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International Journal of Ophthalmology and Clinical Research is an international open access, peer review journal for visual science specialist and ophthalmologists. IJOCR serves the research field by publishing original articles in clinical and basic science research and other articles relating to sense of sight. Excellence in IJOCR is attained through unbiased peer review, elevated learning, advancement in innovation and discovery. IJOCR reviews articles and innovative research reports from clinical observations, clinical investigations and relevant lab investigations apt in the field of ophthalmology. IJOCR themes to publish complete and reliable information on present discoveries.

The journal mainly focused on publishing of medical and clinical research of basic and modern sense of vision, which are involved in recent advances of diseases like glucuma, uvetis, refractive surgery, cataract and other retina problems and also other related advances of eye science. IJOCR will be formally dispatched in June, 2014 are distributed as quarterly journal, on successive handling, while frequencies slowly secure the journal as bi-monthly to monthly along these lines. We are accepting article submissions for the approaching issue inside a month if articles are acknowledged for post-production. If an author interest lies between our necessities, generously go through author guidelines.


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Surgical, pre-, and postoperative data of bilateral pediatric cataract surgery cases performed between 1999 and 2007 were collected from the notes. During a prospective follow-up visit in 2008 full eye examination was done, including best corrected visual acuity (BCVA) assessment and refraction. Functional vision in daily life was assessed using a .. read more

November 22, 2016

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The report presents a case of type 3 pseudo-Duane retraction syndrome secondary to orbital trauma. There was widening of the palpebral fissure in abduction and globe retraction accompanied by narrowing of the palpebral fissure and up-shoot during attempted adduction. Orbital computed tomography scan was normal. .. read more

November 08, 2016

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We reviewed a consecutive series of 70 patients after three monthly intravitreal ranibizumab treatments for primary neovascular AMD. Age, sex, baseline vision, choroidal neovascularization type as well as OCT characteristics were correlated to final vision. On OCT, baseline integrity of the fovea was studied using foveal thickness (FTH), external limiting membrane .. read more

November 08, 2016

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The eye is a vital organ for vision and an important element of facial expression, but also as the first point of contact between people. The loss of an eye has a far-reaching impact on an individual's psyche. Additionally, it affects a patient's professional and social life. Cosmetic rehabilitation with custom .. read more

August 28, 2016

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We included 60 children with unilateral amblyopia, their age ranging between 4 and 10 years. Thirty age and sex matched healthy children were included as a control group. The included children underwent complete ophthalmologic evaluation with focus on subjective monocular visual acuity, cycloplegic refractions, slit-lamp examination, fundus examination, orthoptic evaluation, stereoacuity, .. read more

July 31, 2016

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Peripheral anterior chamber angle images of 27 eyes were taken by slit lamp biomicroscope and analyzed by automated software. The software selected region of interest and applied a light reflection extraction to detect corneal thickness (CT) and peripheral anterior chamber depth (PACD). Three observers manually counted CT (CTm) and PACD (PACDm) .. read more

July 19, 2016

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Pupil size of healthy study participants was measured with infrared-video PupilX pupillometer (MEye Tech GmbH) at 5 different illumination levels (0, 0.5, 4, 32 and 250 lux) before and after cataract surgery. Measurements were performed by the same investigator. 90 images were recorded during a measurement period of 3 seconds. The .. read more

July 08, 2016

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Thirty patients (24 women, 6 men, median age 45.5 yrs) were enrolled. Inclusion criteria were: age ≥ 18 years, good general health, ocular discomfort symptoms for over three months, Ocular Surface Disease Index (OSDI) score ranging from 18 to 36, Schirmer test > 10 mm/5 min, Tear Film Break Up Time .. read more

June 05, 2016

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Introduction: Orbital contracture is a severe cicatricial process within the enucleated orbit prohibiting the use of an ocular prosthesis and often requires socket expansion procedures. We hypothesize that the RFFF provides stable long-term expansion of the contracted orbit and allows for continued ocular prosthesis use without the accumulation of keratin debris. .. read more

