International Journal of Blood Research and Disorders is a peer-reviewed publication in the field of blood research. It focuses on all aspects of hematology including blood cells, hematologic diseases, blood hemostatic mechanisms, hemato-oncology, immunology, and transfusion medicine. It also focuses on all aspects of the prevention and therapy of blood disorders.
International Journal of Blood Research and Disorders aims to publish original articles, research, reviews, case reports, short communications, commentaries etc., layering the spectrum of clinical and laboratory hematological practice and research. The classification terms include but not limited to Anemia, Platelet disorders, Eosinophilic disorders, Leukemia, Myeloma, Coagulation disorders, blood Transfusion, sepsis.
International Journal of Blood Research and Disorders ensures the faster publication of high-quality articles with the support of its eminent Editorial board members. Two independent review comments followed by editor's decision will be considered to publish the article. IJBRD is a permanent archive of information on Blood research, disorders and therapeutics which under open access category provides its global readers with free access to its content, thus serving the scientific community.
Articles Search by Keyword | Journal title | Author name | DOI
Open Access DOI:10.23937/2469-5696/1410038
Article Type: Short review | First Published: April 04, 2019
Identification of novel therapeutic targets has improved diagnostics and treatment of many diseases. Many innovative treatment strategies have been developed based on the newly identified biomarkers and key molecules. Most of the research focused on ways to manipulate signaling pathways by activating or suppressing them, validate new therapeutic targets for treatment, and epigenetic treatment of diseases. With the identification of aberrations in multiple growth pathways, the focus then shifted ...
Open Access DOI:10.23937/2469-5696/1410037
Sinem Namdaroglu, MD and Gizem Yıldırım
Article Type: Research Article | First Published: March 06, 2019
Even though a single high dose administration of intravenous ferric carboxymaltose (FC) is supposed to be effective, it is unknown whether the second dose of FC given one week after the initial dose provides additional benefits. The aim of the present study was to investigate whether two doses of intravenous ferric carboxymaltose is more effective than a single dose of intravenous FC for replenishing iron stores and correction of anemia in patients with iron deficiency....
Open Access DOI:10.23937/2469-5696/1410036
Kodai Kuriyama, Hiroki Hosoi, Masaya Shimanuku, Toshiki Mushino, Shogo Murata, Akinori Nishikawa, Shinobu Tamura, Nobuyoshi Hanaoka and Takashi Sonoki
Article Type: Case Report | First Published: January 25, 2019
In previous studies, it has been reported that 10-20% of acute myeloid leukemia (AML) cases showed immunoglobulin heavy chain gene (IGH) rearrangements, a genetic hallmark of B-cell differentiation. However, the clinical significance of this is uncertain. Here, we report a case of diffuse large B-cell lymphoma (DLBCL) after complete remission (CR) from AML that exhibited an IGH rearrangement. The patient was diagnosed with AML (M4Eo) with inversion of chromosome 16 [inv(16)]. Interestingly, the ...
Open Access DOI:10.23937/2469-5696/1410035
Angeli Ambayya, Andrew Octavian Sasmita, Subramanian Yegappan and Jameela Sathar
Article Type: Research Article | First Published: January 20, 2019
The full blood count (FBC) analyzers, Sysmex XE-5000 and Unicel DxH 800, are equipped to perform routine and extended parameters tests; thus, this study considered extended red blood cell (eRBC) parameters to distinguish iron-deficient erythropoiesis related disorders. Malaysian female subjects comprising three main ethnic groups (Malay, Chinese and Indian) were included. Three groups of findings were distinguished based on FBC, morphology, and iron status of the subjects: normal, latent iron de...
