International Journal of Virology and AIDS is an open access peer reviewed journal that publishes, reviews, original research, news and views, articles, clinical reports, short communications, and letters to the editor and application studies across all fields of virology and publishes the very latest ground breaking research on AIDS. It deals with the various viruses involvement in humans followed by their replication to acquire immune deficiency syndrome, which became a major challenge for many scientist and doctors for treating deadly virus HIV. Main focus will be on various topics from classification of viruses, replication, host-phage interactions immunology, viral infections in humans to their treatment, advances in AIDS research and many more within the scope of subject.

The main objective of the journal is to act as a forum for publication, education, and exchange of opinions, and to promote research and publications globally. Through open access it expands shared knowledge across doctors; it provides the free, immediate, availability of the published work online. This journal also involved into publishing news with time by time developments and advances in research of various viral infections and their treatments, which helps users to understand the severity and precaution measures to be taken.

 
Journal Information

Title: International Journal of Virology and AIDS

ISSN: 2469-567X

Editor-in-chief: Abubaker ME Sidahmed

NLM title abbreviation: Int J Virol AIDS

ISO abbreviation: Int J Virol AIDS

Other titles: IJVA

Category: Biological Science / General Medicine

Country of publication: USA

Language: English

DOI: 10.23937/2469-567X

Publication format (s): Electronic and print

Publication policy: Open Access; COPE guide

Peer review: Double blind

Review speed: 3 weeks

Fast-track review: 10 days

Publication type(s): Periodicals

Publisher: ClinMed International Library

Contact email: contact@clinmedjournals.org

 
Articles Search by   Keyword   |   Journal title   |   Author name   |   DOI

 

 Open Access DOI:10.23937/2469-567X/1510043

90-90-90, Epidemic Control and Ending AIDS: Global Situation and Recommendations

Reuben Granich, Somya Gupta and Brian Williams

Article Type: Review Article | First Published: September 17, 2018

Although human immunodeficiency virus (HIV) first came to our attention thirty-seven years ago, the acquired immunodeficiency syndrome (AIDS) which it causes is, without treatment, 100% fatal with devastating consequences for millions of people...
 

 Open Access DOI:10.23937/2469-567X/1510042

Microhomology of Viral/Host DNAs and Macrostructure of Herpesviral Genome

Felix Filatov and Alexandr Shargunov

Article Type: Research Article | First Published: September 01, 2018

In 2015, we described short continuous fragments of human herpesvirus DNA, identical to the cellular ones, which we called microhomology (hits) because of their small size (≥ 20 nt). We noticed that generally the increase in the density (D) of these hits in human herpesviruses is inversely proportional to a decrease in the pathogenicity of these viruses. In this small work, we are considering the question of the existence of more objective features of HHV DNA (which can accompany the dynamics ...
 

 Open Access DOI:10.23937/2469-567X/1510041

Modeling the HIV Epidemic: Why the 95-95-95 Target and ART Effectiveness Parameters Matter

Reuben Granich, Somya Gupta, Matt Wollmers, Mike Ruffner and Brian Williams

Article Type: Review Article | First Published: August 20, 2018

HIV remains a major global public health threat with one million HIV-related deaths, two million new infections and over 1 million HIV-associated TB cases each year. However, population-based studies suggest marked declines in incidence, prevalence and deaths in the countries in East and Southern Africa that have expanded antiretroviral treatment (ART) at the fastest rate in the world....
 

 Open Access DOI:10.23937/2469-567X/1510040

Viral Infections after Kidney Transplantation: An Updated Review

Ethem Unal and Ahmet Topcu

Article Type: Review Article | First Published: July 01, 2018

Infections are the major cause of morbidity and mortality in kidney transplant recipients. Careful pretransplant screening, immunization, and posttransplant prophylactic antimicrobials may all reduce the risk for posttransplant infections. Chronic immunosuppression, required to maintain allograft function post-organ transplant, predisposes transplant patients to a variety of viral infections....
 

