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International Journal of Neurology and Neurotherapy is an open access peer reviewed journal that publishes discoveries in wide variety of drugs and therapies which are used in modern practice and fundamental understandings in neurological diseases. The main objective of the journal is to act as a forum for publication, education, and exchange of opinions, and to promote research and publications globally. Journal publishes original research articles, reviews, personal views, commentaries, and news in clinical neurology and important findings in neurotherapy and electroencephalography for use in assessing baselines and outcomes of various procedures. Otherwise the publications are invited in all areas of clinical and basic neuroscience, including new technologies, cellular and molecular neurobiology, population sciences, and studies of behavior, addiction, psychiatric diseases, therapies are of interest to the journal.

It accelerates the pace of research, discovery and innovation in various medical and clinical neurological treatment and therapies. Commonly seen disease like Alzheimer's disease, multiple sclerosis, head trauma, sleep disorder, Parkinson diseases, neuropathy, stroke, dementia, epilepsy and various kinds of disease and tumors are related to nervous system. This journal also focuses on treatment, medication, diagnosis of various nervous related diseases. All articles published in the journal are subject to a stringent peer review process. It encourages authors to publish their experimental and theoretical results in as much detailed as possible.


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Patients with ischemic stroke are at high risk of fall. However, few study focused on fall prevention for patients with ischemic stroke in hospital. The aims of the study were to find out the causes of falling in the inpatient ischemic stroke patients and formulate a fall prevention protocol for them. .. read more


10.23937/2378-3001/3/6/1063

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Since the worldwide demographic ageing, prevalence of the most common cause of dementia in the elderly, Alzheimer's disease (AD), will increase dramatically. Although it has been intensively researched for many years, there are still limited treatments for AD. Currently approved pharmacotherapy is generally considered have symptom-relieving rather than disease processing modifying .. read more


10.23937/2378-3001/3/6/1062

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Depression is a common psychiatric disorder in patients with Parkinson's disease (PD), being more prevalent in PD than in any other chronic disabling disease. Its cause, nevertheless, has not yet been elucidated. According to some authors, there is a decrease in serotonin (5-HT) levels compensatory to dopaminergic release impairment, but new .. read more


10.23937/2378-3001/3/6/1061

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Congestive Heart Failure (CHF) is among the heart diseases which accounted for > 54% of deaths world-wide in 2013 in a World Health Organizations report. CHF patients most often have a more sensitized carotid body (CB) chemoreceptor than normal. CB neural output stimulates output from the sympathetic nervous system. Increased CB .. read more


10.23937/2378-3001/3/6/1060

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The EL mice were exposed to the natural proprioceptive sensory stimulation of tossing the animal into the air to provoke an epileptic seizure, which results from an increase in the excitability of the cortical neurons due to low activities of Glutamic acid decarboxylase (GAD) and Gamma-amino butyric acid (GABA). The seizures .. read more


10.23937/2378-3001/3/6/1059

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A prospective study was performedof arandom population sample (n = 1616) in Gothenburg, Sweden; 746 men and 870 women, aged 25-64 years in 1995, from the WHO MONICA Project. Fractures were verified by X-ray, CVD events by medical records and lifestyle factors and medical treatment via a questionnaire. Quantitative Calcaneal Ultrasound .. read more


10.23937/2378-3001/3/5/1058

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The pathogenesis of KD is the polymorphic CAG (cytosine, adenine, guanine) tandem-repeat expansion above 40 repeats in exon 1 of the androgen receptor (AR) gene on chromosome Xq11-12. In normal population the number of CAG codons usually ranges from 12 to 25, with an average size of 21-22. The polymorphism involving .. read more


10.23937/2378-3001/3/5/1057

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All facility residents and their medical decision makers (if necessary) were approached for enrollment in this study. After consent was obtained, two neurologists specializing in movement disorders independently conducted a brief physical examination to ascertain the presence or absence of spasticity. The prevalence of spasticity in veterans residing in this long-term .. read more


