-3516

Early Online

 Open Access DOI:10.23937/2378-3516/1410106

The Bronchoscopy Role for Malignant Central Airway Obstruction

Francisco Leon-Roman, Alfonso Lopez-Frias Lopez-Jurado, Beatriz Pintado-Cort, Joaquin Asensio-Sanchez, Edwin Mercedes-Noboa, Beatriz Prieto-Gonzalez and Deisy Barrios-Barreto

Article Type: Clinical Case Report | First Published: April 26, 2019

We present the case of an active smoking 44-years-old woman (10 pack/years) diagnosed with lung adenocarcinoma T4N3M1a (stage IV) in the right upper lobe (RUL) in January 2017. She received four cycles of cisplatin-pemetrexed and radiosurgery of brain metastasis. The patient had a body mass index (BMI) of 28, with no other significant comorbidities. In July 2017, tumoral growth with secondary airway stenosis and invasion of the superior vena cava was evidenced. Given the progression of the disea...

 Open Access DOI:10.23937/2378-3516/1410105

Determination of Epidermal Growth Factor Receptor (EGFR), KRAS and BRAF Mutation in Non Small Cell Lung Cancers Using Biofilm Chip Based Microarray Technology

Ozlem Ceren Gunizi, Gulay Ozbilim and Mualla Ozcan

Article Type: Research Article | First Published: April 26, 2019

Of the 96 patients included in the study, 58 were adenocarcinomas, 30 were squamous cell carcinomas (SCC), and 8 were large cell neuroendocrine carcinomas (LCNEC). While EGFR mutation was detected in 14 (24.1%) of the adenocarcinoma patients, KRAS mutation was detected in 12 (20.6%) patients. BRAF mutation was observed in 1 patient with adenocarcinoma (1.7%). KRAS mutation was observed in only 1 of the SCCs (3.3%). KRAS mutation was observed in 1 of the LCNECs (12.5%). EGFR mutation in adenocarc...

 Open Access DOI:10.23937/2378-3516/1410104

Forced Mid-Expiratory Flow Can Predict Ventilatory Limitation and Exercise Capacity

Mandeep Hundal, Christian Ghattas, Lori Lyn Price, Peter Lacamera and John Unterborn

Article Type: Original Research Article | First Published: April 03, 2019

Exercise limitation associated with most lung diseases is multifactorial and is due to complex interactions between impaired ventilatory, cardiovascular, and peripheral muscle responses. Cardiopulmonary exercise tests (CPETs) are often required to ascertain the primary cause of exercise limitation particularly in patients with multiple co-morbidities. CPETs are generally offered only at tertiary care medical centers. To evaluate if forced expiratory flow from 25% to 75% of vital capacity (FEF25-...

 Open Access DOI:10.23937/2378-3516/1410103

Prevalence and Associated Risk Factors of Chronic Bronchitis among Aboriginal Children and Adolescents in Canada - Results from 2012 Aboriginal Peoples Survey

Punam Pahwa, Khalid Amin, Chandima Karunanayake, Sylvia Abonyi and James Dosman

Article Type: ORIGINAL RESEARCH ARTICLE | First Published: February 25, 2019

There is limited knowledge about determinants of chronic bronchitis (CB) among Aboriginal children and adolescents in Canada. The objective of the study was to determine the prevalence and associated risk factors of chronic bronchitis in Aboriginal children (6-11 yrs.) and adolescents (12-19 yrs.). Canadian Aboriginal Peoples Survey (APS)-2012 data were analyzed. Logistic regression analysis with appropriate weight variable to estimate regression coefficient and the balanced repeated replicatio...

 Open Access DOI:10.23937/2378-3516/1410102

Tropical Pulmonary Eosinophilia: An Epidemiological and Clinical Review

Joanna V Santeliz

Article Type: Review Article | First Published: February 11, 2019

Pulmonary diseases associated with parasitic infections of the lung are unusual. However, the rise in immunosuppressive conditions such as HIV/AIDS, use of antineoplastic agents and post-transplant medications among others associated with the phenomenon of globalization which entails frequent traveling and migration, has raised their prevalence both in immunocompromised and immunocompetent individuals. Tropical pulmonary eosinophilia (TPE) is a neglected tropical disease of predominantly filaria...

 Open Access DOI:10.23937/2378-3516/1410101

Is A Body Shape Index (ABSI) Predictive of Lung Functions?

Mohsen Soltanifar, Chandima Karunanayake, Dinesh Khadka, Raina Henderson, Niels Konehnck, Sylvia Abonyi, James A Dosman, Punam Pahwa, Mark Fenton and the First Nations Lung Health Project and Saskatchewan Rural Health Research Teams

Article Type: Research Article | First Published: January 19, 2019

The available spirometric lung function equations in Canadian context have been limited to age and height as predictors and Caucasian ethnicity. The plausible equations with other individual predictors and First Nations populations are missing in the current literature. To set an initial investigation in terms of study sample size and simple reference spirometric equations on the association of the set of conventional predictors in companion with two new predictors BMI and ABSI with spirometric ...

Volume 6
Issue 1