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International Journal of

Pathology and Clinical ResearchISSN: 2469-5807

Early Online

 Open Access DOI:10.23937/2469-5807/1510156

Prevalence of Pancreatic Intraepithelial Neoplasia among Resectable Pancreatic Specimens in a Private Tertiary Care Setting in Taiwan

Marissa Krizelda D Santos, MD, Ren Chin Wu, MD, Shih Chiang Huang, MD, Kwai Fong Ng, MD and Tse Ching Chen, MD

Article Type: Research Article | First Published: 2024/08/31

Pancreatic adenocarcinoma remains as the seventh most common cause of mortality in Taiwan (5-year survival rate of 5.2%). Pancreatic intraepithelial neoplasia is an established precursor of pancreatic adenocarcinoma. This study aims to investigate the prevalence, age distribution and variables associated with the presence of pancreatic intraepithelial neoplasia....

 Open Access DOI:10.23937/2469-5807/1510155

Histopathological Findings of Colonoscopic Biopsies from Sudanese Patients

Saeed Bashir Saeed Mohamed, Sahar Abdallah Mohamed Eltayeb, Sahar Hassan Mohamed Osman, Fatima Elbadri Mohammad Nour, Hafsa Adel Hassan Bashier, Namarig Elamin Babiker Mohamed Ahmed, Samah Batran, Aisha Adam Mohmmed, Fathelrahman AE Saaid, Ahmed Amin Mohammed and Hussain Gadelkarim Ahmed

Article Type: Research Article | First Published: 2024/08/02

Colorectal cancer (CRC) is the third most common malignancy and the second major cause of cancer deaths worldwide. The main aim of this study was to assess the histopathological findings of colonoscopic samples collected from Sudanese patients....

 Open Access DOI:10.23937/2469-5807/1510154

The Role of Cell Cycle Division 6 (CDC6) in Cancer: Breast Cancer as a Prototype

Yousif A Kariri

Article Type: Review Article | First Published: 2024/07/08

An increase in cancer-cell division (proliferation) is a distinctive feature of cancer and is acknowledge as a key cell-division checkpoint alteration in cancer cells. Breast cancer is well-known as a heterogeneous disease with variant molecular subtypes, responses to therapy and morphological characteristics, breast malignant cells are identified to deactivate cell-cycle checkpoints to support survival and proliferation. Cell-cycle division 6 (CDC6) plays an important role as a cell-cycle check...

 Open Access DOI:10.23937/2469-5807/1510153

Evaluation of Hematological Parameters with Biochemical Correlation in Malaria a Cross-Sectional Study at Tertiary Care Hospital

Bhumi Patel, Sneha Samir Babaria, Jinal Panchal and Asha Purohit

Article Type: Original Article | First Published: 2024/06/07

Malaria is a major health problem in India leading to anemia, thrombocytopenia, and leukopenia, and also damages the kidneys and liver if left untreated. Evaluation of hematological parameters and biochemical correlation play an important role in malaria....

 Open Access DOI:10.23937/2469-5807/1510151

Scrotal Calcinosis: A Comprehensive Case Report with Literature Review

Wit Tharanon, Narongsak Tang-on, Sarawoot Cherthong and Komson Wannasai

Article Type: Case Report | First Published: 2024/06/03

Idiopathic scrotal calcinosis is a benign disorder characterized by the deposition of calcium salts in the skin layers of the scrotum, leading to the formation of painless nodules. We present a 60-year-old Thai male patient diagnosed with idiopathic scrotal calcinosis. The patient presented with multiple hard nodules in the scrotal region, a characteristic finding of this rare condition. He did not report any associated symptoms, such as pain or discomfort. The diagnosis was confirmed through pa...

 Open Access DOI:10.23937/2469-5807/1510152

Adult Hirschsprung's Disease- A Case Report

Meena Pangarkar, Anuja Nasare and Radhika Pagey

Article Type: Case Report | First Published: 2024/06/03

Adult Hirschsprung's disease (HD) is a rare motor disorder of the gut that is frequently misdiagnosed as refractory constipation and treated with laxatives. The primary pathology of adult HD is the total absence of intramural ganglion cells of the submucosal and myenteric neural plexuses in the affected segment of the bowel. 94% of HD cases are diagnosed before the patient reaches 5-years of age, however, on rare occasion, mild cases of HD may go undiagnosed until they reach adulthood and presen...

