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Case Report  |   Volume 3, Issue 2

Successful Treatment of Chronic Hepatitis C using Pegylated Interferon and Ribavirin in a Patient with Sheehan's Syndrome

Rong Xu, Yong-hong Zhang and Xu Yang

A 50-year-old female with Sheehan's syndrome was treated for chronic hepatitis C using pegylated interferon-α2b and ribavirin. The patient's HCV-RNA status was negative by the fourth week and remained undetectable until the completion of treatment without signs that Sheehan's syndrome had been exaggerated. This case demonstrates that pegylated interferon-α2b and ribavirin does not necessarily exacerbate Sheehan's syndrome.

  PDF   |    Full Text | DOI: 10.23937/2469-567X/1510028

Review Article  |   Volume 3, Issue 2

Human Immunodeficiency Virus Infections in the Middle East and North Africa: Prevalence, Risk, Prevention and Challenges

Ahmed A Abd-Rabou

The Middle East and North Africa (MENA) has few recorded outputs regarding the prevalence of the human immunodeficiency viral (HIV) infections associated with acquired immune deficiency syndrome (AIDS). When we went through the HIV/AIDS in MENA, we found a hole in the scientific publications. Attention towards this issue progressed recently though, with few pre-clinical studies conducted. In the current review, we collected comprehensive data of HIV epidemiology in MENA and discussed the main challenges facing clinicians in charge with ailments in MENA and recommended some prevention strategies.

  PDF   |    Full Text | DOI: 10.23937/2469-567X/1510027

Review Article  |   Volume 3, Issue 2

Elimination of Mother-to-Child Transmission of HIV in Democratic Republic of Congo: Implementation of 'Test &Treat' Approach at Primary Health Centers

Mulamba Diese, Susie Villeneuve, Emile Numbi, Freddy Salumu, Guy Clarysse, Hilo Ilunga, Franck Fwamba, Theodore Assani and Abel Mukengeshayi Ntambue

The 'Test & Treat' approach, also called option B+, using combination antiretroviral treatment (cART) for prevention of mother-to-child transmission (PMTCT) has been very effective in controlled clinical trials in resource-limited settings. We report on our experiences with implementing this approach at primary healthcare settings in Katanga province, Democratic Republic of Congo (DRC). The objective of this study was to evaluate 'Test & Treat' approach for PMTCT interventions implemented between September 2013 and June 2015 at local health centers (LHC) in the DRC, in order to learn on the challenges for its scale up at national level.

  PDF   |    Full Text | DOI: 10.23937/2469-567X/1510026

Commentary  |   Volume 3, Issue 2

The Monitoring of Lymphocyte Populations may be Optional in Patients with Suppressed Viremia: A Two Years Observational Study

Carlos Tornero, Marina Llopis, Julian Diaz and Mariangeles Martinez

The determination of lymphocyte populations (LPs) traditionally has been included in the routine follow-up of HIV-infected patients as an indicator of the degree of immune suppression and of the need to start treatment, select the type of therapy, or prescribe preventive measures against opportunistic infections. However, the variability of the technique produces variations in patients with undetectable viremias that have no clinical consequences but which nevertheless generate uncertainty among the patients - with the resulting need for additional educational and reassurance measures.

  PDF   |    Full Text | DOI: 10.23937/2469-567X/1510025

Review Article  |   Volume 3, Issue 2

HIV Exposed Uninfected Children at School Age: Developing Country Context

Gwendoline Q Kandawasvika, Felicity Z Gumbo and Patience Kuona

With the success of chemoprophylaxis for the prevention of perinatal transmission of the human immunodeficiency virus (HIV), an increasing number of HIV-exposed but uninfected (HEU) children will have in utero and post-partum exposure to antiretroviral drugs and survive beyond infancy. The long term effect of antiretroviral drug exposure is however not fully understood. A few studies from developing countries have reported on growth, morbidity, mortality, nutrition, immunological profiles, neurodevelopment and behavioral disorders of HEU children.

  PDF   |    Full Text | DOI: 10.23937/2469-567X/1510024

Research Article  |   Volume 3, Issue 2

Determinants of Survival in HIV Patients: A Retrospective Study of Dilla University Hospital HIV Cohort

Solomon Hailemariam, Girma Tenkolu, Henok Tadese and Prabhanjan Kumar Vata

Highly Active Antiretroviral Therapy (HAART) has remarkably improved the survival of Human Immunodeficiency Virus (HIV) patients though it is not sufficient alone to achieve better HIV related clinical outcomes. There are many other modifiable factors that might have an impact on survival of HIV-infected patients. So far, few studies with small sample size have tried to assess the survival experience of HIV positive patients who are on treatment in Ethiopia. This study assessed the determinants of survival among HIV infected persons.

  PDF   |    Full Text | DOI: 10.23937/2469-567X/1510023