Open Access DOI:10.23937/2469-5696/1410034
Mingjun He, Xiaoli Zhu, Wei Niu, Lingming Kong, Gaofeng Yao and Li-yi Zhang
Article Type: Research Article | First Published: December 12, 2018
Based on the prior studies, altered lncRNAs in peripheral blood Molecular Cells (PBMC) from depression patients were chosen to perform informatics analysis for lncRNA target gene prediction and functional annotation. Microarray was first used to screen dys regulated lncRNAs in the PBMCs of MDD patients, of which 10 lncRNAs were selected for quantitative real-time Reverse Transcription Polymerase Chain Reaction (RT-PCR) study, as well as bioinformatics analysis....
Open Access DOI:10.23937/2469-5696/1410033
Gennadiy Galstyan, Polina Makarova, Elena Parovichnikova, Larisa Kuzmina, Vera Troitskaya, Eduard Gemdzhian and Valeriy Savchenko
Article Type: Original Article | First Published: October 12, 2018
To investigate the safety of the of bone marrow-derived human multipotent mesenchymal stromal cells (MMSCs) administration in neutropenic patients with septic shock. Mesenchymal stromal cells (MMSCs) may represent a promising cell-based therapy of sepsis. MMSCs, activated by lipopolysaccharide or tumor necrosis factor-α, reprogram macrophages by releasing prostaglandin E2. Prostaglandin E2 acts on the macrophages through the EP2 and EP4 receptors and stimulates the production and release of an ...
Open Access DOI:10.23937/2469-5696/1410032
Camila Marca de Veiga Cabral, Walter Moises Tobias Braga, Adriano de Moraes Arantes, Jose Salvador Rodrigues de Oliveira, Gisele Wally Braga Colleoni and Fabio Rodrigues Kerbauy
Article Type: ORIGINAL ARTICLE | First Published: September 07, 2018
The aim of this study is to characterize Treg (FOXP3) and Th17 (RORC)-related genes in patients who underwent hematopoietic cell transplantation (HCT) and correlate them with graft-versus-host disease (GVHD) onset and patients' outcome. Fifty-one patients undergoing allogeneic HCT from matched related donors (MRD) were studied. Samples were collected before HCT, at acute (aGVHD) or chronic GVHD (cGVHD) onset, and 90 days post-HCT for those who di...
Open Access DOI:10.23937/2469-5696/1410031
Giuseppe Mele and Domenico Pastore
Article Type: Case Reports & Case Series | First Published: July 12, 2018
Patients with relapsed/refractory Multiple Myeloma (rrMM) and End Stage Renal Disease (ESRD) requiring hemodialysis must receive lenalidomide at a dosage of 5 mg daily on days 1-21 of repeated 28-day cycles, due to substantial elimination via the kidneys. Unfortunately, despite dose reduction, severe adverse events occur with a high frequency. Therefore, lenalidomide is recommended mainly in patients with mild-to-moderate renal impairment....
Open Access DOI:10.23937/2469-5696/1410030
Md Serajul Islam and Pavel Kotoucek
Article Type: Case Report | First Published: June 30, 2018
Proteinaceous lymphadenopathy is a rare non-specific lymph node changes incidence of which increases with age. This condition is usually associated with hypergammaglobulinemia or rheumatological conditions. However, this condition can also be due to unknown aetiology as we are presenting a case where no underlying case was found. It may affect nodal function, and rarely may it calcify. Histopathologist needs to be vigilant of this condition as ly...
Open Access DOI:10.23937/2469-5696/1410029
Md Serajul Islam and Pavel Kotoucek
Article Type: Research Article | First Published: June 20, 2018
Multiple myeloma (MM) is characterized by the neoplastic proliferation of plasma cell clones that produce monoclonal immunoglobulin. Dermatomyositis (DM), and to a lesser extent polymyositis (PM), carry a higher risk of cancer than that of the general population as demonstrated by several studies with the prevalence being 32% and 15% for DM and PM respectively. The mechanism underlying the association between idiopathic inflammatory myopathies (IIM) and malignancies remains unclear....
