The Role of Human Papillomavirus in Cervical Cancer
Beata Smolarz, Dariusz Samulak, Marianna Makowska, Hanna Romanowicz, Zbigniew Kojs, Luiza Wojcik and Magdalena M Michalska
Article Type: Review Article | First Published: September 28, 2019
Long-term infection with human papillomavirus (HPV) is the cause of cervical cancer and its precursor - cervical intraepithelial neoplasia (CIN). The presence of HPV infection can be presumed in more than 99% of cases of cervical cancer worldwide. The introduction of DNA testing for the presence of HPV has increased the effectiveness of screening programs for the detection of this cancer. This article contains the latest reports on the structure, function and role of HPV in the development of ce...
TCM Combined Chemoradiotherapy in the Treatment of LimitedStage Small Cell Lung Cancer: Current Status and Perspectives
Shulin He, Rui Liu, Qiujun Guo, Huamin Wei, Yanjiu Bao, Xinyao Xu, Shuntai Chen, Honggang Zheng and Baojin Hu
Article Type: Review Article | First Published: September 21, 2019
About 13% of lung cancer cases are of the small cell subtype, but this variant is highly aggressive, and approximately 40% of patients with small cell lung cancer will have limited-stage disease, which is potentially curable with the combination of chemotherapy and radiation therapy. The standard therapy for limited-stage small cell lung cancer is concurrent chemoradiotherapy, and the 5-year survival rate observed in clinical trials is approximately 25%. For patients who obtain a near complete o...
Expression of P53 and Prognosis in Patients with Head and Neck Squamous Cell Carcinoma (HNSCC)
Amlani Lahin, Bellile Emily, Spector Matthew, Smith Joshua, Brenner Chad, Rozek Laura, Nguyen Ariane, Zarins Katie, Thomas Daffyd, McHugh Jonathan, Taylor Jeremy and Wolf T Gregory
Article Type: Original Article | First Published: August 09, 2019
Mutation of TP53 is the most common genetic abnormality in head and neck squamous cell carcinoma (HNSCC) and results in an accumulation and expression of p53 protein in tumor cells. Disruptive TP53 mutations are consistently associated with poor prognosis but correlations of p53 expression with mutation or prognosis have been variable and the usefulness of p53 as a target for immunotherapy is unknown. Favorable prognosis is associated with the accumulation of T lymphocytes (TILs) in the tumor mi...
Early Aggressive Management of Postoperative Pancreatic Fistulas following Pancreaticoduodenectomy (PD): A Five-Year Single Institution Experience
Rohan Thakkar, FRCS, David Bourne, Msc, Stacey Vass, Bsc, Aditya Kanwar, FRCS, Theodore Tsirilis, FRCS, John S Hammond, PhD, Colin Wilson, PhD, Gourab Sen, MD, Steven White, MD, Jeremy French, MD, Richard Charnley, DM and Derek Manas, FRCS
Article Type: Original Article | First Published: August 07, 2019
We retrospectively analysed the data that underwent PD between 2013-2017. We reviewed for all patients who experienced Grade B POPF. Data included details of total parenteral nutrition received, dose of octreotide infusion administered, serial drain amylase levels, effluent volume and anthropometry. Outcome measures were weight changes associated with treatment, the number of lines used per patient, the length of treatment, treatment associated complications and 90-day mortality rates....
Performance of Three Prognostic Models in Critically Ill Patients with Cancer: A Prospective Study
Frank D Martos-Benitez, PhD, MD, Hilev Larrondo-Muguercia, MD, David Leon-Perez, MD, Juan C Rivero-Lopez, MD, Versis Orama-Requejo, MD and Jorge L Martinez-Alfonso, MD
Article Type: Original Article | First Published: July 17, 2019
Predicting mortality is one of the greatest challenges for critical care physicians. Severity scoring systems integrate clinical data to estimate the probability of death, which can be used to facilitate resource utilization or continuing quality improvement and to stratify patients for clinical research. Prospective validation in different populations of critically ill patients improves the applicability of the model to these settings. Furthermore, the performance of a prognostic score must be ...