 Open Access DOI:10.23937/2469-567X/1510039

Prevalence of Haematological and Serum Biochemical Abnormalities in HIV Infected Patients in Ghana, Before and after Antiretroviral Therapy

Samuel Kwadwo Afari and Emmanuel Awusah Blay

Article Type: Research Article | First Published: June 07, 2018

Highly Active Antiretroviral Therapy (HAART) has led to prolonged survival of HIV-infected patients. However, the long-term use of HAART has the potential to cause haematological and biochemical abnormalities such as cytopenia, liver damage and renal injuries, which may be life threatening....
 

 Open Access DOI:10.23937/2469-567X/1510038

Adherence to Antiretroviral Therapy among Adult Persons Living with HIV/AIDS in Southern Ethiopia

Hailu Chare Koyra

Article Type: Original Research | First Published: 10.23937/2469-567X/1510038

Unlike other chronic diseases, people receiving anti-retroviral treatment should have very high levels of adherence (≥ 95%) to achieve durable suppression of viral load; avoid the emergence of drug resistance and clinical failure. Therefore, this study was aimed to assess level of adherence and predictors of poor adherence among adult ART patients at Dubbo St. Marry Hospital, Southern Ethiopia....
 

 Open Access DOI:10.23937/2469-567X/1510037

Differential Risky Behaviors among HIV Positive and HIV Negative People

Celine Nguefeu Nkenfou, Josiane Gouekem, Antoine Socpa, Blandine Nkenfou Kampa, Elvis Ndukong Ndzi, Alexandre Nkoum and Alexis Njolo

Article Type: Research Article | First Published: December 28, 2017

HIV positive and HIV negative people were recruited in the capital city of Cameroon. Data were collected through a structured questionnaire, pretested and validated, before and after the knowledge of HIV status. The information collected include: Age at first sexual intercourse, number of sexual partners, usage of condoms and frequency of sexual intercourses....
 

 Open Access DOI:10.23937/2469-567X/1510036

p53 Expression Activation of HIV-1 Latency in U1 Cells

Xue Wang , Jiangqin Zhao, Christelle Mbondji and Indira Hewlett

Article Type: Research Article | First Published: November 18, 2017

Latent infection is a major barrier for cure of HIV-1 infection. HIV-1 is capable of establishing latency when its host cells undergo apoptosis and initiate replication in response to this effect. HIV infection results in increased p53 expression that enhances replication in primary infection....
 

 Open Access DOI:10.23937/2469-567X/1510035

Concurrent HIV and Zika Virus Infection, A Problem to be Address in HIV Medicine

Beuy Joob and Viroj Wiwanitkit

Article Type: Letter | First Published: October 25, 2017

The concurrences between HIV infection and Zika virus infection are already reported [1-3]. The first case report was from Brazil. There is no significant important clinical observation on the concurrence. The problem in the HIV pregnant woman is also already reported....
 

 Open Access DOI:10.23937/2469-567X/1510034

Dual Cytomegalovirus and Aspergillus Pneumonia Following Influenza B Infection in a Patient with Polyarteritis Nodosa

Chiu-Yin Yeh, Hsi-Hsing Yang and Wen-Liang Yu

Article Type: Case Report | First Published: September 20, 2017

Polyarteritis Nodosa (PAN) is a systemic necrotizing vasculitis that might require immunosuppressive therapy. We report on a 72-year-old woman of PAN with influenza B infection, who developed dual cytomegalovirus and Aspergillus pneumonia in the later course....
 

 Open Access DOI:10.23937/2469-567X/1510033

Acute Pulmonary Embolism in Dual Dengue Fever and Influenza B Infection

Wen Chi Hsu and Wen Liang Yu

Article Type: Letter to Editor | First Published: September 08, 2017

Acute Pulmonary Embolism (PE) is a life-threatening condition and the common cause of death is due to obstruction of main pulmonary vessels by the embolus, resulting in pulmonary hypertension followed by right-sided heart failure....
 