May 25, 2016

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Aim: To identify challenges inherent in introducing a toric intraocular lens (IOL) to a non-refractive cataract practice, and evaluate residual astigmatism achieved and its impact on patient satisfaction. Methods: Following introduction of a toric IOL to a cataract practice with all procedures undertaken by a single, non-refractive, surgeon (SB), pre-operative, intra-operative .. read more

May 25, 2016

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The medical records of twelve newborn infants between 15 days and 3 months of age, with the presence of an unilateral dark-blue mass in the medial canthal region, as soon as after birth, were rewieved retrospectively. The management protocol was consisted of the warm compress and massage over the mass, and .. read more

May 17, 2016

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Ocular blood flow abnormalities are believed to play an important role in the pathogenesis of primary open angle glaucoma (POAG). For this reason the Color Doppler Imaging (CDI) evaluation of the retro bulbar vessels is used for research purposes to investigate the degree of these abnormalities and their role in the .. read more

May 17, 2016

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Purpose: To investigate the effect of switching patients with neovascular age related macular degeneration (nAMD) non-responsive to bevacizumab or ranibizumab to intravitreal aflibercept 2 mg on best corrected visual acuity, macula volume, and central macula thickness. Methods: 50 patients with nAMD non-responsive to bevacizumab or ranibizumab received 2 mg intravitreal aflibercept, .. read more

May 10, 2016

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Many of visual functions are usually impaired by serious retinal diseases. With different speed of progression, the point of sharpest vision is being damaged and visual acuity as well as contrast sensitivity and fixation stability declines. Instead of the damaged fovea the new preferred retinal points are arising and taking over .. read more

May 23, 2016

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Complete proximal canalicular obstruction is one of the main cause of epiphora among patients complaining about ocular discomfort in their daily life. This functional disturbance is traditionally treated by a lacrimal bypass surgery named conjunctivodacryocystorhinostomy (CDCR). Other indications for this surgery are lacrimal pump failure associated with facial palsy and epiphora .. read more

May 19, 2016

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In this report, we aimed to determine wound leakage by instillation of trypan blue onto main incision and side port incisions during phacoemulsification surgery with clear corneal incision technique. Thirty-four eyes with cataract of 34 patients, who were operated by phacoemulsification method were included in the study. Incision points were hydrated .. read more

May 13, 2016

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The pathogenic mechanism of AMD is poorly understood. The ROS and nitrogen species produced during stress may damage crucial biomolecules of the retinal pigment epithelium (RPE) cells. There is a strong relation between stress oxidative and inflammatory response in the pathology of the AMD. Actually, there are many routes of oxidative .. read more

May 07, 2016

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Tear fluid analysis contributes to the greater understanding of various ocular and systemic diseases. Obtaining adequate samples for tear analysis requires an effective collection method. The direct aspiration method using capillary micropipette may be challenging to the operator and patients especially when collecting non stimulated tear samples. The purpose of this .. read more

February 23, 2016

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Here, we report our experience with explanation of ex - press miniature glaucoma device which extruded due to conjunctival erosion in a case with Ahmed glaucoma valve implant. After explanation of the shunt, opening-insertion site on the cornea was covered with conjunctival autograft. Although transient hypotony and limited choroidal detachtment were .. read more

January 31, 2016

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Different mutations in the CNNM4 (OMIM 607805) gene are known to cause Jalili syndrome (OMIM 217080) which is characterized by a combination of cone-rod dystrophy and amelogenesis imperfecta. In particular one homozygous missense mutation Leu438Profs*9 in exon 1 of the CNNM4 gene has been described in patients originating from the Kosovo. .. read more

January 16, 2016

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Much has been written about the relationship between intraocular pressure (IOP) and glaucoma. An elevated IOP has been found to be a risk factor for both glaucoma development and progression, and IOP reduction has been useful in at least slowing disease progression [1-4]. Some glaucoma patients continue to progress in spite .. read more

December 24, 2015

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It is well established that ultraviolet (UV) radiation induces immunomodulatory effects involved in different chronic conditions including skin cancer, age-related macular degeneration (AMD), refractive errors, glaucoma and cataracts. Epidemiological studies suggest solar radiation is responsible for some of the deteriorating changes that lead to AMD Recent studies have shown that UVA .. read more

