Impact of the Biomechanical 'Pleural Stress' Pressure Vessel Hypothesis on the Pathogenesis of Tuberculosis: Predictors of TB Reactivation and its Application to TB Screening
Aaron R Casha, Roberto Caruana-Gauci, Alexander Manche, Marilyn Gauci, Ruben Gatt, Hannah-Marie Casha-Gauci and Joseph N Grima
Article Type: Review Article | First Published: June 15, 2018
A hypothesis for the pathogenesis of pulmonary TB is presented based on the biomechanics of pleural stress in the context of the lung as a pressure vessel. This hypothesis modelled pleural stress as a marker of pleural tissue destruction and subsequent repair. It identified five predictors of TB reactivation, namely adolescent and young adult age, male gender, apical location, low antero-posterior chest diameter or low thoracic-index rib-cage shape and the presence of pre-existing apical blebs.....
Assessment of Systemic Fungal Infections among Diabetic Patients in Enugu, Nigeria
Theophilus Kachi Udeani, Victoria Nneka Asogwa and Uche Ezenwaka
Article Type: Original Research | First Published: June 15, 2018
Opportunistic invasive fungal infections are emerging health challenges worldwide, especially among immunocompromised hosts. This study investigated systemic fungal infections in diabetic patients. The diabetic patients were recruited from the Diabetic Clinics; Enugu State University Teaching Hospital Parklane, Enugu. A structured questionnaire was used to obtain information on the demographic and risk factors from the subjects....