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International Journal of

Cancer and Clinical ResearchISSN: 2378-3419

Early Online

 Open Access DOI:10.23937/2378-3419/1410189

NMR Spectroscopy-Based Metabolomics Profiling: A Clinically Helpful Approach for Prostate Cancer Early Detection

Pradeep Kumar and Sujeet Kumar Mewar

Article Type: Review Article | First Published: 2024/08/03

PCa diagnosis is difficult since there is/are no acceptable, sensitive, and specific tumor biomarkers. The most common cancer in the world to be diagnosed in males over 50 is prostate cancer (PCa). In its early stages, there are no symptoms, and the cancer grows slowly. Measuring a predetermined list of certain metabolites is the goal of metabolomics. Understanding metabolites and their metabolic pathways is essential for finding new biomarkers, and the most significant pattern may have a big im...

 Open Access DOI:10.23937/2378-3419/1410188

Glucose-6-Phosphate Dehydrogenase Levels and Oxidative Stress Markers among Cancer Patients in Jos, Nigeria

Eugene Bwade Samuel, Amos Dangana, Taofeeq Oduola, Yinka J Oyeniyi, Liviticus Mansura Mangpin, Vileng Felix Gagari, Mercy Ekene Mobi, Ezeama Juliet Chika, Adesuyi A. Omoare, Muhammad Sani Usman and Idris Nasir Abdullahi

Article Type: Research Article | First Published: 2024/07/31

Glucose-6-phosphate dehydrogenase (G6PD) is a sensitive cytosolic antioxidant enzyme that could be associated with carcinogenesis. Hence, its plasma levels are a good indicator to monitor cancer-induced cellular stress. This study aimed to determine the correlation between Glucose-6-phosphate dehydrogenase and oxidative stress markers among cancer patients in Jos, Nigeria....

 Open Access DOI:10.23937/2378-3419/1410187

Plasma Cell Neoplasms with Atypical Features in a University Hospital

Everard Kylie R, MD, Zern Chantel, MD and Ikpatt Offiong Francis, MD

Article Type: Review/Case Series | First Published: 2024/07/08

Plasma cell neoplasms are derived from terminally differentiated B-cells. The distinction between anaplastic plasma cell myeloma and plasmablastic lymphoma, a B cell lymphoma, can be challenging. We present 3 cases of neoplasms with plasmacytic features that highlight the heterogeneity of plasma cell neoplasms and challenges in their diagnosis. Molecular profiling of these cases may provide value in their differential diagnosis....

 Open Access DOI:10.23937/2378-3419/1410186

Risk Factors for Early Recurrence after Upfront Surgery for Resectable Pancreatic Ductal Adenocarcinoma

Yoriko Nomura, Tomoki Ryu, Kazuki Takeishi, Gen Yamamoto, Yoshiyuki Wada and Yuko Takami

Article Type: Original Article | First Published: 2024/02/08

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive and challenging cancers, causing substantial mortality worldwide. Despite advancements in treatment modalities, the prognosis for patients with PDAC remains dismal, emphasizing the critical need for identifying factors influencing early recurrence and survival post-surgery. This study aimed to clarify the risk factors for early recurrence (within 1 year) in patients who underwent upfront surgery for resectable PDAC....

 Open Access DOI:10.23937/2378-3419/1410185

Genomic Profiling of Breast Cancer: A Single Institution's Experience and Impact on Patient Outcomes

Ezzelkdin M. Ibrahim, Bushra A. Al-Quzi, Duaa A. Jabal, Ali M. Bayer, Ahmed Y. Shaheen, Zeinab A. Morsi, Majidah M. Ahmed, Mohammed H. Kulak and Ahmed A. Refae

Article Type: Research Article | First Published: 2024/02/02

Genomic profiling (GP) of breast cancer (BC) tumors is a promising approach to identifying genetic mutations that aid patient management. Herewith, we present a single institutional experience of performing GP to assess its impact on patient outcomes. Tumor tissues of 56 patients were tested using the FoundationOne® next-generation sequencing platform. Patients median age was 54 years; 51 patients had metastatic BC, while 5 had an early-stage disease. The most frequently identified genes were T...

 Open Access DOI:10.23937/2378-3419/1410179

Punicic Acid Inhibits Proliferation and Induces Apoptosis in Human MCF-7 Breast Cancer Cells

Oluwafemi Gbayisomore, Hannah Klausner and Shelley A Phelan, PhD

Article Type: Research Article | First Published: March 08, 2023

One of the main components of Pomegranate Seed Oil is punicic acid, an omega-5 fatty acid that is capable of inhibiting breast and prostate cancer cell proliferation, although the mechanisms of action are not yet known. In order to further understand its potential anti-cancer properties, we investigated the effect of punicic acid on proliferation and cytotoxicity of human MCF-7 breast cancer cells. Cells were treated with punicic acid for up to 72 hours, and cell proliferation, cytotoxicity, and...