December 16, 2015

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The mechanism of flap creation with the IntraLase femtosecond laser has already been described extensively in the literature over the years. Femtosecond laser systems produce energy pulses (600 to 800 femtosecond) at an infrared wavelength of 1053 nm. The ultra-short impulses are focused at a spot size of a few micrometers .. read more

December 15, 2015

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Purpose: CEMAS group has classified nystagmus comprehensively in 2001. From that time, several attempts to make the subject as uniform as possible, needed continuous upgrading. This manuscript is an upgraded clinical approach for diagnosis of Irreversible Congenital Nystagmus, which is in addition to its being one of the major clinical features .. read more

November 26, 2015

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Purpose: To evaluate the efficacy and safety of intravitreal implant of Dexamethasone (Ozurdex, Allergan, Irvine, Calif, USA) for the treatment of refractory and chronic cystoid macular edema secondary to PPV and peeling of ERM and internal limiting membrane (ILM) with or without simultaneous cataract surgery. Methods: Seven eyes of 7 patients .. read more

October 22, 2015

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Purpose: This study examined the seemingly uninjured eye of soldiers with blast injuries involving the head, face, and fellow eye to obtain insight into primary blast ocular injuries. Methods: Serial exams were performed on nineteen U.S. Army Soldiers with a combat-related blast injury involving the head, face and either eye for .. read more

October 16, 2015

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Many clinical tests have been developed to determine the damage of visual function caused by glaucoma. These tests help in early detection of glaucoma, quantification of glaucomatous damage and progression. Currently, perimetry remains the measure of choice for studies of glaucoma progression. Visual field loss is the most prevalent and characteristic .. read more

September 23, 2015

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The ocular manifestations of systemic lupus erythematosus (SLE) are numerous and may be due to complement-activating immune complex deposition causing inflammation or thrombosis, secondary effects of SLE such as hypertension, related diseases such as Sjogren's and Antiphospholipid antibody syndrome, or a combination of these. Left untreated, these manifestations can result in .. read more

September 11, 2015

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A 43-year-old man presented with bilateral visual field defect. Large disc cupping, retinal nerve fiber layer defect, and normal intraocular pressure were found in both eyes. Although the patient was prescribed an anti-glaucoma eye drop, the visual field defect deteriorated after two months of treatment. The patient was diagnosed with sensory, .. read more

September 06, 2015

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The pathogenesis of full-thickness Macular Hole (MH) is not clearly understood but is believed to involve anteroposterior traction and/or tangential traction exerted by the posterior vitreous cortex at the fovea. Retinal Break (RB) and lattice degeneration are one of the most important abnormalities of vitreous and vitreoretinal interface. To figure out .. read more

August 29, 2015

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Purpose: We report our fist experience with the introduction of an external teaching programme in Myanmar, a country that has only recently opened to the rest of the world. Methods: 19 eyes in 18 patients were treated by surgical teams comprising a German senior surgeon and a local ophthalmologist. Diagnoses and .. read more

August 28, 2015

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Definitive surgical treatment of aphakia in the presence of corneal opacity is secondary intraocular lens (IOL) implantation combined with penetrating keratoplasty (PK). The two main locations for IOL implantation are in the anterior chamber (ACIOL) and in the posterior chamber (PCIOL). Insertion of PCIOLs can be performed by capsular-supported, iris-supported, or .. read more

August 25, 2015

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Inflammation and oxidative stress (OS) are common factors involved in the pathogenesis of several retinal diseases that eventually end in vision loss and blindness, such as age-related macular degeneration (AMD), diabetic retinopathy (DR), retinitis pigmentosa and uveitis. Most of the studies on the above mentioned diseases have been focused on the .. read more

August 23, 2015

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A 71 year-old patient presented with vision impairment and pain in the right eye due to entropion associated with trichiasis and mild-ptosis. He had a history of ocular cicatricial pemphigoid together with a lung cancer of the apex of the right lung with pleural involvement. There was a history of central .. read more

August 22, 2015

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Ocular hypertension is a well-recognized and treatable biomarker that is believed to be involved in the etiology of primary open-angle glaucoma, the second leading cause of blindness in the world. This retinopathy is a painless disease that is slow but progressive and steals the patient's sight if left untreated. Over the .. read more