Open Access DOI:10.23937/2469-5696/1410028
Ahmad Al Ghoche, Jean Pegliasco, Jessica Anne-Marie-Sainte, Julien Cuziat, Lucas Meyer, Fatiha Najioullah, Jean Côme Meniane and Samy Chraïbi
Article Type: Case Report | First Published: October 28, 2017
We describe here the first case of a patient with post-ET myelofibrosis treated with ruxolitinib at French West Indies complicated with zika induced meningoencephalitis. Patient presented with fever, confusion along with conjunctivitis, diffuse joints pain and skin rash. PCR was positive for Zika virus in blood, urine and cerebrospinal fluid. Diagnosis of Zika induced meningoencephalitis was confirmed....
Open Access DOI:10.23937/2469-5696/1410027
Poorva Bindal, Heenam Goel, Alexei Shimanovsky, Joseph M Ryan, Jeffrey S Wasser and Enrique Ballesteros
Article Type: Case Report | First Published: September 29, 2017
The incidence of therapy-related Acute Promyelocytic Leukemia (t-APL) has been steadily rising. Radioactive Iodine (RAI) has emerged as a potential leukemogenic insult. Translocation involving the Retinoic Acid Receptor-alpha (RAR-alpha, RARa) gene on chromosome 17 and the Promyelocytic Leukemia (PML) gene on chromosome 15....
Open Access DOI:10.23937/2469-5696/1410026
Georges El Hachem
Article Type: Literature Review | First Published: July 31, 2017
Bone Marrow Necrosis (BMN) is an uncommon syndrome characterized by destruction of hematopoietic tissue with preservation of the bone. It presents as localized or diffuse generalized process. Many underlying diseases can lead to marrow necrosis: most commonly malignancies and rarely sickle cell disease....
Open Access DOI:10.23937/2469-5696/1410025
Article Type: Review Article | First Published: March 20, 2017
In recent years, the Polycomb group (PcG) of proteins has been revealed to be involved in the regulation of hematologic stem cell function and differentiation and have been broadly linked to hematologic malignancies. Polycomb proteins are histone modifiers that contain two multi-protein complexes: Polycomb Repressive Complex 1 and 2 (PRC1 and PRC2)....
Open Access DOI:10.23937/2469-5696/1410024
Diaz De-La-Noval B, Hernandez Gutierrez A, Zapardiel I, De-Santiago Garcia J and Diestro Tejeda
Article Type: Case Report | First Published: August 30, 2016
The incidence of Non-Hodgkin's Lymphoma (NHL) has been increasing in recent decades, the prevalence of extranodal-NHL is about 30 to 50% of all NHL patients. Primary Large B-cell extranodal lymphoma of the cervix is a very rare disease, 0.008% of all cervical tumors. The Diffuse large B-cell lymphoma (DLBCL) is the most common extranodal lymphoid neoplasm in around 25% of all NHL....
Open Access DOI:10.23937/2469-5696/1410023
Rami Nassabein, Mariam al khatib, Marie Helen Abbas, Marie youssef, Daniel Amer and Jaafar Wazni
Article Type: Case Report | First Published: August 30, 2016
Polycythemia Vera (PV) is a myeloproliferative disorder of bone marrow stem cells characterized by erythrocytosis. Elevated erythropoietin level strongly indicates secondary erythrocytosis and excludes PV diagnosis. However, patients with PV who co-present with Budd-Chiari syndrome (BCS) have been documented with elevated serum erythropoietin levels provided that JAK2 mutation is positive....
Open Access DOI:10.23937/2469-5696/1410022
Mariela Del Carmen Moreno, Cinthia Palacios and Yessenia Cruz
Article Type: Case Report | First Published: August 01, 2016
Bilineal leukemia is a very rare health condition, especially in pediatric patients; it is associated with poor prognosis, even without uniformity therapeutic criteria. Hereby, we present a 4-year-old boy, who debuted as T-cell lymphoblastic lymphoma, he initially received treatment induction, which was unanswered, further studies showed evidence of being bilinear leukemia (T-AML M5). He continued the AML induction therapy followed by four consol...