10.23937/2378-3001/3/5/1056

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Central nervous system CNS toxicity is a rare complication of a commonly used antibiotic, metronidazole. We report a representative case of metronidazole-induced encephalopathy in an individual with increased vulnerability due to underlying liver disease. Features included the essential clinical symptoms of dysarthria and ataxia and characteristic MR abnormalities of increased T2 .. read more


10.23937/2378-3001/3/4/1055

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We reported one case of congenital skull depression in a male newborn who delivered by cesarean section due to continued occipitotransverse position. His mother had no history of abdominal trauma during the pregnancy, and there were no complications and difficulties in the process of cesarean delivery. The neurological examination of the .. read more


10.23937/2378-3001/3/4/1054

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Synapse remodeling is an essential physiological phenomenon in maintaining the normal brain function. Traumatic injury is one of the causes that triggers abnormality in synapse remodeling, leading to neurodegeneration. So far, substantial clinical trials have been attempted to cure neurodegeneration. One of the challenging approaches that improves neurodegenerative symptoms is therapeutic .. read more


10.23937/2378-3001/3/4/1053

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The utility of endoscopic biopsy using high-dose fluorescein sodium in biopsy of malignant brain tumors was investigated. The subjects were 9 patients with malignant brain tumors (malignant lymphoma 5, glioblastoma 3, metastatic brain tumor 1). After making an incision in the dura mater, 20 mg/kg fluorescein sodium were administered intravenously. A .. read more


10.23937/2378-3001/3/4/1052

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A host of studies on the cardiac innervation have found a complex link known as cardiac autonomic nervous system (CANS), connecting extracardiac nerves, intracardiac ganglia, and myocardial cells. Now it is well known that CANS plays a critical role in regulating the functions of the heart and its imbalance is regarded .. read more


10.23937/2378-3001/3/3/1051

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Heat stroke is the result of high heat stress and determines multi-organ dysfunction with predominant encephalopathy. Heat stroke only rarely leads to permanent neurologic deficits with a propensity to cerebellar dysfunction while memory disorders are very unusual. We report a unique case of a patient who suffered from a heat stroke .. read more


10.23937/2378-3001/3/3/1050

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Many medical and bioengineering researchers have investigated flow behavior inside intracranial aneurysms using computational fluid dynamics. The majority of these studies assume to be rigid wall, but blood flows through a deformable elastic vessel. A few researchers have tried to simulate using fluid-structure interaction because an elastic wall implicates the decrease .. read more


10.23937/2378-3001/3/3/1049

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A 15-year-old boy presented to our hospital with headache after head trauma caused by a traffic accident. T2-weighted axial MR-images demonstrated the deep medullary veins of the cerebellum converging on the roof of the fourth ventricle. These veins drained into the subependymal vein, which then drained into the precentral cerebellar vein .. read more


10.23937/2378-3001/3/3/1048

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A 38-year-old female with a 7-year history of recurrent high-grade astrocytoma was admitted to our institution presenting with progressive signs of increased intracranial pressure. MRI showed widespread tumor recurrence with diffuse infiltration of the ventricular walls, basal cisterns and concomitant hydrocephalus. After careful consideration a palliative endoscopic third ventriculostomy was performed. .. read more


10.23937/2378-3001/3/2/1047

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With an estimated incidence of 3-4 per every 100,000 individuals among adults 50-99 years of age, Multiple System Atrophy (MSA) is a rare progressive neurodegenerative disease clinically characterized by the following trio: cerebellar ataxia, parkinsonism and autonomic dysfunction in conjunction with pyramidal signs. MSA usually progresses over a 7-9 year period, .. read more


10.23937/2378-3001/3/2/1046

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The anterior junction syndrome is a specific manifestation caused by optic nerve involvement at the junction with the optic chiasm and the contralateral inferonasal nerve fibers (Wilbrand's Knee). Lesions at this point show a specific pattern of visual impairment which is characterized by an advanced monocular visual field loss, together with .. read more


