Modified Non-Invasive Computational Methods of HIV Drug Combinations for Treatment of Coronavirus Disease-19 (COVID-19)
Tamer Ezzat Youssef and Youssef Tamer Moustafa
Article Type: Original Research | First Published: April 11, 2020
As of 18 March 2020, more than 191127 cases of confirmed COVID-19 have been documented globally with over 7807 deaths. The impact of COVID-19 on patients with HIV have common presentations like non-HIV patients include fever, dry cough, difficulty of breath. Parallel evidence indicates that the risk of disease increases with critically more than 66 years age, including chronic lung disease. It is very difficult to use drugs on the market. We apply drug design computer techniques to find the expe...
Molecular Detection of Human Papilloma Virus Type 16 among Conjunctival Intraepithelial Neoplasia Patients in Khartoum State, Sudan
Hala H Ahmed, Aya A Almtry, Isra M Aidrous, Sara M Ali, Mohamed H Arbab and Ali M Badri
Article Type: Research Article | First Published: February 29, 2020
Many factors like exposure to UV radiation, climatic conditions, genetic predisposition, immunological state and, more recently, the presence of HPV have been implicated in the genesis of some lesions of the conjunctiva, especially the carcinoma. The study was carried out to detect Human Papilloma Viruses HPV type 16 in conjunctival intraepithelial neoplasia patient in Khartoum state, Sudan during the period from March to July 2019. A total of 50 Formalin-fixed paraffin- embedded Samples were co...
Pre-analytical Errors in the HIV Anti Retro Viral Therapy (ART) Laboratory of Teaching Referral Hospitals in Addis Ababa, Ethiopia
Abay Sisay Misganaw, Mulugeta Worku, Chala Bashea, Mamaru Nigus, Yisak Yoseph, and Habtamu Molla
Article Type: Brief Report | First Published: October 18, 2019
To assess the magnitude and associated factor of pre-analytical error in the Human Immunodeficiency Virus (HIV) antiretroviral therapy (ART) laboratory of a teaching referral hospitals in Addis Ababa, Ethiopia. A cross-sectional descriptive study design was used from May 1, 2018 to Jun 30, 2018 by using both quantitative and quantitative data collection approach. Data was entered, cleaned using Statistical Package for the Social Science (SPSS) version 21 for Microsoft Windows. Among the 427 spec...
Understanding the Facts and Minding the Gap of (HIV-1/HIV-2) Primate Research and Infectious Disease Laboratories in Africa
Chika Ejikeugwu, Peter Eze, Ifeanyichukwu Iroha, Charles Esimone, Michael Adikwu and Hirofumi AKARI
Article Type: Review Article | First Published: December 31, 2018
With over 2 million annual new infections of human immunodeficiency virus (HIV)-1, and more than 30 million HIV-1 infected people around the globe, the HIV-1 pandemic has continued to remain a front burner in the medical research community and an important public health debate. Till date, there is still no cure or vaccine for HIV-1 infection. Though current antiretroviral therapy (ART) is potent enough to reduce viral load of the infection to below detectable limits (< 50 copies/ml), antiretrovi...
Infectious Characteristics of Ebola Virus
Article Type: Letter to Editor | First Published: November 07, 2018
One of the main feature of Ebola virus is that Ribonucleic acid (RNA) plays more significant part instead Deoxyribonucleic acid (DNA) similarly as its hereditary material. When RNA is mirrored, many more mistakes are made than when DNA is mimicked. This activates viruses like the Ebola viruses a predominantly high mutation rate when distinguished to DNA based viruses like smallpox or chickenpox. In the study of Ebola outbreak, experts found that the virus evolves much faster than it used to be i...
Microhomology of Viral/Host DNAs and Macrostructure of Herpesviral Genome
Felix Filatov and Alexandr Shargunov
Article Type: Research Article | First Published: September 01, 2018
In 2015, we described short continuous fragments of human herpesvirus DNA, identical to the cellular ones, which we called microhomology (hits) because of their small size (≥ 20 nt). We noticed that generally the increase in the density (D) of these hits in human herpesviruses is inversely proportional to a decrease in the pathogenicity of these viruses. In this small work, we are considering the question of the existence of more objective features of HHV DNA (which can accompany the dynamics ...
Modeling the HIV Epidemic: Why the 95-95-95 Target and ART Effectiveness Parameters Matter
Reuben Granich, Somya Gupta, Matt Wollmers, Mike Ruffner and Brian Williams
Article Type: Review Article | First Published: August 20, 2018
HIV remains a major global public health threat with one million HIV-related deaths, two million new infections and over 1 million HIV-associated TB cases each year. However, population-based studies suggest marked declines in incidence, prevalence and deaths in the countries in East and Southern Africa that have expanded antiretroviral treatment (ART) at the fastest rate in the world....
Viral Infections after Kidney Transplantation: An Updated Review
Ethem Unal and Ahmet Topcu
Article Type: Review Article | First Published: July 01, 2018
Infections are the major cause of morbidity and mortality in kidney transplant recipients. Careful pretransplant screening, immunization, and posttransplant prophylactic antimicrobials may all reduce the risk for posttransplant infections. Chronic immunosuppression, required to maintain allograft function post-organ transplant, predisposes transplant patients to a variety of viral infections....
Adherence to Antiretroviral Therapy among Adult Persons Living with HIV/AIDS in Southern Ethiopia
Hailu Chare Koyra
Article Type: Original Research | First Published: 10.23937/2469-567X/1510038
Unlike other chronic diseases, people receiving anti-retroviral treatment should have very high levels of adherence (≥ 95%) to achieve durable suppression of viral load; avoid the emergence of drug resistance and clinical failure. Therefore, this study was aimed to assess level of adherence and predictors of poor adherence among adult ART patients at Dubbo St. Marry Hospital, Southern Ethiopia....