Understanding the Facts and Minding the Gap of (HIV-1/HIV-2) Primate Research and Infectious Disease Laboratories in Africa
Chika Ejikeugwu, Peter Eze, Ifeanyichukwu Iroha, Charles Esimone, Michael Adikwu and Hirofumi AKARI
Article Type: Review Article | First Published: December 31, 2018
With over 2 million annual new infections of human immunodeficiency virus (HIV)-1, and more than 30 million HIV-1 infected people around the globe, the HIV-1 pandemic has continued to remain a front burner in the medical research community and an important public health debate. Till date, there is still no cure or vaccine for HIV-1 infection. Though current antiretroviral therapy (ART) is potent enough to reduce viral load of the infection to below detectable limits (< 50 copies/ml), antiretrovi...
Infectious Characteristics of Ebola Virus
Article Type: Letter to Editor | First Published: November 07, 2018
One of the main feature of Ebola virus is that Ribonucleic acid (RNA) plays more significant part instead Deoxyribonucleic acid (DNA) similarly as its hereditary material. When RNA is mirrored, many more mistakes are made than when DNA is mimicked. This activates viruses like the Ebola viruses a predominantly high mutation rate when distinguished to DNA based viruses like smallpox or chickenpox. In the study of Ebola outbreak, experts found that the virus evolves much faster than it used to be i...
Microhomology of Viral/Host DNAs and Macrostructure of Herpesviral Genome
Felix Filatov and Alexandr Shargunov
Article Type: Research Article | First Published: September 01, 2018
In 2015, we described short continuous fragments of human herpesvirus DNA, identical to the cellular ones, which we called microhomology (hits) because of their small size (≥ 20 nt). We noticed that generally the increase in the density (D) of these hits in human herpesviruses is inversely proportional to a decrease in the pathogenicity of these viruses. In this small work, we are considering the question of the existence of more objective features of HHV DNA (which can accompany the dynamics ...
Modeling the HIV Epidemic: Why the 95-95-95 Target and ART Effectiveness Parameters Matter
Reuben Granich, Somya Gupta, Matt Wollmers, Mike Ruffner and Brian Williams
Article Type: Review Article | First Published: August 20, 2018
HIV remains a major global public health threat with one million HIV-related deaths, two million new infections and over 1 million HIV-associated TB cases each year. However, population-based studies suggest marked declines in incidence, prevalence and deaths in the countries in East and Southern Africa that have expanded antiretroviral treatment (ART) at the fastest rate in the world....
Viral Infections after Kidney Transplantation: An Updated Review
Ethem Unal and Ahmet Topcu
Article Type: Review Article | First Published: July 01, 2018
Infections are the major cause of morbidity and mortality in kidney transplant recipients. Careful pretransplant screening, immunization, and posttransplant prophylactic antimicrobials may all reduce the risk for posttransplant infections. Chronic immunosuppression, required to maintain allograft function post-organ transplant, predisposes transplant patients to a variety of viral infections....
Adherence to Antiretroviral Therapy among Adult Persons Living with HIV/AIDS in Southern Ethiopia
Hailu Chare Koyra
Article Type: Original Research | First Published: 10.23937/2469-567X/1510038
Unlike other chronic diseases, people receiving anti-retroviral treatment should have very high levels of adherence (≥ 95%) to achieve durable suppression of viral load; avoid the emergence of drug resistance and clinical failure. Therefore, this study was aimed to assess level of adherence and predictors of poor adherence among adult ART patients at Dubbo St. Marry Hospital, Southern Ethiopia....