10.23937/2378-3001/3/2/1045

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A 49 years old woman, diagnosed with Neuro-Behcet, was admitted with complains of numbness, aching and periods of electric shock-like pain in right side of the face. Associated with painful oral ulcers, anorexia, nausea and gait instability. Neurological examination revealed dysesthesia on right trigeminal nerve territory, horizontal-rotatory nistagmus on horizontal gaze .. read more


10.23937/2378-3001/3/2/1044

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Neuromyelitis Optica (NMO) is an inflammatory demyelinating, necrotizing disease of the central nervous system, with a predilection for the optic nerves and spinal cord. Clinical, radiological and immunopathological characteristics distinguish it from multiple sclerosis (MS). Recently, new diagnostic criteria have been published, and the terms NMO and neuromyelitis optica spectrum disorder .. read more


10.23937/2378-3001/3/2/1043

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Resective epilepsy surgery is highly effective in the treatment of medically refractory epilepsy. However, it involves an open craniotomy and carries the risks of permanent functional deficits and cosmetic concerns. Multiple minimally invasive surgical approaches have been attempted to destroy seizure foci with minimal damage to surrounding normal tissue. Here we .. read more


10.23937/2378-3001/3/2/1042

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Neurofeedback (NF) emerged to employ neural feedback via EEG as an evolution of biofeedback in the 1960. Specifically, NF entails to learn to self-control the brain activity according to operant principles through a visual, auditory or even tactile representation of participant's brain activity as a feedback, with the aim of improving .. read more


10.23937/2378-3001/3/1/1041

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Brain ischemia is a consequence of stroke and cardiac arrest (CA), leading to short and long-term neurological impact involving cognitive function as well as dementia. An accurate, simple and reproducible model of CA ischemia and reperfusion is valuable in assessing the response to ischemia and therapeutic interventions. In the current study .. read more


10.23937/2378-3001/3/1/1040

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A 85-year-old woman was accepted to our institute with complaints of a headache and vomiting after vertigo and left ear tinnitus. Computed tomography (CT) revealed subarachnoid hemorrhage. CT angiography identified an aneurysm at meatal loop of the left anterior inferior cerebellar artery (AICA). A surgical trapping of aneurysm was performed via .. read more


10.23937/2378-3001/3/1/1039

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In the lateral suboccipital area, the restricted space filled with thick muscles, and dangerous structures prevents neurosurgeons to attain safe and successful surgery. Now we have focus on the disposition of fascial layers and potential spaces of the deep cervical fascia in the posterolateral region of the craniocervical junction, which has .. read more


10.23937/2378-3001/3/1/1038

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Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune disease characterized with multifocal demyelination in peripheral nerves. Hashimoto thyroiditis is autoimmune disease of thyroid gland. We reported a patient having these diseases together in the postpartum period. Twenty-three year-old female patient presented with progressive weakness in lower extremities and walking disability for .. read more


10.23937/2378-3001/3/1/1037

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Turmeric, which is derived from the root of the Curcuma longa plant, is one of the most widely used spices worldwide. Scientists from various disciplines have long studied the medicinal benefits of a polyphenol extract from Curcuma longa, curcumin. It has been shown to have a broad spectrum of pharmacological activities .. read more


10.23937/2378-3001/3/1/1036

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Papaverine is a potent smooth muscle relaxant and has vasodilator properties. Topical use of papaverine is widely accepted in neurosurgery to prevent cerebral vasospasm. Growing evidence supports that papaverine may have a neural toxicity effect. We present a case of a 15 years-old patient that was operated on hemorrhagic cavernoma in .. read more


10.23937/2378-3001/2/2/1035

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Polymorphisms in DNA repair genes have been shown to influence DNA repair processes and to modify cancer susceptibility. Published data regarding the association between excision repair cross-complementing rodent repair deficiency complementation group1 (ERCC1) polymorphisms and glioma risk have been inconsistent and inconclusive. To acquire a more precise effect of the association .. read more


