Evaluating Bone Mineral Density in Pediatric Acute Lymphoblastic Leukemia Survivors: A Tertiary Care Hospital Experience
Ersin Toret, Burcu Dural, Yeter Duzenli Kar, Zeynep Canan Ozdemir, Ilknur Ak Sivrikoz and Ozcan Bor
Article Type: Original Article | First Published: April 30, 2021
Acute leukemias are the most common malignancies seen in children and they account for one third of childhood cancers. Children who survived ALL, experience reduced bone mineral density (BMD) due to the disease, long-lasting glucocorticoid usage, chemotherapy toxicities, nutritional deficiencies and physical immobility. The decreased BMD have determined at all stages of disease. This retrospective cross-sectional study purposes to analyse the results of BMD in children who have completed their A...
COVID-19 and Aplastic Anemia: Friend or Foe
Mohd Mustahsin, Zeba Siddiqi, Ajay Mishra and Garima Singh
Article Type: Case Report | First Published: April 28, 2021
Aplastic Anemia is a rare hematological disorder caused by bone marrow failure leading to pancytopenia. These patients are frequently treated with immunosuppressive therapy which may protect them in developing hyper-inflammatory response which is commonly seen in moderate and severe COVID-19 patients. On the other hand these patients are at high risk for infection and infection related complications. Here we are reporting an adult aplastic anemia patient who developed uncomplicated course of COV...
Somatic Mutational Analysis using Next Generation Sequencing in Predicting Disease Behavior of Cytogenetically Normal Myelodysplastic Syndromes
Francisco Tria IV, Philipp W Raess, Daphne Ang, Jose Jasper Andal, Richard Press, Ngoc Tran, Jennifer Dunlap, Joanna Wiszniewska, Tauangtham Anekpuritanang and Guang Fan
Article Type: Research Article | First Published: March 24, 2021
Myelodysplastic syndromes (MDS) are myeloid neoplasms characterized by peripheral blood cytopenias, with associated morphologic dysplasias, and recurrent cytogenetic abnormalities. However, approximately 40-50% of MDS have no detectable cytogenetic abnormalities or cytogenetically-normal (CN-MDS). MDS cases with concurrent cytogenetics/FISH and molecular testing were identified from a two-year cohort with a median time to follow-up of 506 days. A total of 153 MDS were gathered, and we identified...
Thrombotic Thrombocytopenic Purpura in a Patient with Systemic Lupus Erythematosus
Diana Guavita-Navarro, MD, Jairo Cajamarca-Baron, MD, Jhon Buitrago-Bohorquez, MD, Laura Gallego-Cardona, MD, Diana Guevara, MD, Hector Cubides, MD, Ana Maria Arredondo, MD and Alejandro Escobar, MD
Article Type: Case Report | First Published: February 19, 2021
Thrombotic microangiopathy is a group of syndromes characterized by thrombocytopenia, microangiopathic hemolytic anemia, and acute organ dysfunction secondary to ischemia. It includes a group of diseases such as thrombotic thrombocytopenic purpura. They can be primary or secondary to multiple pathologies, including autoimmune diseases such as systemic lupus erythematosus. These associations are important from the clinical point of view, as they have more severe presentations, high relapse rates,...
Specific Antibody Deficiency in Pediatric Patients with Chronic Rhinosinusitis
Robert G Hill, BA and James A Sipp, MD
Article Type: Case Series | First Published: February 19, 2021
This study was performed to review our experience with pediatric patients adaptive immunity to Streptococcus pneumoniae and Haemophilus influenza in the clinical presentation of chronic rhinosinusitis. Currently, there is no specific routine role in healthcare to check the immune status in patients after receiving the vaccinations. Patients were identified from the EMR using the ICD-10 code for chronic sinusitis and were considered eligible if they had titers drawn to evaluate their immunity. Pa...