International Journal of Medical Nano Research is an open access peer reviewed journal that publishes latest discoveries in wide variety of medical and clinical improvements in the nano research. Nano medical research, an invading technology from the mixture of biomedical and clinical science which has shown great impact in creating structures, systems and devices of length ranging from 1-1000 nanometers. Detailed picture of molecules and events which takes place in a disease can be easily find out by nano science and also used to discovery, develop and testing of novel medicine. This science have already been used in clinical which have good impact for drug development, with increase in demand of nano science many national cancer institute's are attracted towards the nano research for diagnosis, detecting and also treatment for the various cancers. Advancing of the nano science have built a nano sensors which have been used for detecting the biochemical and genetic measurements in living, which make easy to screen the disease and also makes easy for drug discovery.

The main focus of this journal is to publish the recent research in the medical nano technology and also allows for easy access of the articles globally and also various opinions of authors, researchers and doctors for the users online. This journal publishes all types of article like research, review, commentaries and many more. We mainly strengthen and request the authors to submit the results with the clear and detailed explanation to follow by the rigorous review process.

Journal Information

Title: International Journal of Medical Nano Research

ISSN: 2378-3664

Editor-in-chief: Giuseppe De Rosa

NLM title abbreviation: Int J Med Nano Res

ICV: 87.43

ISO abbreviation: Int J Med Nano Res

Other titles: IJMNR

Category: Nanomedicine

DOI: 10.23937/2378-3664

Peer review: Double blind

Review speed: 3 weeks

Fast-track review: 10 days

Publication format (s): Electronic and print

Publication policy: Open Access; COPE guide

Publication type(s): Periodicals

Publisher: ClinMed International Library

Country of publication: USA

Language: English

Contact email:

Articles Search by   Keyword   |   Journal title   |   Author name   |   DOI


 Open Access DOI:10.23937/2378-3664.1410040

En Bloc Staining with Uranyl Acetate Zero (UA-Zero) for Transmission Electron Microscopy

Santhana Raj L, Fauzah Abd Ghani, Jing Siew Ting, Intan Shameha Abdul Razak and Nur Afrina Muhamad Hendri

Article Type: Electron Microscopy | First Published: 2023/12/15

Uranyl acetate (UA) is one of the heavy metals used to stain tissue in sample preparation for transmission electron microscopy (TEM). It gives excellent contrast to ultrastructure morphology. Unfortunately, UA is very toxic and has proven to be a carcinogen and radioactive reagent. Meanwhile, UA-Zero is a UA replacement with improved staining property has shown better for staining due to its safety profile and environmental-friendly properties....

 Open Access DOI:10.23937/2378-3664.1410039

Possible Effect of Nano Characterization of COVID-19 on Infection and Causing Disease

Wang Shenguo

Article Type: Original Article | First Published: February 23, 2023

In this article, based on analysis of chemical composition and morphology structure of the New Coronavirus Disease-19 (COVID-19), that the COVID-19 belongs a kind protein nanoparticle virus with spherical complex structure has been explained. So, the COVID-19 possesses characteristics of ultra-small size, large specific surface, both hydrophilicity and lipophilicity, that just as all of the nanoparticles. It leads to the COVID-19 producing fast spread speed, large spread range and strong infecti...

 Open Access DOI:10.23937/2378-3664.1410038

Study of Mesenchymal Stem Cell in Combination with Self-Assembled Functional Nanopeptide Gel to Promote Angiogenesis

Zhanao Liu, Ailing Tian, Xin Yi, Nianfeng Sun and Yong Di

Article Type: Research Article | First Published: January 15, 2023

To investigate the transplantation of a functionalized self-assembling nanopeptide hydrogel loaded with adipose-derived mesenchymal stem cells (AD-MSCs) into a rabbit hindlimb ischemia model and to evaluate its effect in promoting vascular regeneration in ischemic tissues. Functionalized self-assembling nanopeptide hydrogels were synthesized, and the physical and chemical properties of the hydrogels were observed by electron microscopy. Primary AD-MSCs were isolated, cultured, immunophenotyped, ...

