International Journal of

Cancer and Clinical ResearchISSN: 2378-3419

Current Issue

 Open Access DOI:10.23937/2378-3419/1410132

A Novel Combined Methodology for Isolation and Detection of Circulating Tumor Cells based on Flow Cytometry and Cellular Filtration Technologies

Nikolaos G Grigoriadis, Konstantinos A Kyritsis, Melpomeni G Akrivou, Lefki-Pavlina N Giassafaki and Ioannis S Vizirianakis

Article Type: Original Article | First Published: February 08, 2020

Cancer cell presents a dynamic nature that evolves over time in its microenvironment through a complicating molecular and cellular interaction network. Despite the progress already achieved in the imaging technologies and the molecular tools used for tumor cell diagnosis and treatment approaches, metastasis still remains a major hindering factor that limits clinical outcomes. Circulating tumor cells (CTCs) present the potential in providing critical information to understand the metastasis proce...

 Open Access DOI:10.23937/2378-3419/1410131

Palmoplantar Erythrodysesthesia Associated with Capecitabine, Epidemiological Mapping and Risk Factors in Morocco

Tarik Hanafi, Hicham Titou, Hasna Kerrouch, Rachid Frikh, Naoufal Hjira and Mohammed Boui

Article Type: Brief Reports | First Published: January 27, 2020

A prospective cohort of a descriptive and analytical study, including sixty-one cases of Palmoplantar erythrodysesthesia in patients treated with capecitabine. The objective of this study is to determine an epidemiological mapping of Palmoplantar erythrodysesthesia in cancer patients on capecitabine treatment and to identify possible risk factors. The incidence of PPE was 64%. The median age of the patients who developed PPE was 54 years. 70% of the cohort was female, breast neoplasia represente...

 Open Access DOI:10.23937/2378-3419/1410130

Hyperpigmentation Associated with Anti-Tumor Chemotherapy: A Series of 54 Cases, Demo-Topographic Aspects and Interest of the Dermatological Intervention

Tarik Hanafi, Hicham Titou, Hasna Kerrouch, Rachid Frikh, Naoufal Hjira and Mohammed Boui

Article Type: Case Series | First Published: January 27, 2020

Three-year prospective study, from April 2016 to May 2019, including patients followed in oncology for malignant neoplasia, who developed hyperpigmentation following the start of antitumor chemotherapy for digestive, mammary and hematologic neoplasms, including the following molecules: 5 Fluorouracil, Tegafur, Cyclophosphamides, and Doxorubicin, in an isolated or combined mode. The study enrolled 54 patients, with an average age of 48 years and extremes ranging from 22 years to 67 years, with a ...

 Open Access DOI:10.23937/2378-3419/1410129

Candidate Genetic Polymorphisms and Haplotypes Associated with Endometrial Cancer Risk (United States)

Jane A McElroy, Robin L Kruse, J David Robertson, Helen Yampara-Iquise, Elizabeth C Bryda and Jeremy F Taylor

Article Type: Original Article | First Published: December 30, 2019

Exploration of single nucleotide polymorphisms (SNPs) that alter the expression or function of a gene may enable the development of diagnostics for endometrial cancer susceptibility. We evaluated eleven candidate SNPs that have previously been reported in the literature or that are associated with cadmium sequestering (i.e., metallothionein) for their effects on endometrial cancer risk. We also predicted haplotypes for SNPs within genes on chromosomes 6, 14 and X and tested haplotype effects for...

 Open Access DOI:10.23937/2378-3419/1410128

Research of Prognostic Role of MSI in Endometrioid Adenocarcinoma Cases That Received Postoperative Radiotherapy

Kadriye Sahinturk, MD, Candan Demiroz Abakay, MD, Serdar Sahinturk, MD, PhD, Sebnem Ozemri Sag, Fatma Atalay, Fatma E Can, Meral Kurt, MD, and Sibel Kahraman Cetintas, MD

Article Type: Original Article | First Published: November 11, 2019

One hundred twenty four endometrium cancer patients who were referred for postoperative external radiotherapy and/or brachytherapy during the period between January 2002 and December 2012 at Uludag University Radiation Oncology Department. Out of three all patients received radiotherapy. Since 11 had mixed type pathology, 9 had unspecified paraffine blocks and 2 had unsuccessful MSI analysis, study was performed with 99 patients and all re-staged according to FIGO 2009 staging system. Tumor tiss...

 Open Access DOI:10.23937/2378-3419/1410127

Spontaneous Regression of Hepatic Diffuse Large B-cell Lymphoma in HIV and HCV Positive Patient: A Novel Case Study

Albert Alhatem, Saiaditya Badeti, Chen Liu, Dongfang Liu and Donghong Cai

Article Type: Case Report | First Published: October 23, 2019

Diffuse large B-cell lymphoma (DLBCL) rarely occurs in the liver. Spontaneous regression of this tumor is extremely rare. We are reporting the first case of hepatic DLBCL, and we are reviewing the English literature for cases of spontaneous regression of DLBCL and cancer in general. A 60-year-old gentleman with a history of HIV and HCV infections presented with an incidental liver mass. He was diagnosed with DLBCL germinal cell type with high grade features based on the results of pathological/c...

