Journal of

Rheumatic Diseases and TreatmentISSN: 2469-5726

Early Online

 Open Access DOI:10.23937/2469-5726/1510080

Pregnancy Outcomes in Systemic Sclerosis Patients: Effects of Disease Subtype, Disease Onset, and Type I Topoisomerases

Hadi PoorMoghim, Moghadaseh Shakerian, Zahra Raoofi, Arash Jalali and Elham Andalib

Article Type: Research Article | First Published: March 30, 2020

Pregnancy occurred in 109 (84%) women (diffuse cutaneous systemic sclerosis, 48.8%; limited cutaneous systemic sclerosis, 52.2%). Based on the findings, 20 (15.5%) women were nulliparous. Overall, 229 pregnancies occurred before the disease onset and 49 pregnancies after the disease onset. Spontaneous abortion was reported more frequently in pregnancies occurring after the disease onset, compared to those occurring before the disease (24.4% vs. 9.6%; P = 0.005). Successful pregnancy was reported...

 Open Access DOI:10.23937/2469-5726/1510076

Foot Pain and Lesions in Systemic Sclerosis: Prevalence and Association with Organ Involvement

Hadi Poormoghim, Elham Andalib, Arash Jalali, Maryam Salimi-beni and Gholam Hossein Ghafarpour

Article Type: Research Article | First Published: September 07, 2019

In this cross-section study 133 scleroderma patients were probed throughout a survey in which both forms of digital and non-digital plantar lesions were included. Chi-square test and student’s t-test were used to determine the associations of foot pain and lesion with clinical features and serologic findings of the disease. multivariate analysis was used for determining independent factors associated with foot lesion and pain. Systemic Sclerosis (SSc) is a chronic devastating multi organ disea...

 Open Access DOI:10.23937/2469-5726/1510075

Hidden Toxicity of Human Papillomavirus Vaccine Ingredients

Arthur E Brawer, MD

Article Type: Case Report | First Published: August 07, 2019

Over the past five years clinicians from numerous countries have implicated human papillomavirus (HPV) immunizations as the cause of diverse systemic ailments, egregious injuries, and even death. Vaccine ingredients in Gardasil and Cervarix contain hidden organosiloxanes (organosilicones) and silica (silicon dioxide), all of which are capable of creating biochemical disturbances that are strikingly similar to the metabolic disruptions identified in both chronic fatigue syndrome and the recurrent...

 Open Access DOI:10.23937/2469-5726/1510074

Optimise: An Austrian Multicentre Study on the Effectiveness and Safety of Tocilizumab in Combination with Methotrexate versus Tocilizumab for Mild/Moderate Rheumatoid Arthritis and an Inadequate Response to Methotrexate

Burkhard F Leeb, Raimund Lunzer, Peter Fasching, Manfred Herold, Omid Zamani, Ute Riedlmair, Wolfgang Schimetta and Winfried B Graninger

Article Type: Research Article | First Published: August 03, 2019

As data on the efficacy of biologics in patients with mild/moderate rheumatoid arthritis are limited, this study was performed to assess the efficacy and safety of tocilizumab plus methotrexate versus tocilizumab monotherapy on disease activity. Additional tocilizumab treatment led to improvement in patients with mild/moderate rheumatoid arthritis. The study results give no indication that the combination of Tocilizumab with Methotrexate induces a better outcome (preserving the level of disease ...

 Open Access DOI:10.23937/2469-5726/1510073

ANA-Hep2 Positive with Anti-Rods and Rings Pattern in a Child without Hepatitis C under Treatment: Case Report

Mariana Magerl, Rinaldo Ferreira Gandra and Rafael Andrade Menolli

Article Type: Case Report | First Published: July 11, 2019

The immunofluorescence pattern of antinuclear antibodies (ANA) called rings and rods (RR) has only recently been described. This pattern has been associated with patients with Hepatitis C at treatment. There are few studies that demonstrate their appearance in healthy individuals or with other health conditions. This study reports positivity of this autoantibody in a patient never exposed to the HCV virus, in order to understand its clinical significance....

 Open Access DOI:10.23937/2469-5726/1510072

Dietary Habits of Women with Rheumatoid Arthritis Differ from that of Women without the Disease: Results from a Population-Based Study

Klara Nypelius Standley, Inger Gjertsson, Anna Winkvist and Helen M Lindqvist

Article Type: Research Article | First Published: July 04, 2019

Nutritional status of patients with rheumatoid arthritis (RA) is often poor. In addition, popular trends in avoiding certain foods have been noted among patients with RA yet recent data on dietary intake is lacking. The aim of the present study was to examine possible differences in food intake between Swedish women with and without RA. In total 150 women with RA, selected from the Swedish Rheumatology Quality Register, and 163 women without RA, answered a postal food frequency questionnaire inc...

 Open Access DOI:10.23937/2469-5726/1510071

Urinary VCAM-1, KIM-1, and ET-1 as Biomarkers of Lupus Nephritis: Correlation with Immunological Parameters in Hospital USM

Siti Khadijah SM Nazri, BSc, Wan Syamimee W Ghazali, MD, MMed, Noor Suryani M Ashari, MD, MPath and Wan Zuraida WA Hamid, MD, MPath

Article Type: Research Article | First Published: May 15, 2019

So far, there is no conventional parameters that have been proven to possess the ability to predict the histology of systemic lupus erythematosus (SLE). A few autoimmune serology markers of SLE including anti-dsDNA antibodies, complement C3 and C4, and anti-nucleosome could be helpful clinically, but the correlation between those and lupus renal disease is still imperfect. Recently, the urinary vascular cell adhesion molecule-1 (VCAM-1), kidney injury molecule-1 (KIM-1) and endothelin-1 (ET-1) h...

Volume 5
Issue 2