 Open Access DOI:10.23937/2469-567X/1510032

Etiologic Viral Characterization of Acute Respiratory Infections in Children in the Western Amazon-Brazil

Santos AO, Botelho-Souza LF, Lopes DS, Rodrigues GT, Queiroz JAS, Matos NB, Salcedo JMV and Vieira DS

Article Type: Research Article | First Published: August 31, 2017

Acute Respiratory Infections (ARIs) are classified according to the compromised anatomical site. The etiology can be associated with viruses, bacteria and fungi. The etiological agents that are responsible for the highest incidence in children, around 50 to 90% of occurrences, are viruses....
 

 Open Access DOI:10.23937/2469-567X/1510031

Hepatitis B Induced Kaposi Sarcoma Flare

Ezgi Ozkur , Mehmet Salih Gurel, Sevil Savas, Ayse Esra Koku Aksu and Sumeyre Seda Ertekin

Article Type: LETTER TO EDITOR | First Published: August 19, 2017

Kaposi Sarcoma (KS) is a malignant disease that originates from the vascular endothelium and has a very variable clinical course. KS is a vascular endothelial malignancy and the neoplastic cells are closely related to lymphatic endothelial cells. Although HHV-8 is found in the vast majority of all types of KS, there is no agreement on the exact mechanism of HHV-8 in KS....
 

 Open Access DOI:10.23937/2469-567X/1510030

Sensitive, Subtype Independent HIV-1 PCR Assays for Assessment of Residual Viremia and Total HIV-1 DNA

Tomas Mellberg, Jon Krabbe, Maria J Buzon, Ulrika Noborg, Magnus Lindh, Staffan Nilsson, Bo Svennerholm and Magnus Gisslen

Article Type: Original Research | First Published: July 01, 2017

Correct measurements of residual viremia and reservoir size are crucial in HIV-1 eradication trials and there is a need for sensitive and automated assays. The increasing worldwide diversity of HIV-1 subtypes stresses the importance of subtype independent assays....
 

 Open Access DOI:10.23937/2469-567X/1510029

Virologic Response and Survival Analysis of 281 HbsAg Treatment Naive Patients on Lamivudine Monotherapy in Sierra Leone

Jia B Kangbai, Isata Victoria Mandoh and Peter Bai James

Article Type: Research Article | First Published: June 17, 2017

More than 350 million people are infected with Hepatitis B Virus (HBV) globally. The main aim of any chronic hepatitis B therapy is to prevent liver cirrhosis and its sequelae, including Hepatocellular Carcinoma (HCC)....
 

 Open Access DOI:10.23937/2469-567X/1510028

Successful Treatment of Chronic Hepatitis C using Pegylated Interferon and Ribavirin in a Patient with Sheehan's Syndrome

Rong Xu, Yong-hong Zhang and Xu Yang

Article Type: Case Report | First Published: September 29, 2016

A 50-year-old female with Sheehan's syndrome was treated for chronic hepatitis C using pegylated interferon-α2b and ribavirin. The patient's HCV-RNA status was negative by the fourth week and remained undetectable until the completion of treatment without signs that Sheehan's syndrome had been exaggerated. This case demonstrates that pegylated interferon-α2b and ribavirin does not necessarily exacerbate Sheehan's syndrome....
 

 Open Access DOI:10.23937/2469-567X/1510027

Human Immunodeficiency Virus Infections in the Middle East and North Africa: Prevalence, Risk, Prevention and Challenges

Ahmed A Abd-Rabou

Article Type: Review Article | First Published: September 27, 2016

The Middle East and North Africa (MENA) has few recorded outputs regarding the prevalence of the human immunodeficiency viral (HIV) infections associated with acquired immune deficiency syndrome (AIDS). When we went through the HIV/AIDS in MENA, we found a hole in the scientific publications. Attention towards this issue progressed recently though, with few pre-clinical studies conducted. In the current review, we collected comprehensive data of ...
 

