Open Access DOI:10.23937/2469-570X/1410028
Prospect of Cell Therapy for Treating Perianal Fistula, Including Crohn's Disease
Guadalajara H, Garcia-Arranz M, Georgiev-Hristov T, Cortes D and Garcia-Olmo D
Article Type: Short Review | First Published: March 31, 2016
Novel methods are needed for this condition, and cells appear to have potential to improve fistula healing. Mesenchymal stromal cells (MSCs) have been used in several clinical trials, including phase-III studies. After an analysis of the published papers we can conclude that MSCs have evident anti-inflammatory and immune-regulatory properties, MSCs are safe for clinical practice and have decent results considering the challenging conditions surrounding the procedure and the safety profile of the...
Open Access DOI:10.23937/2469-570X/1410027
Epigenetics, Ethnicity, Bioinformatics and Nanotechnology Opening Frontiers in Cardiac Medicine
Janet L. Paluh
Article Type: Short Review | First Published: March 30, 2016
Stem cell based therapy directed towards improving the long-term therapeutic outcome of heart disease in many regards remains in its infancy. Although strategies with bone marrow derived stem cells have been prevalent in clinical trials, other stem cell resources are less explored. The ability to use reprogrammed somatic cells for patient-optimized therapies, either from direct reprogramming to cardiac lineage or reprogramming first to pluripotent stem cells, requires expanding our understanding...
Open Access DOI:10.23937/2474-3690/1510011
Space Flight and Lunar Dust Hypertension
William J. Rowe
Article Type: Editorial | First Published: April 18, 2016
As a member of a North American Fitness Delegation to China in 1988, with an invitation to present a paper in Guangzhou, I chose as a role model Sy Mah, holder of the Guinness Book of Records for having completed 524 marathons. Mah, a professor of physical education at the University of Toledo, was on a sabbatical in Boston and drove all night for his stress test in the morning; it was very abnormal with evidence of severe ischemia. Because of time constraints, I took him to the Medical College ...
Open Access DOI:10.23937/2474-3690/1510010
Prevalence of Hypertensive Emergency in Emergency Room of Rajavithi Hospital
Sumitra Piyanuttapull and Jaruboot Angsanakul
Article Type: Research Article | First Published: April 09, 2016
Hypertensive crisis is common among patients visiting emergency room (ER). Majority of these patients can be treated on an outpatient basis (hypertensive urgency). Other patients have acute end-organ damage and higher morbidity and mortality (hypertensive emergency). However, no study on the prevalence of hypertensive emergency in ER in Thailand was found. We aim to evaluate the prevalence and also potential predictors of hypertensive emergency....
Open Access DOI:10.23937/2474-3690/1510009
Noninvasive Tools Used Nowadays in both, Clinical Practice and Trials in Order to Assess Blood Pressure
Martyna Zaleska, Olga Mozenska, Katarzyna Nikelewska, Magdalena Chrabaszcz, Weronika Rygier, Jan Gieraltowski, Monika Petelczyc and Dariusz A Kosior
Article Type: Short Review | First Published: April 02, 2016
Hypertension affects currently around 1 billion people worldwide and cardiovascular disease remains the most frequent cause of mortality worldwide. Hypertension societies publish cyclically recommendations how to diagnose and manage this illness. Some of them describes tools used to diagnose this disease, others do not. However nowadays many new methods are introduced to assess blood pressure (BP) values. Some of them allow only to obtain central or systolic BP, others are used currently only in...
Open Access DOI:10.23937/2572-4193.1510019
Cellular Rhinitis: A Therapeutic Proposal
A Macchi, F De Bernardi, A Peirolo and D Simoncini
Article Type: Original Article | First Published: May 01, 2016
Rhinitis, a common condition throughout the world, are classified in non-allergic (NAR) and allergic rhinitis (AR). The data collected by recent studies show that NAR affects more than 200 million patients world-wide, among which 8% to 10% suffer from NARES and NARESMA. Nevertheless, respiratory diseases, and in particular rhinitis, are not considered real and serious diseases, and, as a result, they remain frequently underdiagnosed and undertreated despite the heavy burden they place on patient...
Open Access DOI:10.23937/2572-4193.1510018
An Unusual Complication of Maxillary Subperiosteal Implant Removal: Dislocation of the Parotid Gland Duct
Marciante Giulia Anna, Saibene Alberto Maria, Pisani Antonia, Biglioli Federico and Giovanni Felisati
Article Type: Case Report | First Published: April 30, 2016
A 73-year-old man, treated with a maxillary subperiosteal implant in 1985, was referred to our ENT clinic by his dental practitioner due to the onset of sudden edema, pain and purulent nasal discharge. Although the patient had experienced painful recurrent mobilization of the implant from 1995, he did not approach his dentist until 2006, when edema and purulent nasal discharge occurred. The radiologic imaging revealed a maxillary sinusitis with severe maxillary bone resorption and an oro-nasal/o...
Open Access DOI:10.23937/2469-5858/1510012
Short Term Quality of Life Following Transcatheter Aortic Valve Replacement
Yaar Aga, Ximena Marincic, Christian Marin y Kall, Peter de Jaegere and Eduardo De Marchena
Article Type: Research Article | First Published: April 01, 2016
Transcatheter Aortic Valve Replacement (TAVR) has emerged as an alternative treatment modality for patients with severe aortic stenosis (AS) who are at high or extreme risk for surgical aortic valve replacement (SAVR). Previous studies have shown that TAVR results in substantial reductions in symptoms and mortality. Despite these health benefits, the assessment of quality of life (QOL) remains critical in these patients who often express quality of life over quantity of life....
Open Access DOI:10.23937/2469-5750/1510021
Facial Follicular Mucinosis in Adolescence
Gokce Isil Kurmus, Filiz Canpolat, Muzeyyen Gonul and Murat Alper
Article Type: Case Report | First Published: April 12, 2016
Follicular mucinosis (FM), also known as alopecia mucinosa, is a rare inflammatory disorder that characteristically presents as follicular papules or infiltrated plaques with prominent follicular openings associated with alopecia. Histologically, the disorder is characterized by mucin deposition in the follicular epithelium and sebaceous glands. FM was classified in two distinct entities: a primary or idiopathic form, usually presents in children and young adults with a benign course, and a seco...
Open Access DOI:10.23937/2469-5750/1510020
New Insights and Therapeutic Implications in Cutaneous Melanoma
Pinar Ozuguz, Seval Dogruk Kaca and Serap Polat
Article Type: Review Article | First Published: April 11, 2016
Melanoma is a highly aggressive tumour with poor prognosis in the metastatic stage that arises and evolves due to a myriad of genetic and epigenetic events. Among these, the interaction between epigenetic alterations (i.e., DNA methylation, histone modifications, mRNA silencing by miRNAs and nucleosome repositioning) has been recently identified as playing an important role in melanoma development and progression by affecting key cellular pathways such as cell cycle regulation, DNA repair, apopt...