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Journal of Clinical Gastroenterology and Treatment is an international, open access, peer reviewed journal that publishes clinical information in all areas of gastro-enteric system. The journal aims to set a forum for publication, education, and exchange of opinions, and to encourage research and publications globally. The Journal provides the clinicians, surgeons and health professionals with a platform to contribute their findings and help raise awareness on management of the gastrointestinal tract and liver diseases. We aim to publish highest quality clinical content via open access platform providing the readers at no cost, immediate and unlimited access.

Journal of Clinical Gastroenterology and Treatment is an open journal providing the readers information on research updates, discovery and innovation in various aspects of Biology of the Gastrointestinal Tract and Liver, Acute Abdominal Pain, Chronic Abdominal Pain, Esophageal Disease, Dyspepsia, Nausea and Vomiting, Diarrhea, Intestinal Gas, Constipation, Gastrointestinal Bleeding, Nutrition in Gastrointestinal Disease, Eating Disorders, Stomach and Duodenum, Pancreas, Biliary Tract, Small and Large Intestine, Liver, Psychosocial Disorders, Advances in Treatment, Endoscopy, Gastric Cancer, Ulcerative Colitis, Disease Pathology, Prevention and Management, etc. The journal accepts all manuscript formats such as Original Article, Reviews, Mini Reviews, Short Communications, Case Reports, Clinical Image, Perspectives/Opinions, Letters, Short Note and Commentaries. All articles published in the journal are subject to a rigorous peer review process. It encourages authors to publish their experimental and theoretical results in detail to disseminate the updated research findings.


Articles

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Inflammatory bowel disease (IBD) is influenced by genetic susceptibility and surrounding environmental factors. Despite unknown etiology, the environmental factors are continuously unraveled. Studying ethnical differences in a well characterized and stable region might disclose etiologies and pathophysiological mechanism. The ethnical trends in IBD in Israel disclosed incidents, epidemiological, clinical, therapeutical and .. read more


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Matrix metalloproteinases (MMPs) are enzymes involved in the degradation of extracellular matrix proteins and in several functions such as wound repair. The regulation of MMPs occurs at various levels including expression and inhibition by tissue specific inhibitors of MMPs (TIMPs). An alteration of intracellular redox state can modulate the activation and/or .. read more


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A 71-year-old man was diagnosed with squamous cell lung cancer in the right lower lobe. He was treated with chemotherapy (first line: TS-1/CDDP; second line: carboplatin/nab-paclitaxel) and radiation therapy (41.4 Gy), but his disease continued to progress. The patient complained of relatively sudden-onset chest pain and high-grade fever. Computed tomography (CT) .. read more


10.23937/2469-584X/1510038

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Uveal melanoma is the most common primary intraocular malignant tumor in adult. Here, we present a patient who died due to hepatic encephalopathy, which was attributed to liver metastasis, which occurred nine years after the revelation of the uveal melanoma. .. read more


10.23937/2469-584X/1510037

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Purpose: This study aimed to investigate whether patients with hepatitis C virus (HCV)-related cirrhosis and clinically significant portal hypertension (CSPH) could show satisfactory virological and safety outcomes on direct-acting antiviral (DAA) therapy. Methods: Patients with HCV-related cirrhosis treated with DAA therapy were collected in the period between December 2014 and December .. read more


10.23937/2469-584X/1510036

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Extrahepatic portal vein obstruction (EHPVO), although rare in children, is a significant cause of portal hypertension (PHT) which leads to life-threatening gastrointestinal bleeding in the pediatric age group. PHT may also lead to other complications such as hypersplenism, cholangiopathy, ascites, and even hepatopulmonary syndrome and portopulmonary hypertension that may require organ .. read more


10.23937/2469-584X/1510035

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The management process of colorectal cancer (CRC) comprises a large number of strategic moments for disease treatment. Key points of progress on this disease research range from the the initial screening phase, where screening tests and maximum population coverage are crucial, to the decision on what is the best personalized treatment .. read more