 Open Access DOI:10.23937/2378-3664.1410037

Therapeutic Application of Nanomaterials in the Management of Health Care: ‘An Updated Review’

Pooja Mishra, Irum, Akhtar Hussain and Abu Baker

Article Type: Review Article | First Published: November 14, 2021

The provision of healthcare, which is a fundamental human right, has frequently been the subject of cutting-edge technology development. The availability of high-quality, timely, acceptable, and reasonably priced healthcare has greatly benefited from technological advancement. A new generation of nanostructures has emerged as a result of developments in nanoscience. They each have a distinct set of characteristics that contribute to their amazing uses....

 Open Access DOI:10.23937/2378-3664.1410036

Encapsulation of Alendronate in Chitosan based Polymeric Nanoparticles for Effective Management of Osteoporosis - Development to Release Kinetic Study

Sandhya Pathak, Satyendra Kumar Tripathi, Chandni Pachouri and Archna Pandey

Article Type: Research Article | First Published: January 31, 2022

Osteoporosis means "Porous bone” is a disease characterized by progressive bone thinning. The deterioration of bone tissue can lead to bone fragility and fracture, especially of the hip, spine, shoulder and wrist. Osteoporosis is characterized by decreasing bone mineral density (BMD). Bisphosphonates are the most commonly prescribed drugs for the treatment of osteoporosis in the US and many other countries including India. Alendronate (Aln) is a widely used anti-osteoporosis drug, exhibits str...

 Open Access DOI:10.23937/2378-3664.1410035

Recent Trends in Nanoparticles Based Drug Delivery for Tuberculosis Treatment

Chandni Pachouri, Bharat Patel, Sandhya Shroti, Sandeep Shukla and Archna Pandey

Article Type: Review Article | First Published: November 26, 2021

Current treatment therapeutic approach for tuberculosis is the administration of first line drugs in the form of tablets and capsules for 4-6 months however; this approach leads to sever adverse effect. Therefore, present study was designed to achieving local and sustained targeting of ant tuberculosis drugs in order to reduce dose n frequency. Nanoparticles (NPs) have been found to be potential targeted and controlled release drug delivery systems. Various drugs can be loaded in the NPs to achi...

 Open Access DOI:10.23937/2378-3664.1410034

Silver Nanoparticles Impregnated Nanocollagen as Scaffold for Soft Tissue Repair-Synthesis, Characterization, and In vitro Investigation

V Subha, S Kirubanandan, R Ilangovan and S Renganathan

Article Type: Research Article | First Published: July 09, 2021

The regeneration of soft tissue is challenging task in the medicine due to infection at the wound site. Therefore, it requires a rapid regeneration scaffold for dermis and epidermis in the soft tissue. The silver nanoparticles (AgNPs) impregnated nanocollagen has been developed for soft tissue repair. The nano-collagen contained silver nanoparticles facilitates the rapid regeneration of wounded skin, when compared to collagen microfibers. Collagen was extracted from scales of Catla fish and made...

 Open Access DOI:10.23937/2378-3664.1410033

New Preparation Method of Reynolds' Stain for Transmission Electron Microscope for Liver Samples

Santhana Raj L, Nur Dayana MA, Norzarila SN, Tan CV and Nur Afrina MH

Article Type: Original Research | First Published: July 09, 2021

This preparation would maintain good contrast and reduce the formation of lead carbonate in resin-embedded tissue sections. This new method provides a shorter staining protocol of fewer than 5 minutes, extended storage duration, improved contrast, higher broad differential range, and prevents contamination from the environment. Introducing 20% ethanol to the lead citrate formula makes it to be more stable than lead nitrate formula. Although this technique is well known, contrasting is one of the...

 Open Access DOI:10.23937/2378-3664.1410032

Implantations and Applications of Brain Computer Interfaces as Medical Devices: A Short Review of Engineering Ethics

Akram Jassim Jawad

Article Type: Short Review | First Published: March 28, 2021

Nowadays, smart home devices have started to take a part in everything in our life, which mainly have been developed to consist from brain computer interface (BCI). In recent months, Neuralink BCI (1024-Electode) has been approved to be used by Food and Drug Administration (FDA) in the USA. That makes the ethical related studies have more attention to apply these devices and technologies in our daily life with more security. In this work, the ethical challenges of smart home systems that use BCI...

