Open Access DOI:10.23937/2469-5726/1510027
Aspirin-Triggered Resolvin D1 Versus Dexamethasone in the Treatment of Sjogren's Syndrome-Like NOD/ShiLtJ Mice - A Pilot Study
Justin T Easley, Joel W Nelson, Rachel E Mellas, Salah Sommakia, Chunhua Wu, Bryan Trump, and Olga J Baker
Article Type: Research Article | Indexed Archive: Volume 1
Resolvin D1 (RvD1) and its aspirin-triggered epimeric form (AT-RvD1) are endogenous lipid mediators (derived from docosahexaenoic acid, DHA) that control the duration and magnitude of inflammation in models of complex diseases. Our previous studies demonstrated that RvD1-mediated signaling pathways are expressed and active in salivary glands from rodents and humans. Furthermore, treatment of salivary cells with RvD1 blocked TNF- -mediated inflammatory signals and improved epithelial integrity. T...
Open Access DOI:10.23937/2469-5726/1510026
A Rare Coexistence of Seronegative Enthesopathy and Arthropathy Syndrome with Familial Mediterranean Fever
Hakan Genc, Alper Gumustepe, Fikriye Figen Ayhan and Aynur Karagoz
Article Type: Case Report | Indexed Archive: Volume 1
The juvenile-onset spondyloarthropathies begin at age of 16 years or younger and are associated with the HLA-B27 allele. They are classified as the enthesitis-related arthritis (ERA) subgroup of juvenile idiopathic arthritis (JIA) by the international league of associations for rheumatology (ILAR) [1]. Although the adult form has inflammatory low back pain as the predominant clinical symptom, the juvenile form has peripheral enthesitis and arthritis as its main clinical features. For this reason...
Open Access DOI:10.23937/2469-5726/1510024
Hypercoagulation in Patients with Rheumatoid Arthritis Correlates with Activation of Act1/NF-kb Signaling Pathway
Pingheng Zhang, Jian Liu and Bing Tan
Article Type: Research Article | Indexed Archive: Volume 1
Peripheral blood samples were taken from 30 RA patients and 20 healthy volunteers, as controls. Ex vivo correlates of disease severity, such as C-reactive protein, erythrocyte sedimentation rate, anti-cyclic citrullinated peptide and rheumatoid factor, and immunological activation, such as interleukin (IL)-10, IL-17 and IL-6 were measured biochemically. Factors derived from the coagulation fibrinolytic system were also determined, such as the number of platelets, platelet activating factor, plat...
Open Access DOI:10.23937/2469-5726/1510023
Fatigue in Patients with Early-Stage Systemic Lupus Erythematosus Before Receiving Corticosteroid Therapy: A Prospective Cross-Sectional Study
Katsuji Nishimura, Masako Omori, Yasuhiro Katsumata, Eri Sato, Yasushi Kawaguchi, Masayoshi Harigai, Hisashi Yamanaka and Jun Ishigooka
Article Type: Original Article | Indexed Archive: Volume 1
Objective: Fatigue has been intensively studied in patients with systemic lupus erythematosus (SLE). However, previous studies have mostly included patients with long-term disease who have been treated with corticosteroids. We investigated fatigue in corticosteroid-naive patients with early-stage SLE. Methods: Forty-three SLE inpatients without neuropsychiatric SLE manifestations and 30 healthy control subjects with similar demographic characteristics participated in this study. The Profile of M...