10.23937/2469-584X/1510034

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The aim of this study was to find out the risk factors of gastric intestinal metaplasia (IM) in northwest of China. A retrospective case-control study was conducted with a well-designed questionnaire, including basic information and related factors. Totally 2157 subjects with benign upper gastrointestinal disorders from Xijing hospital and the second .. read more


10.23937/2469-584X/1510033

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The systemic erythematous lupus (LES) is a chronic inflammatory disease of autoimmune aetiology, characterized by the involvement of multiple organs and systems. It can be related to the production of different antibodies and the formation of immune complexes. It is a universally distributed disease which most frequently affects young females in .. read more


10.23937/2469-584X/1510032

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A 29-year-old woman in her third pregnancy (at 22 weeks), with a history of arterial hypertension under treatment with enalapril, which medication was switched to α-methyldopa on gestation week 8. She then began to experience coluria, generalized pruritus, and asthenia. Four days before consultation, she presented with jaundice. .. read more


10.23937/2469-584X/1510031

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The gastrostomy is a procedure that aims to ensure a feeding pathway for patients who are unable to maintain adequate long term oral intake. Currently there are described the classical open technique and minimally invasive techniques, such as percutaneous endoscopic and percutaneous fluoroscopic gastrostomy, each one with its profile of indications .. read more


10.23937/2469-584X/1510030

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We report a 52-year-old man who underwent a screening colonoscopy, which revealed a sessile rectal polyp with neoplastic features on magnified chromo-endoscopy. Based on pit pattern analysis and endoscopic Ultrasound (EUS), Endoscopic Submucosal Dissection (ESD) was performed for a presumptive diagnosis of an early rectal neoplastic lesion (limited to the mucosa .. read more


10.23937/2469-584X/1510029

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Lipomas are benign tumors rarely found in the digestive tract, particularly rare in the colon, that were first described by Bauer in 1757 as an unusual cause of intussusception in the adult. Lipomas are most often small, asymptomatic and identified as incidental findings during colonoscopy. Nonetheless, up to 25% are symptomatic .. read more


10.23937/2469-584X/1510028

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In multiple-injury patients, the stomach and duodenum are part of the injury pattern to varying degrees in around 0.5-2% of the documented cases. In industrialized countries, abdominal injuries are mostly caused by a blunt accident mechanism. And yet, the abdominal upper GI injury is frequently not directly life-threatening. In 30-40% of .. read more


10.23937/2469-584X/1510027

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iver biopsy is not routinely recommended for the diagnosis of hepatocellular carcinoma (HCC). Identification of characteristic imaging findings is usually sufficient for diagnosis and biopsy is recommended for a subset of patients with indeterminate lesions based on imaging or clinical characteristics. The study aim was to determine real-world utilization and accuracy .. read more


10.23937/2469-584X/1510026

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Jejunal diverticulae are a rare phenomenon that is usually asymptomatic but can present with chronic abdominal pain or as an acute abdomen when complicated by intestinal diverticulitis, obstruction, haemorrhage or perforation. The clinical presentation is often atypical and therefore diagnosis occurs at surgical intervention or occasionally during an imaging investigation. Surgical .. read more


10.23937/2469-584X/1510025

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Listeria monocytogenes, a gram-positive rod, infects the central nervous system in neonates, pregnant woman and those immunosuppressed by naturally occurring illnesses and by therapeutic agents, including agents such as infliximab. We report here the first published case of Listeriosis complicating Infliximab therapy in Crohn's disease in Australia. .. read more


10.23937/2469-584X/1510024

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Meckel's diverticulum has an incidence of 2-4% and is the most common congenital defect of the gastrointestinal tract. It is usually asymptomatic, it may become clinically evident in the presence of complications such as haemorrhage, obstruction or diverticulitis. We here report the case of a young patient of 11 years old .. read more


10.23937/2469-584X/1510023

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Haemosuccus pancreaticus (HP) is a rare life threatening and difficult to diagnose cause of upper gastro-intestinal hemorrhage. It presents bleeding from the ampulla of Vater via the pancreatic duct. A 34-year-old woman was discharged from the Surgery Department after operation of pancreatic pseudocysts. Later she was rehospitalized twice due to bleeding .. read more