 Open Access DOI:10.23937/2469-567X/1510026

Elimination of Mother-to-Child Transmission of HIV in Democratic Republic of Congo: Implementation of 'Test &Treat' Approach at Primary Health Centers

Mulamba Diese, Susie Villeneuve, Emile Numbi, Freddy Salumu, Guy Clarysse, Hilo Ilunga, Franck Fwamba, Theodore Assani and Abel Mukengeshayi Ntambue

Article Type: Review Article | First Published: July 30, 2016

The 'Test & Treat' approach, also called option B+, using combination antiretroviral treatment (cART) for prevention of mother-to-child transmission (PMTCT) has been very effective in controlled clinical trials in resource-limited settings. We report on our experiences with implementing this approach at primary healthcare settings in Katanga province, Democratic Republic of Congo (DRC). The objective of this study was to evaluate 'Test & Treat' a...
 

 Open Access DOI:10.23937/2469-567X/1510025

The Monitoring of Lymphocyte Populations may be Optional in Patients with Suppressed Viremia: A Two Years Observational Study

Carlos Tornero, Marina Llopis, Julian Diaz and Mariangeles Martinez

Article Type: Commentary | First Published: July 25, 2016

The determination of lymphocyte populations (LPs) traditionally has been included in the routine follow-up of HIV-infected patients as an indicator of the degree of immune suppression and of the need to start treatment, select the type of therapy, or prescribe preventive measures against opportunistic infections. However, the variability of the technique produces variations in patients with undetectable viremias that have no clinical consequences...
 

 Open Access DOI:10.23937/2469-567X/1510024

HIV Exposed Uninfected Children at School Age: Developing Country Context

Gwendoline Q Kandawasvika, Felicity Z Gumbo and Patience Kuona

Article Type: Review Article | First Published: July 14, 2016

With the success of chemoprophylaxis for the prevention of perinatal transmission of the human immunodeficiency virus (HIV), an increasing number of HIV-exposed but uninfected (HEU) children will have in utero and post-partum exposure to antiretroviral drugs and survive beyond infancy. The long term effect of antiretroviral drug exposure is however not fully understood. A few studies from developing countries have reported on growth, morbidity, m...
 

 Open Access DOI:10.23937/2469-567X/1510023

Determinants of Survival in HIV Patients: A Retrospective Study of Dilla University Hospital HIV Cohort

Solomon Hailemariam, Girma Tenkolu, Henok Tadese and Prabhanjan Kumar Vata

Article Type: Research Article | First Published: July 01, 2016

Highly Active Antiretroviral Therapy (HAART) has remarkably improved the survival of Human Immunodeficiency Virus (HIV) patients though it is not sufficient alone to achieve better HIV related clinical outcomes. There are many other modifiable factors that might have an impact on survival of HIV-infected patients. So far, few studies with small sample size have tried to assess the survival experience of HIV positive patients who are on treatment ...
 

 Open Access DOI:10.23937/2469-567X/1510022

Survival among Dually Infected HIV Patients Compared to HIV-1 Mono-Infected Patients Receiving ART in Senegal: A Twelve-Year Cohort Study

Assane Diouf, Amandine Cournil, Sabrina Eymard-Duvernay and Louise Fortes-Deguenonvo

Article Type: Research Article | First Published: June 27, 2016

A total of 403 HIV infected patients (10 HIV-D infected and 393 HIV-1s infected) who initiated ART in Senegal between 1998 and 2002 were included in a prospective cohort and followed until June 2010. Initial ART regimens combined two nucleoside-reverse transcriptase inhibitors (NRTI) plus either one non-nucleoside-reverse transcriptase inhibitor (NNRTI) or one protease inhibitor (PI). Clinical and biological assessments were performed at ART init...
 

 Open Access DOI:10.23937/2469-567X/1510021

Comprehensive Programme to Prevent Cervical Cancer - the Case of Hungary

Dobrossy L, Oroszi B, Kovacs A and Budai A

Article Type: Case Report | First Published: April 30, 2016

The overall purpose of a comprehensive cervical cancer prevention programme is to coordinate HPV vaccination (primary prevention) and cervical screening (secondary prevention). Harmonization of the HPV vaccination and population screening is expected to reduce the burden of cervical cancer by reducing human papillomavirus (HPV) infections, and detecting cervical pre-cancer lesions and invasive cancer earlier, providing timely treatment. In 2015, ...
 