 Open Access DOI:10.23937/2378-3664.1410031

Origami-Induced Alignment of MNP Inside of DNA Nanotubes

Adele Rafati, Ali Zarrabi and Pooria Gill

Article Type: Original article | First Published: February 20, 2020

The advent of nanotubes in the nanotechnology world has led to significant advances in a number of biological and materials application, due to their structural properties such as the surface to volume ratio and potential to surface carrying or inside capsulation any materials. Among the various types of nanotubes, DNA nanotubes, due to their unique characteristics, such as precis controllability and programmability in shape/size/length/diameter and its biological origin compared to different ty...

 Open Access DOI:10.23937/2378-3664.1410030

The Case for Viscoelastic Treatment of Excessive Girth in Treatment of the Presentation of a Spastic Colon: A Role for a Girth Injury Index?

Gareth R Williams, Timothy J Prior, Geoffrey Hayes, Barry L Chuckle, and Chas N Dave

Article Type: Short Communication | First Published: August 26, 2019

Spastic colon injure tangible introduces viscoelastic jumpy moist introduces value overconfident tangible value introduces tame; tame tangible overconfident efficacy tame tangible curtail overconfident tangible overconfident injure girth moist island spastic colon. Viscoelastic tangible island and therefore spastic colon injure viscoelastic and therefore tame spastic colon moist curtail efficacy island girth introduces spastic colon jumpy in tangible and therefore moist girth viscoelastic tame o...

 Open Access DOI:10.23937/2378-3664.1410029

A Supramolecular Indicator System for Detecting Urea Based on the Cellulose-Nanodiamond Composite Material and Urease

Ekaterina Posokhina, Nikita Ronzhin, Olga Mogilnaya, Alexey Baron and Vladimir Bondar

Article Type: Research Article | First Published: August 14, 2019

A supramolecular indicator system (cellulose-nanodiamonds- urease) for reusable biochemical detection of urea has been fabricated using sequential immobilization of the components. Modified nanodiamonds (MNDs) were covalently immobilized onto DEAE cellulose granules via the nucleophilic addition reaction. At DEAE cellulose: MND ratio of 4:1 (w/w), up to 110 μg of nanoparticles bound onto 1 mg of the polymer during the addition reaction. Urease was immobilized by covalent conjugation onto the po...

 Open Access DOI:10.23937/2378-3664.1410028

Monitoring the Anticancer Effects of Two Different Gold Nanostructures Shapes towards Hep-2 Cells

Maii I Sholqamy, Ehab S Abd-ElHamid, Amr H Mostafa El-Bolok, Aly F Mohamed and Waleed A El-Said

Article Type: Research Article | First Published: July 17, 2019

The change in cell size and alterations in the distribution of cells at different phases of the cell cycle are indicators of change in cell homeostasis. In this study, the HEp-2 cell line cells were treated for 24 hours by two shapes of Gold nanoparticles (GNPs): Gold nanospheres (GNSs) and Gold nanorods (GNRs). The cytotoxic effect of GNPs was evaluated by different methods. The MTT assay revealed that GNPs have a cytotoxic effect on HEp-2 cells and the GNRs are more toxic than GNSs. Image morp...

 Open Access DOI:10.23937/2378-3664.1410027

Multimodal AGuIX® Nanoparticles: Size Characterization by HF5 and Optimization of the Radiolabeling with Various SPECT/PET/Theranostic Tracers

S Huclier-Markai, E Ntsiba, E Thomas, C Alliot, CS Cutler, F Luxc and O Tillement

Article Type: RESEARCH ARTICLE | First Published: February 25, 2019

Diagnostics that combine imaging techniques such as PET and MRI could enhance disease detection and location if effective multimodal contrast agents can be developed. A nanoparticle called AGuIX has been developed that is comprised of gadolinium-bound by chelates and additional free chelates that can be further labelled with radioactive isotopes enabling both PET and MRI imaging. Herein, we describe the size characterization of these nanoparticles together with their size distribution, which is ...

