Open Access DOI:10.23937/2469-5793/1510035
Microbiological Safety of Food, Particularly for Vulnerable People
Barbara M Lund
Article Type: Review Article | First Published: June 25, 2016
Foodborne illness affects about one in six Americans each year. Certain groups of people are particularly susceptible to foodborne illness, these include the very young, the elderly, pregnant women and people whose immune system is suppressed by disease or medication. These groups are most likely to incur infection and to suffer severe consequences. Major foodborne pathogens and foods that are particularly associated with hazards are outlined. Factors leading to outbreaks are described and illus...
Open Access DOI:10.23937/2469-5793/1510034
Obesity and Lifestyle Recommendations in the Light of Islam
Rahila Iftikhar, Muhmmad Albar and Mahdi Qadi
Article Type: Review Article | First Published: June 20, 2016
The prevalence of obesity and, consequently, obesity-related disorders is increasing globally, imposing a burden on health care and costs. Lifestyle interventions are the mainstay of treatment owing to the risks associated with surgery and medications. Although Islam advocates a healthy lifestyle and dieting, Muslim countries are also plagued by a rise in the prevalence of obesity and its associated disorders due to substitution of the traditional diet for a Western diet, which is rich in fats a...
Open Access DOI:10.23937/2378-3397/1410043
Alternatives to Liver Transplantation in Pediatric Liver Diseases
Clara T Nicolas and Scott L Nyberg
Article Type: Mini Review | First Published: July 18, 2016
Inherited metabolic disorders and acute liver failure (ALF) are often indications for liver transplantation in pediatric patients. Liver transplantation, however, is limited by the shortage of donor organs, as well as by the need for chronic immunosuppression. This review focuses on the latest advancements made in the field of liver regenerative medicine as possible future alternatives to pediatric liver transplantation or as a means of temporary liver function support. Cell transplantation offe...
Open Access DOI:10.23937/2378-3397/1410042
Approach to Interdigital Pilonidal Sinus: Our Clinical Experience and Literature Review
Vahit Onur Gul, Sebahattin Destek, Ergin Etkin, Serkan Ahioglu, Zeynep Tatar, Serhat Ozer and Yesim Erbil
Article Type: Review Article | First Published: June 11, 2016
Interdigital pilonidal sinus disease, also called barber's disease, is an acquired occupational disease. Although sacrococcygeal pilonidal sinus disease is a common surgical issue, interdigital pilonidal sinus disease is rare and more likely localized between the fingers and toes. Approximately 50 cases of this disease have been published. However, there are insufficient publications on the incidence of this disease. This disease is caused by the penetration of newly cut, short, and sharp hair t...
Open Access DOI:10.23937/2474-3690/1510014
Analysis of the Phenomenon of Endoleak of Type I A. Influence of the Mechanical Characterization of the Aorta
Altnji HE, Mbodj C, Bou-Said B and Walter-Le Berre H
Article Type: Research Article | First Published: June 08, 2016
Models of the mechanical behaviour of arterial walls are required for mechanical applications in cardiovascular disease treatments, such as Endovascular Aneurysm Repair (EVAR) in particular, to contribute to the ability to predict type IA endoleak. In this work, an explicit finite-element in-house code was used to evaluate the stresses generated by the blood flow in a whole system consisting of the endograft, plaque, and aneurysmal aorta. The developed numerical model was modified to...
Open Access DOI:10.23937/2378-3419/3/4/1061
Impact of Eribulin Monotherapy on Post-Progression Survival in Patients with HER2-Negative Advanced or Metastatic Breast Cancer
Takeshi Kotake, Yuichiro Kikawa, Sachiko Takahara, Shigeru Tsuyuki, Hiroshi Yoshibayashi, Eiji Suzuki, Yoshio Moriguchi, Hiroyasu Yamashiro, Kazuhiko Yamagami, Hirofumi Suwa, Toshitaka Okuno, Takahito Okamura, Takashi Hashimoto, Hironori Kato, Akihito Tsuji and Masakazu Toi
Article Type: Original Article | First Published: July 25, 2016
Introduction: A multicenter observational retrospective study was conducted to assess the clinical response and survival impact, especially post-progression survival impact, of eribulin monotherapy in HER2-negative advanced or metastatic breast cancer (A/MBC) patients. Patients and methods: This retrospective observation cohort study contains 110 A/MBC patients treated with eribulin monotherapy during April 2011 and August 2014 in 12 Kyoto Breast Cancer Research Network (KBCRN) institutions....
Open Access DOI:10.23937/2378-3419/3/3/1060
Rapid Fatal Progression of Cervical Cancer during Pregnancy Treated by Neoadjuvant Chemotherapy
Iptissem Naoura, Lise Selleret, Frederic Selle and Emile Darai
Article Type: Case Report | First Published: June 29, 2016
Cervical cancer is the most commonly diagnosed gynaecological malignancy in pregnant women. The prognosis of this cancer does not seem to be influenced by the pregnancy. However, the cancer management comes into competition with maternal and foetal outcomes, especially during the 2nd trimester of pregnancy. Challenging issues lie in the cervical screening during pregnancy, the evaluation of lymph node status and the indication of neoadjuvant chemotherapy to avoid foetal prematurity without compr...
Open Access DOI:10.23937/2378-3419/3/3/1059
Appendiceal Metastasis in a Patient with Advanced Breast Cancer on Hormonal Therapy
Edmond Kwan, Nezor Houli, Meron Pitcher and Shirley Wong
Article Type: Case Report | First Published: June 20, 2016
A 70-year-old woman presented with abdominal pain nine months after the diagnosis of de-novo, hormonal-receptor positive advanced breast cancer. Imaging revealed appendiceal stranding likely representative of acute appendicitis. Surgery was performed, and pathological examination of the inflamed appendix revealed metastatic carcinoma consistent with breast primary. The case highlights the diagnostic challenges of abdominal pain in a patient with advanced cancer....
Open Access DOI:10.23937/2378-3419/3/3/1058
ADAM17: A Gatekeeper in Immune-Oncology?
Peter R Lowe and Nathalie Corvaia
Article Type: Mini Review | First Published: June 20, 2016
Recent therapeutics searching to reactivate and target the immune system to destroy tumors have demonstrated remarkable success in the treatment of patients with previously intractable disease such as metastatic melanoma. Current research is enlarging the spectrum of targets and strategies for enhancing the immune response against tumors, in order to further improve treatment efficacy. In that respect, ADAM17, has frequently been described for it's over expression or over activation in the tumor...