 Open Access DOI:10.23937/2378-3419/1410178

Expression Levels of GHRH-Receptor, pAkt and Hsp90 Predict 10-Year Overall Survival in Patients with Locally Advanced Rectal Cancer

Dávid Fodor, Eva Pozsgai, Andrew V. Schally, Zoltán László, Éva Gömöri, Éva Szabó, László Rumi, Dorottya Lőcsei, Árpád Boronkai and Szabolcs Bellyei

Article Type: Review Article | First Published: December 31, 2022

Rectal cancer constitutes nearly one-third of all colorectal cancer diagnoses and certain clinical and molecular markers have been studied as potential prognosticators of patient survival. The main objective of our study was to investigate the relationship between the expression intensities of certain proteins: Growth Hormone- Releasing Hormone Receptor (GHRH-R), Hsp90, Hsp16.2, p-Akt and SOUL in specimens of locally advanced rectal cancer patients and time to metastasis as well as 10-year Ove...

 Open Access DOI:10.23937/2378-3419/1410177

Colorectal Cancer Screening: Ratios from Hemogram to the Rescue

Purva Trivedi, Mahesh Patel, Sanjay Dhotre and Hansa Goswami

Article Type: Original Article | First Published: October 20, 2022

Colorectal Cancers (CRC) are one of the top ten cancers to increase the burden on the health care system in India. Often patients experience symptoms after carcinoma has significantly progressed. Timely and accurate screening in the target population remains a challenge for clinicians....

 Open Access DOI:10.23937/2378-3419/1410176

The Role of Adjuvant Metronomic Chemotherapy in Increasing Overall Response Rate in Patients with Breast Cancer

Bhushan Jain and Akhila Pakalapati

Article Type: Review Article | First Published: September 18, 2022

Treatment paradigms against cancer have continuously evolved over the years. Having said that, with its prevalence of more than 2 million cases each year, breast cancer represents an urgent global priority [1]. Breast carcinomas accounted for 11.6 % of cancer cases and were the cause of mortality in as many as 6.6 % of women in the world in 2018 [2]. Toxicity and chemoresistance are significant hurdles in conventional chemotherapy and to avoid these issues, a new approach to drug administration,...

 Open Access DOI:10.23937/2378-3419/1410175

Awareness of Breast Cancer and Practice of Breast Self- Examination Amongst Female Students of a Tertiary Institution in South-South Nigeria

Alabrah PW, Eguvbe AO, Agbo J and Allagoa DO

Article Type: Original Article | First Published: August 19, 2022

Breast cancer is the leading cause of cancer deaths presently, representing about 23% of all cancer cases and approximately 18% percent of deaths are attributed to it in Nigeria. It is presently the most prevalent kind of cancer worldwide, with 2.26 million cases reported in 2020. Breast Self-Examination (BSE) is a way to watch for signs of breast cancer....

 Open Access DOI:10.23937/2378-3419/1410174

Malignant Neural Sheath Tumors of the Head and Neck

Carlos Santiago Ruggeri, Gabriel Rondón Gonzalez, Ana Clara Ragoni and Inés Fagalde

Article Type: Research Article | First Published: August 19, 2022

Malignant neural sheath tumors located in the head and neck region are very rare. Surgical treatment if possible is the best option, trying to obtain wide resection margins free of tumor. To determine the incidence of malignant tumors of neural histology, in relation to nerve tumors originating in the head and neck and description of two clinical cases....

 Open Access DOI:10.23937/2378-3419/1410173

Proposed Experimental Preparation and Administration of Dendritic Cell Vaccine for Treatment of Cancer (Metastatic Castration-Resistant Prostate Cancer)

Behzad Niakan

Article Type: Letter to Editor | First Published: July 09, 2022

It is suggested that a cause of inefficacy in dendritic cell vaccine is dendritic cell dysfunction. It is proposed that dendritic cell dysfunction is possibly due to the immuneregulatory function of activated platelets in cancer patients. It is suggested that activated platelets in cancer patient suppress dendritic cell activity against a malignant growth. A low platelet count prior to the removal of dendritic cells would possibly yield less dysfunctional dendritic cells....

 Open Access DOI:10.23937/2378-3419/1410172

Proposed Biology of the Spontaneous Remission of Merkel Cell Carcinoma after Biopsy

Behzad Niakan

Article Type: Letter to Editor | First Published: July 08, 2022

The medical literature has many case reports of the spontaneous remission of Merkel cell carcinoma after biopsy. It is noteworthy that prior to the biopsy the Merkel Cell Carcinoma was growing rapidly. It is suggested that the biopsy has possibly resulted in the breakage of a vessel and blood loss within the malignant tissue....