 Open Access DOI:10.23937/2469-5807/1510150

Primary Testicular Lymphoma in Newfoundland and Labrador, Canada: A 10-Year Evaluation

Jeremy O'Brien, MD, Zern Chantel, MD and Ikpatt Offiong Francis, MD

Article Type: Review/Case Series | First Published: 2024/05/29

Primary large B-cell lymphoma of immune privileged sites (IP-LBCL) is a rare B-cell lymphoma that arises in the central nervous system (CNS), vitreoretinal tissues, and testis of immunocompetent patients. A search of the health records in the Canadian province of Newfoundland and Labrador over 10 years identified three cases. We highlight pertinent clinical and microscopic features from these cases and discuss the differential diagnosis of this uncommon condition....

 Open Access DOI:10.23937/2469-5807/1510149

Non-Familial Acrokeratosis Verruciformis of Hopf: A Rare Case Report

Tummidi Santosh and Manoj Kumar Patro

Article Type: Case Report | First Published: 2024/05/18

Acrokeratosis verruciformis of Hopf is a rare genodermatosis with an autosomal dominant mode of inheritance. It is a disorder of keratinization, characterized by multiple, flat-topped, skin-coloured keratotic lesions resembling plane warts typically observed on the dorsum of the hands and feet....

 Open Access DOI:10.23937/2469-5807/1510148

Expression of Survivin and Ki67 in Biopsy Proven Prostatic Carcinoma and Benign Prostatic Hyperplasia and its Correlation with Gleason's Score in Patients from A Tertiary Health Care Center in South Kerala

Angela Varghese P, MBBS, Rebecca Mathews, MD and Jessy MM, MD

Article Type: Original Article | First Published: 2024/02/23

The present study has been undertaken to compare the immunoexpression of Survivin and Ki67 in biopsy proven tissues of prostate cancer and benign prostatic hyperplasia as well as to determine whether this immunoexpression could correlate with Gleason's score, S.PSA levels....

 Open Access DOI:10.23937/2469-5807/1510147

Adults and Paediatrics Renal Cell Carcinoma with Mit/TFE3 Family Translocation Subtype: Case Series

Sumaira Siddiqui

Article Type: Case Series | First Published: 2023/12/02

Renal cell carcinoma (RCC) is the most common malignant neoplasm of the kidney and constitutes about 2-3% of all cancers worldwide. In 30% of tumours, patients present with metastasis. The prognosis of patients with RCC varies according to the stage and histological grade....

 Open Access DOI:10.23937/2469-5807/1510146

Acantholytic Squamous Cell Carcinoma Mimicking Angiosarcoma in the Oral Cavity - A Case Report and Literature Review

Rohit Parab, Laya Chadalawada, Shaina Machado and Manana Jikurashvili

Article Type: Case Report and Literature Review | First Published: 2023/11/18

Although angiosarcoma and squamous cell carcinoma represent completely different tumor entities their histologic features in some cases might be similar, especially in the head and neck region. Interestingly the clinical features might be also identical....

 Open Access DOI:10.23937/2469-5807/1510143

Aggressive Angiomyxoma (AAM) at an Uncommon Site: Case Report

Reena VK, Umashankar T and Jayaprakash CS

Article Type: Case Report | First Published: April 03, 2023

Aggressive angiomyxoma are rare myxoid soft tissue neoplasms, affecting the pelvis and the perineum, rarely encountered in extragenital sites, with a marked preponderance for females in the reproductive age group. AAMs are thought to be benign, locally infiltrative and non-metastasizing. Here is case report of AAM located in the posterior chest wall....

 Open Access DOI:10.23937/2469-5807/1510142

Crystal-Storing Histiocytosis in a Patient with Nodal Marginal Zone Lymphoma

Madeline Fitzpatrick, MD, Amrah Pirzada, MD and Offiong Ikpatt, MD

Article Type: Case Report | First Published: December 24, 2022

We present a case of a 72-year-old male diagnosed with concurrent crystal-storing histiocytosis and nodal marginal zone lymphoma with plasmacytic differentiation following a finding of new axillary lymphadenopathy during active surveillance for an early stage lung cancer. A panel of ancillary studies was performed to help establish the diagnosis and to exclude other histologic mimics. We share this case to promote awareness of this rare entity, discuss its association with immunoglobulin-produci...

 Open Access DOI:10.23937/2469-5807/1510141

Sinus Histiocytosis with Massive Lymphadenopathy (Rosai Dorfman Disease) of the Liver Masquerading as a Metastatic Malignancy

Sheba SK Jacob and Elankumaran Krishnan

Article Type: Case Report | First Published: December 01, 2022

Sinus histiocytosis with massive lymphadenopathy (SHML) (Rosai Dorfman disease) is a disorder first described in lymph nodes but eventually has been described in many organs. Liver involvement is rare and is a great mimicker of infection, metastases or a lymphoma which commonly involve the liver. We describe a case of a middle-aged female who presented with abdominal pain in the emergency. CT scan of the upper abdomen showed multiple hypodense lesions in the liver, pancreas, left sacral ala and ...