10.23937/2469-584X/1510022

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Cryptogenic multifocal ulcerous stenosing enteritis is a rare idiopathic condition, characterized by multiple small intestinal fibrous strictures with superficial ulcerations. It typically has a chronic or relapsing clinical course and has been mainly reported from Asia and Europe. We report a case of cryptogenic multifocal ulcerous stenosing enteritis (CMUSE) in a .. read more


10.23937/2469-584X/1510021

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Optimal management of the Inflammatory Bowel Diseases (IBD) aims for low levels of inflammation to reduce complication rates and disease burden. Scoring systems have been developed to monitor disease but most have not been validated or have shortcomings that limit their practical use. Our aim was to compare two patient related .. read more


10.23937/2469-584X/1510020

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Helicobacter pylori, a gram-negative, helical bacilli that live in the gastric epithelium was first isolated in 1983. It was discovered by Marshall and Warren who cultured Campylobacter pyloridis, which was later reclassified as Helicobacter pylori. It is transmitted via the fecal-oral, gastro-oral, or oral-oral routes. .. read more


10.23937/2469-584X/1510019

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Acute appendicitis is the most common cause of abdominal pain in the pediatric population and requires surgery. Its diagnosis is suspected on the basis of clinical findings widely known. However, the classic signs are not always present and symptoms may be nonspecific and overlap with other causes of abdominal pain. The .. read more


10.23937/2469-584X/1510018

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Ascites is the most common complication of cirrhosis, and is associated with increased mortality. Diagnostic paracentesis is recommended for patients who are admitted to the hospital with ascites. However, it is unknown if diagnostic paracentesis in Canadian teaching hospitals are done according to recommended guidelines. We analyzed the rate of paracentesis, .. read more


10.23937/2469-584X/1510017

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An appendectomy is one of the most commonly performed abdominal surgical procedures. During this operation, a Meckel's diverticulum (MD) can occasionally be found as an incidental finding, but the coexistence of both appendicitis and a perforated MD is fairly rare. Complications associated with an MD commonly occur in males, but the .. read more


10.23937/2469-584X/1510016

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Duodenal polyps are typically found during routine screening esophagogastroduodenoscopy for patients who have known hereditary polyposis syndromes. When polyps enlarge they may cause obstruction of the gastrointestinal tract, which is rare. We report an adolescent male without history of an underlying polyposis syndrome found to have multiple duodenal polyps comprised of .. read more


10.23937/2469-584X/1510015

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Helicobacter pylori is a common infection linked to dyspepsia, peptic ulcer disease, gastritis, gastric cancer, and MALT lymphoma. Endoscopic and nonendoscopic options may be used to diagnose H. pylori and confirm its eradication. Fourteen days of triple or quadruple therapy may be used as initial therapy, although clarithromycin-based triple therapy has .. read more


10.23937/2469-584X/1510014

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The patient is a 16 year-old male with CD and no family history of IBD, nephrotic disease or hypertension. CD was diagnosed at age 15 after intestinal biopsies demonstrated severe disease in the terminal ileum, ascending and transverse colon. Initial attempts to treat his disease with 5-aminosalicylic acid (800 mg mesalamine .. read more


10.23937/2469-584X/1510013

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Clostridium difficile infection (CDI) costs the national healthcare system billions of dollars annually, and is reaching epidemic proportions. The current study seeks to evaluate the efficacy and long term outcomes of outpatient colonoscopy-assisted fecal microbiota transplant (FMT) therapy in between 2011-2013 for recurrent or refractory CDI as part of a single .. read more


10.23937/2469-584X/1510012

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This review is a comprehensive summary of different variants of anti-Helicobacter pylori therapy from past strategies to the current state of the art. Nowadays we see a progressive decreasing of eradication rate in many countries in case of use standard triple therapy. It can be associated with high clarithromycin resistance of .. read more