Utility of Magnetic Resonance Imaging (Imaging) in Target Volume Definition for Radiosurgery of Acoustic Neuromas
Omer Sager, Ferrat Dincoglan, Selcuk Demiral, Hakan Gamsiz, Bora Uysal, Bahar Dirican and Murat Beyzadeoglu
Article Type: Original Article | First Published: June 20, 2019
Acoustic neuromas, also known as vestibular schwannomas are benign and slow-growing tumors arising from neural crest-derived Schwann cells. Treatment of acoustic neuromas targets to achieve local control while preserving hearing without comprimising cranial nerve functionality. In this context, radiosurgery in the form of Stereotactic Radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT) offer viable therapeutic options for effective management. Multimodality imaging has gained utm...
Frailty as a Prognosis Factor in Cancer for the Elderly
Miguel Angel Acosta-Benito, Rosa Ana Garcia-Pliego, Jaime Barrio-Cortes and Veronica Rodriguez-FernAndez
Article Type: Research Article | First Published: June 20, 2019
Frailty is a geriatric syndrome related to adverse health outcomes in the elderly, due to a decrease systems' functional reserve. Cancer is a common pathology in the elderly, and we need tools for identifying the response to treatment and prognosis of elderly cancer patients. This short revision aims to assess the significance of the detection of frailty in the elderly patient with a tumor as a possible prognostic factor in terms of mortality, and the impact of the 2013 Frailty Consensus in the ...
Current Recommendations of Radioactive Seed ~ (125)I Implantation in Lung Brachytherapy: Moving Forward in Medical Care
Wang Yuchan, Yuan Gengbiao, Lee Changyi, Ran Lifeng and Yang Wei
Article Type: Review Article | First Published: June 20, 2019
Isotopes of radioactive iodine have a persistent lethal effect on the uncontrolled proliferation of tumor cells with a definite curative effect on tumors. It has been proved, up to 87.2% of 3-year's survival rate that could be achieved by radioactive seeds. Iodine-125 radioactive seeds have a long half life and low energy with excellent stable outcomes. Various effective isotopes with advanced techniques are used to place radioactive sources directly into a tumor, tumor bed in treating lung canc...
Breast Cancer Survivors: Is Routine 'Mammographic Only' follow up Imaging Enough or is it Time for Personalised follow up?
Gaurav Jyoti Bansal, Thomas Telford and Kevin Pinto
Article Type: Original Article | First Published: June 20, 2019
Breast cancer is the most common cancer in women, accounting for approximately 15% of all cancers. Over 85% of these people survive beyond 5 years after diagnosis, due to continual progressions in early detection and treatment quality. Despite advances in detection and treatment, 20-30% of patients develop local relapse or distant metastasis. Molecular subtyping of breast cancers based on receptor expression has been introduced in clinical practice and has developed into an important tool in pre...
Breast Fibromatosis: Case Report, Case Series, and Mini Review
Alicia Huff Vinyard, DO, Rachel Berger, MS-IV, TolgaOzmen, MD and Eli Avisar, MD
Article Type: Case Report | First Published: June 15, 2019
Fibromatosis of the breast is a rare, benign tumor, lacking metastatic potential, but can be aggressive and create issues with loco-regional control if not adequately treated. In the literature, fibromatosis of the breast is often discussed only in case reports and small case series. The consensus on treatment remains wide local excision, however, other therapies have been described. In discussion of an interesting case presentation of what we have defined as secondary breast fibromatosis, we re...
A Single Institution Study Experience of Secondary Breast Angiosarcoma after Breast Conserving Treatment: Multidisciplinary Management
Angela Strazzanti, MD, Claudio Trovato, MD, Santi Gangi, MD, Dario Marletta, MD, Roberto Milazzotto, MD and Corrado Spatola, MD
Article Type: Multidisciplinary | First Published: May 08, 2019
The aim of this study, focusing on a small number of cases, is to deal with the angiosarcoma of the breast, representing less than 1% of all soft tissue breast tumors, and finally share our experience. As a consequence of breast-conserving therapy (BCT) that is the standard treatment nowadays, a new type of angiosarcoma has been highlighted: Radiation-Induced Angiosarcoma (RIAS). Here is reported a retrospective analysis of RIAS patients' characteristic features, together with an account of the ...