 Open Access DOI:10.23937/2469-5807/1510140

Pathological Changes in Postmortem Covid-19 Biopsies

Alexis J Leon-Guerrero, MD, Nazario A Ortiz-Muchotrigo, MD, Paola G Gutierrez-Gutierrez, MD, Alejandra M Bahamonde-Pacheco, MD, Lis N Zelada-Hernandez, MD, Daniela I Medina-Valdivia, MD, Cesar A Chian-Garcia, MD and Fiorella Rosas, MD

Article Type: Case series and literature review | First Published: November 23, 2022

The COVID-19 epidemic has caused thousands of deaths all over the world. This virus is known to produce an atypical pneumonia that can lead to death. There are few studies concerning pathological examination of tissues from COVID-19 patients. To describe the pathological findings in tissues from deceased patients with COVID-19 infection....

 Open Access DOI:10.23937/2469-5807/1510139

Expression of Vitamin D Receptor (VDR) in Urinary Bladder Carcinoma: Immunohistochemical and Histopathological Study

Rehab Mohamed Sharaf Eldin, MD, Basma Mostafa Mahmoud Abdalla, MSc, Samia Ibrahim El Naggar, MD and Wesam Ismail Moustafa, MD

Article Type: Original Article | First Published: November 19, 2022

Bladder cancer is the most common malignancy of the urinary tract. Calcitriol [1,25(OH)2 vitamin D3] has anticancer effects mediated through binding to vitamin D receptor (VDR). The expression of VDR is present in many normal and cancer tissues. But there is little information about its expression in urinary bladder carcinoma. This study aimed to analyze VDR immunohistochemical expression in 74 Egyptian patients with urinary bladder carcinoma and to evaluate its association with different clinic...

 Open Access DOI:10.23937/2469-5807/1510138

Study of Spectrum of Lesions in Bone Marrow Aspiration and Trephine Biopsy from a Tertiary Care Centre in South India

Gaurvi Piplani and Teerthanath S

Article Type: Original Article | First Published: October 28, 2022

Bone marrow examination is an important diagnostic tool widely used in various haematological and non-haematological disorders. Bone marrow evaluation may either confirm clinically suspected disease or may provide the previously unsuspected diagnosis. To study the spectrum of lesions, comparison and evaluation of diagnostic efficacy of the bone marrow aspiration and bone marrow biopsy findings in various haematological and non-haematological disorders....

 Open Access DOI:10.23937/2469-5807/1510137

Do Messenger RNA Vaccines Induce Pathological Syncytia?

Adonis Sfera, MD, Karina G Thomas, DAN O Sfera, Jonathan J Anton, Christina V Andronescu, Nyla Jafri, Sarvin Sasannia and Zisis Kozlakidis

Article Type: Review Article | First Published: October 20, 2022

The Pfizer and Moderna COVID-19 vaccines are composed of lipid nanoparticles (LNP) containing a modified messenger RNA (mRNA) that encodes for the Spike S protein. The LNP transfection likely involves particle engulfment by the host immune cells due to their resemblance to apoptotic bodies, vesicles with externalized phosphatidylserine (ePS). As the LNPs are decorated with PS-like ionizable phospholipids, including 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), they encourage human phagocyte...

 Open Access DOI:10.23937/2469-5807/1510136

Congenital Cystic Pulmonary Airway Malformation with Intralobar Sequestration in 15 Weeks Old Fetus- Peculiarity of Early Developmental Stage

Daria Kozlova, Sharon Perlman, Roee Birnbaum, Ori Mayer and Yinon Gilboa

Article Type: Case Report | First Published: August 20, 2022

Congenital pulmonary airway malformations (CPAMs) consist of a spectrum of cystic or non-cystic lung malformations often associated with bronchial atresia during in utero development. Several classifications for these lesions have been proposed using radiologic or pathologic criteria based on cyst size and histology, with the Stocker classification being perhaps the most commonly used in the pathology literature....

