Explantation of Silicone Breast Implants Ameliorates Gel Bleed Related Health Complaints in Women with Breast Implant Illness
Rita M Kappel, MD, PhD and Ger JM Pruijn, PhD
Article Type: Original Article | First Published: March 24, 2020
During the last decade the international debate on adverse health effects of silicone breast implants has intensified and recently the related disorder has been termed Breast Implant Illness (BII). This study aimed to explore the effects of explantation of silicone implants. In a retrospective study, women with silicone breast implants, who consulted plastic surgeons for a variety of reasons, were requested to fill out a questionnaire, which was aimed at an evaluation of health complaints. In total, 101 questionnaires of the women with silicone breast implants and 34 questionnaires filled out ...
The Infectious Headache- A Case of Neurocysticercosis
Supraja Thunuguntla, MD, Obinna Echeruo, MD and Jose Campo Maldonado, MD
Article Type: Case Report | First Published: March 05, 2020
A 50-year-old Hispanic female presented to her primary care physician with a progressively worsening headache over a week, associated with visual disturbances, prosopagnosia and episodes of disorientation. Outpatient workup with head CT showed abnormality in the ventral aspect of the left thalamus showing 1.2 × 1 cm low density cyst with approximately 2-3 mm right-left midline shift locally. Left basal ganglia showed multiple well-defined foci of low density measuring up to 3 mm reflecting edema. On admission, pertinent physical exam findings were left sided nystagmus, positive deep tendon re...
Factors Associated with the Nutritional Status of Schoolchildren in the Main City of Benin Republic, Sub-Saharan Africa
Colette S Azandjeme, Florence Alihonou, Charles J Sossa, Ulrich Gbatcho, Fabien Gounongbe, Michel Makoutode and Victoire D Agueh
Article Type: Research Article | First Published: March 05, 2020
This was a cross-sectional study conducted in July 2016. It involved data collection regarding food and nutritional knowledge, nutritional habits and practices, physical activity level and health status which were obtained using survey research. The study took place in four schools from the Friendly School of Nutrition Initiative (FNSI) in Cotonou and focused on schoolchildren aged from eight to eleven (n = 182). Anthropometric data including weight and height were collected, BMI indices weight-for age and height-forage were calculated, making it thereby possible to assess the nutritional stat...
Slight Increases of Phosphorus and Sulfur in Human First Septal Perforator Branches of the Left Anterior Descending Artery with Aging
Yoshiyuki Tohno, Setsuko Tohno, Takeshi Minami, Nutcharin Pakdeewong-Ongkana, Noppadol Phasukdee and Pasuk Mahakkanukrauh
Article Type: Original Article | First Published: March 12, 2020
To elucidate age-related changes of the first septal perforator branch (FSB), the authors investigated age-related changes of elements in the FSBs by direct chemical analysis. In addition, the effects of different arterial sizes and genders on element accumulation were investigated in the FSBs. Sixty-two formalin-fixed adult Thai hearts were used and the FSBs were carefully dissected in the hearts. After the arteries were incinerated with nitric acid and perchloric acid, element contents were determined by inductively coupled plasma-atomic emission spectrometry. It was found that both the P an...
Radiofrequency Ablation as a Treatment Modality for Hypertrophic Cardiomyopathy
Kareem M. M. Ibrahim, MBBCH
Article Type: Review Article | First Published: March 07, 2020
Hypertrophic cardiomyopathy is one of the major causes of cardiac death that affects 1 in every 500 persons worldwide. Surgical myectomy and alcohol septal ablation have been the gold standard well established procedures for the treatment of this condition. Starting 2004 a new procedure, radiofrequency septal ablation, has been applied and showed significant improvement in the NYHA classification as well as the left ventricular outflow tract (LVOT) gradients of these patients. With overall less complications, as compared to the surgical myectomy and the alcohol septal ablation, this procedure ...
Percutaneous Repair of an Aortic Pseudoaneurysm Status Post-Surgical Repair of Stanford Type A Dissection
Brinder S Kanda, MD, FACC, FSCAI, Nicholas E Hoyt , John Haas, MD, Houman Tavaf-Motamen, MD, Ronald Morford, MD, Tina Wesley, BSN, Kenneth Saum, MD and Michael MacCormac, MD
Article Type: Case Report | First Published: March 05, 2020
A middle-aged Caucasian woman presented with an ascending aortic pseudoaneurysm (AAP) located at the suture site of her previous surgical dissection repair. The pseudoaneurysm was located along the anterior aspect of the ascending thoracic aorta, above the right coronary cusp. We demonstrate successful percutaneous repair of the pseudoaneurysm using a ventricular septal occluder (VSO) and discuss the significance of this procedure for future cardiovascular care. A 56-year-old Caucasian woman with a history of active tobacco abuse, systemic lupus erythematosus, and hypothyroidism underwent emer...
Acute Pneumonia: The Beginning of a Revision of Views or Just a Statement of Known Facts?
Igor Klepikov, MD
Article Type: Commentary | First Published: March 14, 2020
The author conducted research on the topic under discussion in the USSR at the State Institute for advanced training of doctors (Novokuznetsk). To date, the USSR and the mentioned Institute no longer exist. However, research and clinical trials of new approaches to the treatment of children with acute pneumonia and the results of this work can provide answers to a number of questions facing us today, which allows us to consider the research of thirty years ago relevant and worthy of mention....
Safety and Effectiveness of Neuromuscular Blockers in the Treatment of Acute Respiratory Distress Syndrome: Systematic Review and Meta-Analysis
Alfredo Aisa-Alvarez MsC, MD, Cesar A Rojas-Gomez, MD and Gilberto Camarena-Alejo MHA, MD
Article Type: Research Article | First Published: March 07, 2020
Two review authors independently screened the abstracts and titles for relevance. Screening for inclusion, data extraction, and risk of bias assessment were performed by one author and checked by the second. We assessed trials for the overall quality of evidence using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) instrument. We calculated the risk ratios (RR) and 95% confidence intervals (95% CI) for dichotomous outcomes, while for continuous results we obtained the mean difference and performed a random-effects meta-analysis. Six RCTs including 3351 patients...
Proteasome and Autophagy Pathway in Corneal Epithelial Cells with Limbal Stem Cell Deficiency
Fawzia Bardag-Gorce, Michael Di Lorenzo, Robert Niihara, Sarah Sunada, Amanda Laporte, Kavita Narwani, Daileen Cortez, Jeremy Stark, Mynor Garcia, Alissa Diaz, Joan Oliva, Richard Hoft, and Yutaka Niihara
Article Type: Original Article | First Published: February 28, 2020
Immunofluorescent staining showed that both pathways were positive in normal corneal epithelium. However, while proteasome subunits were decreased in LSCD-CEC, autophagy biomarker MAPLC3B and ATG12-ATG5 complex were significantly increased in LSCD-CEC, compared to healthy CEC. These results indicate that LSCD-induced impairment of UPP may cause a compensatory stimulation of autophagy. However, despite autophagy up regulation, damaged and unwanted proteins, such as modified keratin K4 and K13 aggregates, still deposited and accumulated in LSCD-CEC without clearance, possibly contributing to CEC...