10.23937/2378-3001/2/2/1034

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Alzheimer's disease (AD) and diabetes mellitus (DM) are the two most common and devastating health problems in the elderly. DM is a known risk factor for the development of cognitive dysfunction and dementia. Epidemiological and biological evidences support a link between type 2 DM (T2DM) and AD, but the precise mechanisms .. read more


10.23937/2378-3001/2/2/1033

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Citicoline is an endogenous nucleotide that has historically been used to treat stroke, traumatic brain injury, and cognitive dysfunction. Research has also shown that citicoline treatment is associated with improved cognitive performance in substance-abusing populations. We hypothesized that marijuana (MJ) smokers who received citicoline would demonstrate improvement in cognitive performance as .. read more


10.23937/2378-3001/2/2/1032

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The presence of corpora amylacea (CA) in the CNS is associated with both normal aging and neurodegenerative conditions including Alzheimer's disease (AD) and vascular dementia (VaD). CA are spherical bodies ranging in diameter (10-50 micro meter) and whose origin has been documented to be derived from both neural and glial sources. .. read more


10.23937/2378-3001/2/2/1031

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A 49-year-old man with refractory hypertension was admitted to our hospital in a coma caused by hemorrhagic stroke. Severe hypertension was observed during hospitalization despite a full antihypertensive therapy. Considering the risk of enlargement of the intracranial hematoma, the decision was made to perform renal denervation (RDN). A significant blood pressure .. read more


10.23937/2378-3001/2/2/1030

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Mild cognitive impairment (MCI) was originally used to describe a transitional state between normal condition and dementia. Revised and extended definition of MCI has been proposed that covers a broader range of cognitive impairment, distinct from normal ageing and from Alzheimer's disease. Despite the existence of reports regarding analyses of the .. read more


10.23937/2378-3001/2/2/1029

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The Barthel Index (BI) is widely used to measure disability also in Italy, although a validated and culturally adapted Italian version of BI has not been produced yet. This article describes the translation and cultural adaptation into Italian of the original 10-item version of BI, and reports the procedures for testing .. read more


10.23937/2378-3001/2/1/1028

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Marburg's variant of multiple sclerosis (MS) is a malignant and rapidly progressive form of MS that typically leads to deterioration or death within weeks to months. Here we present a case involving a 25-year-old woman who presented with fluctuating mild encephalopathy of one-week duration who progressed to coma and ultimately died .. read more


10.23937/2378-3001/2/1/1027

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Dual Diagnosis (DD), defined as the co-occurrence of a Substance Use Disorder (SUD) and a Severe Mental Illness (SMI), is associated with several negative outcomes. Typical antipsychotics (TAP) are not of great value for patients with DD as they are associated with poorer responses and can worsen SUD. Atypical antipsychotics (AAP) .. read more


10.23937/2378-3001/2/1/1026

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Over 2 million people are homebound in the United States with an increase of 50% expected over the next twenty years. Though home-based primary care programs are effective in reducing hospitalizations among this population, they have been slow to develop and lack subspecialty care. The objective of this pilot program was .. read more


10.23937/2378-3001/2/1/1025

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Cognitive dysfunction associated with schizophrenia is a core symptom that is strongly related to functional levels. In fact, cognitive dysfunction in patients with schizophrenia is due to a combination of the cognitive impairment induced by schizophrenia itself and that induced by the medications that psychiatrists prescribe. It is difficult to differentiate .. read more


10.23937/2378-3001/2/1/1024

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Fall is the number one mechanism of injury for admissions to trauma centers across the US. The use of anticoagulation therapy has also increased significantly, particularly among the older population. We hypothesized that anticoagulation with warfarin increases the risk of intracranial hemorrhage (ICH) and death after a ground level fall. Methods: .. read more


10.23937/2378-3001/2/1/1023

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Multiple System Atrophy (MSA) is a rare adult-onset neurodegenerative disorder of uncertain etiology, clinically manifesting with parkinsonism, cerebellar impairment, autonomic dysfunction and pyramidal signs. The pathological process affects striatonigral, olivopontocerebellar, and autonomic nervous systems. The major clinical variants correlate to the morphologic phenotypes of striatonigral degeneration (MSA-P) and olivopontocerebellar atrophy (MSA-C). .. read more