 Open Access DOI:10.23937/2378-3664.1410026

Pharmaceutical Particle Engineering via Nano Spray Drying - Process Parameters and Application Examples on the Laboratory-Scale

Arpagaus Crpagaus

Article Type: Review Article | First Published: December 05, 2018

Spray drying plays a crucial role in the processing of pharmaceutical products such as pills, capsules, and tablets as it is used to convert drug-containing liquids into dried powdered forms. Nano spray drying is in particular used to improve drug formulation by encapsulating active ingredients in polymeric wall materials for protection and delivering the drugs to the right place and time in the body. The nano spray dryer developed in the recent years extends the spectrum of produced powder part...

 Open Access DOI:10.23937/2378-3664/1410025

Folate Targeted Galactomannan Coated Iron Oxide Nanoparticles as a Nanocarrier for Targeted Drug Delivery of Capecitabine

Subha Veeramani, Kirubanandan Shanmugam and Renganathan Sahadevan

Article Type: Research Article | First Published: November 22, 2018

Iron oxide nanoparticle is the most promising nanoparticles (NPs) capable in Drug Delivery and targeting. Iron oxide nanoparticles were synthesized by green synthesis. Galactomannan, when attached to the surface of the nanoparticles, increases the biocompatibility of the nanoparticles. Folic acid (FA) is used as the ligand to target folate receptors, which are found abundant in cancer cells. FeNPs-GM-FA could target cancer cells when used as drug carriers. The synthesized iron oxide nanoparticle...

 Open Access DOI:10.23937/2378-3664.1410024

Silver Nanoparticles - Green Synthesis with Aq. Extract of Stems Ipomoea Pes-Caprae, Characterization, Antimicrobial and Anti-Cancer Potential

Subha Veeramani, Ernest Ravindran RS, Preethi Ramadoss, Cyrril Joseph, Kirubanandan Shanmugam and Renganathan S

Article Type: Research Article | First Published: October 10, 2018

Green synthesis is a novel process for the preparation of numerous metallic nanoparticle and provides a safer and eco-friendly process simultaneously achieving functionalization of nanoparticles with bioactive molecules in the plants extract. Green synthesis of silver nanoparticles (AgNPs) is performed using the aqueous extract of Ipomoea pes-caprae stems which acts as a bio-reducing agent. UV spectroscopic investigation confirms the formation of AgNPs by noticing the peak at 448 nm due to its s...

 Open Access DOI:10.23937/2378-3664/1410023

In Vitro Dissolution Studies on Naproxen-PVP Nanoformulations Show Enhanced Oral Bioavailability of Naproxen

Sandeep Patnaik, Aditya D Kurdekar, LA Avinash Chunduri, C Prathibha and K Venkataramaniah

Article Type: Research Article | First Published: October 08, 2018

Phase solubility behavior, physico-chemical characteristics, cytotoxicity, morphology and dissolution enhancement of Naproxen-PVP Nanoformulations have been studied. Drug-polymer ratios of 1:1, 1:2, 1:3, 1:4 for the poorly water-soluble drug, naproxen and the polymer PVP are prepared via wet milling using a conventional Retsch Planetary ball mill. The highest dissolution enhancement over that of the pure drug, 310% was achieved for the formulation ratio of 1:4. This ability of amphiphilic surfac...

 Open Access DOI:10.23937/2378-3664/1410022

Production of Electrochemiluminescence (ECL) Biosensor Using Os-Pd/HfC Nanocomposites for Detecting and Tracking of Human Gastroenterological Cancer Cells, Tissues and Tumors

Alireza Heidari

Article Type: Research Article | First Published: October 08, 2018

In the current paper, the first step for using Os-Pd/HfC nanocomposites as luminophore in producing Electrochemiluminescence (ECL) biosensor-namely increasing the sensitivity of biosensor through creating Os-Pd/HfC nanocomposites and using it instead of other nanocomposites for detecting and tracking of human gastroenterological cancer cells, tissues and tumors, is evaluated. Further, optimization of tri-n-propylamine (TPrA), 2-(dibutylamino) ethanol (DBAE) and benzyl peroxide (BPO) concentratio...

