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Review Article 

Titanates and Titanate-Metal Compounds in Biological Contexts

Yen-Wei Chen, Jeanie L. Drury, Whasun Oh Chung, David T. Hobbs and John C. Wataha
Abstract

Metal ions are notorious environmental contaminants, some causing toxicity at exquisitely low (ppm-level) concentrations. Yet, the redox properties of metal ions make them attractive candidates for bio-therapeutics. Titanates are insoluble particulate compounds of titanium and oxygen with crystalline surfaces that bind metal ions; these compounds offer a means to scavenge metal ions in environmental contexts or deliver them in therapeutic contexts while limiting systemic exposure and toxicity. In either application, the toxicological properties of titanates are crucial.

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Editorial 

Micro and Nanofabrication: Is a Practical Three-Dimensional Cell Culture Platform for Drug Discovery Achievable?

Ze-Zhi Wu and William S. Kisaalita
Abstract

It is a great challenge to simultaneously engineer the three MEFs in a single effort to create physiologically relevant cell culture microenvironments. A survey of the literature has shown that in such a scenario some MEFs may not be as important as others.

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Commentary 

Bnct and Nanoparticles: A Long Way to a Routine Clinical Method

Cesare Achilli, Stefania Grandi, Annarita Ciana and Giampaolo Minetti
Abstract

We have recently had the chance to read the editorial 'Boron Neutron Capture Therapy of cancer as a part of modern nanomedicine', by Alexander V. Safronov, in which the potential of nanomaterials as boron-carriers for the treatment of many types of tumors by BNCT is discusses. The author argues that "Most of the modern papers on BNCT report 'potential' BNCT agents [...] and don't even include cell studies", and "In some cases the abbreviation BNCT may become a 'golden ticket' for authors who just want to public their current study without intent to continue". We agree with the first assertion, which is unequivocally verifiable by reading the recent literature about BNCT, but not with the second, that is somewhat speculative.

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