Open Access DOI:10.23937/2377-4630/3/2/1046
A Retrospective Review of Corneal Abrasions after Oncologic Surgery in a Tertiary Cancer Center
SJ Gandhi, A Zavala, U Williams, A Van Meter, P Hsu, DS Gombos and P Owusu-Agyemang
Article Type: Research Article | First Published: May 07, 2016
Corneal abrasions are the single most common ocular injury in the perioperative period. The exact etiology of perioperative corneal abrasions is usually unclear, and several risk factors have been described. The aim of our study was to determine the incidence of known and hypothetical risk factors for corneal abrasion in a cohort of cancer patients who had developed corneal abrasion after oncologic surgery. Our review showed a high incidence of risk factors which were similar to that reported fo...
Open Access DOI:10.23937/2469-5807/1510038
Myofibroblasts Role in Wound Healing of Εyelid Lesions
Trisevgeni Ntinioti, Georgia-Heleni Thomopoulou, Eugene Danas, Nikolaos G Kavantzas, Emmanuel Agapitos and Andreas C Lazaris
Article Type: Letter to the Editor | First Published: May 25, 2016
In injured tissues, the repair of the extracellular matrix is organized by activated myofibroblasts. The latter cells support harmonious mechanical tissue organization. At the end of the normal repair process, myofibroblasts disappear by apoptosis but in pathological situations, myofibroblasts likely remain leading to excessive scarring. The eyelids are movable folds of tissue the core of which is represented by a tarsal plate, composed of dense connective tissue, embedded in loose connective ti...
Open Access DOI:10.23937/2469-5807/1510037
Atypical Retinal Arterial Macroaneurysm
Hans Hoerauf, Philipp Steven and Nicolas Feltgen
Article Type: Case Report | First Published: May 25, 2016
A patient with an atypical retinal arterial macroaneurysm masked by a persistent vitreous haemorrhage mimicking a neoplasm is presented. During vitrectomy a pigmented peripapillary tumour located at large vessels with circinate lipid exsudates was detected. Examination of removed tissue revealed haemosiderin-loaded macrophages resulting in pigmentation. The histologic finding of phagocytosis of intraretinal blood remnants allowed to diagnose an atypical retinal arterial macroaneurysm....
Open Access DOI:10.23937/2469-5807/1510036
BRAF V600E Immunohistochemistry in Cutaneous Langerhans Cell Histiocytosis: An Analysis of 20 Cases
Ryan C Romano, Wonwoo Shon, Sarah M Jenkins and Karen J Fritchie
Article Type: Review Article | First Published: May 25, 2016
Twenty dermatologic biopsy specimens from 14 patients (9 adults and 5 children) were retrieved. All cases were immunostained with BRAF mutation-specific antibody. Selected BRAF V600E IHC-positive cases were analyzed for BRAF V600E mutation by pyrosequencing. Clinical parameters were correlated with IHC status. BRAF V600E protein overexpression was identified in 15 of 20 (75%) cases (9/14 patients; 5 adults and 4 children). All pediatric patients with bone involvement were BRAF V600E IHC positive...
Open Access DOI:10.23937/2469-5807/1510035
Severe Complication of POPS: Mesh Malposition in the Bladder
Sabine Kersting, Dirk Kusche, Klaus-PeterJung and Eugen Berg
Article Type: Case Report | First Published: April 30, 2016
The authors present a case of a 68-years-old woman suffering of persistent urinary tract infections accompanied by intermittent fever. She had a history of pelvic organ prolapse suspension (POPS) for descending perineal syndrome with rectal prolapse, carried out elsewhere 15 months ago. Cystoscopy revealed a part of the prolene mesh that was incrusted along the fundus of the bladder to be the source of symptoms. This is probably the first case that reports a complication of POPS, which is a rela...
Open Access DOI:10.23937/2469-5807/1510034
Opana-Induced Renal and Hepatic Injury: A Case Report and Review
Yahya M Kurdi, Sergey Brodsky and Martha Yearsley
Article Type: Case Report and Literature Review | First Published: April 30, 2016
A 34-year-old Caucasian female presented with headache, fatigue, mild abdominal pain, and dehydration. She admitted to intravenous abuse of "melted" Opana ER tablets (extended-release oral formulation of oxymorphone hydrochloride). Noted clinical signs included tachycardia, tachypnea, and trace peripheral edema. Abnormal laboratory tests included low creatinine clearance, hemoglobin, hematocrit, and platelet. Histological studies of hepatorenal biopsies showed evidence of severe active thromboti...
Open Access DOI:10.23937/2469-5807/1510033
Anaplastic Large Cell Lymphoma as a Potential Diagnostic Challenge and Pitfall in Aspiration Biopsies of Thoracic Tumours
Justin Bateman, Celeste Morley, Bruce F. Burns and Shahid Islam
Article Type: Case Report and Literature Review | First Published: April 01, 2016
The patient is a 54 year-old male who presented in January 2015 with increasing dyspnea and weight loss over several months, eventually requiring intubation and admission to ICU for respiratory failure. He had a remote history of testicular seminoma and 'melanoma'. A trans-bronchial Wang needle aspirate biopsy of the right sub-carinal lymph node was preformed and showed sheets of large malignant cells with pleomorphic nuclei, multiple prominent nucleoli, and abundant cytoplasm. The tumour cells ...