Nimotuzumab in Advanced Cervical Cancer: Safety and Efficacy Profile
Raiza Ruiz Lorente, Sayly Alfonso, Yamilka Sanchez, Carmen Elena Viada, Ramon Ortiz, Mayelin Troche, Meylan Cepeda, Ana Rosa Vals, Leticia Cabrera, Annia Gorte, Delmis Maira Batista, Milagros Domenech, Jessica Garcia Viamontes, Conrado Ramos Mico and Mayra Ramos Suzarte
Article Type: Review Article | First Published: July 29, 2019
The EGF receptor is over expressed in tumors of epithelial origin and is associated with a poor prognosis of the disease. An Expanded Clinical Access Program was carried out, in which patients with cervical uterine cancer in advanced stages of the disease without another therapeutic alternative were treated with nimotuzumab, anti-epidermal growth factor receptor humanized monoclonal antibody to evaluate the safety and efficacy of this therapy. Seventy-five patients with confirmed histological diagnosis of advanced cervical cancer were included, with previous onco-specific treatments (surgery, ...
Hyponatremia in Children with Systemic Inflammatory Response Syndrome Presenting to the Emergency Department
Osama El-Assal, MD, PhD, Sarah A Marzec, MD, Michael L Forbes, MD, Michael Bigham, MD, Ryan Reichert, MD, Jeffrey D Solomon, MD and Miraides F Brown, MS
Article Type: Retrospective Study | First Published: July 25, 2019
Hyponatremia is observed in children with meningitis, encephalitis, pneumonia, urinary tract infections, and Kawasaki disease. The presence of hyponatremia is associated with increased morbidity and mortality in adults. The clinical significance of hyponatremia in febrile pediatric patients is unknown. The objective of this study was to evaluate the prevalence and prognostic value of hyponatremia in children presenting to the emergency department (ED) with systemic inflammatory response syndrome (SIRS). ...
Prevalence and Risk Factors of Malaria among HIV Infected Pregnant Women Attending Antenatal Clinics at Sokoto, Nigeria
Chisom Emmanuel Okechukwu, Kabiru Mohammed, Eugene I Ikeh, Thompson HI Spencer, Nwoke Clinton Chinedu and Idris Abdullahi Nasir
Article Type: Original Research | First Published: May 31, 2019
Malaria during pregnancy remains a serious public health problem especially in cases when there is a co-infection with Human Immunodeficiency Virus (HIV). The aim of this cross-sectional study was to determine the prevalence of malaria parasitaemia and their associated risk factors amongst HIV infected pregnant women in Sokoto State, North-Western Nigeria. After informed consent was obtained, one hundred and three (103), HIV infected pregnant women attending antenatal clinics (ANC) participated in the study. A socio-demographic profile and risk factors of malaria was assessed from all partici...
Canine and Human Leishmaniasis: Disease Progression to Brazilian Urbanized Areas
Danilo C Miguel and Danilo C Guarnier, DVM
Article Type: Mini Review | First Published: July 17, 2019
Leishmaniasis is a complex disease considered one of the most neglected tropical diseases of the world. The importance and role of domestic dogs and wild canids as a source of leishmaniasis infection is well recognized. The present mini-review discusses a series of epidemiological studies that reinforce the need to understand the role of reservoirs and vectors in the expansion of leishmaniasis to Brazilian urbanized areas, as Brazil is a country of continental dimensions and endemic for leishmaniasis. Emphasis isgiven on the diagnostic tools and treatment options that must be recognized as cru...
Complex Maxillofacial Trauma with Wide-Spread Soft-Tissue Defects
Nguyen Hong Loi, MD, PhD, Tran Xuan Phu, MD, Hoang Le Trong Chau, MD and Nguyen Huu Son, MD
Article Type: Case Report | First Published: July 29, 2019
The management of soft tissue injury after complex facial trаumа poses unique chаllenges to the plаstic surgeon, given the speciаlized nаture of fаciаl tissue аnd the аesthetic importаnce of the fаce. We report 8 cаses with wide-spreаd soft-tissue defects due to complex fаciаl trаumа who presented аt Odonto-stomаtology center - Hue centrаl hospitаl during the yeаr 2018. Of these cаses were surgicаlly mаnаged by fixаtion аnd fаciаl reconstruction аt Odonto-stomаtology center - Hue centrаl hospitаl; аnd they were very well recovery in function аnd аesthetics...