 Open Access DOI:10.23937/2378-3664/1410021

Aptamer-Conjugated Magnetic Bead Pull Down and Detection of Human Growth Hormone Releasing Peptides from Serum and Urine by Mass Spectrometry

John G Bruno and Taylor Phillips

Article Type: Research Article | First Published: April 30, 2018

DNA aptamers were developed against human growth hormone releasing peptide (GHRP)-6 and the major metabolite of GHRP-2 (pralmorelin) known as AA-3 (D-Ala-D(β-naphthyl)-Ala-Ala-OH) in 10% human serum or 50% human urine. The lead 5'-biotinylated candidate aptamers from ELISA-like microplate screening were conjugated to commercially available Dynal™ streptavidin-polystyrene-coated 2.8 µm diameter magnetic (magnetite) microbeads (MBs) and used to "pull down" and purify or enrich for their cognat...

 Open Access DOI:10.23937/2378-3664/1410020

Methotrexate-Loaded PLGA Nanoparticles: Preparation, Characterization and their Cytotoxicity Effect on Human Glioblastoma U87MG Cells

Hassan Maleki, Farid Dorkoosh, Mahdi Adabi, Masood Khosravani, Hossein Arzani and Morteza Kamali

Article Type: Research Article | First Published: November 23, 2017

The purpose of the current study was to prepare Methotrexate (MTX) loaded Poly Lactic-Co-Glycolic Acid (PLGA) Nanoparticles (NPs) and investigates their toxicity effect on human glioblastoma cells. The influence of different experimental parameters including polymer concentration....

 Open Access DOI:10.23937/2378-3664/1410019

Silver Nanoparticles for the Rapid Healing of Diabetic Foot Ulcers

Cesar Alejandro Almonaci Hernandez, Karla Juarez-Moreno, Martin E Castaneda-Juarez, HoracioAlmanza-Reyes, Alexey Pestryakov and Nina Bogdanchikova

Article Type: Case Report | First Published: September 28, 2017

Diabetic foot ulcers are one of the major complications of patients with diabetes mellitus. And, due to their high susceptibility to microbial infections, are the leading cause of hospitalization and amputation of lower limbs. It has been well studied the antimicrobial properties of silver nanoparticles (AgNPs), therefore their use in biomedicine is a trend. ...

 Open Access DOI:10.23937/2378-3664/1410018

Protease Biosensors Based on Peptide-Nanocellulose Conjugates: From Molecular Design to Dressing Interface

J Vincent Edwards, Krystal R Fontenot, Nicolette T Prevost, David Haldane, Nicole Pircher, Falk Liebner, Alfred French and Brian D Condon

Article Type: Research Article | First Published: August 19, 2016

The development of point of care diagnostic protease sensors applied to wound healing has received increased interest in chronic wound treatment as an interface for chronic wound dressings. Biosensor technology and the use of nanomaterials have grown exponentially in recent years. A biosensor is fundamentally a biomolecule (functioning as a transducer) attached to a transducer surface, which is activated by a biochemical property that prompts a detection signal specific to a target biomarker. Fo...

 Open Access DOI:10.23937/2378-3664/1410017

Ovarian Cancer Treatment by Suicide Gene Therapy: Beauty of Nanotechnology in Medicine

Abhimanyu Thakur, Mahadi Hasan MA Shahed, Aishwarya Roy and Nabila Sayed

Article Type: Short Commentary | First Published: February 09, 2016

There has been a global interest worldwide in the recent trend of medical researches, which is basically a merge up between basic biology and engineering tools/technology. Imaging, microfluidics, nanofluidics, surface plasmon resonance (SPR) sensor systems, etc. are the widely used engineering tools in medical researches and has given effective clinical results. The most effective and widely used technology amongst these would be nanotechnology which employs methods like nano drug delivery, nano...

