Open Access DOI:10.23937/2469-5866/1510014
Predictive Factors of Brain Death in Acute Neurocritical Patients Identified as Potential Organ Donors
Guixing Xu, Ping Xu, Jing Zhao, Zhiyong Guo and Xiaoshun He
Article Type: Prospective Observational Study | First Published: August 25, 2016
In this prospective observational study, we collected clinical data of acute neurocritical patients with a potential progression to BD, who was admitted in the First Affiliated Hospital of Sun Yet-sen University from May 2015 to April 2016. Final endpoint was adjudicated brain death (BD). The clinical data were compared between patients who identified as BD within 7 days and those who identified beyond 7 days, the time of spontaneous respiratory arrest as start point. Neurological examination, l...
Open Access DOI:10.23937/2378-3397/1410045
A Rare Case of Subtotal Parotidectomy of Bilateral Oncocytomas with Facial Nerve Preservation
Constantinos Aristotelous, Sofia Georgiou Korsavva and Georgios Pantelas
Article Type: Case Report | First Published: September 02, 2016
Oncocytomas are a group of rare tumours of the parotid glands which have benign epithelial origin with incidence about 1% of parotid neoplasms but can exist in many organs. Bilateral non-malignant parotid oncocytomas are very rare. We report the case of a 63-year-old female patient who presented to the outpatients' clinic of Oral and Maxillofacial Surgery (OMFS) service with bilateral facial swelling of one year duration. Clinical examination determined bilateral parotid oncocytoma. Imaging stud...
Open Access DOI:10.23937/2378-3419/3/4/1066
Rapid Development of Type 1 Diabetes Mellitus after Initiation of Anti-PD-1 Therapy
Muneeb Shah, Luke Maxfield, Rehan Feroz and Kevin Donohue
Article Type: Case Report | First Published: August 25, 2016
Programmed death protein 1 (PD-1) is a receptor on immune cells that serves as a checkpoint and plays an important role in preventing the activation of T-lymphocytes. Malignant cells are known to activate this receptor, thereby allowing them to evade immune surveillance. Programmed death 1 immune-checkpoint inhibitor antibodies (anti-PD-1), such as nivolumab, act to revamp the immune response against tumor cells by preventing activation of this PD-1 receptor....
Open Access DOI:10.23937/2378-3419/3/4/1065
Culture of Circulating Tumor Cells - Holy Grail and Big Challenge
Tianyu Guo, Claire S Wang, Wen Wang and Yongjie Lu
Article Type: Review Article | First Published: August 19, 2016
Circulating tumor cells (CTCs), the most important representation of 'liquid biopsy', provides a minimally invasive approach to tumor tissue, and has been a hot topic in cancer research for years. CTCs bear great potential to provide a surrogate for traditional biopsy, and the culture of CTCs is essential to investigate the biological features of CTCs and their roles in cancer metastasis as well as to provide the opportunity for in vitro therapeutic sensitivity tests to guild treatment selection...
Open Access DOI:10.23937/2469-570X/1410040
Generation of Antigen-Presenting Cells from Human Vascular Adventitia-Resident Progenitors
Mohamad Almoussa, Volha Stoll, Diana Klein and Suleyman Ergun
Article Type: Original Article | First Published: August 13, 2016
Macrophages and dendritic cells play a central role in the immune system. Here, we identify CD44(+) vascular wall-resident multipotent stem cells (VW-MPSCs) as progenitors for macrophages and dendritic cell-like cells. Using human internal thoracic artery (hITA) tissue specimens we performed ex vivo sprouting assays followed by immunohistochemistry....
Open Access DOI:10.23937/2469-570X/1410039
Adult Brain Neurogenesis, Neural Stem Cells and Neurogenic Niches
Lina Maria Delgado-Garcia and Rogerio Martins Amorim
Article Type: Mini Review | First Published: July 28, 2016
During the late 60's, the experiments with brain lesions in rats, suggested the possibility of neurogenesis in the adult brain. Three decades later, the conceptual link between adult neurogenesis and stem cells was proposed. We now know that the adult mammalian brain may have the ability to regenerate through adult neural stem cells (NSCs). Here are briefly reviewed classical and current theories in adult neurogenesis, NSCs and neurogenic niches....
Open Access DOI:10.23937/2378-346X/1410061
Flash Visual Evoked Potential versus Pattern Visual Evoked Potential in the Diagnosis of Strabismic Amblyopia
Amany Abd El-Fattah El-Shazly, Walid Mohamed Abd E, Raouf El-Zawahry and Noha Ezzat Elsherbiny
Article Type: Research Article | First Published: August 01, 2016
We included 60 children with unilateral amblyopia, their age ranging between 4 and 10 years. Thirty age and sex matched healthy children were included as a control group. The included children underwent complete ophthalmologic evaluation with focus on subjective monocular visual acuity, cycloplegic refractions, slit-lamp examination, fundus examination, orthoptic evaluation, stereoacuity, worth 4-dot test....
Open Access DOI:10.23937/2378-346X/1410060
The Accuracy of Automated Angle Closure Screening Software
Anita Manassakorn, Chonlada Theeraworn, Pished Bunnun, Sirichai Nithi-Uthai, Rangsarit Vanijjirattikhan, Kittipong Ekkachai, Waree Kongprawechnon, Toshiaki Kondo, Direk Patikulsila and Kanokvate Tungpimolrut
Article Type: Research Article | First Published: July 19, 2016
Peripheral anterior chamber angle images of 27 eyes were taken by slit lamp biomicroscope and analyzed by automated software. The software selected region of interest and applied a light reflection extraction to detect corneal thickness (CT) and peripheral anterior chamber depth (PACD). Three observers manually counted CT (CTm) and PACD (PACDm) pixels and compared with the CT and PACD pixel counts that were obtained by the software (CTa and PACDa)....