 Open Access DOI:10.23937/2469-567X/1510020

PrEP Works, But Only When You [Have Access to] Take it: Improving PrEP Access for Young People in Chicago and Philadelphia

S Caitlin Conyngham, Cassie R Warren and Helen C Koenig

Article Type: Commentary | First Published: March 31, 2016

The 2012 United States Food and Drug Administration approval of Tenofovir/Emtricitabine for HIV pre-exposure prophylaxis (PrEP) has added a highly effective, safe biomedical option to the HIV prevention toolbox. In the United States, young black and Latino men who have sex with men (MSM) and transgender women are disproportionately affected by HIV risk over the course of their lifetime. Nearly 1 in 10 black MSM under age 25 is infected with HIV e...
 

 Open Access DOI:10.23937/2469-567X/1510019

Non Alcoholic Fatty Liver Disease and Bone Fractures in Patients with HIV

Pollo-Flores P, BicudoA, Cruz-FilhoR and Soares DV

Article Type: Short Review | First Published: March 31, 2016

Human immunodeficiency virus infection has posed a challenge for mankind and now this disease is more of a challenge for quality of life than for virus related mortality. This review aims to study two prevalent diseases that may affect this population by decreasing their quality of life. Bone fractures are much more common in the HIV-positive population and have many etiopathogenesis implicated. Non-alcoholic fatty liver disease is also common in...
 

 Open Access DOI:10.23937/2469-567X/1510018

Nucleoside Reverse Transcriptase Inhibitor (NRTI) Associated Macrocytosis

Wesley D. Kufel, Cory M. Hale, Eric F. Sidman, Cesar E. Orellana and Christopher D. Miller

Article Type: Short Review | First Published: March 31, 2016

Macrocytosis has been associated with several disease states, vitamin deficiencies, and medications, with nucleoside reverse transcriptase inhibitors (NRTIs) being a less commonly identified cause. NRTIs are frequently utilized as the two-drug backbone for the treatment of Human Immunodeficiency Virus (HIV). Amongst the NRTI drug class, zidovudine (AZT) and stavudine (d4T) are the most widely reported cause of macrocytosis. Fortunately, AZT and d...
 

 Open Access DOI:10.23937/2469-567X/1510017

The AIDS Myth at 30

Erhard Geissler

Article Type: Short Review | First Published: March 03, 2016

In 1985 the KGB and East Berlin's professor of Biology started the AIDS disinformation campaign by accusing the United States of America of having constructed and spread the AIDS agent in the course of biological weapons research. Now, 30 years later, a German authority, The Federal Commissioner for the Records of former East Germany's State Security Service, the "Stasi", is spreading disinformation regarding the alleged substantial involvement o...
 

 Open Access DOI:10.23937/2469-567X/1510015

Organotropic Kinetics in Acute Sublethal Transient Cytomegalovirus Infection in Mice

Daniel Benharroch, Ory Rouvio, Aharon Palmon and Bracha Rager

Article Type: Research Article | First Published: January 03, 2016

Murine cytomegalovirus (MCMV) shows many similarities with the human virus (HCMV). This is a ubiquitous DNA virus from the betaherpesvirus group. A self-limiting acute phase of viral infection and a persistent latent phase normally characterize the pathogenesis of MCMV infection in the immunocompetent host. The MCMV widespread distribution occurs via the blood and its mononuclear cells. In the more common congenital viral infection, the HCMV caus...
 

