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 Short Chart Review 


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Published Date
May 31, 2016

Vol. 3, Issue 4

Breast Cancer Screening and Chemoprevention

J Drew Payne, Menfil Orellana-Barrios, Teri Payne, Anita Sultan and Catherine Jones

Corresponding author: J Drew Payne, Department of Internal Medicine, Texas Tech University Health Science Center, 3601 4th Street, Lubbock, TX 79430, USA

Breast cancer is the most commonly diagnosed cancer in women and the second leading cause of cancer related death among women in the United States. Breast cancer chemoprevention is a proven way to reduce breast cancer incidence. This article will present a short literature review and an assessment and description of breast cancer screening and chemoprevention in an outpatient internal medicine clinic. Records were reviewed to provide description of the screening in an outpatient internal medicine clinic.

Citation: Payne JD, Orellana-Barrios M, Payne T, Sultan A, Jones C (2016) Breast Cancer Screening and Chemoprevention. Int J Cancer Clin Res 3:056.



 Review Article 


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Published Date
April 25, 2016

Vol. 3, Issue 4

Second Line and Maintenance Therapy for Advanced Non-Small Cell Lung Cancer without Driver Mutation: An Evolving Paradigm

Stephanie Brule and Paul Wheatley-Price

Corresponding author: Stephanie Brule, The Ottawa Hospital Cancer Centre, 501 Smyth Road, Ottawa, ONK1H 8L6, Canada

Lung cancer is the most commonly diagnosed cancer amongst men and women combined, and is responsible for the greatest number of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) represents about 85% of all lung cancers, and is the umbrella term that includes the most common histological subtypes: adenocarcinoma, squamous cell carcinoma and large cell carcinoma. Due to the fact that it is frequently diagnosed at an advanced stage or recurs after potentially curative treatment, the five-year survival rate for all patients diagnosed with NSCLC is only 17%.

Citation: Brule S, Wheatley-Price P (2016) Second Line and Maintenance Therapy for Advanced Non-Small Cell Lung Cancer without Driver Mutation: An Evolving Paradigm. Int J Cancer Clin Res 3:055.



 Review Article 


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Published Date
April 16, 2016

Vol. 3, Issue 4

New Insights into Functional Implication of Genetic Variation in Association with Cancer

Yanfeng Zhang

Corresponding author: Yanfeng Zhang, Hudson Alpha Institute for Biotechnology, Huntsville 35806, USA

Investigations of the genetic basis of cancers have identified hundreds of robust risk loci associated with cancers using large-scale, case-control, candidate gene studies as well as genome-wide association studies (GWASs) during the past ten years. Most leading single nucleotide polymorphisms (SNPs) associated with cancer sensitivity lie in non-protein-coding regions, suggesting the potentially regulatory functions as targets for susceptible variants. That is a critical question to understand the molecular mechanisms and causality within cancer susceptible loci.

Citation: Zhang Y (2016) New Insights into Functional Implication of Genetic Variation in Association with Cancer. Int J Cancer Clin Res 3:054.



 Original Research 


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Published Date
April 08, 2016

Vol. 3, Issue 4

Prdx Overexpression in Tumor Tissue of Breast Cancer Patients

Jillian Muhlbauer and Shelley A Phelan

Corresponding author: Shelley A. Phelan, PhD, Department of Biology, Fairfield University, 1073 North Benson Road, Fairfield, CT 06824, USA

Peroxiredoxin (Prdx) proteins are evolutionarily conserved thiol-specific antioxidant enzymes that reduce various cellular peroxides, protecting cells from oxidative damage. Prdxs also have been demonstrated to play an important role in regulating redox-sensitive cell signaling in a number of cell processes. Prdxs have been implicated in cancer biology, and are upregulated in many cancers including breast cancer, as well as several breast cancer cell lines. To explore the entire Prdx family in breast cancer, we analyzed the expression of all six Prdx proteins in breast tumor tissue and adjacent normal breast tissue from 14 patients. We found that most patients have a marked elevation of Prdx expression in tumor tissue, with many patients overexpressing multiple Prdxs.

Citation: Muhlbauer J, Phelan SA (2016) Prdx Overexpression in Tumor Tissue of Breast Cancer Patients. Int J Cancer Clin Res 3:053.



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International Journal of Brain Disorders and Treatment (ISSN: 2469-5866)
International Journal of Cancer and Clinical Research (ISSN: 2378-3419)
International Journal of Clinical Cardiology (ISSN: 2469-5696)
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Clinical Medical Reviews and Case Reports (ISSN: 2378-3656)
Journal of Dermatology Research and Therapy (ISSN: 2469-5750)
International Journal of Diabetes and Clinical Research (ISSN: 2377-3634)
Journal of Family Medicine and Disease Prevention (ISSN: 2469-5793)
Journal of Genetics and Genome Research (ISSN: 2378-3648)
Journal of Geriatric Medicine and Gerontology (ISSN: 2469-5858)
International Journal of Immunology and Immunotherapy (ISSN: 2378-3672)
International Journal of Medical Nano Research (ISSN: 2378-3664)
International Journal of Neurology and Neurotherapy (ISSN: 2378-3001)
International Archives of Nursing and Health Care (ISSN: 2469-5823)
International Journal of Ophthalmology and Clinical Research (ISSN: 2378-346X)
International Journal of Oral and Dental Health (ISSN: 2469-5734)
International Journal of Pathology and Clinical Research (ISSN: 2469-5807)
International Journal of Pediatric Research (ISSN: 2469-5769)
International Journal of Respiratory and Pulmonary Medicine (ISSN: 2378-3516)
Journal of Rheumatic Diseases and Treatment (ISSN: 2469-5726)
International Journal of Sports and Exercise Medicine (ISSN: 2469-5718)
International Journal of Stem Cell Research & Therapy (ISSN: 2469-570X)
International Journal of Surgery Research and Practice (ISSN: 2378-3397)
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