International Journal of

Blood Research and DisordersISSN: 2469-5696

Current Issue

 Open Access DOI:10.23937/2469-5696/1410054

Influence of ABO Blood Group on Fibrinogen Levels and Platelet Count in Apparently Healthy Nigerian Subjects

Okeke CO and Iloka VC

Article Type: Original Article | First Published: July 25, 2020

A close association has been shown to exist between ABO blood type and the risk of some diseases with non-O (A, B, or AB) individuals having an increased differential disposition to thrombotic disorders. The present study evaluated the fibrinogen levels and platelet count in subjects of different ABO blood groups with the view of ascertaining if disparity exists in the levels of fibrinogen and platelet count amongst the different ABO blood groups....

 Open Access DOI:10.23937/2469-5696/1410053

First Report of Hemoglobin Le Lamentin [Alpha 20 (B1) His -> Gln] in the Alpha1 Globin Gene in an Indian Patient and a Brief Update

Sona B Nair, Arundhati S Athalye, Prochi F Madon and Firuza R Parikh

Article Type: Case Report | First Published: July 13, 2020

Alpha globin gene structural variants are caused mainly due to point mutations in the alpha globin gene. They are generally asymptomatic but in rare cases cause problems in association with other structural variants of thalassemia. We report here for the first time in Indian population a rare alpha globin gene structural variant named Hb Le Lamentin. Our main aim of presenting this case is to create awareness that this variant may be commonly present in the Indian population also though the prev...

 Open Access DOI:10.23937/2469-5696/1410052

Hemopure, HBOC-201, for Life Threatening Anemia in a Jehovah’s Witness

Joseph R Nellis, MD, MBA, Michael J Devinney, MD, PhD, Christopher C Young, MD

Article Type: Case Report | First Published: June 04, 2020

There are over 1 million Jehovah’s Witnesses in the United States and nearly 8.5 million worldwide. Within the medical community, they are most notably known for their refusal of blood transfusions. Prior studies have shown that healthy euvolemic volunteers tolerate hemoglobin of 5 g/dL, although when faced with the stress of surgery their operative mortalities are over 30%. Herein we explore the use of Hemopure, HBOC-201, an investigational blood substitute, for a frail 72-year-old female Jeh...

 Open Access DOI:10.23937/2469-5696/1410050

Atypical Clinical Picture of Breast Cancer with Dominant Symptoms of Hematologic and Gastrointestinal Malignancies

Malwina Rybicka-Ramos, Grzegorz Kasiarz, Katarzyna Pluta, Tomasz Wilczynski, Jerzy Pruszynski and Ewa Ziolko

Article Type: Case Report | First Published: June 03, 2020

Gastrointestinal malignancy was suspected in a 68-year-old woman with long-term anemia, thrombocytopenia, leukopenia, the presence of fecal occult blood and elevated levels of CEA and CA 19- 9. However, malignancy was not confirmed. The patient was later hospitalized in the Department of Hematology where hematologic disease was excluded. Cervical and inguinal lymphadenopathy and atypical bone marrow cells collected by aspiration biopsy gave rise to the suspicion of bone marrow involvement by tum...

 Open Access DOI:10.23937/2469-5696/1410048

Effects of TSH on Erythrocyte Osmotic Fragility: Signaling Pathway

Evelyn Mendonca-Reis, Camila Cristina Guimaraes Nobre, Artur Paes-Chagas, Leandro Miranda-Alves and Clemilson Berto-Junior

Article Type: Original Article | First Published: March 09, 2020

TSH is a peptide hormone synthetized and secreted by pituitary with fundamental importance for thyroid function. TSH receptors are found in other tissue than thyroid playing diverse roles, including erythrocyte. Based on the fact that deformability is one of the most important features of a mature erythrocyte, we aimed to verify if TSH modulates erythrocytes volume and, if does, which signaling is involved in this modulation. Using hemolysis assay, we create a hemolysis curve of erythrocyte in p...

 Open Access DOI:10.23937/2469-5696/1410047

Analysis of Twelve Cardiovascular Disease Related Gene Mutations among Turkish Patients with Coronary Artery Disease

Gulsah Durmus, Nevin Karakus, Serkan Yuksel and Nurten Kara

Article Type: Research Article | First Published: February 12, 2020

Coronary artery disease (CAD) is a multifactorial disorder. It is important to identify gene mutations that may be responsible for the development of CAD. The aim of this study was to determine the frequency of twelve cardiovascular disease (CVD) related gene mutations in coronary artery patients. The CVD StripAssay (Vienna Lab, Austria) was performed to analyze the twelve gene mutations on 52 coronary artery patients and 39 healthy controls. After DNA isolation from blood samples, hybridization...

 Open Access DOI:10.23937/2469-5696/1410046

First Observation of Two TMPRSS6 Gene Mutations (G603R and K636AFSX17) in Turkish Population

Yasemin Ardicoglu Akisin, Gulnaz Kurt, Hüseyin Onay, Ferda Ozkinay and Nejat Akar

Article Type: Case Report | First Published: December 20, 2019

Iron is one of the elements that participate numerous reaction on the body and the structure of hemoglobin to the purpose of carrying oxygen to the tissues. Thus, iron deficiency causes different problems in the body. Iron-refractory iron deficiency anemia (IRIDA) is a genetic disorder that has some signs of iron deficiency anemia (IDA) but refractory to oral iron and partially refractory to intravenous iron. The mutation in TMPRSS6 gene causes matriptase-2 protein deficiency that negatively reg...

