Identification of PSEN1 and PSEN2 Gene Variants and Clinical Findings with the Literature
Nadide Cemre Randa, Elçin Bora, Esra Ataman, Ozlem Oz, Gorsev Yener and Ayfer Ulgenalp
Article Type: Original Article | First Published: April 11, 2019
Alzheimer's disease is an age-related and irreversible disease and characterized progressively decline in cognitive functions such as memory, speech, executive functions and visual-spatial skills. Currently, there is no a simple and definitive diagnosis method for clinical management. It is possible to diagnose with 85-90% accuracy with clinical assesment and neuropsychological tests. The precisel...
Assessment of the Degree of Stress during Pediatric Ground Transport
Carme Alejandre, MD, David Vila, PhD, Ana Olego, M Jose Tovar, Angels Llorens, Marta Hernandez, M Paz Larrosa and Elisabeth Esteban, PhD
Article Type: Original Research Article | First Published: April 11, 2019
A total of 220 patients were included, of whom 135 were male (61.4%) with a median age of 2.5 months (IQR 3 days-21 months). Median transfer time was 29 minutes (IQR 13-52 minutes). Sixty-three patients needed non-invasive ventilation (28.6%). The median score before the transfer was 16 (IQR 15-19) and after it 16 (IQR 14-18). In 23 cases (10.5%) patients were accompanied by their parents in the ambulance; no statistically significant differences were observed in the value of the score (p 0.959). Sucrose was used in 45 patients (20.5%) and some type of sedation in 31 cases (14.1%). Statistical...
Magnitude of Cardiovascular Risk Factors among Adult Hypertensive Patients Attending in Ayder Comprehensive Specialized Hospital, Ethiopia, 2018
Degena Bahrey, Tekleweyni Mariye, Gebreamlak Gebremedh, Ayehu Kassa, Alem Girmay, Girmay Teklay, Hagos Tasew, Hagos Berihu and Yohannes Ashebir
Article Type: Research Article | First Published: April 10, 2019
A total of 578 hypertensive patients were taken from cardiac follow-up. Among the hypertensive patients the magnitude of cardiovascular risk factors was 212 (36.7%). The magnitude of each cardiovascular risk factor was high. Magnitude of overweight and obesity was 33.7%. Concurrently 30.4% had habit of taking high salt diet and 27.3% were patients with dyslipidaemia. Patients with less physically active were 89.1% and 23.5% were consuming alcohol regularly. Whereas 15.9% was smoker. This study also showed that 43.3% had uncontrolled blood pressure among the hypertensive patients. After adjustm...
Frank-Ter Haar Syndrome, Report of a Case with a Novel Mutation from Iran
Z Hadipour, F Hadipour, H van Bokhoven, R Hennekam and Y Shafeghati
Article Type: Case Report | First Published: April 10, 2019
Frank-ter Haar syndrome is a genetic disease that is transmitted by autosomal recessive pattern with characteristic features such as megalocornea or glaucoma, a developmental delay and multiple congenital anomalies. It was first recognized as a separate entity by Frank, et al. and subsequently confirmed by ter Haar, et al. The main characteristics are brachycephaly, wide fontanels, prominent foreh...
BMI, Waist Size, GFR: In African American Blacks
Clive O Callender, MD, Denee T Mwendwa, PhD, Georica Gholson, PhD, Regina Sims Wright, PhD, Larry Keen II, PhD, Babwande Adesibikan, MD, Serge Madhere, PhD, Victor Apprey, PhD, George Bonney, PhD, Miriam Michael, MD, Bomi Magnus-Lawson, MD, Gabriel Ivy, MD, Linda Idris-Suleiman, MD, Arturo Hernandez, MD, Olga Herren, MS, and Alfonso L Campbell, PhD
Article Type: Research article | First Published: April 10, 2019
Blacks have a greater need for kidney transplants than other American ethnic groups. Overrepresented on kidney transplant waiting lists (13%), they account for 35% of those waiting. Recent studies show that Black live donors are at greater risk for kidney failure, (44%) after donation, compared to other ethnicities. Explanations for these live donation data are few. While diabetic, hypertensive or morbidly obese Blacks are excluded as live donors; those overweight or obese are not. Participants included 214 Black community volunteers from the Washington, DC area. Physical exams, laboratory and...
