Open Access DOI:10.23937/2378-3516/1410138
Valproic Acid in Prevention and Treatment of COVID-19
Shweta Singh and Krishna K Singh
Article Type: Research Article | First Published: August 07, 2020
The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has posed a serious threat to the global public health. Respiratory failure, followed by cardiovascular complications with wide-spread endothelial dysfunction and inflammation, is rapidly emerging as a key threat in COVID-19. ACE-2 receptors are the cell-entry gate for SARS-CoV-2. The purpose of the present study is to evaluate Valproic Acid (VPA) as a potential drug to treat COVID-19 and look into its mechanism of action....
Open Access DOI:10.23937/2469-5769/1510067
Cronobacter sakazakii in Infant Food Contamination and Its Survival Strategies in Hostile Conditions
Gedif Meseret Abebe
Article Type: Review Article | First Published: August 08, 2020
Cronobacter sakazakii is an opportunistic foodborne pathogen that causes diseases like meningitis, necrotizing enterocolitis, and bacteremia in immunocompromised, low weight individuals, neonates, infants, and elders. Cronobacter sakazakii has the ability to persist in extremely dried foods such as powdered infant formula (PIF). Infant food contamination by this bacterium is attributed to biofilm which are microbial communities attached to biotic or abiotic surfaces using a self-produced matrix ...
Open Access DOI:10.23937/2378-3001/1410101
Migraines and CGRP Monoclonal Antibodies: A Review of Cardiovascular Side Effects and Safety Profile
Kimberly Boldig, MMS and Nitin Butala, MD
Article Type: Review Article | First Published: July 31, 2020
Migraine headaches are a very common complaint described by patients and few medications have been designed solely for their treatment. Current knowledge of migraine pathogenesis relates to various neuropeptides, including calcitonin gene related peptide (CGRP), acting on blood vessels within the brain and causing vasodilation. Sensory fibers detect this change and it is perceived as pain. This understanding has led to the development of CGRP monoclonal antibodies as possible migraine treatment....
Open Access DOI:10.23937/2378-3672/1410055
Thymalin as a Potential Alternative in the Treatment of Severe Acute Respiratory Infection Associated with SARSCoV- 2
Lukyanov Sergey A, Kuznik Boris I, Shapovalov Konstantin G, Khavinson Vladimir K, Smolyakov Yuri N, Tereshkov Pavel K, Shapovalov Yuri K, Konnov Valery A and Magen Eli
Article Type: Case Report | First Published: August 08, 2020
Polypeptide medication Thymalin obtained from the calf thymus has beneficial effects on cell-mediated immunity and blood coagulation. Here we present a patient with COVID- 19 severe pneumonia, who has first treated with Lopinavir/ Ritonavir + hydroxychloroquine without clinical benefit; and was then given Thymalin treatment with impressive clinical and laboratory improvement. Infection induced by a novel coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARSCoV- 2), causes acut...
Open Access DOI:10.23937/2643-3885/1710048
Subtle Cavovarus Foot: A Missed Risk Factor for Chronic Foot and Ankle Pathologies
Benjamin Green, Anne-Laure Ménard, PhD, Stéphane Leduc, MD and Marie-Lyne Nault, MD, PhD
Article Type: Review Article | First Published: August 03, 2020
This literature review investigated the subtle cavovarus foot with a search in Pubmed and Google Scholar using the following keywords: Subtle cavovarus foot, cavovarus foot or cavus foot and one or more of the following: Associations, injuries, ankle sprains, ankle instability, sports, plantar pressure, dynamic pedobarography, Tekscan and footprint, from January 1980 to February 2019....
Open Access DOI:10.23937/2378-2951/1410193
A Case of New Onset Iohexol Contrast Induced Kounis Syndrome after Prior Contrast Exposure
Ahmed Shahab and Maheep Sangha
Article Type: Case Report | First Published: July 31, 2020
A 76-year-old male with past medical history significant for prostate cancer (in remission), diabetes, hyperlipidemia and tobacco dependence but no identified coronary artery disease presented to emergency room complaining of Left abdominal and flank pain which started at rest. His initial work-up only revealed significant hematuria and his pain resolved IV Tylenol administration. The cause of hematuria was investigated with...
Open Access DOI:10.23937/2690-3172/1710007
Neurophysiological Signature of Memory Performance during the DRM Task
Grégoire Favre, Sibylle K Horat, François R Herrmann, Isabelle Gothuey, Marco CG Merlo and Pascal Missonnier
Article Type: Original Article | First Published: July 31, 2020
The Deese-Roediger-McDermott (DRM) task is a typical experimental paradigm used to induce false memory production. Previous investigations using event-related potentials (ERPs) revealed differences in a late negative component, FN400, in healthy subjects performing the DRM. However, false memory production may be related to the earlier engagement of cortical circuits. To date, there is no study exploring the electrophysiological activation of early and late neural networks DRM-related in healthy...
Open Access DOI:10.23937/2377-4630/1410111
A Comparison of qSOFA and SIRS in the Early Diagnosis of Severe Pneumococcal Sepsis: A Retrospective Cohort Study
Pernille Ursin Rein, Dag Jacobsen, Vidar Ormaasen, Vera Djordjilović and Oona Dunlop
Article Type: Original Article | First Published: August 10, 2020
In 2016 quick Sequential [Sepsis-related] Organ Failure Assessment (qSOFA) was presented as a simple bedside screening tool in identifying sepsis and is now replacing the Systemic Inflammatory Response Syndrome (SIRS) criteria in many Emergency Departments. We wanted to study whether these diagnostic criteria were sensitive enough to identify sepsis on the initial hospital admission in a cohort of patients who rapidly developed pneumococcal septic shock....
Open Access DOI:10.23937/2572-407X.1510021
A Case of Severe Hyponatremia Secondary to Pituitary Macroadenoma with Covid-19 Infection, Endocrinological Responses
José Carlos de la Flor Merino, MD, Laura Mola Reyes, MD, Francisco Valga Amado, MD, Alexander Marshall and Miguel Rodeles del Pozo, MD
Article Type: Letter to the Editor | First Published: August 03, 2020
SARS-CoV-2 disease (COVID-19) has dramatically increased since March 2020. There is insufficient data to establish the risk of acquiring the hyponatremia in patient with COVID-19 infection. We report here the clinical features and therapeutic course of the severe hyponatremia secondary to pituitary macroadenoma with confirmed COVID-19 pneumonia. This is a 59-year-old man without renal disease, who developed severe hyponatremia, hardly explained by the emetic episode and/or diuretic treatment wit...