Xenotransplantation of the Pancreas: A Reality Check of Its Historical Emergence
Article Type: Historical Analysis | First Published: December 21, 2020
Recent advancements being made in the humanization of Crispr-based gene-edited animals have now provided a sophisticated molecular platform for exogenic organ production and xenotransplantation. Although this amazing and novel medical step into the future holds significant therapeutic promise for pancreas xenotransplantation presently impeded by lack of sufficient donors, its origins arose in an era that is often portrayed as an age of medical quackery and iatrogenesis. The present study reexami...
Changes and Outcome of Cardiac Function in Children with SARS-CoV-2 Multisystem Inflammatory Syndrome
Chloé Huet, MD, Thibault Blache, MD, Thomas Perouse de Montclos, MD, Claire Bertail Galoin, MD, Cécile Leconte, MD, Mohamed Bakloul, MD, Etienne Javouhey, MD, PhD, Elodie Perdreau, MD and Sylvie Di Filippo, MD, PhD
Article Type: Original Article | First Published: December 26, 2020
Cardiac involvement has been reported in children with SARS-CoV-2 inflammatory syndrome. The objectives herein were to assess changes in cardiac parameters and compare cardiac pathologies observed in SARS-CoV-2 to Kawasaki-(KW) and myocarditis-(MY). Patients < 18 years of age, with symptoms of Kawasaki disease (KW group) and/or of acute myocarditis (MY group) from March 1 to May 31 2020 were included. Clinical, laboratory data, and cardiac parameters were recorded upon diagnosis and at several p...
Chiasmus as an Alternative Pattern of Teaching
Dhouha Bacha, Wael Ferjaoui, Lasaad Gharbi, Sana Ben Slama and Ahlem Lahmar
Article Type: Editorial | First Published: October 15, 2020
Etymologically the word chiasm comes from the Greek word khiasmós which means crossing. The chiasm construction is a repetition crossing 2 segments A-B around a center C creating an AB/C/BA structure. This is a rhetorical figure of speech expressing repetition. In linguistics, the purpose of repetition is the emphasis on the message to be conveyed. In pedagogy, the 3 goals of repetition are: Consolidation, deepening and feedback. In the domain of procedural knowledge, repetition makes it possib...
Meta-Analysis and Evidence Base for the Efficacy of High Frequency Oscillatory Ventilation (HFOV) in ARDS Management: Systematic Review and Quality Assessment
Mohamed E Awad, MD, MBA, Mohamed Gaber, MD, Suhib I Alhusban, MD, Sung Chu, BS, Colville HB Ferdinand, MD, FACS and Mohamed Ben Omran, MD
Article Type: Original Article | First Published: December 30, 2020
To evaluate the efficacy of high frequency oscillatory ventilation (HFOV) in management of acute respiratory distress syndrome and determine whether if there is any superiority over the conventional mechanical ventilation (CMV). A systematic review and meta-analysis were conducted according to PRISMA checklist and the Cochrane Handbook for Systematic Reviews of Interventions. The search of the literature was performed through several search databases: PubMed, MEDLINE via Ovid, and web of science...
Nursing Students’ Anxiety Levels and Coping Strategies during the COVID-19 Pandemic
Zeynep Temiz, PhD
Article Type: Research Article | First Published: December 30, 2020
Anxiety is very prevalent among nursing students even in normal circumstances. In Turkey during the COVID-19 pandemic, nursing students encountered a new reality of that includes economic uncertainty, fear of infection, the challenges of distance education and more. This study was carried out to determine the relationship between the anxiety levels and the coping methods of nursing students during the COVID-19 pandemic. This study was carried out to determine the relationship between the anxiety...
Medication-Related Osteonecrosis of the Jaw by Concomitant Nivolumab and Denosumab Treatment
Gianfilippo Nifosì, Lorenzo Nifosì and Antonio Fabrizio Nifosì
Article Type: Case Report | First Published: December 31, 2020
Medication-related osteonecrosis of the jaw is a multifactorial disease described in association with antiresorptive drugs, such as bisphosphonates and denosumab. More recently, cases due to non-antiresorptive medications, particularly, some cases by immune checkpoint inhibitors, have also been reported. Dentists and oral surgeons in the coming years will see an increasing number of patients who are receiving treatment potentially toxic to bone. We reported a case of a cancer patient treated wit...
Modification of Staged Embolization-Hysterectomy Procedure for Placenta Accreta to Avoid Non-Target Embolisation of Ovaries
Catherine Louise Davis, Bishoy Hanna, John Keogh, Eisen Liang and Amir Hanna
Article Type: Case Series | First Published: December 21, 2020
Placenta accreta spectrum describes the abnormal adherence of the placenta to, into or beyond the myometrium of the uterus. Three women who were antenatally diagnosed with placenta accreta underwent a modified staged embolization- hysterectomy procedure consisting of; placement of prophylactic bilateral common iliac artery occlusion balloons, a classical caesarean section, surgical dissection of the ovaries from the uterus, embolization of the uterine arteries, followed by hysterectomy. The thre...
A Pelvic Mass Masquerading as High Stage Malignancy - An Interesting Presentation of Psuedo-Meigs Syndrome
Cathy Monteith, PhD, Tamara Kalisse, Robert A Farrell, Yulia Shahabuddin and Thomas John D’Arcy, MD
Article Type: Case Report | First Published: December 21, 2020
The lifetime risk of developing an ovarian malignancy is reported to be 1.4%. Invasive epithelial ovarian cancers have the highest prevalence in women between 60-64 years while germ cell or borderline tumours pre-dominate in women under 40 years. We report the case of a 33-yearold nulliparous woman with a 7 kg leiomyoma, extensive endometriosis and several radiological features suggestive of a high stage ovarian malignancy. Meigs syndrome typically presents as a triad of ascites, pleural effusio...
Trocar-Site Herniation (TSH) of the Small Bowel following Laparoscopy Despite Rectus Sheath Closure, Resulting in Subacute Bowel Obstruction in the Early Post-Operative Period: A Case Discussion and Review of Literature
Senadheera, DI, Jayasundara, DMCS and Jayewardene, IA
Article Type: Case Report and Literature Review | First Published: December 12, 2020
Laparoscopy is becoming the gold slandered of access to the abdomen and pelvis. However, it’s not without unique complications. Trocar site hernia is a rare but a serious complication which can cause diagnostic confusion, in the early post-operative period. It can be potentially life threatening with obstruction, strangulation, incarceration and finally perforation of the bowel, after a seemingly uncomplicated laparoscopy. First ever TSH, reported by “Fear in 1968”. Early studies described...
De Novo Cavernoma in the Sensory Cortex Causing Cervicobrachialgia
Dhruv Jain, MS, Michael Broduhn, MD, Sophie Rosahl and Steffen K Rosahl, MD, PhD
Article Type: Case Study and Review of Literature | First Published: December 17, 2020
A 32-year-old female presented with neck pain radiating to the ulnar forearm along with occasion-al tingling sensations. Three years earlier, she had suffered from left-sided cerebellar infarction caused by dissection of the left vertebral artery. The dissection was provoked by manual therapy administered by a certified physiotherapist. Antiplatelet treatment with Aspirin 100 mg/day was established. One year later, she experienced tingling in the left side of her face. At the time, intracerebral...