Transversus Abdominis Plane (TAP) Block as a Potential Diagnostic and Therapeutic Tool for Treatment of Chronic Post Herniorrhaphy Pain: A Case Report
Valentini Pogiatzi, Dimosthenis Petsas, Evripidis Efthymiou, Maria Drogouti, Athanasios Ntonas, and Georgios Ntonas
Article Type: Case Report | First Published: July 27, 2019
The dual nature of CPSP -both nociceptive and neuropathic- can cause confusion regarding comparisons of pain in the literature. Treating this condition can be complicated and difficult. There is a variety of modalities, ranging from medication in pain clinic, revision surgery or invasive procedures (neurolysis, nerve blocks). A feasible and reproducible solution seems to be ultrasound guided nerve block. Nerve blocks might work in multiple ways. First of all providing a temporary break of the vicious cycle of chronic pain development pathophysiology (sensitization, hyperalgesia and allodynia)....
Role of Oxidative Stress and Apoptosis in the Hepatic Toxicity Induced by Cerium Oxide Nanoparticles Following Intratracheal Instillation in Male Sprague-Dawley Rats
Siva K Nalabotu, Nandini DPK Manne, Madhukar B Kolli, Geeta Nandyala, Radha K Para, Kevin M Rice, Cynthia B Jones and Eric R Blough
Article Type: Research Article | First Published: July 04, 2019
Inhaled cerium oxide (CeO2) nanoparticles have been shown to be capable of translocation to the liver where they can cause dose dependent toxic effects. Herein, we investigate if the deposition of cerium in the liver is linked to increased oxidative stress and cellular apoptosis. Specific pathogen free male Sprague-Dawley rats were instilled with either vehicle (saline) or CeO2 nanoparticles (7.0 mg/kg) and euthanized 1, 3, 14, 28, 56, or 90 days post exposure. Liver samples were evaluated for evidence of ceria deposition, oxidative stress and apoptosis. Inductively coupled plasma mass spectro...
OR-MRS Cannot be used for Morbidity in Laparoscopic Sleeve Gastrectomy
Evrim Kucur Tulubas
Article Type: Original Research | First Published: July 15, 2019
A reliable method to predict postoperative risks may improve surgical risks and ensure preventive precautions to reduce complication risks. American Society of Anesthesiologists (ASA) is a common method to determine surgical risk, but at first glance it appears to be insufficient to determine the risk of morbid obesity surgery. The greatest advantage of Obesity Surgery Mortality Risk Score (OS-MRS) is the use of five easily obtained clinical variables. A possible disadvantage is that it may only show mortality. It was reported that OS-MRS can be used for morbidity. However, there are inconsist...
Implementation of Same-Day Sputum Smears Microscopy in Addis Ababa, Ethiopia: Programmatic Qualitative Study
Boja Dufera Taddese, KumeraTerfa Kitila, Abay Sisay Misganaw, Daniel Melese Desalegn, Tinsae Kidanemariam Hailu and MeronSeifu Tebeje
Article Type: Research Article | First Published: July 19, 2019
In countries that have ensured effective External Quality Assessment (EQA) sputum smear microscopy, World Health Organization (WHO) has recommended the implementation of same-day smear sputum microcopy. In Addis Ababa, Ethiopia, the status of the same-day sputum smear microcopy implementation was not yet assessed. In-depth interview of Health Care Providers (HCPs) at Outpatient Departments (OPDs), clinical laboratories and Directly Observed Treatment Short Course (DOTS) centres was conducted to assess the status of same-day sputum smear microscopy policy uptake, implementation and practices in...