Join Us | Latest Articles | Contact

Journal Home


Editorial Board


Recent Articles


Submit to this journal


Special Issues


Current issue

Journal of Rheumatic Diseases and Treatment





DOI: 10.23937/2469-5726/1510006



Connective Tissue Disease-Associated Interstitial Lung Disease

Marcelo Fernandez Casares*


Department of Medicine, Pulmonary Section, Hospital Nacional A. Posadas, Argentina


*Corresponding author: Marcelo Fernandez Casares, Department of Medicine, Pulmonary Section, Hospital Nacional A. Posadas, Illia s/n Marconi, El Palomar, Buenos Aires, Argentina, E-mail: mfercasar@intramed.net
J Rheum Dis Treat, JRDT-1-006, (Volume 1, Issue 1), Editorial; ISSN: 2469-5726
Received: February 20, 2015 | Accepted: February 25, 2015 | Published: March 02, 2015
Citation: Fernández Casares M (2015) Connective Tissue Disease-Associated Interstitial Lung Disease. J Rheum Dis Treat 1:006. 10.23937/2469-5726/1510006
Copyright: © 2015 Fernández Casares M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Interstitial Lung Diseases (ILDs) also known as Diffuse Parenchymal Lung Disease (DPLD), include a large group of lung diseases characterized by various patterns of inflammation and fibrosis on high-resolution CT and in lung biopsy.

ILD is one of the most serious pulmonary complications in Connective Tissue Diseases (CTDs), resulting in significant morbidity and mortality with an overall incidence estimated at 15%.

The spectrum of ILD in CTD (ILD-CTD) includes all of the disease classified in the idiopathic interstitial pneumonias [1], but the prevalence differs between the CTD.

ILD can be secondary to CTD, but can also be caused by the medications used to treat them. Several anti-inflammatory and biologic drugs have been associated with the development of ILD [1].

It is now recommended that all patients with CTD are checked for ILD. Early detection is very important for the initiation of therapy. Progressive exertional dyspnea is the most frequently symptom. However, its presence is not reliable in identifying lung involvement because it may also reflect the increased work of locomotion in individuals with arthritis or myositis. In addition, patients with severe systemic disease may be unable to exercise sufficiently to experience dyspnea, even when significant pulmonary abnormalities are present [2].

There are some risk factors for the development of CTD-ILD. Some of these risk factors may be disease-specific and peculiar to a particular CTD, whereas others are host-specific and attributable to individual patient factors [3].

Some patients may not require therapy, and we do not initiate it with asymptomatic or mild ILD and suggest serial monitoring of symptoms and pulmonary function [4,5]. The management of ILD in patients with subclinical disease remains unclear. It is not known whether treatment will alter the course of the disease in these patients.

When deciding whether a patient with CTD-ILD may benefit from immunosuppressive therapy, we evaluate the following factors: rate of disease progression, severity of disease, underlying CTD, likelihood of response based on radiographic and histopathology patterns, patient age, and ability to comply with therapy and monitoring [5].

We believe that multi-disciplinary assessment of patients with CTD-ILD between rheumatologists and pulmonologists improves its diagnosis and management of this important complication of CTD.


References
  1. Argiriadi PA, Mendelson DS (2009) High resolution computed tomography in idiopathic interstitial pneumonias. Mt Sinai J Med 76: 37-52.

  2. Goh NL (2009) Connective Tissue Disease and the Lung. Clin Pulm Med 16: 309-314.

  3. Ryu JH, Bongartz T, Matteson EL (2005) Interstitial lung disease in connective tissue diseases: what are the important questions? Arthritis Rheum 53: 488-490.

  4. Antoniou KM, Margaritopoulos G, Economidou F, Siafakas NM (2009) Pivotal clinical dilemmas in collagen vascular diseases associated with interstitial lung involvement. Eur Respir J 33: 882-896.

  5. Vij R, Strek ME (2013) Diagnosis and treatment of connective tissue disease-associated interstitial lung disease. Chest 143: 814-824.

International Journal of Anesthetics and Anesthesiology (ISSN: 2377-4630)
International Journal of Blood Research and Disorders   (ISSN: 2469-5696)
International Journal of Brain Disorders and Treatment (ISSN: 2469-5866)
International Journal of Cancer and Clinical Research (ISSN: 2378-3419)
International Journal of Clinical Cardiology (ISSN: 2469-5696)
Journal of Clinical Gastroenterology and Treatment (ISSN: 2469-584X)
Clinical Medical Reviews and Case Reports (ISSN: 2378-3656)
Journal of Dermatology Research and Therapy (ISSN: 2469-5750)
International Journal of Diabetes and Clinical Research (ISSN: 2377-3634)
Journal of Family Medicine and Disease Prevention (ISSN: 2469-5793)
Journal of Genetics and Genome Research (ISSN: 2378-3648)
Journal of Geriatric Medicine and Gerontology (ISSN: 2469-5858)
International Journal of Immunology and Immunotherapy (ISSN: 2378-3672)
International Journal of Medical Nano Research (ISSN: 2378-3664)
International Journal of Neurology and Neurotherapy (ISSN: 2378-3001)
International Archives of Nursing and Health Care (ISSN: 2469-5823)
International Journal of Ophthalmology and Clinical Research (ISSN: 2378-346X)
International Journal of Oral and Dental Health (ISSN: 2469-5734)
International Journal of Pathology and Clinical Research (ISSN: 2469-5807)
International Journal of Pediatric Research (ISSN: 2469-5769)
International Journal of Respiratory and Pulmonary Medicine (ISSN: 2378-3516)
Journal of Rheumatic Diseases and Treatment (ISSN: 2469-5726)
International Journal of Sports and Exercise Medicine (ISSN: 2469-5718)
International Journal of Stem Cell Research & Therapy (ISSN: 2469-570X)
International Journal of Surgery Research and Practice (ISSN: 2378-3397)
Trauma Cases and Reviews (ISSN: 2469-5777)
International Archives of Urology and Complications (ISSN: 2469-5742)
International Journal of Virology and AIDS (ISSN: 2469-567X)
More Journals

Contact Us

ClinMed International Library | Science Resource Online LLC
3511 Silverside Road, Suite 105, Wilmington, DE 19810, USA
Email: contact@clinmedlib.org
 

Feedback

Get Email alerts
 
Creative Commons License
Open Access
by ClinMed International Library is licensed under a Creative Commons Attribution 4.0 International License based on a work at https://clinmedjournals.org/.
Copyright © 2017 ClinMed International Library. All Rights Reserved.