 Open Access DOI:10.23937/2378-3664/1410016

Studying Complex Interaction of B2H4 with HOR(R = H, CH3) and Nhn(CH3)3-N (N = 0-3) Molecules

Reza Tayebee and Abedien Zabardasti

Article Type: Research Article | First Published: February 02, 2016

Borane complexes are extensively studied and have even been the subject of Nobel Prize by Brown [1]. Many scientific data exist that have shown that boron is an essential microelement in animal cells. With the knowledge that borate linkages function in cell-to-cell adhesion, it has been hypothesised that boronates target structural glycoproteins located along the cytoskeletonplasma membrane-cell wall assembly....

 Open Access DOI:10.23937/2378-3664/1410015

Nanoparticles: From Diagnosis to Therapy

Derya Ilem-Ozdemir, Evren Gundogdu, Meliha Ekinci and Makbule Asikoglu

Article Type: Review Article | First Published: January 29, 2016

Cancer is a leading cause of death, the second most common cause, exceeded only by heart disease. Still, the current clinical imaging methods and treatments are in many situations unable to provide timely detection and curative therapy. The field of drug delivery stands to be significant advances in nanotechnology and benefits of novel nanotechnology in oncology already starts. New strategies are being designed to deliver chemotherapeutic drugs or imaging agents to the tumor at higher concentrat...

 Open Access DOI:10.23937/2378-3664/1410014

Estimating Binding Capability of Radiopharmaceuticals by Cell Culture Studies

Derya Ilem-Ozdemir, Meliha Ekinci, Evren Gundogdu and Makbule Asikoglu

Article Type: Review Article | First Published: January 02, 2016

Radiopharmaceuticals have applications in biologic research, drug discovery, diagnosis of human disease and molecular therapeutics for a wide variety of medical conditions. With the increasingly central role of radiotracers for non-invasive imaging of animal models and human research, small animal imaging centers are likely to have a growing interest in development of radiopharmaceutical science. Although animal experiments are giving the most valuable information about the drug behavior in the ...

 Open Access DOI:10.23937/2378-3664/1410013

Modification of the Uranyl Acetate Replacement Staining Protocol for Transmission Electron Microscopy

Santhana Raj L, Paramsavaran S, Koay BT, Izan Shahrina A and Siti Aminah N

Article Type: Review Article | First Published: January 02, 2016

A uranyl acetate replacement staining protocol has eliminated the need for highly toxic uranyl acetate in the electron microscopy laboratory. However, the method is results in undesirable charging effects when viewed under the transmission electron microscope and can be further improved. A modification of the uranyl acetate replacement staining protocol that simplifies the process is described. The modified method takes less time, and produces better contrast and less charging effects compared t...

 Open Access DOI:10.23937/2378-3664/1410012

Bio-Active Designer Materials and Dentures: from Design to Application

V Tamara Perchyonok, John Souza, Shengmiao Zhang, Desigar Moodley and Sias Grobler

Article Type: Research Article | First Published: November 02, 2015

The bio-active modified polymethyl methacrylate denture resins (PMMA) were prepared by dispersion of the corresponding component in glycerol and acetic acid with the addition of chitosan gelling agent. The release behaviors at physiological pH and also under acidic conditions and stability of the antioxidant-chitosan were also evaluated. Mechanical performance such as tensile strength and compressive strength were measured as well bio-adhesive studies were investigated in order to assess the sui...

 Open Access DOI:10.23937/2378-3664/1410011

Facile DNA Detection Based on Fluorescence Switching of A Hydrophobic AIE Dye-Labeled Peptide Nucleic Acid Probe by Aggregation/Disaggregation

Koji Kawamura, Ai Matsumoto and Takashi Murashima

Article Type: Research Article | First Published: September 21, 2015

A novel, facile DNA detection method based on aggregation/disaggregation of an AIE (aggregation induced emission) dye-labeled peptide nucleic acid (PNA) probe was developed. This PNA probe plays the role of both target recognition and signal emission, thus it can quantify the target DNA without requiring additives such as intercalators and can distinguish the target from other sequences....

