Association of TNF-α Promoter Polymorphisms and Some Inflammatory Cytokines with Susceptibility to Rheumatoid Arthritis in Saudi Population
Amani A. Alrehaili, Khadiga A. Ismail, Afrah A. Alshehri, Salwa M. Fadel, Morouj M. Alharthi, Nada S. Alqurashi, Seham H. Al Ajmani and Amal F. Gharib
Article Type: Research Article | First Published: June 27, 2020
Rheumatoid arthritis (RA) is a chronic inflammatory condition that results in joint deformity and function loss within10 years after initiation. It is characterized by inflammation of the synovial membrane and damage of the joint by the immune cell results in severe arthritis with a progressive deterioration of the joint cartilage. It has a major negative effect on the ability to perform daily activities, including work which household tasks, and health related quality of life. Epidemiological e...
Study on Accuracy of Blind and Ultrasound-Guided Arthrocentesis of Hip Joint
Lyubomir Sapundzhiev, Tanya Sapundzhieva, Anastas Batalov, Marya Staikova, and Sevdalina Lambova
Article Type: Research Article | First Published: May 09, 2020
Ninety-six patients with uni- or bilateral radiologically proven hip osteoarthritis (OA) were included in the study. A total number of 187 hip joints were injected. One blind arthrocentesis by lateral approach was performed on each patient. The accurate position of the needle was verified by a following injection of 0.5-1.0 ml contrast and radiological assessment. After seven days, the same patients (187) underwent a second arthrocentesis under US guidance....
The Relationship Between Disease Activity, Demographic and Characteristic Features in Individuals with Rheumatoid Arthritis
Elif GUR KABUL, Bilge BAŞAKCI ÇALIK, Ceren KORKMAZ, Ummuhan BAŞ ASLAN, Murat TASCI, and Veli COBANKARA
Article Type: Research Article | First Published: March 02, 2020
A total of 143 participants (120 females, 23 males, mean age = 50.32 ± 12.14 years) diagnosed with Rheumatoid Arthritis (RA) according to the American College of Rheumatology 2010 criteria, were included in the study. Demographic features (gender, body mass index) and disease-related characteristics features (duration of disease, morning stiffness, presence of deformity, presence of nodules, dry eye, nail abnormalities, Raynaud's phenomenon, osteoporosis, dyspnea at rest, exertional dyspnea...
Bechet or Not, that is the Question?
Adnan N Kiani, Monthida Fangtham, Wilmer Sibbitt, Roderick Fields and Nicole S Emil
Article Type: Brief Report | First Published: January 30, 2020
A 20-year-old female with recurrent childhood ear infections, and reported history of recurrent oral, genital ulcerations and UTIs, presented as transfer from outside hospital with concern for Behcet syndrome. The patient initially had a 3-4-month history of fever, oral and genital ulcerations and worsening respiratory symptoms. She was initially treated at urgent care with antivirals and nitrofurantoin. She was later admitted to an outside hospital with worsening of aforementioned symptoms and ...
The Clever Deception by Silicone Gel-filled Breast Implant Manufacturers Regarding the Phenomenon of Gel Bleed
Arthur E Brawer, MD
Article Type: Commentary | First Published: November 08, 2019
From April of 1992 through November of 2006 a moratorium existed in the USA prohibiting the use of silicone gel-filled breast implants for routine cosmetic enhancement. This mandate, implemented by the Food and Drug Administration (FDA), centered around escalating claims of device-related systemic illness affecting hundreds of thousands of recipients who had these devices placed in their bodies during the 1970's and the 1980's. Varied theories of disease causation were proposed by numerous resea...
Severe MTX Toxicity in Rheumatic Diseases - Analysis of 22 Cases
Bergner R, Wadsack D and Loffler C
Article Type: REVIEW ARTICLE | First Published: Febrayry 25, 2019
Severe MTX (methotrexate) toxicity due to low dose MTX used in rheumatic diseases is rare but linked with a high mortality ranging from 13 to 44%. We analyzed 22 cases with a minimum toxicity of CTC (common toxicity criteria) grade 2, that were admitted to our hospital. We retrospectively analyzed epidemiological data, the weekly MTX dosage, renal function before and at the beginning of the adverse event, co-medication with influence on MTX toxicity or on renal function and potential other co-fa...
Muscle Ultrasound in Inflammatory Myopathies: A Critical Review
Kristofoor E Leeuwenberg and Jemima Albayda
Article Type: Review Article | First Published: February 11, 2019
Muscle ultrasonography is an upcoming tool in the evaluation of neuromuscular disorders. It is easily applicable in multiple clinical settings, has no contraindications, and provides a cost-effective alternative to other imaging modalities such as MRI. However, a known disadvantage of ultrasound is its dependence on examiner expertise. Furthermore, the assessment of muscle quality is done mainly through an assessment of muscle echo intensity, which is affected by machine/system settings, hamperi...
Clinical Pharmacological Management Status of Systemic Lupus Erythematous Population: Situational Analysis
Farida Al Balushi, Issa Al Salmi, Abdel Masiah Metry, Mohammed Abdalla Yousef and Suad Hannawi
Article Type: Research Article | First Published: December 20, 2018
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease that has various manifestations among different populations. This study aims to provide an overview of medical pharmacological management that SLE population received immediately at time of diagnosis. This is a retrospective analysis using patients’ registry medical information system. All patients diagnosed with SLE were reviewed by accessing their medical records including pharmacy prescription and dispersions at the Royal ...
Rheumatologic Diseases as Paraneoplastic Syndromes - A Paradigmatic Case
Ines Rego de Figueiredo, Rita Vieira Alves, Sara Guerreiro Castro, Filipa Lourenco, Ana Margarida Antunes, Heidi Gruner and Antonio Panarra
Article Type: Case Report | First Published: October 15, 2018
Rheumatic diseases can be a paraneoplastic syndrome for an occult neoplasia. Some syndromes are more characteristic than others. In this case report, we present a patient with musculoskeletal symptoms suggestive of both carcinomatous arthritis and polymyalgia rheumatica that was shown to have adenocarcinoma of the lung. The musculoskeletal symptoms accompanied the course of the disease, disappearing with the treatment and re-occurring when it relapsed. We present a 63-year-old male, native from ...