 Open Access DOI:10.23937/2469-5807/1510135

PRAME Expression in Mimickers of Melanoma in Situ: Paget’s Disease, Extramammary Paget’s Disease, and Pagetoid Squamous Cell Carcinoma in Situ

Cary Chisholm, MD, Michael Hatch, MD, Sage Post and Sage Chain

Article Type: Research Article | First Published: August 19, 2022

Antibodies towards Preferentially Expressed Antigen in Melanoma (PRAME) have shown promise to discriminate between melanoma in situ (MIS) and benign melanocytic lesions. Paget’s disease, extramammary Paget’s disease, and squamous cell carcinoma in situ may mimic the morphologic features of MIS, and PRAME expression in these lesions has not yet been described....

 Open Access DOI:10.23937/2469-5807/1510134

Monoclonal Light Chains in Multiple Myeloma: The Sinister Immunoglobulin

Gurmukh Singh, MD, PhD, MBA, Hongyan Xu, PhD and Roni J Bollag, MD, PhD

Article Type: Clinical Research | First Published: August 04, 2022

Multiple myelomas are the commonest hematological malignancy in adults, next to the heterogeneous group non- Hodgkin lymphomas, and account for about 10% of such tumors. About 21% of the multiple myelomas are associated with higher levels of free monoclonal light chains. This subgroup of patients exhibits high incidence of renal disease manifested by significantly lower estimated glomerular filtration rate, higher incidence of dialysis and significantly shorter survival....

 Open Access DOI:10.23937/2469-5807/1510133

Assessment of Serum Copper and Zinc Status in Patients Receiving Highly Active Antiretroviral Therapy in A Tertiary Health Institution in Southwest Nigeria

Taiwo Oloyede, Elizabeth Oke, Taiwo Alatishe, Samson Ojedokun, Adeolu Akinboro, Kunle Oreagba and Abdulkareem Afolabi Salawu

Article Type: Original Research | First Published: July 30, 2022

The poor prognosis and mortality in HIV infection has been associated with deficiency of micronutrients such as zinc and copper. This study aimed to investigate the level and deficiency of some trace elements in HIV-seropositive subjects receiving HAART treatment....

 Open Access DOI:10.23937/2469-5807/1510132

Basal-Like Atypical Ductal Hyperplasia and Basal-Like Ductal Carcinoma In Situ: Evidence for Precursor of Basal-Like Breast Cancer

Jing Wang and Lavinia P. Middleton

Article Type: Original Article | First Published: July 28, 2022

Basal-like breast cancer (BLBC) is identified by gene expression profiling studies and is associated with worse overall survival. The identification of possible precursors of BLBC is important to gain insight into tumorigenesis and therapeutic targets. This retrospective study evaluated the characteristics of possible precursors of BLBC, including basal-like atypical ductal hyperplasia (bADH) and basal-like ductal carcinoma in situ (bDCIS); basal cytokeratin (CK) expression in bADH and bDCIS; an...

 Open Access DOI:10.23937/2469-5807/1510131

Cellular Angiofibroma: A Rare Tumor Behind the Ear

Canan Firat, Ayca Ersen Danyeli, Yuksel Olgun and Sulen Sarioglu

Article Type: Case Report | First Published: July 28, 2022

Cellular angiofibroma (CA) is an uncommon benign soft tissue tumor and typically arises in genitourinary region. There are only three reported cases at the head and neck region to the best of our knowledge; two different sites at eyelid and buccal mucosa. A 67-year-old man presented to the otorhinolaryngology unit with a painless nodule behind the left ear. Ultrasonography revealed a subcutaneous non-vascular, hyperechoic, homogenous, solid, 15×15 mm mass....

 Open Access DOI:10.23937/2469-5807/1510130

Hidradenocarcinoma Treated with Mohs Surgery

Jenna Lee, MS, Carolina Puyana, MD, MSPH, Wenhua Liu, MD, Vassilios Dimitropoulous, MD and Roger Haber, MD

Article Type: Case Report | First Published: August 18, 2022

Hidradenocarcinoma (HAC) is an exceedingly rare and aggressive malignant tumor of the adnexal eccrine and apocrine sweat gland. Due to its low incidence rate, nonspecific clinical presentation, and similar histopathological features to benign hidradenoma (HA), HAC is often misdiagnosed as its benign counterpart. Histologically, even the absence of cellular atypia does not rule out malignancy....

 Open Access DOI:10.23937/2469-5807/1510129

Primary Pulmonary Colloid Adenocarcinoma: A Case Report with Literature Review

Emna Braham, Farah Sassi, Mehdi Abdennadher, Mona Mlika and Faouzi El Mezni

Article Type: Case Report | First Published: July 16, 2022

Pulmonary colloid adenocarcinomas are uncommon tumors individualized as a distinct entity in the histological classification of World Health Organisation of lung tumors characterized by extensive pool of extracellular mucin distending and destroying alveolar walls. We herein report a case of a 63 year-old active man smoker who presented with a worsening dyspnea. A chest computed tomography scan showed a highly suspected irregular nodule of 23 mm in the left-upper lobe....