10.23937/2378-3001/2/1/1022

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Patients with Parkinson's Disease (PD) treated with Deep Brain Stimulation (DBS) typically reduce anti-PD medication use by 25-50% within 6 months of device placement, but whether the reduction is maintained long-term is less clear. We performed a medical record review of 18 patients with PD treated with DBS and 18 matched .. read more


10.23937/2378-3001/2/1/1021

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Psychogenic Nonepileptic Seizures (PNES) are episodes of movement, sensation or behavior changes similar to epileptic seizures but without neurological origin. They are somatic manifestations of psychological distress. Patients with PNES are often misdiagnosed and treated for epilepsy for years, resulting in significant morbidity. Video-EEG monitoring is the gold standard for diagnosis. .. read more


10.23937/2378-3001/2/1/1020

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Determining recurrent stroke etiology and subsequent therapeutic approaches is an important, but not always straightforward task. Lambl's Excrescences (LE) are cardiac valve strands that can be a source of recurrent cerebral ischemic events. We report the case of a 60 year old female that was seen in neurologic consultation for recurrent .. read more


10.23937/2378-3001/2/1/1019

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Introduction : Refractory status epilepticus (RSE) is seizure activity that persists despite acute administration of standard anticonvulsant therapy. It often occurs after cardiac arrest, indicating a poor prognosis. Therapeutic hypothermia (TH) reduces neurological injury in this patient population, and post cardiac arrest protocols now incorporate TH into the treatment algorithm. However, .. read more


10.23937/2378-3001/2/1/1018

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Red ginseng root (Panax Ginseng C.A. Meyer) has been used clinically by many Asian people for thousands of years without any detrimental effects. Subsequent studies that focused on gRb1-induced expression of gene products responsible for neuronal death or survival revealed that gRb1 upregulated the expression of not only Bcl-XL, but .. read more


10.23937/2378-3001/2/1/1017

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Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative disease characterized by rapidly progressive dementia, ataxia and myoclonus. MRI is an important tool in discriminating CJD from other dementias. Among mimics of CJD are rapidly evolving Alzheimer's disease, vascular dementia, frontotemporal dementia and paraneoplastic or immune-mediated limbic encephalitis. A CJD diagnosis can be .. read more


10.23937/2378-3001/2/1/1016

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This synopsis is a brief report about the conclusions in which we have engaged from considering that Alzheimer's disease, cognitive impairment and aging could progress with analogous molecular signaling, with no frontiers between their phenotypes. We have also proposed that chronic depression, with or no anxiety and/or stress comorbidindication may interact .. read more


10.23937/2378-3001/2/1/1015

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Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by an array of symptoms affecting memory and cognition. Some common symptoms of AD include memory loss that disrupts daily life, challenges in planning or solving problems, confusion with time or place, and changes in mood and personality. Central dogma to the .. read more


10.23937/2378-3001/2/1/1014

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The impact of stimulation cycle on the outcome of patients submitted to Vagal Nerve Stimulation (VNS) has been only marginally investigated in the literature. Nonetheless this is an important factor in term of tolerability of side effects, duration of generator and costs of therapy. Here the role of this parameter was .. read more


10.23937/2378-3001/1/1/1013

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Objectives: To analyse the clinical efficacy of a Gluten-Free Diet (GFD) compared with a Regular Diet (RD) in Relapsing-Remitting Multiple Sclerosis (RRMS) patients.
Methods: Seventy-two RRMS patients were included into a prospective study. Annual relapse rate (ARR), Expanded Disability Status Scale (EDSS) and lesional activity were compared. Patients were randomly separated .. read more


10.23937/2378-3001/1/1/1012

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Prion disease is an infectious and fatal disease. The pathogen consists of an abnormal form of the prion protein; designated PrPSc. PrPSc is insoluble, highly resistant to digestion by proteases and all disinfectants. In contrast, the cellular form of prion protein PrPC is easily soluble and digested by proteases. Direct interaction .. read more


