Multicentric Castleman’s Disease with Disseminated Kaposi’s Sarcoma: A Report of Prolonged Misdiagnosis
Xiao Hu, Monika Pilichowska and Cindy Varga
Article Type: Case Report | First Published: June 06, 2020
54-year-old gentleman was diagnosed with acquired immunodeficiency syndrome (AIDS) when presenting with shingles in 2016. He was started on HAART but soon noted a very rapid increase in the size of his cervical, axillary and inguinal lymph nodes, along with profound constitutional symptoms. Immune reconstitution syndrome was suspected and prednisone was tried but did not alleviate symptoms. One month later, a core biopsy of the left axillary lymph node was undertaken and demonstrated predominant...
Heparin-Induced Thrombocytopenia Presenting as Splenic Hemorrhage Following Cardiac Surgery: A Case Report
J Ferry, S Youssef, P WU and L Hegerova
Article Type: Case Report | First Published: May 25, 2020
Heparin induced thrombocytopenia with thrombosis (HIT) is a paradoxical prothrombotic complication of anticoagulant therapy. We report a case of atraumatic splenic hemorrhage due to splenic vein thrombosis as main indicator to diagnosis of HIT. The presentation is reminiscent of the rare bilateral adrenal hemorrhage due to adrenal necrosis that occurs in HIT. Alternative anticoagulation is mainstay of therapy for HIT despite hemorrhage, given the underlying acquired hypercoagulability....
Repeat Ultrasonographic Examinations Reveal Accessory Spleen in a Case with Relapse ITP
Ahmet Sarici, Ayshe Slocum, Hilal Er Ulubaba, Mehmet Hanifi Kandemir, Mehmet Ali Erkurt, Emin Kaya and Irfan Kuku
Article Type: Original Article | First Published: August 09, 2019
The aim of treatment in patients with primary immune thrombocytopenia (ITP) is to obtain a safe platelet count to prevent clinically significant bleeding (major bleeding) rather than normalizing the platelet count. In light of this information, treatment indications for newly diagnosed ITP patients include, I) Thrombocyte counts below 30,000/microL and II) Platelet counts above 30,000/microL in correlation with clinically significant bleeding. Corticosteroids make-up the first-line treatment of ...
Is There Any Relationship between ABO Blood Groups and Coronary Ectasia?
Article Type: Research Article | First Published: July 17, 2019
Coronary artery ectasia (CAE) is known as dilatations of coronary vessels which are 1.5 times greater than the adjacent healty segment and it is known to variant of atherosclerosis. Previous reports have shown that the ABO blood groups are associated with atherosclerosis. In this study, it was investigated whether coronary artery ectasia is related to genetically transmitted ABO blood groups. This retrospective study involved 620 subjects who underwent coronary angiography in our center from 201...
ABO Blood Group: Its Relationship with Anthropometric Parameters Among Young Adult Nigerians of Yoruba Ethnicity
Asafa MA, Ogunlade O, Bolarinwa RA, Bisiriyu LA and Asafa ST
Article Type: Research Article | First Published: June 17, 2019
It had been established that ABO blood group system associated with some diseases or disorders. The objective of this study was to determine the effect of ABO blood group on anthropometric indices among apparently healthy young adults of Yoruba ethnicity. Eighty apparently healthy young adults who were purposely selected participated in the study after screening for the ABO blood groups following the standard protocol. They were divided into four equal groups; 20 in each of blood groups A, B, AB...
Fatal Systemic Mucormycosis after Rabbit Anti-Thymocyte Globulin Therapy in a Severe Aplastic Anemia Patient
Haruko Tashiro MD, PhD, Yasutoshi Oshima, Ritsu Sumiyoshi, Takuji Matsuo, Tadashi Yamamoto, Kensuke Matsumoto, Jun Ooi, Naohisa Matsunaga, Yoshinao Kikuchi and Naoki Shirafuji
Article Type: Case Report | First Published: May 16, 2019
Survival rates for patients with severe aplastic anemia have greatly improved with the development of better supportive care including transfusion strategies and the availability of anti-fungal agents. However, invasive fungal infection remains the main cause of death and increases mortality in severe aplastic anemia patients. Among invasive fungal infections, mucormycosis is one of the fatal diseases in immunocompromised patients. We report the case of a 72-year-old man with severe aplastic ane...
MEK1/2 as a Therapeutic Target in Sickle Cell Disease
Article Type: Short review | First Published: April 04, 2019
Identification of novel therapeutic targets has improved diagnostics and treatment of many diseases. Many innovative treatment strategies have been developed based on the newly identified biomarkers and key molecules. Most of the research focused on ways to manipulate signaling pathways by activating or suppressing them, validate new therapeutic targets for treatment, and epigenetic treatment of diseases. With the identification of aberrations in multiple growth pathways, the focus then shifted ...
Is an Additional Dose of Intravenous Ferric Carboxymaltose Useful in the Treatment of Iron Deficiency Anemia?
Sinem Namdaroglu, MD and Gizem Yıldırım
Article Type: Research Article | First Published: March 06, 2019
Even though a single high dose administration of intravenous ferric carboxymaltose (FC) is supposed to be effective, it is unknown whether the second dose of FC given one week after the initial dose provides additional benefits. The aim of the present study was to investigate whether two doses of intravenous ferric carboxymaltose is more effective than a single dose of intravenous FC for replenishing iron stores and correction of anemia in patients with iron deficiency....
Diffuse Large B-Cell Lymphoma during Complete Remission of Acute Myeloid Leukemia (M4Eo) Exhibiting Immunoglobulin Heavy Chain Gene Rearrangement and Inv(16)
Kodai Kuriyama, Hiroki Hosoi, Masaya Shimanuku, Toshiki Mushino, Shogo Murata, Akinori Nishikawa, Shinobu Tamura, Nobuyoshi Hanaoka and Takashi Sonoki
Article Type: Case Report | First Published: January 25, 2019
In previous studies, it has been reported that 10-20% of acute myeloid leukemia (AML) cases showed immunoglobulin heavy chain gene (IGH) rearrangements, a genetic hallmark of B-cell differentiation. However, the clinical significance of this is uncertain. Here, we report a case of diffuse large B-cell lymphoma (DLBCL) after complete remission (CR) from AML that exhibited an IGH rearrangement. The patient was diagnosed with AML (M4Eo) with inversion of chromosome 16 [inv(16)]. Interestingly, the ...
Utilizing Extended Red Blood Cell Parameters to Distinguish Iron-Deficient Erythropoiesis - Related Disorders in Malaysian Female Population
Angeli Ambayya, Andrew Octavian Sasmita, Subramanian Yegappan and Jameela Sathar
Article Type: Research Article | First Published: January 20, 2019
The full blood count (FBC) analyzers, Sysmex XE-5000 and Unicel DxH 800, are equipped to perform routine and extended parameters tests; thus, this study considered extended red blood cell (eRBC) parameters to distinguish iron-deficient erythropoiesis related disorders. Malaysian female subjects comprising three main ethnic groups (Malay, Chinese and Indian) were included. Three groups of findings were distinguished based on FBC, morphology, and iron status of the subjects: normal, latent iron de...