 Open Access DOI:10.23937/2378-3664/1410010

Biomedical Applications of Natural Polymer Based Nanofibrous Scaffolds

Preethi GU, Manu M Joseph, Unnikrishnan BS, Shiji R and Sreelekha TT

Article Type: Review Article | First Published: September 17, 2015

Nanotechnology is one of the most popular branches of science in the current decade where nanofiber scaffolds (NS) attain principal attraction. NS are composed of several nanometer to micrometer diameter fibers similar in nature to collagen, keratin and elastin fibers of the extracellular matrix (ECM) and helps in cell attachment, proliferation and differentiation. NS with desired features can be fabricated using various chemical, physical and biological methods such as electrospinning, phase se...

 Open Access DOI:10.23937/2378-3664/1410009

Titanates and Titanate-Metal Compounds in Biological Contexts

Yen-Wei Chen, Jeanie L. Drury, Whasun Oh Chung, David T. Hobbs and John C. Wataha

Article Type: Review Article | First Published: June 13, 2015

Metal ions are notorious environmental contaminants, some causing toxicity at exquisitely low (ppm-level) concentrations. Yet, the redox properties of metal ions make them attractive candidates for bio-therapeutics. Titanates are insoluble particulate compounds of titanium and oxygen with crystalline surfaces that bind metal ions; these compounds offer a means to scavenge metal ions in environmental contexts or deliver them in therapeutic contexts while limiting systemic exposure and toxicity. I...

 Open Access DOI:10.23937/2378-3664/1410008

Micro and Nanofabrication: Is a Practical Three-Dimensional Cell Culture Platform for Drug Discovery Achievable?

Ze-Zhi Wu and William S. Kisaalita

Article Type: Editorial | First Published: April 06, 2015

It is a great challenge to simultaneously engineer the three MEFs in a single effort to create physiologically relevant cell culture microenvironments. A survey of the literature has shown that in such a scenario some MEFs may not be as important as others....

 Open Access DOI:10.23937/2378-3664/1410007

Bnct and Nanoparticles: A Long Way to a Routine Clinical Method

Cesare Achilli, Stefania Grandi, Annarita Ciana and Giampaolo Minetti

Article Type: Commentary | First Published: January 22, 2015

We have recently had the chance to read the editorial 'Boron Neutron Capture Therapy of cancer as a part of modern nanomedicine', by Alexander V. Safronov, in which the potential of nanomaterials as boron-carriers for the treatment of many types of tumors by BNCT is discusses. The author argues that "Most of the modern papers on BNCT report 'potential' BNCT agents [...] and don't even include cell studies", and "In some cases the abbreviation BNCT may become a 'golden ticket' for authors who jus...

 Open Access DOI:10.23937/2378-3664/1410006

Optimization and Validation of a New Method for the Production of Lipid Nanoparticles for Ophthalmic Application

Rosario Pignatello, Antonio Leonardi and Sarha Cupri

Article Type: Research Article | First Published: December 29, 2014

Within a wider research project aimed at the pre-industrial development of nanotechnology platforms for the treatment of eye diseases, this work exploited the possibility of obtaining solid lipid nanocarriers (SLN) using ingredients and operating conditions that could be compatible with the technological requirements of medical formulations used for ophthalmic therapies and, above all, capable of an easy industrial scale-up....

 Open Access DOI:10.23937/2378-3664/1410005

Development of A Cellular Hepatocarcinoma Animal Model for the Evaluation of Pt(Acac)2/Tio2 Nanoparticles Effect

Tessy Lopez Goerne, Mayra Alvarez Lemus, Gustavo Jardon Guadarrama, Paola Ramirez Olivares, Aurora Sanchez Garcia, Daniel Rembao Bojorquez, Ruben Arguero Sanchez and Octavio Novaro Penalosa

Article Type: Research Article | First Published: December 16, 2014

Because of the worldwide increasing incidence of cancer new alternative therapies are needed. The use of nanotechnology for clinical applications is constantly growing. The objective of this work was to evaluate the effect of the administration of platinum inorganic nanoparticles over livers from Wistar rats. In order to reach this goal cellular Hepatocarcinoma was fist induced with N-nitrosodiethylamine (NDEA) and Carbon tetrachloride....