Open Access DOI:10.23937/2469-5696/1410021
Naglaa M Hassan, Nevin M Al-azhary and Marwa M Hussein
Article Type: Research Article | First Published: May 28, 2016
The aim of the study is to assess the level of soluble CD86 (sCD86) in patients with de novo AML and to compare them with a normal control group to determine any possible role with prognosis and clinical outcome, as the significance of sCD86 in hematologic malignancies is still controversial....
Open Access DOI:10.23937/2469-5696/1410020
Viviane Chaves Pereira, Karoline Honorato Costa and Leonardo Rodrigues de Oliveira
Article Type: Case Report | First Published: May 28, 2016
Although they are rare, severe hematologic adverse effects are described and may be fatal. The current study describes the case of a patient presenting psoriatic arthritis, and under prolonged treatment with adalimumab. His condition worsened due to severe acute thrombocytopenia and severe hemorrhagic manifestations. Adalimumab was considered to be the probable cause of the thrombocytopenia and, therefore, its use was discontinued. The treatment ...
Open Access DOI:10.23937/2469-5696/1410019
DA Ammon, H Andruszkow, L Sieg, M Wilhelmi, CF Weber, N Rahe-Meyer and AA Hanke
Article Type: Research Article | First Published: November 27, 2015
Hypothermia and acidosis are risk factors for coagulopathy during trauma. We investigated influence of fibrinogen and factor XIII on whole blood coagulation under hypothermia and acidosis in an In vitro model. Fibrinogen, but not FXIII improved coagulation significantly. Furthermore, combined administration of fibrinogen and FXIII did not show differences to administration of fibrinogen alone....
Open Access DOI:10.23937/2469-5696/1410018
CIFTCIOGLU Sule and EFE Emine
Article Type: Perspective | First Published: September 23, 2015
Hematopoietic stem-cell transplantation (HSCT) is used primarily for hematologic and lymphoid cancers but also for many other disorders. Autologous HSCT (in which stem cells are derived from the patient) is mainly used to treat chemosensitive malignancies. Allogeneic HSCT (in which the stem cells are derived from a donor) is often the preferred treatment option, particularly in patients with acute leukaemia. Oral complications are a significant c...
Open Access DOI:10.23937/2469-5696/1410017
Koksal Deveci, Serdal Korkmaz, Enver Sancakdar, Duygu Acibucu, Filiz Alkan, Hatice Terzi and Mehmet Sencan
Article Type: Research Article | First Published: September 17, 2015
A monoclonal gammopathy is defined as the electrophoretically and antigenically homogeneous protein product of a single clone of B lymphocytes and/or plasma cells that has proliferated beyond the constraints of normal control mechanisms. Monoclonal gammopathies are detected in serum and/or urine from individuals with a wide variety of neoplastic, potentially neoplastic, neurological and infectious conditions....
Open Access DOI:10.23937/2469-5696/1410016
Oktay Bilgir, Ferda Bilgir, Mehmet Calan and Giray Bozkaya
Article Type: Research Article | First Published: September 05, 2015
Generally, ET is a myeloproliferative disorder characterized by persistent peripheral thrombocytosis and abnormal megakaryocytic proliferation in the bone marrow. ET is a rare cause of thrombocytosis and may be associated with both venous and arterial thrombosis in 10-75% of cases, depending largely on the study and whether vasomotor symptoms are included in thrombotic manifestations....
Open Access DOI:10.23937/2469-5696/1410015
Tom Rider, John Jones, John Brewin, Gillian Horne, Jack Wills, Hannah Barton, Kevin Boyd, Timothy Corbett, Sabina Dizdarevic and Timothy Chevassut
Article Type: Research Article | First Published: July 09, 2015
Early stage Hodgkin's Lymphoma (HL) has excellent outcomes and recent research has focused on minimising treatment-related toxicities. However, the role of 18F-florodeoxyglucose positron emission tomography (FDG PET) imaging in this setting is not fully determined. We retrospectively calculated overall survival (OS) and relapse free survival (RFS) in stage I-II HL when radiotherapy was omitted if post-chemotherapy FDG PET imaging was negative....