 Open Access DOI:10.23937/2469-5696/1410045

Prevalence of Antiphospholipid Antibodies in HIV-Infected Children in Ile-Ife, South-Western Nigeria

Oyelese AT, Salawu L, Adejuyigbe EA and Olasanmi O

Article Type: Review Article | First Published: December 12, 2019

Lupus anticoagulant (LA) and anticardiolipin antibodies (aCL) are acquired autoantibodies referred to as antiphospholipid antibodies (aPL). They can be found in infective and non-infective conditions. Infection with the Human immunodeficiency virus (HIV) can predispose patients to having these antibodies and this has been documented in Nigerian adult patients but not in the pediatric age group. To determine the prevalence of antiphospholipid antibodies in HIV-infected children and its associatio...

 Open Access DOI:10.23937/2469-5696/1410034

Bioinformatics Analysis of Altered lncRNAs in Peripheral Blood Molecular Cells from Major Depressive Disorder (MDD) Patients

Mingjun He, Xiaoli Zhu, Wei Niu, Lingming Kong, Gaofeng Yao and Li-yi Zhang

Article Type: Research Article | First Published: December 12, 2018

Based on the prior studies, altered lncRNAs in peripheral blood Molecular Cells (PBMC) from depression patients were chosen to perform informatics analysis for lncRNA target gene prediction and functional annotation. Microarray was first used to screen dys regulated lncRNAs in the PBMCs of MDD patients, of which 10 lncRNAs were selected for quantitative real-time Reverse Transcription Polymerase Chain Reaction (RT-PCR) study, as well as bioinformatics analysis....

 Open Access DOI:10.23937/2469-5696/1410033

The Results of the Single Center Pilot Randomized Russian Clinical Trial of Mesenchymal Stromal Cells in Severe Neutropenic Patients with Septic Shock (RUMCESS)

Gennadiy Galstyan, Polina Makarova, Elena Parovichnikova, Larisa Kuzmina, Vera Troitskaya, Eduard Gemdzhian and Valeriy Savchenko

Article Type: Original Article | First Published: October 12, 2018

To investigate the safety of the of bone marrow-derived human multipotent mesenchymal stromal cells (MMSCs) administration in neutropenic patients with septic shock. Mesenchymal stromal cells (MMSCs) may represent a promising cell-based therapy of sepsis. MMSCs, activated by lipopolysaccharide or tumor necrosis factor-α, reprogram macrophages by releasing prostaglandin E2. Prostaglandin E2 acts on the macrophages through the EP2 and EP4 receptors and stimulates the production and release of an ...

 Open Access DOI:10.23937/2469-5696/1410032

Expression of Foxp3 and Rorc Genes in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation: Impact in the Development of Acute and Chronic Graft-Versus-Host Disease

Camila Marca de Veiga Cabral, Walter Moises Tobias Braga, Adriano de Moraes Arantes, Jose Salvador Rodrigues de Oliveira, Gisele Wally Braga Colleoni and Fabio Rodrigues Kerbauy

Article Type: ORIGINAL ARTICLE | First Published: September 07, 2018

The aim of this study is to characterize Treg (FOXP3) and Th17 (RORC)-related genes in patients who underwent hematopoietic cell transplantation (HCT) and correlate them with graft-versus-host disease (GVHD) onset and patients' outcome. Fifty-one patients undergoing allogeneic HCT from matched related donors (MRD) were studied. Samples were collected before HCT, at acute (aGVHD) or chronic GVHD (cGVHD) onset, and 90 days post-HCT for those who did not have signs of aGVHD. FOXP3 and RORC gene exp...

 Open Access DOI:10.23937/2469-5696/1410031

Lenalidomide Plus Dexamethasone is an Active Rescue Treatment for Myeloma with Severe Renal Impairment Failing to Bortezomib-Based Induction Therapy

Giuseppe Mele and Domenico Pastore

Article Type: Case Reports & Case Series | First Published: July 12, 2018

Patients with relapsed/refractory Multiple Myeloma (rrMM) and End Stage Renal Disease (ESRD) requiring hemodialysis must receive lenalidomide at a dosage of 5 mg daily on days 1-21 of repeated 28-day cycles, due to substantial elimination via the kidneys. Unfortunately, despite dose reduction, severe adverse events occur with a high frequency. Therefore, lenalidomide is recommended mainly in patients with mild-to-moderate renal impairment....

 Open Access DOI:10.23937/2469-5696/1410030

Benign Lymphadenopathy Presented in a Malignant Pathway - A Rare Case of Proteinaceous Lymphadenopathy

Md Serajul Islam and Pavel Kotoucek

Article Type: Case Report | First Published: June 30, 2018

Proteinaceous lymphadenopathy is a rare non-specific lymph node changes incidence of which increases with age. This condition is usually associated with hypergammaglobulinemia or rheumatological conditions. However, this condition can also be due to unknown aetiology as we are presenting a case where no underlying case was found. It may affect nodal function, and rarely may it calcify. Histopathologist needs to be vigilant of this condition as lymphoma with lymph node sclerosis should be conside...

 Open Access DOI:10.23937/2469-5696/1410029

Multiple Myeloma Associated with Dermatomyositis: A Short Report and Mini-Review

Md Serajul Islam and Pavel Kotoucek

Article Type: Research Article | First Published: June 20, 2018

Multiple myeloma (MM) is characterized by the neoplastic proliferation of plasma cell clones that produce monoclonal immunoglobulin. Dermatomyositis (DM), and to a lesser extent polymyositis (PM), carry a higher risk of cancer than that of the general population as demonstrated by several studies with the prevalence being 32% and 15% for DM and PM respectively. The mechanism underlying the association between idiopathic inflammatory myopathies (IIM) and malignancies remains unclear....

Volume 5
Issue 1