Open Access DOI:10.23937/2469-5726/1510036
Vogt-Koyanagi-Harada-Syndrome Concurrent with Morbus Darier
Claudia Eve Thieme, Sibylle Winterhalter, Bianca Apitzsch and Nicole Stuebiger
Article Type: Case Report | First Published: June 02, 2016
Vogt-Koyanagi-Harada-syndrome (VKH) is a multisystemic, T-cell mediated autoimmune disorder which is characterized by bilateral granulomatous panuveitis with extraocular manifestations in the central nervous and auditory system as well as in the integumentary field. Neurological and auditory manifestations include aseptic meningitis, meningism, tinnitus and cerebrospinal fluid pleocytosis. Integumentary findings can include alopecia, poliosis and vitiligo. The etiology of this disease is thought...
Open Access DOI:10.23937/2469-5726/1510035
Association of Markers of Oxidative Stress, Medication Therapy and Life Habits in Fibromyalgia
Joao Eduardo Torrecillas Sartori, Luiz Fernando Cireia, Denise Poltronieri Martins, Gabriela do Prado Rocha, Juliany Roberta Cintra, Ana Luiza de Aquino Oliveira, Juliana Goncalves Yogolare, Lucas Romagnolli, Alexandre de Andrade Budin, Sabrina Mayara Cezario, Marcela Augusta de Souza Pinhel, Camila Ive Ferreira Oliveira, Doroteia Rossi da Silva Souza, Gerardo Maria de Araujo Filho and Lazslo Antonio Avila
Article Type: Research Article | First Published: May 10, 2016
Objective: To evaluate the association among genetic polymorphisms of glutathione S-transferase, oxidative stress, lifestyle habits and medication therapy in patients with fibromyalgia (FM). Patients and methods: A total of 187 women (22-84 years) were studied: 81 patients with fibromyalgia (G1) and 106 individuals without the disease (G2). They had their peripheral blood sample submitted for analysis of GSTM1 and GSTT1 polymorphisms, serum levels of thiobarbituric acid reactive substances (TBAR...
Open Access DOI:10.23937/2469-5726/1510034
HLA-DR Frequency in Individuals with Rheumatoid Arthritis and Lung Affection
Maria do Socorro Teixeira Moreira Almeida, Joao Vicente Moreira Almeida, Manoel Barros Bertolo, Catarina Fernandes Pires and Viriato Campelo
Article Type: Research Article | First Published: April 01, 2016
Rheumatoid arthritis (RA) is an autoimmune disease whose etiology is unknown, while its immunopathogenesis involves the participation of both genetic and environmental factors. Human leukocyte antigen DR4 (HLA-DR4) exhibits a strong association with RA in various populations and ethnic groups; in addition, a heightened frequency of HLA-DR1 among individuals with RA has been found in some populations....
Open Access DOI:10.23937/2469-5726/1510033
Novel Application of Behavioral Assays Allows Dissociation of Joint Pathology from Systemic Extra-Articular Alterations Induced by Inflammatory Arthritis
Ann K Harvey, Mariah J Lelos, Claire J Greenhill, Ashley T Jones, Susanne P Clinch, Michael J Newton, Stephen B Dunnett, Sean L Wyatt, Anwen S Williams and Simon A Jones
Article Type: Research Article | First Published: April 01, 2016
Although rheumatoid arthritis (RA) is a disease of articular joints, patients often suffer from co-morbid neuropsychiatric changes, such as anxiety, that may reflect links between heightened systemic inflammation and abnormal regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Here, we apply behavioral neuroscience methods to assess the impact of antigen-induced arthritis (AIA) on behavioral performance in wild type (WT) and interleukin-10 deficient (Il10-/-) mice. Our aim was to identi...