Open Access DOI:10.23937/2469-5696/1410014
Apostolos Pourtsidis, Marina Servitzoglou, Margarita Baka, Despina Bouhoutsou, Maria Varvoutsi, Dimitrios Doganis, Katherine Strantzia-Michail and Helen Kosmidis
Article Type: Research Article | First Published: May 10, 2015
Aims and background: Our objective was to analyze the clinical and demographic characteristics of children with B-cell lymphoma treated in a single center over the last two decades. Methods: Data was collected by a retrospective review of the charts of all 76 patients treated to our unit, from 1990 to 2010, with FAB LMB 89, 96 protocols and 2003 modifications....
Open Access DOI:10.23937/2469-5696/1410013
Hacene Brouk and Hanifa Ouelaa
Article Type: Review Article | First Published: April 30, 2015
Fetal and neonatal alloimmune thrombocytopenia (F/NAIT), caused by fetomaternal mismatch for human platelet (PLT) alloantigens (HPAs), is the commonest cause of severe thrombocytopenia in term neonates and is analogous to the fetal/neonatal anaemia caused by haemolytic disease of the newborn (HDN). The most feared complication of this syndrome is the occurrence of intracranial hemorrhage leading to death or neurological sequels....
Open Access DOI:10.23937/2469-5696/1410012
Gebrewahd Gebretsadkan, Kebede Tessema, Henock Ambachew and Misganaw Birhaneselassie
Article Type: Research Article | First Published: April 01, 2015
Hematocrit is a test that measures a percentage of blood that is comprised of red blood cell. This is often referred to as packed cell volume (PCV) or erythrocyte volume fraction. It is considered as an integral part of a person's complete blood count, along with hemoglobin concentration, white blood cell count and platelet counts....
Open Access DOI:10.23937/2469-5696/1410011
Shefali Nath and Joshua R Peck
Article Type: Case Report | First Published: March 26, 2015
We report a case of Zieve's syndrome in a patient with a longstanding history of alcohol abuse admitted for acute alcoholic hepatitis. Zieve's syndrome is defied as the triad of hemolytic anemia, hypertriglyceridemia, and jaundice in patients with known liver disease. It is an uncommon diagnosis, but is an important one to consider in patients with known liver disease admitted with these constellation of signs and symptoms....
Open Access DOI:10.23937/2469-5696/1410010
Adrienne A. Phillips, Jalanni Giddings, Shing M. Lee and Steven M. Horwitz
Article Type: Case Report | First Published: March 21, 2015
Adult T-cell Leukemia/Lymphoma (ATLL) is resistant to chemotherapy and the acute and lymphomatous subtypes of disease have a dismal prognosis. There is no standard therapy for relapsed or refractory disease in Western countries and new agents are being explored. Lenalidomide is an immunomodulatory agent with promising activity in hematologic malignancies, including non-Hodgkin's lymphoma and represents a novel therapeutic option. ...
Open Access DOI:10.23937/2469-5696/1410009
Kee Kiat Yeo, Jonathan G. Murnick, Marijean M. Miller and Anne L. Angiolillo
Article Type: Case Report | First Published: February 23, 2015
Intraocular relapse of Acute Lymphoblastic Leukemia (ALL) is rare. Prompt diagnosis and treatment can minimize vision loss. We report a case of a young girl diagnosed with pre-B ALL who was initially treated successfully with chemotherapy....
Open Access DOI:10.23937/2469-5696/1410008
Fatma H Sajwani and Moza A Khuzam
Article Type: Research Article | First Published: February 20, 2015
Thrombophilia is a group of disorders that increases the patient's risk of thrombosis. Inherited causes of thrombophilia are challenging to diagnose and once diagnosed may subject the patient to prolonged treatment. The extent of the condition is not well established in UAE and data on prevalence and demographics are lacking. This study aimed at setting a baseline data on the prevalence, demographics and clinical presentation of thrombophilia in ...