10.23937/2469-584X/1510011

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Esophageal adenocarcinoma (EAD) has been recently described as 'the silent epidemic' because of its rapidly rising incidence. Two-thirds of patients with esophageal adenocarcinoma present with locally advanced disease. In spite of recent advances in cancer therapy, the treatment of locally advanced esophageal and gastroesophageal junction (GEJ) adenocarcinoma remains challenging. Current standard .. read more


10.23937/2469-584X/1510010

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Endoscopic retrograde colangio-pancreatography (ERCP) in children is currently widespread and utilized, particularly for therapeutic indication, as in adulthood. ERCP considered efficacy and safe in children, if performed by expert endoscopists. In the last year, the incoming progress of magnetic resonance image (MRI), especially in collaborator pediatric patients, eliminated many diagnostic indications .. read more


10.23937/2469-584X/1510009

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Liver transplantation (LT) is performed worldwide with immunosuppression being an indispensable component of the perioperative management. Calcineurin inhibitors and steroids have been the most popular and widely used drugs for a long time. However, steroids hold long-term adverse effects, as increased susceptibility to infection, hyperglycemia, hyperlipidemia, obesity, hypertension and osteopenia. Furthermore, .. read more


10.23937/2469-584X/1510008

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Gastrostomy tube (G-tube) placement, once a staple of surgeons and gastroenterologists, has propagated into other fields of medicine with interventional radiology (IR) performing percutaneous radiologic gastrostomy (PRG). With more G-tubes being placed by IR, there have been novel complications associated with this technique. In the following case series, we describe one .. read more


10.23937/2469-584X/1510007

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Gastroesophageal Reflux Disease (GERD) is a highly prevalent disease in the western world and affects approximately up to 20% of adults and nearly 25 million experience heartburn on a daily basis. Reflux esophagitis (RE) is caused by the excessive exposure of esophageal mucosa to aggressive factors like acid and pepsin leading .. read more


10.23937/2469-584X/1510006

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Lipomas form lobulated masses enclosed by thin and fibrous capsules. Colonic lipomas are usually discovered on colonoscopy, and gentle palpation with biopsy forceps reveals soft nature of the submucosal mass. Submucosal lipomas are usually not fixed to the underlying fascia. Large colonic ones may manifest as luminal obstruction, intussusception, volvulization or .. read more


10.23937/2469-584X/1510005

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Angiodysplasia of the gastrointestinal (GI) tract can present both diagnostic and therapeutic challenges. Despite the recent advances in endoscopy, many patients continue to suffer from recurrent bleeding. We report a remarkable case of a multi-year history of transfusion-requiring obscure overt recurrent GI bleeding, refractory to multiple endoscopic therapies as well as .. read more


10.23937/2469-584X/1510004

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The incidence of inflammatory bowel disease (IBD) in children has increased over the past 20 years and treatment with biologics is increasingly used.

Objective: We assessed the associations of biologics to IBD outcomes in children.

Methods: A retrospective investigation was conducted on a cohort of children with IBD between 1988/2008 who were enrolled .. read more


10.23937/2469-584X/1510003

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More and more studies have shown that mucosal healing on endoscopy has been the key prognostic parameter for inflammatory bowel disease (IBD) that predicts sustained clinical remission and resection-free survival of patients. It raised a big question as why the prognosis and long term remission of IBD are most strongly related .. read more


10.23937/2469-584X/1510002

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The incidence of hepatitis B virus (HBV)-related HCC has not declined for the past several decades. HBV is essentially a disease that could potentially be eradicated by a vaccine. According to the World Health Organization (WHO), two billion people (one-third of the global population) have been infected with HBV worldwide, and .. read more


10.23937/2469-584X/1510001

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Contact our editorial office at: gastroenterology.editor@clinmedlib.com


Editor-in-Chief

Bo Jin
Professor of Medicine
Department of Gastroenterology
The 309th Hospital of the People's Liberation Army
Beijing, China


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International Journal of Cancer and Clinical Research (ISSN: 2378-3419)
International Journal of Clinical Cardiology (ISSN: 2469-5696)
Journal of Clinical Gastroenterology and Treatment (ISSN: 2469-584X)
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International Journal of Oral and Dental Health (ISSN: 2469-5734)
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