10.23937/2378-3001/1/1/1011

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Background and purpose: Homocysteine has been implicated in many kinds of neurologic diseases by inducing oxidative injury which is considered one of the pathogenic mechanisms of neuromyelitis optica (NMO). The aim of this study was to investigate whether there were any relationship between plasma homocysteine and clinical features of NMO patients. .. read more


10.23937/2378-3001/1/1/1010

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Background: Myotonic dystrophy is the most common form of muscular dystrophy in adults. Pain is reported in various hereditary muscular diseases at a frequency of 64%83%.
Methods: A group of 70 patients with myotonic dystrophy (21 persons with type 1 and 49 with type 2) was investigated by means of questionnaires .. read more


10.23937/2378-3001/1/1/1009

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We present a case of a posterior communicating (Pcom) artery infundibulum that progressed to an aneurysm in a patient with Polycystic liver disease without kidney cyst after embolization of the controlateral Pcom aneurysm. The infundibulum had been documented on angiography 4 years earlier, while a ruptured controlateral Pcom aneurysm was embolised. .. read more


10.23937/2378-3001/1/1/1008

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Multiple Sclerosis (MS) is an inflammatory demyelinating autoimmune disorder of the Central Nervous System (CNS). The typical disease course is Relapsing-Remitting (RR) MS and treatment with Disease Modifying Treatment (DMT) should be initiated as soon as possible following a diagnosis of relapsing MS for individuals with a first clinical event and .. read more


10.23937/2378-3001/1/1/1007

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Celiac disease is a common immune mediated disorder elicited by gluten that may manifest with neurological symptoms independent to gastrointestinal manifestations. The real prevalence of celiac disease in multiple sclerosis is still unclear because of limited population studies, different diagnostic assessment and possible non-celiac related response to gluten free diet. Recent .. read more


10.23937/2378-3001/1/1/1006

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Introduction: Hypereosinophilic syndrome is a rare heterogeneous disorder characterized by persistent eosinophilia with eosinophil mediated tissue infitration and organ dysfunction in the absence of a secondary cause. Clinical presentations involving nervous system vary markedly causing encephalopathy, thromboembolic disease or peripheral neuropathy. Eosinophilic infitration of meninges and central nervous system causing meningo-encephalitis .. read more


10.23937/2378-3001/1/1/1005

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Hemichorea-Hemiballism (HCHB) is a hyperkinetic condition characterized by abnormal, migratory, continuous, non-patterned movements of one side of the body. It results from involvement of contralateral basal ganglia that may be affected by metabolic, neoplastic, infectious, autoimmune [1], toxic or neurodegenerative processes [2]. The most common cause is ischemia from a focal .. read more


10.23937/2378-3001/1/1/1004

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Deep brain stimulation (DBS) is emerging as a viable alternative therapy in intractable epilepsy (IE), and although the exact mechanism and electrophysiology of its action remain elusive, some neuroscientists even believe that DBS may in near future become a first line treatment for the patients with IE who are not suitable .. read more


10.23937/2378-3001/1/1/1003

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More than a century ago, in 1885 Friedrich Pelizaeus, a German Physician first identified a genetic disorder in five boys in a single family with nystagmus, spasticity of the limbs and developmental delay. Twenty-five years later in 1910, Ludwig Merzbacher independently reexamined this family and described further the neuropathology of 14 .. read more


10.23937/2378-3001/1/1/1002

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Deep Brain Stimulation (DBS) is an effective therapeutic modality for patients with Parkinson's Disease who have developed complications from longstanding levodopa such as dyskinesias and motor fluctuations. It produces robust responses to segmental symptoms (ie, bradykinesia, tremor, rigidity) while attenuating involuntary dyskinetic movements and smoothing out 'on' and 'off' period cycling. .. read more


10.23937/2378-3001/1/1/1001

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