August 11, 2015

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Retinitis Pigmentosa (RP) is the most common hereditary progressive retinal degenerations and is fist cause of irreversible blindness in developed countries among persons under 70 years of age. It is characterised by progressive degeneration of the retinal photoreceptors. The objective of this review was to determine the burden of RP in .. read more

July 28, 2015

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Pseudoxanthoma elasticum (PXE) is a rare, systemic disease with typical ophthalmological findings including angioid streaks (AS) (represent breaks in the Bruch's membrane). A serious and common complication of AS is the development of choroidal neovascularization (CNV), which can result in significant and irreversible vision loss. The introduction of intravitreal agents that .. read more

July 20, 2015

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Purpose: To report the first case of acute ophthalmic artery occlusion as initial manifestation of Acquired Immunodeficiency Syndrome (AIDS) in context of marked Human Immunodeficiency Virus-1 (HIV-1) viremia and otherwise negative work-up. Methods: Report of a 25 year-old previously healthy man who presented to a hospital-based tertiary care referral center with .. read more

July 20, 2015

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Orbital exenteration is a disfiguring procedure that leaves a large defect. Free flaps are increasingly widely used to fill this. We report our single centre series of free flap reconstruction, which adds to the literature base on flap choice and potential complications. Methods: A retrospective single centre consecutive case series of .. read more

June 25, 2015

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We present a case of compressive optic neuropathy from a small hemangioma in the orbital apex causing a mostly temporal visual field defect with some extension nasally on the pattern deviation plot. Given the visual field defect, the location of this lesion was expected to be in the anterior chiasm or .. read more

June 23, 2015

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Ependymomas constitute the third most common histological type of CNS tumor in children. Compared to classic cellular ependymoma (WHO grade II), anaplastic ependymoma is a more aggressive and less common subtype of ependymal neoplasm. We report a case of a supratentorial anaplastic ependymoma in a child presenting with a right sixth .. read more

June 01, 2015

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Retinal Angiomatous Proliferation (RAP) is a process that occurs in patients with Age-Related Macular Degeneration (AMD) in which retinal capillaries proliferate and invade posteriorly into the choroid. RAP lesions have a characteristic appearance of finger like projections at the level of the outer retina which can resemble inflammatory neovascularization. This case .. read more

May 25, 2015

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Background and objective: Silicone oil (SO) is important in vitreoretinal surgery. The incidence of glaucoma after silicone oil tamponade (SOT) was investigated. Study design/patients and methods: A retrospective chart review of patients with SOT at the University of Chicago from 2005 to 2008 was conducted to determine the incidence of Silicone .. read more

May 14, 2015

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The use of antiangiogenic drugs (anti-VEGF) has been described in several retinal diseases, so their use has become a common practice in most eye centers around the world. Since its application involves an invasive procedure, several complications have been described associated with their use, including from subconjunctival hemorrhage to devastate endophthalmitis. .. read more

May 11, 2015

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Purpose: To determine whether those myopes who respond like hyperopes when tested with a multivergence hologram are progressive myopes and to investigate the role of latent accommodation in the development of progressive myopia. Methods: Recently, we introduced a specially designed hologram to test the vision of spectacle corrected subjects. A subject .. read more

April 10, 2015

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Retrospective review of the case of a nineteen year old gentleman who presented with a purulent ocular discharge and in whom peripheral corneal melt occurred. .. read more

April 02, 2015

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Corticosteroids are currently the mainstay treatment for IRD but are associated with adverse side effects, recurrence on discontinuation of medication, and limited response if significant fibrosis is already present. Pentoxyphylline (POF) and α-tocopherol (AT) are anti-inflammatory and anti-fibrosing agents that can be effective in treating both the acute inflammatory and chronic .. read more

March 31, 2015

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We report the case of a 30-year-old woman implanted with an irisfixated lens (Artisan, OPHTEC) in the right eye (RE) and with an implantable contact lens (ICL) (V4, STAAR) the left eye (LE) for the correction of high myopia. The patient complained of halos and distortion on the RE 4 years .. read more

