Nikolovski A, Rallis S (2020) The Impact of Dairy Elimination on Pediatric Atopic Dermatitis. J Nutri Med Diet Care 6:044.

Case Report | OPEN ACCESS DOI: 10.23937/2572-3278.1510044

The Impact of Dairy Elimination on Pediatric Atopic Dermatitis

Aleksandra Nikolovski and Stefan Rallis*

Dr. Rallis Wellness Group, Ontario, Canada


Atopic dermatitis (AD) is a relatively common, inflammatory skin condition of variable severity. Known food allergens such as dairy may play a role in the exacerbation of this T-cell mediated autoimmune condition. A four-year-old patient with severe, non-resolving AD was placed on a dairy-free elimination diet. Quantitative analysis included the use of the Hanifin and Rajka diagnostic tool and the Scoring Atopic Dermatitis Calculator (SCORAD). The patient demonstrated a 76% improvement in her symptoms within 10 days of eliminating dairy products from her diet, illustrated by a SCORAD reduction from 70.9 to 16.7. A further 30% relative SCORAD improvement of 16.7/100 to 11.6/100 was demonstrated at the patient's four-month follow-up. Potential food allergens such as cow's milk and other dairy products should be considered as potential inflammatory mediators of this dermatological condition.


Atopic dermatitis, Dairy, Cow's milk, IgG


Atopic dermatitis (AD) is a chronic, inflammatory skin disease affecting up to 20% of children [1]. Characterized by the presence of pruritis and elevated skin lesions, AD is a T-cell mediated autoimmune condition resulting in elevated levels of inflammatory cytokines such as IL-9, IL-17 and IL-22 [2]. This inflammatory cascade is both IgE and IgG-mediated [3]. Dermatological literature consistently identifies potential correlations between intake of cow's milk products, elevations in IgG levels, and aggravation of AD in children [3,4]. Consequently, the elimination of cow's milk and milk products can often result in a reduction in inflammatory cytokines [5] and the potential improvement in childhood AD.

Case Report/Case Presentation

A 4-year-old, Caucasian female presented with severe, non-resolving atopic dermatitis on both legs, upper extremities, abdomen, and back. The onset of the disease occurred at 3.5 years of age, beginning with an elevated, pruritic lesion of 3 cm in diameter on her posterior thigh. This was followed by further elevated lesions on her arms and back, which were also pruritic. The patient's family physician initially diagnosed the lesions as Pityriasis rosea, and recommended the use of Benadryl. With little relief and progressive exacerbations over 6 weeks, the patient was diagnosed with eczema at a walk-in clinic, followed by Atopic Dermatitis (AD), by an emergency room physician. The latter diagnosis was confirmed by a pediatric Dermatologist four months after her initial visit with her family physician. The severity of her AD continued to increase, with progressive lichenification, oozing, and crusting, requiring bandaging of the lower extremities. She was prescribed hydrocortisone cream and advised to minimize time in water and to use unscented detergents. Daily use of topical hydrocortisone and adherence to environmental modifications over 4-6 months provided only marginal relief, with severe intermittent exacerbations persisting.

The patient first attended our clinic on March 5, 2019 seeking an alternative perspective on care. A dermatological examination revealed a severe exacerbation, consisting of erythema, swelling, crusting, and lichenification (Figure 1). The patient fulfilled 3 major and 4 minor criteria on the Hanifin and Rajka Diagnostic Criteria for Atopic Dermatitis [6]. To quantify the severity of the condition, the Scoring Atopic Dermatitis Calculator (SCORAD), developed by the European Task Force on Atopic Dermatitis, was used, which assesses severity of three domains: Extent or breadth, intensity, and subjective symptoms including itchiness and sleep loss [7,8]. The patient's overall condition severity was quantified as 70.9 out of 100 using the SCORAD assessment. The patient's diet was also assessed as part of her initial examination. Her diet consisted of a minimum of 2 servings of dairy per day, most commonly in the form of cheese, milk, or yogurt. Breakfast consisted of waffles or pancakes with a glass of chocolate milk and fruit. Lunch consisted of vegetables, fruit, and yogurt, and dinner included pasta, meat, and occasional dairy-based sauce or seasoning. The patient often consumed milk-based ice-cream for dessert.

Figure 1: Exacerbation at initial assessment (March 5, 2019). View Figure 1

A modified elimination diet was prescribed which included the elimination of dairy. A follow-up was scheduled 10 days later, at which time the patient demonstrated dramatic improvement (Figure 2). A follow-up SCORAD was also conducted which demonstrated a 76.4% improvement, with a SCORAD rating of 16.7 out of 100. Due to the significant improvement in dermatitis, it was suggested that the patient re-introduce dairy to her diet to affirm the correlation. The patient re-introduced dairy and noted severe exacerbation, reporting a pruritus rating of 9/10 and the presence of broken skin, lichenification, and swelling, all of which was relieved with a secondary elimination. A 4-month follow-up after the initial elimination illustrated further improvement with a SCORAD of 11.6 out of 100 (Figure 3). Table 1 illustrates the progressive improvements, including the relapse during, and the remission after dairy was reintroduced. At the 4-month follow-up appointment, the patient reported 95% compliance with dairy elimination, with the exception of less than 5 occurrences where dietary accommodation was unavailable. On these occasions, the patient reported increases in pruritus from a 0 to 7 out of 10, lasting for 2-3 days following dairy consumption.

Figure 2: Reduction in symptoms after 10-day dairy elimination. View Figure 2

Figure 3: Reduction in symptoms at four-month follow-up. View Figure 3

Table 1: SCORAD rankings at intake, 10-day follow-up, dairy reintroduction and 4-month follow up. View Table 1


The patient demonstrated dramatic improvement in her AD once dairy was eliminated. After multiple forms of intervention including topical creams, steroids, and environmental modifications were deemed ineffective in resolving her case, the elimination of dairy was introduced. This intervention was easy to implement and was deemed both safe and well tolerated, with no adverse events noted. This case further exemplifies the gross underutilization of dietary interventions in the primary care management of most dermatological conditions [9]. This is most likely due to the paucity of research implicating known food allergens such as dairy, eggs or wheat with inflammatory skin conditions such as AD. Consequently, the full extent of the pathophysiology surrounding the effects of these dietary interventions is lacking. Because AD is partially IgG-mediated, it is reasonable to assume that as the child's immune system matures, she will experience less reactivity to these eliminated food groups. It is our hope that the findings of this case may help propagate further research and may lead primary care providers to consider food sensitivities as potential inflammatory mediators in dermatological conditions such as AD.


There are no acknowledgements to declare. All contributors are authors.

Statement of Ethics

Informed, written consent for publishing the case including photographs was obtained from the patient and her parents. This research was conducted ethically in accordance with the World Medical Association Declaration of Helsinki.

Disclosure Statement

The authors declare no conflict of interest.

Funding Sources

There was no funding of this publication.

Author Contributions

Clinical interventions and patient care were directed by Dr. Rallis. Outcome assessments and progress reporting was managed by Ms. Nikolovski Research and authorship, including literature reviews were conducted collaboratively for this case study.


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Nikolovski A, Rallis S (2020) The Impact of Dairy Elimination on Pediatric Atopic Dermatitis. J Nutri Med Diet Care 6:044.