FMTVDM/BEST Imaging Equally Applicable for Male Breast Cancer
Richard M Fleming, PhD, MD, JD, Matthew R. Fleming, BS, Tapan K Chaudhuri, MD, William C Dooley, MD and Andrew McKusick, BS Pharm
Article Type: Commentary | First Published: April 10, 2019
Prior to FMTVDM/BEST Imaging, diagnostic testing was limited to looking for breast cancer either using "qualitative" imaging defining disease as either present or absent, or semiquantitative methods which is also limited to the same yes you have breast cancer or no you don’t interpretation. These imaging methods include mammography, ultrasound, CT, MRI, as well as other SPECT/Planar and PET imag...
FMTVDM/BEST Imaging for Women with Breast Implants and Dense Breasts
Richard M Fleming, PhD, MD, JD, Matthew R Fleming, BS, Tapan K Chaudhuri, MD, William C Dooley, MD, and Andrew Mc Kusick, BS Pharm
Article Type: Commentary | First Published: April 08, 2019
Prior to FMTVDM/BEST Imaging, diagnostic testing was limited to looking for breast cancer either using "qualitative" imaging defining disease as either present or absent, or semiquantitative methods which is also limited to the same yes you have breast cancer or no you don't interpretation. These imaging methods include mammography, ultrasound, CT, MRI, as well as other SPECT/Planar and PET imagin...
Five Years Survival Trend and Outcome among HIV Infected Children Followed Up in the Pediatric Department in a Tertiary Hospital
Adedemy JD, Agbeille MF, Agossou J, Noudamadjo A, Kpanidja G, Aisso U, Chabi Biaou A, Lalya HF, Seydou L and Koumakpaï-Adeothy S
Article Type: Original Article | First Published: April 08, 2019
HIV infection still contributes significantly to high leatlity among infant and child. The aim of this work was to assess survival rate after five years of routine follow up among HIV 1-infected children in the pediatric ward of the Parakou Teaching Hospital. It was a descriptive cohort study with analytical purpose covering Five years from 2011 to 2016. It focused on 89 HIV 1-infected children. Kaplan-Meier method was used to estimate the survival probabilities. The survival trends were compared with Log-rank test. Cox regression test was used to identify factors associated with child deaths....
Predictive Value of Cerebrovascular Reserve in Patients with Carotid Artery Stenosis for Choosing Treatment Strategy
Аliev VA, Semenyutin VB and Panuntsev GK
Article Type: Review Article | First Published: April 08, 2019
The choice of treatment of carotid artery stenosis is firstly based on assessment of the degree of stenosis and embologeneity of the atherosclerotic plaque. But even in "good-risk" population it is still difficult to identify the patients who are particularly at high threat of stroke and would most benefit from carotid reconstruction. Along with common criteria numerous studies also focus on a prognostic role of a cerebrovascular reserve (CVR) and its state which allows to carry out more objective and pathogenetically substantiated selection of cases for surgical and medical treatment. The pre...
The Relation between Functional Play and Other Forms of Cooperation and Word Learning in ASD
Christina F Papaeliou, Kokonitsa Sakellaki and Asimenia Papoulidi
Article Type: Original Article | First Published: April 08, 2019
This study focuses on the relation between functional play and other aspects of cooperation with language, especially vocabulary production, in children with Autism Spectrum Disorder (ASD). Ten children with ASD (mean CA 54.1 months) were compared with 10 typically developing (TD) children matched for mental and language age (mean CA 17.1 months). Children's behaviors were assessed from video-recordings during spontaneous mother-child play. Results demonstrated that children with ASD take significantly less initiatives for joint attention and spent significantly less time in Elaborated Functio...