March 31, 2015

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Congenital retinal macrovessel is a large aberrant vessel discovered as an incidental finding. These aberrant vessels are mostly single, unilateral veins. CRMs do not affect vision unless there are associated foveolar cysts, foveal ectopic, pigmentary changes at fovea, macular haemorrhage, exudates, serous macular detachment or the macrovessel crosses the fovea. Thorough .. read more

March 12, 2015

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Aim: We propose the use of lamellar keratoplasty associated with nasal mucosal graft for the reconstruction of the ocular surface in multiple recurrent pterygium. Methods: Our patient had undergone four operations of nasal pterygium excision on the right eye, using different surgical procedures: simple excision, excision plus conjunctival autograft, removal plus .. read more

February 28, 2015

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A 35 year-old male patient with pellucid marginal corneal degeneration underwent crescentic lamellar excision with autolamellar dissection on his left eye. One month later, the patient developed localized corneal edema overlying the area of the crescentic resection due to Descemet membrane detachment. .. read more

February 26, 2015

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Medical records of 32 patients (56 eyes) were retrospectively analysed. Primary outcomes included ocular inflammatory activity, frequency of uveitis attacks and steroid-sparing effect. Results: Mean follow-up was 33,2 months while mean age of patients at disease onset was 33,3 years. Ocular inflammation was bilateral in 75% of cases and consisted in .. read more

February 26, 2015

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Purpose: We report a case of a 35-year old male who presented with unilateral conjunctival extranodal marginal zone (MALT) lymphoma and underwent systemic Rituximab immunotherapy as primary treatment. After an excellent initial response and four years of complete remission he presents with MALT lymphoma to the contralateral conjunctiva. Methods: MALT lymphoma .. read more

February 23, 2015

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Purpose: To evaluate the phonotypical and functional effect of interferon alfa-2a therapy on peripheral blood CD4+CD25+ T regulatory (Treg) cells in patients with Behcet uveitis. Methods: Blood was taken from 5 patients with refractory Behcetpanuveitis and 5 age-matched healthy controls. Flow cytometric analysis of CD4+CD25+Treg cells was performed. CD4+CD25+Treg cells were .. read more

February 13, 2015

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We previously reported successful establishment of retinal progenitor cell clones. Here, we cultured them on temperature reversible gelation polymer, with supplementation of several chemokines. The retinal progenitor cell clones formed a cell sheet with extension of their axon like processes. RT-PCR of the cell sheets after two week culture, they were .. read more

February 05, 2015

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Purpose: To investigate the causes of multifocal granular hyperfluorescence at the macula on Fluorescein Angiography (FA) in Japanese patients. Methods: I retrospectively studied 1,457 consecutive Japanese patients (1,457 eyes) who underwent digital simultaneous FA and indocyanine green angiography (ICGA). Results: One hundred forty-seven of the 1,457 eyes had multifocal granular hyperfluorescence .. read more

January 30, 2015

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Measuring optic disc size is an essential part of the optic nerve head for evaluation for glaucoma. Large discs that appearing to have large cups may in fact be physiologic because of normal neuroretinal rim area. Small discs may appear to have a normal cup to disc ratio, but have decreased .. read more

January 25, 2015

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Purpose: To report on the development of macular hole after treatment of choroidal neovascularization (CNV) in a patient with high myopia and epiretinal membrane (ERM). Methods: Retrospective single case report.Patients: A 60-year-old man presented with reduced vision in his right eye. On the initial examination, the right eye was high myopic .. read more

January 21, 2015

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Objective: To study the association of spectral domain optical coherence tomography (SD-OCT) based alterations in macular thickness and inner segment-ellipsoid band (ISel) with severity of retinopathy in cases of type 2 diabetes mellitus. Method: Two hundred thirty eight consecutive cases and seventy nine healthy controls were included. Eyes of cases were .. read more

January 14, 2015

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Purpose: To evaluate the effectiveness of biweekly (twice-permonth) bevacizumab for treatment-resistant neovascular agerelated macular degeneration (nAMD). Methods: The charts of nAMD subjects treated with biweekly bevacizumab injections because of persistent retinal edema on optical coherence tomography (OCT) despite consecutive monthly anti-vascular endothelial factor (VEGF) therapy were retrospectively reviewed. Results: There were .. read more

