ClinMed International Library

The ClinMed International Library is a repository and an open access publisher for medical research that covers a wide range of areas in Clinical Medicine. ClinMed serves as a global platform for medical practitioners and research scholars to foster their learning and professional acumen through an extensive portfolio of research articles and publications that can be accessed without any restrictions.

Dedicated to clinical medical research, we now publish over 70 quality peer-reviewed journals making all the articles freely accessible. The manuscripts submitted to ClinMed will be processed through standard parameters and international peer review systems. This has enabled us to establish new milestones in the global research arena in terms of cogency and integrity, and to disseminate highly credible and accredited research content for researchers, scholars, and practitioners across the globe.

We ensure that all researchers and authors publishing their papers with us retain copyrights, licensed under Creative Commons Attribution License that permits the unrestricted use and re-use of the content with proper citation.

ClinMed International Library

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Articles Published

All articles are fully peer reviewed, free to access and can be downloaded from our ClinMed archive.

Articles Search by   Keyword   |   Journal title   |   Author name   |   DOI

 Open Access DOI:10.23937/2378-3419/2/4/1027

Metastatic Squamous Cell Carcinoma of the Neck from Unknown Primary Sites: the Ottawa Regional Cancer Centre (ORCC) Experience

Osama Marglani, Ameen Zaid Alherabi, Ali Safar, Suliman Alghamdi, Libni Eapen, Helen Caetano and Martin Corsten

Article Type: Original Research Article | First Published: September 25, 2015

Metastatic squamous cell carcinoma (SCC) to the neck from an unknown primary site presents a challenging diagnostic and therapeutic disease entity, despite a thorough diagnostic workup. The optimal management of patients who have this syndrome is still unclear and controversial. We present our experience in management of patients with unknown primary....

 Open Access DOI:10.23937/2378-3419/2/4/1026

Systematic Review and Meta-Analysis to Determine the Optimum Staging modality for Primary Breast Cancer

Berney M, Manning A, Carter M, Sacchini V, Kell M R. Barry M

Article Type: Original Article | First Published: September 24, 2015

Staging of primary breast cancer can radically alter the management if stage IV disease is accurately detected. A systematic review and meta-analysis were performed to determine whether conventional CT TAP or PET-CT provides the optimum staging modality. A meta-analysis involving 158 patients with primary breast cancer showed that PET-CT was more sensitive than CT-TAP for detection of metastatic disease (OR 3.28, 95% CI 2.37 - 4.53, p < 0.0001). A systematic review of 1780 patients undergoing PET-CT was compared with 709 patients having a CT TAP for staging....

 Open Access DOI:10.23937/2378-3419/2/4/1025

Common Polymorphisms in the USF1 Gene and Cancer Susceptibility: A Meta-Analysis

Meng Zhang, Jian Bai1, Junjie Huang, Yukun Ge, Hu Xiong, Wei Lu, Jizhou Shi, Lu Fang, Song Wu and Zhiming Cai

Article Type: Original Article | First Published: September 21, 2015

Upstream transcription factor 1(USF1) has been identified to be implicated in the development of many cancer categories. In view of recent studies, several polymorphisms in USF1 gene appeared to exert diverse influence on cancer susceptibility. However, the association between USF1 polymorphisms and cancer susceptibility remains inconclusive due to the finite relevant published discoveries. Therefore, we conducted a meta-analysis by pooling all available published data on the susceptibility of USF1 (rs2516838, rs2516839, rs2774276 and rs3737787) polymorphisms to cancer....

 Open Access DOI:10.23937/2469-570X/1410011

Potential Immune Modulatory Action of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Type 1 Diabetes

Andrea Carpanetto, Chiara Gai, Enrica Favaro, Maria Maddalena Zanone and Giovanni Camussi

Article Type: Short Review | First Published: September 28, 2015

Several preclinical studies have shown potential immune-modulatory properties of mesenchymal stem cells (MSC) in type 1 diabetes leading to phase I/II clinical trials. Immune-modulatory properties of MSC have been mainly ascribed to their secretome. The extracellular vesicles (EV) have emerged as paracrine mediators of MSC actions. In fact, MSC-derived EV have been shown to carry proteins and nucleic acids capable to mimic the effect of originating cells. In the present short review we discuss evidences for contribution of EV to the immune-modulatory properties of MSC and mechanisms involved.....