 Open Access DOI:10.23937/2378-3664/1410004

Reliability for Drug Targeting In Cancer Treatment through Nanotechnology (A Psychometric Approach)

Nader Ebrahimi and Ali Mansoori G

Article Type: Research Article | First Published: November 28, 2014

The primary focus of the nanotechnology therapeutic approaches has been on early disease detection, drug discovery and monitoring, controlled release of therapeutic agents, and targeted drug delivery. Targeted drug delivery system requires more research including statistical modelling to establish the reliability in success of drug targeting. This part of every nanotechnology therapeutic approach is especially fundamental for reaching stronger therapeutic effects with lower side effects....

 Open Access DOI:10.23937/2378-3664/1410003

Graphene: A Multifaceted Nanomaterial for Cutting Edge Biomedical Application

Reshma S Cherian and Mohanan PV

Article Type: Review Article | First Published: October 27, 2014

Graphene, a discrete class of nanomaterial, has come into the limelight after its discovery in 2004. Its unique physico-chemical characteristics like electrical, optical, thermal properties and high mechanical strength has piqued the curiosity of the scientific community worldwide. These properties have been utilized for innovative and novel applications in the field of nanoelectronics and biomedicine. The review focuses on the opportunities and prospects of graphene in biomedical field mainly d...

 Open Access DOI:10.23937/2378-3664/1410002

Anti-Oxidant and Anti-Inflammatory Effects of Vildagliptin in NonAlcoholic Fatty Liver Disease of Mice

Sahar Mohamed Kamal

Article Type: Research Article | First Published: October 13, 2014

Background: Vildagliptin is one of the Dipeptidyl Peptidase-4 (DPP-4) inhibitors. It is used as a novel oral anti-diabetic drug for the treatment of Type 2 Diabetes Mellitus (T2DM) with significant control of glycated hemoglobin and a lower incidence of hypoglycemia or weight gain. Aim: The present study hypothesized that the DPP-4 inhibitor vildagliptin may exert protective effects on liver in Non-Alcoholic Fatty Liver Disease (NAFLD) in cholesterol-fed albino mice. Methods: Thirty six albi...

 Open Access DOI:10.23937/2378-3664/1410001

Boron Neutron Capture Therapy of Cancer as a Part of Modern Nanomedicine

Alexander V. Safronov

Article Type: Editorial | First Published: August 16, 2014

Boron neutron capture therapy (BNCT) is a method of cancer therapy with a simple idea behind it. Positioning a certain amount of 10B-enriched boron-containing compounds into tumor cells with subsequent irradiation of the tumor tissue by thermal or epithermal neutrons causes tumor damage and death. The mechanism of the tumor cell damage during BNCT is based on the capture-fission reaction between the boron-10 nucleus and a neutron resulting in an α-particle release inside the cell. A success...


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Clinical Medical Image Library: 93.51

International Journal of Critical Care and Emergency Medicine: 92.83

International Journal of Sports and Exercise Medicine: 91.84

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Journal of Clinical Nephrology and Renal Care: 90.33

Journal of Family Medicine and Disease Prevention: 89.99

Journal of Clinical Gastroenterology and Treatment: 89.54

Journal of Dermatology Research and Therapy: 89.34

International Journal of Clinical Cardiology: 89.24

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ISSN: 2378-2951 | ICV: 89.24



Obstetrics and Gynaecology Cases - Reviews

ISSN: 2377-9004 | ICV: 88.42



Journal of Hypertension and Management

ISSN: 2474-3690 | ICV: 87.69



International Journal of Diabetes and Clinical Research

ISSN: 2377-3634 | ICV: 87.97



Journal of Infectious Diseases and Epidemiology

ISSN: 2474-3658 | ICV: 91.55