January 13, 2015

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Purpose: To ascertain the etiology of fourth (CN4) and sixth nerve palsies (CN6) in an ophthalmology clinic. Methods: This retrospective study consisted of 176 patients with fourth and sixth nerve palsies in a strabismus clinic. Demographic features and etiology were recorded. Results: One hundred and three patients with fourth nerve palsy .. read more

December 29, 2014

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Background: To evaluate retinal function and fixation stability in major depressive disorder (MDD) and the influence of antidepressant therapy, using the MP-1 microperimeter. Methods: 25 patients with MDD (57 +/- 13.73 years) and 25 healthy subjects (HS) (56.41 +/- 15.73 years) were enrolled. According to the Diagnostic and Statistical Manual of .. read more

December 29, 2014

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A decade ago, the treatment of choroidal neovascularization (CNV) secondary to various macular diseases like age related macular degeneration, pathologic myopia, and angioid streaks was a crucial challenge. Laser photocoagulation could might be performed for juxtafoveal and extrafoveal CNVs and different surgical treatment options like macular translocation surgery and subretinal CNV .. read more

October 29, 2014

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Objective: To demonstrate AD plaques in retina.
Methods: We examined 30 patients with Mild Cognitive İmpairment (MCI). In the patients in whom we found hyper or hypo florescent lesions on Fundus Auto Fluorescence (FAF), Optical Scanning Tomography (OCT) was performed through these regions to reveal depositions in the retina. Drusen like .. read more

October 17, 2014

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Aims: To compare reading performance in children with and without visual function anomalies and identify the influence of abnormal visual function and other variables in reading ability.
Methods: A cross-sectional study was carried in 110 children of school age (6-11 years) with Abnormal Visual Function (AVF) and 562 children with Normal .. read more

October 17, 2014

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Editor-in-Chief

Vernon Odom
Professor
Departments of Ophthalmology and of Physiology and Pharmacology
West Virginia University
USA


International Journal of Anesthetics and Anesthesiology (ISSN: 2377-4630)
International Journal of Blood Research and Disorders   (ISSN: 2469-5696)
International Journal of Brain Disorders and Treatment (ISSN: 2469-5866)
International Journal of Cancer and Clinical Research (ISSN: 2378-3419)
International Journal of Clinical Cardiology (ISSN: 2469-5696)
Journal of Clinical Gastroenterology and Treatment (ISSN: 2469-584X)
Clinical Medical Reviews and Case Reports (ISSN: 2378-3656)
Journal of Dermatology Research and Therapy (ISSN: 2469-5750)
International Journal of Diabetes and Clinical Research (ISSN: 2377-3634)
Journal of Family Medicine and Disease Prevention (ISSN: 2469-5793)
Journal of Genetics and Genome Research (ISSN: 2378-3648)
Journal of Geriatric Medicine and Gerontology (ISSN: 2469-5858)
International Journal of Immunology and Immunotherapy (ISSN: 2378-3672)
International Journal of Medical Nano Research (ISSN: 2378-3664)
International Journal of Neurology and Neurotherapy (ISSN: 2378-3001)
International Archives of Nursing and Health Care (ISSN: 2469-5823)
International Journal of Ophthalmology and Clinical Research (ISSN: 2378-346X)
International Journal of Oral and Dental Health (ISSN: 2469-5734)
International Journal of Pathology and Clinical Research (ISSN: 2469-5807)
International Journal of Pediatric Research (ISSN: 2469-5769)
International Journal of Respiratory and Pulmonary Medicine (ISSN: 2378-3516)
Journal of Rheumatic Diseases and Treatment (ISSN: 2469-5726)
International Journal of Sports and Exercise Medicine (ISSN: 2469-5718)
International Journal of Stem Cell Research & Therapy (ISSN: 2469-570X)
International Journal of Surgery Research and Practice (ISSN: 2378-3397)
Trauma Cases and Reviews (ISSN: 2469-5777)
International Archives of Urology and Complications (ISSN: 2469-5742)
International Journal of Virology and AIDS (ISSN: 2469-567X)
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