 Open Access DOI:10.23937/2469-567X/1510014

Characterization of Human Influenza Viruses Propagated by Madin-Darby Canine Kidney Cells or Embryonated Eggs

Ewan P Plant, Laura Couzens, Samuel Mindaye, Elizabeth M Coyle, Surender Khurana, Hang Xie, Hana Golding, Maryna C Eichelberger and Zhiping Ye

Article Type: Research Article | First Published: November 22, 2015

The hemagglutination assay is a commonly used method to titer influenza virus. It relies on the interaction between virus particles and red blood cells being sufficient to prevent the settling of the blood cells. During additional assessment of human influenza virus stocks titrated by the hemagglutination assay we noted that virus grown in cell culture had a greater number of virus particles than analogous virus grown in eggs. Virus grown in both...
 

 Open Access DOI:10.23937/2469-567X/1510013

Salviae and Cinnamomi Herbal Medicines have Antiviral Activity against a Broad Range of Human Immunodeficiency Virus

Fu-Shi Quan, Young Jae Lee, Richard W Compans and Sang-Moo Kang

Article Type: Research Article | First Published: October 23, 2015

Development of broadly effective anti-human immunodeficiency virus (HIV)-1 compounds is a high priority since the number of individuals having HIV infections continues to grow worldwide and vaccines are not available yet. From herbal extracts commonly used in humans, Salviae miltiorrhiza (Salviae), Cinnamomi Ramulus (Cinnamomi), Astragali Radix (Astragali), Asari Radix et Rhizome (Asari), Panax Ginseng (Korean red ginseng), we screened candidate ...
 

 Open Access DOI:10.23937/2469-567X/1510012

Impact of Human T-Lymphotropic Virus (HTLV I/II) Diagnosis on the Frequency of Mood Disorders in a Non-Endemic Area

Sergio Monteiro de Almeida, Meri Bordignon Nogueira, Rafaela Miravalhes, Thiago Mestre, Francisco Jaime Barbosa, Marise Zonta, Gabriel Santos Schafer, Indaiara Felisbino, Suzana Carstensen, Ana Cristina Medeiros, Indianara Rotta, Mirian Pelegrino Beltrame, Sonia Mara Raboni and Luine Rosele Vidal

Article Type: Research Article | First Published: October 22, 2015

Chronic diseases cause different impact to different people. We performed this study to evaluate the impact of human T-lymphotropic virus (HTLV I/II) diagnosis on the frequency of mood disorders. Of six HTLV I/II infected patients, including one asymptomatic, four reported depression at the moment of HTLV diagnosis. The findings reveal that it is crucial to inform patients of the HTLV diagnosis only after conducting confirmatory tests, as indicat...
 

 Open Access DOI:10.23937/2469-567X/1510011

Exposure to HIV-1 Altered CCR7-Mediated Migration of Monocytes: Regulation by PGE2

Sandra C Cote, Stamatoula Pasvanis and Nancy Dumais

Article Type: Research Article | First Published: October 04, 2015

Transmission and pathogenesis of the Human Immunodeficiency Virus type-1 (HIV-1) are interconnected during all stages of the disease with cells of the monocyte/macrophage lineage. Monocytes are constantly exposed or are targets of HIV-1 and their migratory behaviors are implicated in the dissemination of the infection throughout the host. Monocytes arising from quiescent and infected cells of the myeloid precursor lineage in bone marrow have been...
 

 Open Access DOI:10.23937/2469-567X/1510010

Codon Usage as a Possible Source of Sofosbuvir Genetic Resistance Bias in HCV Patients Infected with Different Genotypes

Carlos Campayo, Antonio Mas and Rosario Sabariegos

Article Type: Commentary | First Published: September 28, 2015

Hepatitis C virus (HCV) is responsible for liver chronic infections that in a high percentage of cases lead to cirrhosis and hepatocellular carcinoma. In the past, treatment consisted on a combination of pegylated interferon plus ribavirin. However, since 2012 a new wave in treatment options appears with the new family of drugs targeting viral components, the so-called direct-acting antivirals. Now we have a battery of drugs directed against vira...
 

