Open Access DOI:10.23937/2377-4630/2/2/1029

Early Signs and Perinatal Diagnosis of Tracheal Agenesis

Mayke E. van der Putten, Viola Christmann, Lucas E. Matthyssens, Arthur R.T. Scheffer and Chris Bleeker

Article Type: Case Report | First Published: May 11, 2015

A preterm boy of 30 weeks and fie days did not breathe spontaneously at birth and despite visualization of the vocal cords, intubation attempts did not succeed, until a tube 2.0 was placed using an Eschmann stylette, mistakenly considered endotracheal. A few hours later, suspicion of tube dislocation arose and renewed intubation attempts failed. The ENT specialist performed a tracheoscopy and found a blind ending of the trachea in the subglottic area....

 Open Access DOI:10.23937/2377-9004/1410036

Case Report: 7q11 Microdeletion in Swyer Syndrome Patient

Patrick T Reeves, Axel G Moreira, Tochi M Amagwula, Toy G Lee, Dominique D Washington, AkilaMuthukumar and John Y Phelps

Article Type: Case Report | First Published: May 04, 2015

Swyer syndrome or XY gonadal dysgenesis is caused by genetic mutations in testis-determining factors, such as the SRY gene, that lead to streak gonads in phenotypical females. The following case demonstrates a patient with a 7q11 microdeletion, a region which governs the coding of a transcription regulator called Zinc Finger 92 (ZNF92)....

 Open Access DOI:10.23937/2377-9004/1410035

Retained Placenta Accreta Presenting as Secondary Postpartum Hemorrhage

Yilun Koethe, Gabrielle A Rizzuto and Maureen P Kohi

Article Type: Case Report | First Published: May 02, 2015

Abnormal placentation and retention of products of conception (RPOC) are common causes of postpartum hemorrhage. Case: A 37-year-old gravida 4 para 1 woman with history of Asherman's syndrome from prior dilatation and curettage presented in spontaneous labor. Following normal vaginal delivery, portions of the placenta were retained and had to be manually extracted....

 Open Access DOI:10.23937/2469-5807/1510003

Histological Findings in the Kernicterus-Associated Vulnerable Brain Regions are Linked to Neurodegeneration, Alterations in Astrocyte and Pericyte Distribution, and Vascular Modifications

Ines Palmela, Pedro Pereira, Masaharu Hayashi, Dora Brites and Maria A. Brito

Article Type: Research Article | First Published: April 29, 2015

Kernicterus is a severe manifestation of neonatal unconjugated hyperbilirubinemia. We investigated the neuro-glia-vascular alterations in autopsy material from three infants with kernicterus. Histological and immunohistochemical studies were performed in the cerebellum, hippocampus and basal ganglia, the most vulnerable brain regions to bilirubin-induced neurotoxicity. The data obtained were compared with the relatively spared temporal cortex, as well as with three aged-matched controls with no ...

 Open Access DOI:10.23937/2572-4010.1510004

Exenatide Effects on Cardiometabolic Risk and Weight in Adolescents with Morbid Obesity and Type 2 Diabetes Mellitus: Two Case Reports

Marisa Censani, Vivian L Chin and Ilene Fennoy

Article Type: Case Report | First Published: May 06, 2015

Glucagon-like peptide-1 (GLP-1) receptor agonist Exenatide is an incretin mimetic approved by the US Food and Drug Administration in 2005 as an adjunct to diet and exercise for glycemic control in adults with type 2 diabetes. Improvements in cardiometabolic risk factors and weight in type 2 diabetes patients using Exenatide are well described in adults; however, reports in adolescents are limited to non-diabetic youth with obesity....

 Open Access DOI:10.23937/2377-9004/1410034

Haemoglobin Electrophoretic Patterns, ABO and Rhesus D Blood Groups Distribution among Antenatal Women in Sokoto, Nigeria

Udomah FP, Isaac IZ, Aliyu N, Erhabor O, Ahmed MH, Yakubu A, Hassan M and John RT

Article Type: Research Article | First Published: April 23, 2015

All human red blood cells contain a pigmented metalloprotein called haemoglobin which is of different types. Hemoglobin is the oxygen carrying pigment of the red blood cells. Defects in its genes can produce abnormal haemoglobin which leads to conditions known as haemoglobinopathies. Haemoglobin electrophoretic patterns include the normal haemoglobin which is the most prevalent and is referred to as hemoglobin A (HbA) and other abnormal ones also exist, like hemoglobin S (HbS), which is a varian...

 Open Access DOI:10.23937/2572-4045.1510005

Immunogenicity of Shared Molecular Epitopes in the Humoral Response as Biomarker of the Rupture of Immune Tolerance in Transplantation

Manuel Muro, Francisco Boix, Jorge Eguia, Maria R. Moya-Quiles, Gema GonzalezMartinez and Santiago Llorente

Article Type: Editorial | First Published: March 06, 2015

Th true role of donor-specific human leukocyte antigen (HLA) antibody (DSA) response to a solid allograft is not fully understood. Recently, new serum-screening assays (mainly based in the luminex technology) have strongly increased and defined the detection and specificity analysis of DSA in allosensitized patients in waiting list of transplantation or in transplanted recipients....

 Open Access DOI:10.23937/2469-5777/1510001

Algorithms of Flap Reconstruction in High-Voltage Electrical Injuries: 26 Years Experience

Cengiz Eser, Erol Kesiktas, Eyuphan Gencel, Omer Kokacya, Metin Yavuz and Rauf Kerimov

Article Type: Research Article | First Published: May 02, 2015

Electricity is an indispensable part of a comfortable modern life. However, multipurpose electricity use in daily life increases the risks of accidents, injury or death. High-voltage (>1000 volts) electrical burns cause the greatest tissue damage and sequelae, as well as the largest number of deaths. To minimize the functional effects caused by delayed recovery, reconstruction with skin flaps or grafts should be performed as soon as possible in a High-voltage Electrical Injury (HVEI)....

 Open Access DOI:10.23937/2377-9004/1410033

Case Report on a 10cm Pelvic Mass: Unruptured Chronic Ectopic versus Neoplasm

Christine Rojas, Kerry Ann Hudson and Kevin Byrd

Article Type: Case Report | First Published: April 14, 2015

Ectopic pregnancy is the leading cause of maternal death in the first trimester. Approximately 18% of ectopic pregnancies present to the emergency department with vaginal bleeding, abdominal pain or both....

 Open Access DOI:10.23937/2469-5726/1510009

Tei Index in a Sample of Patients with Ankylosing Spondylitis

Rodrigo Eduardo Rosa, Admar Moraes de Souza, Lucio Ricardo Hiurko Felippe, Pedro Grachinski Buiar, Pedro Gabriel Lorencetti, Chayanne Natielle Rossetto and Valderilio Feijo Azevedo

Article Type: Research Article | First Published: April 13, 2015

Ankylosing spondylitis (AS) is an inflammatory disease of immunological origin which has been correlated with higher cardiovascular risk. Although the risk factors are not clear, many cardiac alterations have been described, such as conduction disturbances, coronary heart disease, aortic root dilation, cardiac valve alterations, and ventricular diastolic dysfunction....