 Open Access DOI:10.23937/2469-5807/1510128

IMP3 Expression in Thyroid Cancers and its Relationship with Prognostic Parameters

Gamze Ozcan, Mihriban Gurbuze, MD and Serap Pamak Bulut, MD

Article Type: Original Article | First Published: May 26, 2022

The study included 60 cases diagnosed with thyroid carcinoma in the pathology department of Haseki Hospital. As the control group, two follicular adenomas, three Hurthle cell adenomas, and five nodular hyperplasia cases were included in the study....

 Open Access DOI:10.23937/2469-5807/1510127

Evaluation of Pathological Parameters of Two-Year Bladder Urothelial Carcinomas in Association with Literature

Mürüvvet Akçay Çelik, MD and Yeliz Kaşko Arıcı

Article Type: Research Article | First Published: April 21, 2022

In this study, it was aimed to evaluate the pathological parameters in cases with bladder urothelial carcinoma diagnosed in our department, and to investigate the relationship between the cases in the literature and age, gender correlation. In our Faculty of Medicine, Department of Pathology, 68 bladder biopsy cases diagnosed with urothelial carcinoma between 2018-2019 were included in the study. The pathology reports of the cases were evaluated retrospectively. According to the one-way chi-squa...

 Open Access DOI:10.23937/2469-5807/1510126

Lung Abscess as a Complication of SARS-CoV-2 Infection Associated with Mucormycosis in a Romanian Patient

Maria Sajin, Florina Almarii, MD, Iona Eliza Gaianu and George Simion

Article Type: Case Report | First Published: April 08, 2022

Formation of lung abscesses after Covid-19 is a newly emerging complication and superimposed mucormycosis infection is quite rare. We report the case of 62-years-old male who developed a lung abscess after being infected with SARS-COV-2. Because of the unresponsiveness to pharmacological treatment and ongoing lung damage, surgical approach was required. This is the case of a 62-years-old patient who was transferred to our hospital for the management of a non-resolving lung abscess. He was treate...

 Open Access DOI:10.23937/2469-5807/1510125

Criteria for Presumptive Diagnosis of IgD Multiple Myeloma

Gurmukh Singh, MD, PhD, MBA

Article Type: Research Article | First Published: March 25, 2022

IgD myelomas constitute about 1% of myelomas, have worse prognosis, have higher association with lambda light chains, and are associated with excess free involved light chains. Standard immunofixation protocols stain only for IgG, IgM and IgA heavy chains. Proper attribution of a monoclonal gammopathy as having a delta heavy chain requires additional testing that is not available in most clinical laboratories. Retrospective review of protein electrophoresis and other laboratory results showed ch...

 Open Access DOI:10.23937/2469-5807/1510124

Diffuse Intestinal Ganglioneuromatosis: A Case Report with Review of Literature

Hussein Kaouk, Josiane Mansour, Layla Abou Khana, Rosy Feghaly and Georges Aftimos

Article Type: Case Report | First Published: February 19, 2022

Intestinal ganglioneuromatosis is a rare neoplastic disease characterized by an important proliferation of Schwann cells, nerve fibers and ganglion cells in the intestinal wall. We present a case of 36-years-old male who presented with abdominal pain, constipation and vomiting of several days duration. On admission, intestinal occlusion was suspected and urgent laparotomy was done during which numerous nodules were found in the small bowel. Eventually, a segment of the bowel was resected and his...

 Open Access DOI:10.23937/2469-5807/1510123

High Expression of RAGE and HMGB1 in Lung Tissue of Decedents with COVID-19 and Diabetes

Yared Tekabe, Anjali Saqi, Geping Zhang, Monica Goldklang and Lynne L Johnson

Article Type: Original Research | First Published: February 17, 2022

Serum biomarker studies on patients with severe COVID-19 lung disease indicate that increased ligands for Receptor for Advanced Glycation End-products (RAGE) and diabetes are risk factors for severe acute respiratory distress syndrome (ARDS). To investigate in situ RAGE expression in coronavirus disease-19 (COVID-19) ARDS, we obtained lung tissue from autopsies performed on COVID-19 decedents with clinical ARDS and corresponding pathology showing diffuse alveolar damage (DAD) both with and witho...

Volume 8
Issue 1