Open Access DOI:10.23937/2378-3516/1410059
Clinical and Radiological Predictor of Polymyositis and Dermatomyositis Associated Interstitial Lung Disease
Tomoo Kishaba, Hiroaki Nagano, Yuichiro Nei, Shin Yamashiro and Harumi Ito
Article Type: Original Article | First Published: October 03, 2016
Background: Polymyositis (PM) and dermatomyositis (DM) often have interstitial lung disease (ILD) and progression of ILD is important cause of death. Objectives: This study is conducted to clarify the important clinical, radiological factors of PM/DM ILD patients. Methods: We reviewed medical records, pulmonary function test (PFT), chest high-resolution computed tomography (HRCT) findings from January 1, 2001 to December 31, 2014 retrospectively at Okinawa Chubu Hospital....
Open Access DOI:10.23937/2378-3516/1410058
Drainage using Chest Tubes Smaller than 20 French is Suitable for Patients with Thoracic Empyema
Ryo Matsunuma, Kazumasa Kase, Nobuhiro Asai, Satoshi Watanabe, Yuko Waseda, Norihiro Kaneko, Masahiro Aoshima, Masaki Fujimura and Kazuo Kasahara
Article Type: Original Article | First Published: October 01, 2016
Background: Patients with thoracic empyema occasionally require chest tubes for drainage. Several studies have reported that smaller chest tubes are effective and cause fewer complications. The aim of this study was to investigate the outcomes of patients with empyema who underwent drainage using a smaller-size chest tube. Methods: We retrospectively reviewed all patients at 2 institutions with thoracic empyema. We performed both univariate and multivariate analysis to examine the relation betwe...
Open Access DOI:10.23937/2378-3516/1410056
Sarcoidosis Presenting with Severe Thrombocytopenia
Yusuf Kayar, Nuket Bayram Kayar, Nurcan Unver and Iskender Ekinci
Article Type: Case Report | First Published: September 02, 2016
Sarcoidosis is a systemic granulomatous disorder of unknown causes. Haematological manifestations in sarcoidosis are uncommon and may include haemolytic anemia, leukopenia, eosinophilia and peripheral lymphopenia, but severe thrombocytopenia is rare. Causes of thrombocytopenia in sarcoidosis were identified a few mechanisms. There are no current guidelines concerning the treatment of thrombocytopenia in sarcoidosis. However, in emergency situations with major thrombocytopenia, it seems reasonabl...
Open Access DOI:10.23937/2378-3516/1410055
Impact of Bariatric Surgery on Obstructive Sleep Apnoea in Morbidly Obese Patients; Single Centre Experience and a Literature Review
Muhammad Ali Karim, Muhammad Josheel Naveed, Amir Hussein and Abdulmajid Ali
Article Type: Original Article | First Published: September 01, 2016
Purpose: Bariatric surgery is an established treatment of morbid obesity and effectively controls symptoms of OSAHS. The aim of this study was to evaluate impact of bariatric surgery on OSAHS. Methods: Validated Epworth Sleepiness Score (ESS) and STOP-Bang questionnaires were used to assess the impact of bariatric surgery on OSAHS in morbidly obese patient's undergone bariatric surgery from May 2008 to December 2011. Change in ESS, STOP-Bang score, weight and BMI, co-morbidities and CPAP require...
Open Access DOI:10.23937/2378-3516/1410054
The Role of Histone Deacetylase Inhibitors in Myocardial Infarction
Ping Zeng and Jian Yang
Article Type: Review Article | First Published: August 25, 2016
Myocardial infarction is usually recognized as the final stage of coronary artery stenosis or occlusion in response to coronary atherosclerosis and thrombosis involving dysfunction and activation of resident vascular cells as well as the release of t-PA. As a member of family proteins for deacetylation of core histones in eukaryotic cells, Histone deacetylases are implicated in various biological processes....
Open Access DOI:10.23937/2469-5726/1510040
MR Imaging of Degenerative Cartilage Lesions of the Knee Joint in Floor Layers and Graphic Designers
Soren Rytter, Birthe Lykke Thomsen, Birgitte Schutt Christensen and Lilli Kirkeskov
Article Type: Research Article | First Published: September 21, 2016
Kneeling work leads to an additional risk of developing knee osteoarthritis (OA). Previous studies have primarily been based on radiography, but radiography is limited by its inability to visualize articular cartilage, in which the earliest signs of OA occur. The objective of this explorative study, based on available data, was to examine the prevalence of magnetic resonance imaging (MRI)-detected knee cartilage lesions in male floor layers exposed to kneeling work, as compared to non-exposed ma...
Open Access DOI:10.23937/2572-3278.1510019
A Protocol for Human Serum Fucoxanthinol Quantitation using LC-MS/MS System
Nana Mikami, Masashi Hosokawa, Masayuki Abe, Kazuo Miyashita, Hitoshi Sohma and Yasuo Kokai
Article Type: Original Article | First Published: September 30, 2016
ucoxanthin, a marine carotenoid widely distributed in brown algae, is known to possess various health promoting activities including anti-obesity effects in humans, but little is known about its kinetics partly because of its low bioavailability. We have developed a simple and reproducible protocol for quantifying system of human serum fucoxanthinol, a fucoxanthin metabolite, used LC-MS/MS multiple reaction monitoring (MRM), and have applied for clinical trial to study fucoxanthin absorption....