 Open Access DOI:10.23937/2378-3419/1410171

The Impact of Chemotherapy Schedule Modification on Survival Outcome among Breast Cancer Patients Receiving Adjuvant or Neoadjuvant Treatment Modalities

Gobi Hariyanayagam Gunasekaran, Wan Mohd Akmal Bin Wan Sabri, Shargunan Selvanthan Gunasekaran, Sera Selvanthansundram Gunasekaran and Kavisha Selvarajoo

Article Type: Research Article | First Published: July 08, 2022

Chemotherapy schedule has been reported to increase the risk of suboptimal outcomes among cancer patients receiving chemotherapy with variying outcome between treatment modality. This study investigates the Overall Survival (OS) and Hazard of Death (HR) of breast cancer patients with chemotherapy schedule modification stratified against adjuvant (ACT) and neoadjuvant (NACT) treatment modalities....

 Open Access DOI:10.23937/2378-3419/1410170

Oncology and Reproductive Outcomes Over Sixteen Years of Malignant Ovarian Germ Cell Tumors Treated with Fertility Sparing Surgery

Muangloei Rungoutok, MD and Prapaporn Suprasert, MD

Article Type: Original Article | First Published: June 30, 2022

Malignant Ovarian Germ Cell Tumors (MOGCT) are rare and frequently occur in the young reproductive age and the oncologic and reproductive outcome after Fertility-Sparing Surgery (FSS) this disease is still limited....

 Open Access DOI:10.23937/2378-3419/1410169

Carcinosarcoma EX Pleomorphic Adenoma of Parotid: An Unusual Entity, A Report of Two Cases with Brief Review of Literature

Aparna Devi, MD, DM, Usha Amirtha, MD, Geeta V Patil Okaly, MD and Raghavendra HV, MD

Article Type: Case Report | First Published: June 30, 2022

A 58-year-old male, underwent total parotidectomy for longstanding preauricular swelling. Histomorphology revealed a biphasic neoplasm composed of carcinoma with plasmacytoid morphology and osteosarcoma in the background of pleomorphic adenoma. Carcinoma component was confirmed to be myoepithelial carcinoma by immunohistochemistry. The patient presented with local recurrence two months later....

 Open Access DOI:10.23937/2378-3419/1410166

Chemoprevention of 1,2 Dimethyl Hydrazine-Induced Colon Tumor in Albino Rat by Meloxicam and its Correlation with Immunoassay of Serum CEA

Saeed Mahmoud Saeed Mohamed, Afaf Mosaad Amin, Suzanne William Skander, Taha Ismail Mahmoud Hewala, Eithar Omer Mohamed Saleh, Aisha Mohammed Osman Salih, Sabah Ali Mugahed Al-Qadasi, Marwan Mustafa Badawi and Mahmoud Assem Hamed

Article Type: Research Article | First Published: April 28, 2022

Colorectal Cancer (CRC) is among the most common types of cancer in the world. Globally a steadily increasing proportion of elderly people in the world result in approximately 16 million new cases of cancer by the year 2021. Regarding treatment; Meloxicam was shown to prevent the initiation of chemical-induced tumors, and considered as anticancer agent by virtue of its anti-proliferative effect, capacity for cell cycle arrest, and pro-apoptotic effects, also acted as free radical scavenger, in p...

 Open Access DOI:10.23937/2378-3419/1410168

Squamous Cell Carcinoma Arising from Inverted Papilloma

Carlos Santiago Ruggeri, Claudina Aguirre, Claudia Esper and Guillermo Sebastian Aragon

Article Type: Research Article | First Published: May 28, 2022

To determine the incidence of squamous cell carcinoma in patients with IP of the paranasal sinuses andlocal control in patients treated for cancer associated with IP....

 Open Access DOI:10.23937/2378-3419/1410167

Proposed Immunology of the Spontaneous Remission of Acute Myleiod Leukemia Treated with G-CSF

Behzad Niakan

Article Type: Hypotheses | First Published: April 29, 2022

It is suggested that the spontaneous remission of acute myeloid leukemia, particularly hypoplastic acute myeloid leukemia seen after G-CSF treatment is possibly due to G-CSF augmenting an acute inflammatory response. The acute inflammatory response is one occurring during a low count of activated platelets. Furthermore, it appears if a low platelet count (absence of hyper-coagulation or thrombocytosis) is present then G-CSF administration are more likely to induce a remission of acute myeloid le...

 Open Access DOI:10.23937/2378-3419/1410165

Treatment of Cancer Patients in the Era of the Covid-19 Pandemic

Budi Tulaka, Harlinda Haroen, Linda Wilhelma Ancella Rotty, Pearla Fidei Cindy Lasut and Cecilia Hendratta

Article Type: Research Article | First Published: April 18, 2022

Coronavirus Disease 2019 (COVID-19) is an outbreak of respiratory disease caused by novel coronavirus and has reached pandemic state. Cancer patients have increase susceptibility to infection caused by the malignancy itself and anticancer systemic therapy. Based on individual patient assessment, the oncologist's decision regarding the need for immediate oncological intervention classifies patients into 'urgent' and 'non-urgent' conditions. Consideration of risk and benefit for active interventio...

Volume 9
Issue 1