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 Research Article 


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Published Date
October 22, 2016

Vol. 3, Issue 5

Validation of Measurement Based Dose Volume Metrics for the Quality Assurance of VMAT Plans

Sankar Arumugam, Aitang Xing, Tony Young, David Thwaites and Lois Holloway

Corresponding author: Sankar Arumugam, Department of Radiation Oncology, Cancer Therapy Centre, Liverpool Hospital, Sydney, NSW 2170, Australia

Ten each of prostate and head and neck (H&N) VMAT plans were considered for this study. Three types of errors were introduced into the original plans: gantry angle independent and dependent MLC errors, and gantry angle dependent dose error. The percentage difference in PTV-D95 between TPS and 3DVH was compared for no-error and error introduced plans.

Citation: Arumugam S, Xing A, Young T, Thwaites D, Holloway L (2016) Validation of Measurement Based Dose Volume Metrics for the Quality Assurance of VMAT Plans. Int J Cancer Clin Res 3:070.



 Case Report 


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Published Date
October 19, 2016

Vol. 3, Issue 5

A First Case of Male Breast Cancer Responding to Combined Aromatase Inhibitor/Palbociclib Therapy

Steven Sorscher

Corresponding author: Steven Sorscher, MD, Professor of Medicine, Department of Oncology, Wake Forest Medical School, Medical Center Blvd, Winston-Salem, NC 27104, USA

For men with metastatic breast adenocarcinoma standard therapies typically involve the same therapies used for woman. Recently the FDA approved the aromatase inhibitor letrozole combined with the inhibitor of cyclin dependent kinase 4/6 (CDK4/6) palbociclib as first line therapy for women with metastatic breast cancer. Here we report a first case of a man with metastatic breast cancer whose tumor responded to palbociclib and letrozole. This combination might be effective for other men with metastatic breast cancer as well.

Citation: Sorscher S (2016) A First Case of Male Breast Cancer Responding to Combined Aromatase Inhibitor/Palbociclib Therapy. Int J Cancer Clin Res 3:069.



 Original Article 


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Published Date
October 17, 2016

Vol. 3, Issue 5

Three-Dimensional Ultrasound: Is it Useful for Decision Making in the Management of Rectal Cancer? Is 3D Ultrasound Useful in Rectal Tumor?

Sthela M Murad-Regadas, Romulo M Almeida, Rosilma G Lima Barreto, Doryane MR Lima, Francisco Sergio Pinheiro Regadas, Lusmar Veras Rodrigues, Francisco Coracy C Monteiro, Paulo G Oliveira, Joao Batista Barreto and Univaldo Etsuo Sagae

Corresponding author: Sthela M Murad-Regadas, Associate Professor, Department of Surgery, Coordenator of Unit of Pelvic Floor and Anorectal Physiology, School of Medicine, Clinical Hospital, Federal University of Ceara; Department of Colorectal Surgery San Carlos Hospital, Fortaleza-CE, Av Pontes Vieira, 2551, Fortaleza, Ceara, 60130-241 Brazil

Consecutive patients treated for rectal cancer or adenomas in 4 colorectal centers in Brazil were included. Patients with early-stage rectal cancer identified by 3D-US were assigned to receive resection only, and those with a later stage were assigned to receive CRT. A second 3D-US was performed after CRT to detect the presence of residual tumor and metastatic lymph nodes or complete response.

Citation: Murad-Regadas SM, Almeida RM, Barreto RGL, Lima DMR, Regadas FSP, et al. (2016) Three-Dimensional Ultrasound: Is it Useful for Decision Making in the Management of Rectal Cancer? Is 3D Ultrasound Useful in Rectal Tumor? Int J Cancer Clin Res 3:068.



 Original Research Article 


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Published Date
September 22, 2016

Vol. 3, Issue 5

Magnetic Resonance Imaging Targeted Biopsies alone are not Sufficient for Detection of Clinically Significant Prostate Cancer - A Systematic Review and Meta-Analysis

Cayce B Nawaf, Nathanial T Ondeck, Laura A Skrip, Rollin K Say, John M Gunselman, Jamil Syed, Peter G Schulam and Preston C Sprenkle

Corresponding author: Preston C Sprenkle, MD, Assistant Professor of Urology, Yale School of Medicine, New Haven, CT 06520-8058, USA

Magnetic resonance imaging targeted biopsies (MRI-Tbx) has the potential to detect significant prostate cancer with a small number of cores; however, there are concerns that some clinically significant (CS) cancers may not be visible on MRI or identified with targeted biopsies alone.

Citation: Nawaf CB, Ondeck NT, Skrip LA, Say RK, Gunselman JM, et al. (2016) Magnetic Resonance Imaging Targeted Biopsies alone are not Sufficient for Detection of Clinically Significant Prostate Cancer - A Systematic Review and Meta-Analysis. Int J Cancer Clin Res 3:067.



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