Open Access DOI:10.23937/2469-5696/1410007
Michael Bursey, Kane Curtis, Robert Gibson, Hongyan Xu and Matthew Lyon
Article Type: Research Article | First Published: February 17, 2015
Hemoglobin (Hgb) measurement is an important risk-stratification tool for patients presenting to the Emergency Department with vaso-occlusive crisis (VOC) from sickle cell disease (SCD). Point-of- care (POC) Hgb testing such as the HemoCue device decreases time to identification of significant anemia. However, there are no studies evaluating the accuracy of HemoCue testing in patients with SCD and VOC. The purpose of this study was to evaluate th...
Open Access DOI:10.23937/2469-5696/1410006
Starkova AV, Syropyatov B Ya, Sobin FV and Pulina NA
Article Type: Case Report | First Published: February 08, 2015
The aim of this research is to study the mechanism of action of the newly synthesized substance - Thiazoline Ammonium 4-Chlorophenyl-2-Hydroxy-4-Oxo-2-Butenoate (FS-169), which possesses the direct anticoagulant activity. The research was conducted with the use of 'АPG4-02-P' coagulometer. For the purposes of the study the rabbit plasma was used. The results show that FS-169 effectively changes Partial thromboplastin time and prothrombin ti...
Open Access DOI:10.23937/2469-5696/1410005
Manuela Pagano, Chiara Galletto, Maurizio Bianchi and Franca Fagioli
Article Type: Case Report | First Published: January 21, 2015
Background: Caffey disease is a rare syndrome caused by mutation in the alpha-1 collagen type I gene, not described in literature as a predisposing condition to cancer development. Observation: We report a case of a 6-years-old female diagnosed with Caffey disease that developed a localized neuroblastoma. The patient had a poor clinical and radiological response with unusual disease dissemination and progression until death. Conclusion: The case ...
Open Access DOI:10.23937/2469-5696/1410004
Nabeel Al Moamen, Fawzia Mahdi, Ahmed Thabet, Rugaya Abbas, Ebtihal Salman and Ahmed Al Alawi
Article Type: Letter to Editor | First Published: January 15, 2015
A total of 1187 patients with α-thalassemia phenotype presentation have been recruited for this investigation. Preliminary diagnosis of α-thalassemia was based on low hematological indices (MCV and MCH) of the red blood cells and/or persistently low hemoglobin levels, along with low or normal levels of HbA2 and absence of iron deficiency. Th molecular diagnosis of α-thalassemia was established by using a commercially available ^...
Open Access DOI:10.23937/2469-5696/1410003
Chakra P Chaulagain and Kenneth B Miller
Article Type: Case Report | First Published: December 22, 2014
Malignancy associated Sweet syndrome (acute febrile neutrophilic dermatosis) accounts for approximately 20% of all cases of Sweet syndrome and is characterized by painful, erythematous inflammatory papules and nodules that can precede, coincide or follow malignancies with predilection for hematologic malignancies. Corticosteroids are the cornerstone of treatment with exquisite response which has made many clinicians to include steroid responsiven...
Open Access DOI:10.23937/2469-5696/1410002
Article Type: Editorial | First Published: July 31, 2014
Some medicines may interact with mineral, with the result that changes occur in the concentration of minerals and other blood parameters that are associated with mineral status. Interpretation of the results of morphological and biochemical blood analyses therefore needs to take into account the drugs used by patients....
Open Access DOI:10.23937/2469-5696/1410001
Article Type: Editorial | First Published: July 30, 2014
Oncolytic reovirus continues to pick up momentum as a novel agent in the treatment of cancer. Since the initial discovery of the virus' tendency to preferentially replicate in transformed cell lines from studies in the late 1970s, reovirus has rapidly progressed from preclinical to clinical trials evaluating its efficacy across a spectrum of malignancies, including hematologic....
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