 Open Access DOI:10.23937/2469-567X/1510009

Oral Health Care to HIV-Infected Children

Gerardo Rivera Silva and Hector R Martinez Menchaca

Article Type: Commentary | First Published: June 25, 2015

The prevalence of oral lesions in human immunodeficiency virus (HIV)-infected children in developed countries is equivalent to 72%, meanwhile in developing countries it equates to 60%. For this reason health professionals should identify and treat the numerous oral manifestations in HIV-infected children. There are several oral lesions that could be present in HIV-infected children....
 

 Open Access DOI:10.23937/2469-567X/1510008

Liver Fibrosis in HIV and HCV Co-Infection: Independent Mechanisms versus Collective Efforts

Jose D Debes, Paul R Bohjanen and Andre Boonstra

Article Type: Review Article | First Published: May 27, 2015

Liver disease is the leading cause of death not related to AIDS in patients infected with human Immunodeficiency Virus (HIV). Patients co-infected with HIV and hepatitis C virus (HCV) experience a more rapid progression liver to fibrosis and develop hepatocellular carcinoma at a younger age than those infected with either virus alone. The mechanisms promoting this accelerated progression to fibrosis are not totally understood. Moreover, it is unc...
 

 Open Access DOI:10.23937/2469-567X/1510007

Monocyte-Derived Dendritic Cells from Feline Immunodeficiency Virus Positive Cats are Productively Infected and Maintain CD8+ T Cell Stimulatory Capacity

Hood SF, Thompson EM, Akaronu NO, Miller MM and Fogle JE

Article Type: Research Article | First Published: April 03, 2015

Dendritic cells (DCs) have been utilized to enhance CD8+ T cell responses to pathogen-associated peptides for enhancement of vaccine efficacy. CD8+ T cells play a central role in the elimination of viruses during acute viral infection and control of viremia during chronic viral infection. For lentiviral infections such as HIV and FIV, dendritic cell vaccines may be useful for augmenting CD8+ T cell function....
 

 Open Access DOI:10.23937/2469-567X/1510006

International Journal of Virology and AIDS is Committed to Publishing High Quality Papers in Current Virology and AIDS Research

Christopher J. Menzie and Shu-Feng Zhou

Article Type: Editorial | First Published: March 30, 2015

Understanding how viruses work and interact with the host is of the upmost importance. For example, the Ebola virus disease (formerly known as Ebola hemorrhagic fever) first appeared in 1976 in two simultaneous outbreaks, one in Nzara, Sudan, and the other in Yambuku, Democratic Republic of Congo....
 

 Open Access DOI:10.23937/2469-567X/1510005

T-reg are the Predominant CD4+ T-Cell Subset Productively Infected with HIV-1 at Sites of Dual HIV/TB Infection

Christina S Hirsch, Shigou Liu, Joy Baseke, John Lusiba Kafuluma, Mary Nserko, Harriet Mayanja-Kizza and Zahra Toossi

Article Type: Research Article | First Published: February 10, 2015

Background: Regulatory T-cells (T-reg) are expanded during active tuberculosis (TB) regardless of HIV-1-infection, particularly at sites of M. tuberculosis infection. In HIV-1 disease, T-reg are targeted by HIV-1 infection. However, whether they contribute to promotion of HIV-1 infection at sites of HIV/TB is unknown. Methods: Pleural fluid mononuclear cells (PFMC) from HIV/TB patients with pleural TB were characterized by immunostaining and FACS...
 

 Open Access DOI:10.23937/2469-567X/1510004

Hepatocellular Carcinoma in HIV-Infected Patients: Clinical Characteristics and Prognostic Factors

Antonio Diaz-Sanchez, Pilar Miralles, Ana Matilla, Teresa Aldamiz-Echevarria, OscarNunez Ana Carrero, Beatriz Merino, Cristina Diez, Rafael Banares, Gerardo Clemente and Juan Berenguer

Article Type: Research Article | First Published: December 26, 2014

We analyzed 53 HIV-infected patients with hepatocellular carcinoma (HCC) diagnosed at our institution from 1998 to 2012. All patients were coinfected with hepatitis virus (77% HCV; 12% HBV; 11% HCV+HBV), and 95% had liver cirrhosis. HCC was diagnosed under surveillance in 41% of patients. Potentially curative therapy was given to 32% of patients and palliative therapy to 30% patients. Median survival was 2 months in those diagnosed from 1998 to 2...
 