 Open Access DOI:10.23937/2378-3419/1410126

Cancer Patterns in Odisha - An Important Mining State in India

Sharmila Chatterjee, MBBS, MPH, CPH, Paul H Levine, MD, Surendra Nath Senapati, MD, Dipti Rani Samanta, MD and Pinaki Panigrahi, MD, PhD

Article Type: Original Research | First Published: October 14, 2019

Odisha, a populous state and a major mining belt in India has high levels of environmental carcinogens. There is no population-based cancer registry in Odisha, thus giving no opportunity to develop systematic studies on important regional carcinogens. This paper highlights current patterns of cancer as seen at Acharya Harihar Regional Cancer Centre (AHRCC), and provides the first opportunity to determine the most important research questions that could drive cancer control programs in Odisha. Tw...

 Open Access DOI:10.23937/2378-3419/1410113

Treatment of Nephroblastoma in Developing Countries - Experience from a Single Center in Vietnam with NWTS 5 and SIOP 2001 Protocols

Hau Duc Tran and Ba X Hoang

Article Type: Original Research Article | First Published: April 29, 2019

We analyzed outcomes, advantages and disadvantages in application of SIOP 2001 and NWTS 5 protocols in our hospital. Patients with nephroblastoma admitted to National Children's Hospital in Hanoi, Vietnam, had been treated according to the NWTS 5 protocol from 2000-2005, and from 2008-2013 according to the SIOP 2001 protocol. 33 patients, stages I-III treated with NWTS 5 had estimated 5 year EFS 90.1% and OS 96.7% (mean follow up time 30.4 months); 58 patients, stages I-V, treated with SIOP 2001...

 Open Access DOI:10.23937/2378-3419/1410112

Common Factors among Some of the Reported Cases of the Spontaneous Remission and Regression of Cancer after Acute Infections

Behzad Niakan, Pharm D

Article Type: Hypotheses | First Published: April 25, 2019

An immunological mechanism has been suggested for the case reports of the spontaneous remission of cancer after an acute infection. The basic suggestion made is that a few acute inflammatory responses are occurring at about the same time in these cancer patients. Furthermore, it is suggested that a few acute inflammatory responses occurring at about the same time may negate the inhibitory effect of systemic inflammation on innate immunity. It is suggested that the activation of innate immunity c...

 Open Access DOI:10.23937/2378-3419/1410111

Importance of Time to Chemotherapy Initiation in Small Cell Lung Cancer

Gregory J Kubicek, Rachel Koehler, Matthew J Rossi, Christian Squillante, Alexander Hageboutros, Melvin Pratter, Stephen Akers and Polina Khrizman

Article Type: Original Article | First Published: April 20, 2019

Small cell lung cancer (SCLC) is an aggressive malignancy with a short median survival time. Because of the rapid growth rate there may be an advantage to emergently beginning chemotherapy as soon as SCLC diagnosis is made. All SCLC patients evaluated at Cooper University Hospital from January 2011 to September 2014 were reviewed. Multiple clinical factors were analyzed including timing between diagnosis and start of chemotherapy....

 Open Access DOI:10.23937/2378-3419/1410110

The Use of Carboranes in Cancer Drug Development

Emilia O Zargham, Christian A Mason and Mark W Lee Jr

Article Type: Review Article | First Published: April 18, 2019

Over the past decade, there has been a rising interest in the use of carboranes as a potential pharmacophoric moiety in the development of new drugs for the treatment of various types of cancer. The unique physical and chemical properties of carboranes make their use attractive in drug development. In several instances, the inclusion of carboranes into a drug structure has increased the agent's binding affinity, potency, or bioavailability. The purpose of this review is to highlight applications...

 Open Access DOI:10.23937/2378-3419/1410109

Does a New Information Structure about Cosmetic Outcome of Breast-Conserving Treatment Result in a Better Informed Patient? Outcome of a Comparative Case Study

ATPM Brands-Appeldoorn, MSc, AJG Maaskant-Braat, MD, PhD, VCG Tjan-Heijnen, MD, PhD and RMH Roumen, MD, PhD

Article Type: Original Article | First Published: April 17, 2019

A comparative case study compared data of two cross-sectional studies. The historical group (HG) was treated in 2013, the implementation group (IG) in 2016. The HG received a questionnaire, which resulted in implementation of the following items in our practice, expansion of the BCT brochure and photo book, incorporation of the Harvard and Numeric Rating scale. The IG received the same questionnaire, with the addition of nine more questions concerning specific implementation aspects....

 Open Access DOI:10.23937/2378-3419/1410108

Well Differentiated Neuroendocrine Uncommon Primary Breast Carcinoma: A Case Report

Angela Strazzanti, MD, Claudio Trovato, Angelo Caponnetto, Santi Gangi, Loredana R Villari, Pietro Gangemi and Francesco Basile

Article Type: Case Report | First Published: April 11, 2019

Neuroendocrine breast carcinomas (NEBC) are rarely malignant with a frequency of less than 0.1-0.3% of all breast tumors. The actual incidence of NEBC in BC (Breast Cancer) populations being still largely unknown due to the lack of a clear cut diagnostic criteria. In 2003, the World Health Organization (WHO) Classification of Tumors of the Breast and Female Genital Organs definitely established that the immunohistochemical expression of NE markers is the unique requirement for NEBC diagnosis....

Volume 6
Issue 2