Osteoporosis: Bisphosphonate Therapy in Postmenopausal Women
Amber Rowe, Erin Zamora and Tamera Pearson
Article Type: Case Report | First Published: July 19, 2019
Osteoporosis is the deterioration of bone tissue and strength, which leads to an increased risk of fractures. Postmenopausal women are at increased risk for osteoporosis. Bisphosphonates have long been the mainstay of osteoporosis treatment to prevent fractures, especially hip fractures by increasing bone mineral density. Extending treatment to up to 10 years is currently recommended. In lieu of possible adverse events such as atypical fractures and osteonecrosis of the jaw, drug holidays are an important consideration although research is currently inconclusive. Providers need to consider ind...
Histological Modifications of Postmenopausal Vaginal Mucosa after Regenerative Solid State Laser Treatment: A Multicenter Study
D Dodero, F Frascani, M Angelucci, G Bernabei, E Merlo, F Locatelli, D Recalcati and F Murina
Article Type: Research Article | First Published: July 17, 2019
Vulvovaginal atrophy (VVA) is a condition afflicting more than 50% of women and nowadays has changed his name in Genitourinary syndrome of menopause (GSM) due to the multiple aspects involved having an adverse impact on quality of life. Many treatment are now available and laser represent a new powerful option. The aim of this work is assess the histological effect of a new type of non-ablative laser, Solid State Vaginal Laser (SSVL), on vaginal tissue in women treated for GSM....
Complex Hip Spine Syndrome in Young Athlete: A Diagnosis Dilemma
Mohamad Azwan Aziz and Redzal Abu Hanifah
Article Type: Case Report | First Published: July 20, 2019
This is a case of Mr. D, a 32 Chinese gentleman. He is an active in recreational body building exercise for 10 years with an athletic physique. He was diagnosed with prolapse intervertebral disc in the past 7 years however his condition worsening for the past 3 years with multiple episode of severe back pain requiring admission and he develops reduces sensation over left lower limb at L3 and L4 dermatomes associated with reduced motor power in dorsiflexion of ankle and extension of big toe over left lower limb. His first Magnetic Resonance Imaging (MRI) Spine in 2015 showed left lateral disc p...
Diagnostic Yield of Fiberoptic Bronchoscopy for the Evaluation of Chronic Cough in Patients with Normal Chest X-Ray
Zainab Syed, Ro- Jay Reid and Roberto Solis
Article Type: Research Article | First Published: July 25, 2019
Approximately 30 million annual clinic visits are attributed to cough in the United States. Moreover, evaluation and management of persistent cough in pulmonary clinics account for roughly 40% of patient volume. The most common etiologies are: Upper airway cough syndrome (UACS), asthma, non-asthmatic eosinophilic bronchitis (NAEB) and gastro-esophageal reflux disease (GERD) - all of which are treatable. However, despite avoidance of triggers and medical therapy, there remains an elusive diagnosis for some individuals with persistent cough. Further investigation warrants bronchoscopy, which is ...
Use of the Electrical Stimulation Therapy in the Lower Esophageal Sphincter for the Treatment of Gastroesophageal Reflux Disease in Paediatric Patients, Two First Cases Reported
Rodrigo Hipolito Cifuentes, Rene Carmona Barba, Antonio Vega Valdes and Placido Espinosa Rosas
Article Type: Research Article | First Published: July 18, 2019
One female patient, on chronic acid-suppressive therapy who underwent successful laparoscopic implantation of the LES stimulation system, surgery time 1 hour, trans surgical endoscopy with absence of perforation, closure of pillars; measured by GERD daily symptom diaries the patient symptoms improved soon. Two weeks after the surgery, the patient reported better symptom control without the intake of PPI, and the absence of heartburn and regurgitation. One month follow-up with esophageal ph shows decrease of the Demeester score to 20.2, and 3 months esophageal ph shows decrease to 3.9 (Normal D...
Influence of Image Manipulation Restricted to Global Alterations on Diagnosis by an Oral Cytologist
Aman Chowdhry, Keya Sircar and Deepika Bablani Popli
Article Type: Original Research | First Published: July 24, 2019
Cytology has always proudly been in forefront to absorb new technologic advances for practical use. The extensive and passionate implementation of digital imaging in telecytology, automated screening, education, training and certification, research, and publications is an appropriate example. Digitalization cytology records make its manipulation very simple. Several such manipulations, however, correspond to inappropriate changes and can affect final diagnosis of digital slides....
Positive Airway Pressure Compliance in Patients with Epilepsy and Obstructive Sleep Apnea
Jacob Pellinen MD, Christopher K Cheng MD and Alcibiades J Rodriguez MD
Article Type: BRIEF REPORT | First Published: July 26, 2019
Obstructive sleep apnea (OSA) affects approximately one third of patients with epilepsy. Treatment with Continuous Positive Airway pressure (CPAP) is associated with improved seizure control, but is difficult for patients to tolerate. Patients with epilepsy and co morbid OSA may be at higher risk of recurrent seizures if they are noncompliant with CPAP. This study investigates short-term compliance with CPAP therapy in patients with OSA and epilepsy, as this can predict long-term adherence. Identifying factors influencing compliance rates in this population may help improve compliance and redu...
Unawareness of Olfactory Dysfunction in Older Adults
Amal Loudghi, Majed Alotaibi, Melissa Lessard-Beaudoin, Denis Gris, Kate Busch, Pierrette Gaudreau and Rona K Graham
Article Type: Research Article | First Published: July 15, 2019
Deterioration of olfaction is a common phenomenon observed in the senior population. A number of factors may cause this deficit including infections, aging and neurodegenerative diseases. The aim of this study was to evaluate the reliability of the self-report as a measure of olfactory function in seniors. A total of 93 community-dwelling participants (43 men and 50 women) from the Quebec NuAge cohort on Nutrition and Successful Aging participated in the Olfactory Response and Cognition in Aging (ORCA) study. The age range was 80-95 years and all subjects had a telephone mini mental state exam...
Monitoring the Anticancer Effects of Two Different Gold Nanostructures Shapes towards Hep-2 Cells
Maii I Sholqamy, Ehab S Abd-ElHamid, Amr H Mostafa El-Bolok, Aly F Mohamed and Waleed A El-Said
Article Type: Research Article | First Published: July 17, 2019
The change in cell size and alterations in the distribution of cells at different phases of the cell cycle are indicators of change in cell homeostasis. In this study, the HEp-2 cell line cells were treated for 24 hours by two shapes of Gold nanoparticles (GNPs): Gold nanospheres (GNSs) and Gold nanorods (GNRs). The cytotoxic effect of GNPs was evaluated by different methods. The MTT assay revealed that GNPs have a cytotoxic effect on HEp-2 cells and the GNRs are more toxic than GNSs. Image morphometric analysis showed a decrease in the mean values of Nuclear Area Factor (NAF) of HEp-2 cells t...