International Journal of

Allergy MedicationsISSN: 2572-3308

Early Online

 Open Access DOI:10.23937/2572-3308.1510038

The Burden of Allergic Rhinitis and Impact of GRAZAX Grass Allergy Immunotherapy Treatment on Quality of Life in Germany and The Netherlands: Results from A Qualitative Study

Germain N, Gerth van Wijk R, Aballea S, Abetz-Webb L, Domdey A, Romano M and Toumi M

Article Type: Research Article | First Published: April 03, 2019

Allergic rhinitis is a major chronic respiratory disease that affects between 10% and 30% of adults and up to 40% of children globally. The purpose of this study was to understand the impact of allergic rhinitis and subsequent GRAZAX grass allergy immunotherapy (AIT) treatment on adults' and adolescents' quality of life. Clinicians treating allergic rhinitis in the Netherlands and Germany recruited adults and adolescents who had received at least 3 years of GRAZAX® treatment. Telephone intervie...

 Open Access DOI:10.23937/2572-3308.1510037

H1-Antihistamines for Allergic Diseases: Old Aged but Not Old-Fashioned Drugs

Luisa Ricciardi, Fabiana Furci and Isola Stefania

Article Type: REVIEW ARTICLE | First Published: March 04, 2019

Histamine is a chemical messenger synthesized from the amino acid histidine by L-histidine decarboxylase. It plays an important role in the system of immunoregulation and in acute and chronic allergic inflammation binding to four subtypes of receptors H1, H2, H3 and H4, described as heptahelical transmembrane molecules that activate specific G-proteins. These receptors placed on the membranes of different cellular jambs (mast cells, endothelial cells, sensory nerve fibres, bronchial smooth muscl...

Volume 5
Issue 1