 Open Access DOI:10.23937/2469-5831/1510006

Noise Analysis of Gene Regulatory Networks Using Particle Filter

Haixin Wang and Dawit Aberra

Article Type: Original Article | First Published: October 03, 2015

One of the most important properties in gene expression is the stochasticity. Gene expression process is noisy and fluctuant. In this paper, the noise of gene regulatory networks (GRNs) using polynomial model and S-system model is analyzed by proposed approach on the basis of particle filter. The measurement noise and process noise are analyzed to test noise effects on the synthetic GRNs. The relation among Root Mean Square (RMS) error, measurement noise, and system noise covariance is analyzed. Microarray data are used to testify the noise analysis model by particle filter....

 Open Access DOI:10.23937/2469-5726/1510022

Lupus-Associated Pancreatitis: Clinical Aspects

Maria Helena Favarato

Article Type: Review Article | First Published: September 28, 2015

Systemic lupus erythematosus (SLE) is a systemic autoimmune inflammatory disease, with several different clinical manifestations. Its annual incidence is about 5 cases per 100000 inhabitants. The prevalence is around 52 cases per 100000 inhabitants. The gastrointestinal tract may be affected, either by the disease itself or by adverse reactions of medications or by opportunistic infections. Although common, the incidence of gastrointestinal manifestations may be underestimated, as the symptoms may be absent or nonspecific....

 Open Access DOI:10.23937/2469-5726/1510021

Eosinophilic Fasciitis Treated with Tocilizumab: Demonstration of Efficacy after Withdrawal and Re-Challenge in a Patient

Glen T D Thomson, Janine L Johnston and Brent R J Thomson

Article Type: Case Report | First Published: September 28, 2015

A 41-year-old man presented with clinical features of eosinophilic fasciitis (EF) confirmed on biopsy. The patient responded to high-dose prednisone but subsequent steroid sparing medication including methotrexate, hydroxychloroquine, etanercept, golimumab and rituximab failed to deliver steroid sparing response. Tocilizumab provided rapid and sustained improvement in the patient's symptoms and signs. Withdrawal of tocilizumab resulted in a flare of the clinical manifestations of EF; retreatment provided rapid recovery. Tocilizumab appears to have a therapeutic benefit in treatment resistant E...

 Open Access DOI:10.23937/2469-5726/1510020

A Case of Rhabdomyolysis and Polyarticular Inflammatory Arthritis May be the Initial Presentation of Chronic Myelogenous Leukemia (CML)

Yelliann Ruiz-Irizarry and Petros Efthimiou

Article Type: Case Report | First Published: September 24, 2015

Rhabdomyolysis and inflammatory arthritis are common rheumatologic conditions that manifest in people of all ages. Proximal muscle weakness associated to rhabdomyolysis is frequently the initial presentation of inflammatory myopathies such as dermatomyositis (DM) and polymyosistis (PM) both, extensively described in literature to be related to paraneoplastic process. Inflammatory arthritis has been associated to certain paraneoplastic syndromes, but not in relation to Chronic Meylogenous Leukemia (CML)....

 Open Access DOI:10.23937/2469-5726/1510019

A MRI Assessment of the Response of Chronic, Occult, Synovial-Based Inflammation of Gout to Serum Urate Lowering Therapy

John D. Carter, Michelle Patelli, Scott R. Anderson, Neelesh Prakash, Ernesto J. Rodriquez and Louis R. Ricca

Article Type: Research Article | First Published: September 09, 2015

Clinical gout begins as an acute intermittent and intensely painful arthritis that can progress to a chronic, inflammatory, destructive condition. The initial episodes may last several days and are often followed by pain-free, inter-critical periods that may last months to years. Chronic gouty arthritis is manifested by shorter inter-critical periods, boney destructive changes and possible development of visible tophi. Advanced gout leads to chronic pain, decreased quality of life, and an increased global economic burden....

 Open Access DOI:10.23937/2469-5696/1410018

The Management of Mucositis of Pediatric Hematopoietic Stem-Cell Transplantation

CIFTCIOGLU Sule and EFE Emine

Article Type: Perspective | First Published: September 23, 2015

Hematopoietic stem-cell transplantation (HSCT) is used primarily for hematologic and lymphoid cancers but also for many other disorders. Autologous HSCT (in which stem cells are derived from the patient) is mainly used to treat chemosensitive malignancies. Allogeneic HSCT (in which the stem cells are derived from a donor) is often the preferred treatment option, particularly in patients with acute leukaemia. Oral complications are a significant cause of morbidity and potential mortality for children undergoing HSCT....

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