Transplantation of Decellularized Venous Valvular Grafts in an Ovine Model
Alexandru Mogaldea, Karolina Theodoridis, Klaus Hoffler, Axel Haverich, Andres Hilfiker and Serghei Cebotari
Article Type: Research Article | First Published: August 31, 2017
The surgical treatment of end-stage chronic venous insufficiency involves valvular repair or transplantation to restore venous valve function and structure. Current valve substitutes can have issues with durability, thrombogenicity, susceptibility to infection, and a lack of growth potential. Therefore, the development of tissue-engineered venous valves represents a promising solution....
Impact of Conditioning Including Anti-Thymocyte Globulin on Engraftment Kinetics and GvHD after Matched Related Allogeneic Stem Cell Transplantation
Olga Blau, Axel Nogai, Kathrin Rieger, Lutz Uharek, Antonio Pezzutto, Eckard Thiel and Igor Wolfgang Blau
Article Type: Research Article | First Published: August 12, 2017
Graft-Versus-Host Disease (GvHD) remains a major complication of Allogeneic Stem Cell Transplantation (alloSCT). Anti-Thymocyte Globulin (ATG), however, reduces the incidence and severity of GvHD after alloSCT. A small number of studies suggest a role for ATG in Match-Related Donor (MRD) alloSCT. The aim of this study was to assess the risk of acute and chronic GvHD, engraftment, survival, and mortality in patients who received ATG prior to MRD alloSCT....