 Open Access DOI:10.23937/2469-567X/1510003

Modification of Antiretroviral Therapy in a Cohort Study of HIV-Infected Patients Attending an Urban Teaching Hospital in Kenya

AO Owuor, GN Lule, CF Otieno, EO Omonge, MC Maritim and P Memiah

Article Type: Research Article | First Published: November 28, 2014

Objective: To determine the prevalence and factors associated with ART modification among HIV patients on 1st line therapy attending a large Teaching Hospital in Kenya. Methods: A retrospective cross-sectional clinical record review. All patients who commenced ART from January 2005 to June 2011 and had at least 1 follow-up visit were evaluated. Baseline data, including socio demographic and clinical variables was collected using a standard char...
 

 Open Access DOI:10.23937/2469-567X/1510002

Prognostic Value of Some Acute Phase Reactants in the Management of Pulmonary Tuberculosis Disease

Akpotuzor Josephine O, Ekarika Evelyn A and Akwiwu Euphoria C

Article Type: Research Article | First Published: November 16, 2014

This study was conducted to assess the relevance of serum C- reactive protein (CRP), erythrocyte sedimentation rate (ESR), relative plasma viscosity (RPV) and fibrinogen level in the management of pulmonary tuberculosis (PTB) disease. One hundred (100) PTB patients attending the TB clinic of Dr Lawrence Henshaw Memorial Specialist Hospital Calabar, and 70 age and sex-matched apparently healthy subjects between 15-65 years of age were selected and...
 

 Open Access DOI:10.23937/2469-567X/1510001

Therapeutic Targeting of Structural RNA Motifs in Viral RNA Genomes

Joanna Sztuba-Solinska

Article Type: Editorial | First Published: July 19, 2014

Viral RNA genomes have evolved functional motifs, which act at different stages of their life cycle. These unique structural domains, their interactions and association with host proteins and ligands, together orchestrate the multifunctionality of viral RNA genomes. Often, long-range RNA-RNA interactions bring regulatory elements into proximity, changing our view of a functional viral RNA genome from a linear molecule to one whose three-dimension...

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Elder Mistreatment and its Subtypes across Different Sociodemographic and..
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Balance and its Clinical Assessment in Older Adults - A Review..
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Caregiver Abuse of Chicago Chinese Older Adults in a Community..
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The Relationship of Older Adults' Physical Pain to Depression and..
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Sphingosine 1-Phosphate Receptor 2 Regulates the Migration,..
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Mammary Epithelial Cell Lineage Analysis via the Lyon's Hypothesis..
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Epigenetic Loss of MLH1 Expression in Normal Human Hematopoietic Stem Cell..
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Long-Term Function, Pain and Medication Use Outcomes of Radiofrequency..
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Caspase Cleaved Tau in Alzheimer's Disease: A Therapeutic Target..
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Corpora Amylacea in Neurodegenerative Diseases: Cause or Effect?..
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Differences in ME and CFS Symptomology in Patients with Normal and..
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Gene-Specific Promoter Methylation Status in Hormone-Receptor-Positive..
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A Derivative of Differentiation-Inducing Factor-3 Inhibits PAK1..
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Overcoming Endocrine Resistance in Hormone-Receptor Positive Advanced..
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Zinc Ionophore (Clioquinol) Inhibition of Human ZIP1-Deficient Prostate..
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Electron Microscopic Analysis of Silicate and Calcium Particles..
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Effects of chest physical therapy in patients with non-tuberculous mycobacteria
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A Community-Based Exercise and Support Group Program Improves Quality..
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Four Weeks of Balance Training Does Not Affect Ankle Joint Stiffness in Subjects..
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Social Ecology and Diabetes Self-Management among Pacific Islanders..
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Examining Characteristics of Hospitalizations in Heart Failure Patients: Results..
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