Open Access DOI:10.23937/2378-3001/1/1/1003

Therapeutic Significance of Frequency of Deep Brain Stimulation in Intractable Epilepsy

Alok Gupta and Harinder Jaseja

Article Type: Letter to Editor | First Published: September 30, 2014

Deep brain stimulation (DBS) is emerging as a viable alternative therapy in intractable epilepsy (IE), and although the exact mechanism and electrophysiology of its action remain elusive, some neuroscientists even believe that DBS may in near future become a first line treatment for the patients with IE who are not suitable candidates for epilepsy brain surgery. In addition to the exact placement of electrodes in the target site, the successful outcome of DBS depends largely upon correct choice ...

 Open Access DOI:10.23937/2378-3001/1/1/1002

Pelizaeus-Merzbacher Disease: An Inherited Leukodystrophy Natural History Studies in Understanding Neurogenetic Disorders

Jeremy J. Laukka

Article Type: Editorial | First Published: September 29, 2014

More than a century ago, in 1885 Friedrich Pelizaeus, a German Physician first identified a genetic disorder in five boys in a single family with nystagmus, spasticity of the limbs and developmental delay. Twenty-five years later in 1910, Ludwig Merzbacher independently reexamined this family and described further the neuropathology of 14 affected individuals and found that all affected members shared a common ancestor. Together, Pelizaeus and Merzbacher identified the exclusive X-linked inherit...

 Open Access DOI:10.23937/2378-3419/1/1/1005

Squamous Cell Carcinoma and Squamous Differentiation Histologic Variant of Urothelialcarcinoma of Urinary Bladder: Oncological Outcome Following Definitive Surgical Treatment

Mohamed Wishahi, Hossam Elganzoury and Mohamed Badawy

Article Type: Research Article | First Published: September 29, 2014

Objectives: To investigate the impact of variant histologic patterns of urothelialcarcinoma of the bladder on oncological outcomes of patients treated with Radical Cystectomy (RC). Three histologic patterns were evaluated: Urothelial Carcinoma (UC), Squamous Cell Carcinoma (SCC), and urothelial carcinoma with Squamous Differentiation (SqD). Materials and methods: Retrospective archival study included 258 patients treated with RCfor muscle-invasive carcinoma. Data were reviewed in demographic a...

 Open Access DOI:10.23937/2378-3397/1410009

Laparoscopic Resection of a Large Mesenteric Cyst - A Case Report

Willem M Deserno, Jeroen Heemskerk and Kim WFM Lambregts

Article Type: Case Report | First Published: October 03, 2014

Mesenteric cysts are rare lesions occurring in the abdomen. These cystic lesions can be asymptomatic or present with a specific symptoms. The decision whether to perform open or laparoscopic surgery depends on different features of the cystic lesion. If the cyst is thought to be of benign origin, a laparoscopic resection can be performed. We present a case of a young female with a large mesenteric cyst of 28cm, resected with laparoscopic approach....

 Open Access DOI:10.23937/2378-3397/1410008

Analysis of the Results on Perioperative Blood Loss after a Total Knee Arthroplasty Employing Tranexamic Acid Before or After Inflating the Tourniquet

Ana Torres, Mariano Fernandez-Fairen, Daniel Hernandez Vaquero and Jose Sueiro Fernandez

Article Type: Research Article | First Published: September 30, 2014

Introduction: Tranexamic acid has showed its good results reducing blood loss in total knee arthroplasties. It has also probed being cost-effective (red cell concentrate: 350 euros/ TXA vial 3, 05 euros) but it remains not being clear at what time during the surgery we have to administrate it. In this prospective, randomized study, we have investigated the effects of the use of tranexamic acid before or after inflating the tourniquet on blood loss, transfusion needs and thromboembolic complicati...

 Open Access DOI:10.23937/2378-3397/1410007

Renal Transitional Cell Carcinoma: Case report from the Regional Hospital Buea, Cameroon and Review of Literature

Eyongeta DE, Weledji and Enow Orock GE

Article Type: Case Report | First Published: September 29, 2014

Although transitional cell carcinoma is the most common tumour of the renal pelvis, we report the first histologically-confirmed case in our service in a period of about twenty years. The patient is a midaged female African, with no apparent risks for the disease. She presented with the classical sign of the disease (hematuria) and was treated by nephrouretectomy for a pT3N0MX grade II renal pelvic tumour. She is reporting well one year after surgery. The case highlights not only the peculiar di...

 Open Access DOI:10.23937/2378-3397/1410006

Predictors of Survival after Adult to Adult Living Donor Liver Transplantation (A-ALDLT)

Ayman Alsebaey, Maha Lotfy and Emad Hamdy Gad

Article Type: Research Article | First Published: September 26, 2014

Objectives: Adult-to-adult living donor liver transplantation (A-A LDLT) is an effective therapeutic modality to treat patients with end-stage liver disease. The aim of this study was to define the pre-, intra- and post- operative factors that may influence patient outcome. Methods: The data from 161 (A-A LDLT) patients who had operations between 2003 and 2013 were collected and analyzed retrospectively after exclusion of mortality due to intra-operative bleeding. Data were analyzed using uni-...

 Open Access DOI:10.23937/2378-3397/1410005

Vascular Complications after Adult to Adult Living Donor Liver Transplantation: Single Center Experience

Emad Hamdy Gad, Ahmed Elshawadfy Sherif, Hosam Solyman, Mohammed Elwarraky, Khaled AbouElela, Tarek Ibraheem and Koichi Tanaka

Article Type: Research Article | First Published: September 25, 2014

Objectives: Vascular complications (VC) after living donor liver transplantation (LDLT) are one of the most feared problems that result in graft and patient loss. The aim of this study was to assess the incidence, treatment, and outcome of vascular complications of patients after adult to adult LDLT in a single Egyptian center. Methods: Between April 2003 and February 2013, we performed 167 adult to adult LDLT. The overall male/female ratio was 147/20. We retrospectively identified and analyzed ...

 Open Access DOI:10.23937/2378-3397/1410004

Precision of Measurements from Computed Tomography (CT), Cone Beam Computed Tomography (CBCT) and their Reformatted Images in Pre-Operative Implant Assessment

Mushira M. Dahaba, Sherouk Khalifa and Walid Samir Salem

Article Type: Research Article | First Published: September 23, 2014

Background: Preclude the accuracy of dimensional, and linear measurements yielded from CBCT images, panoramic images reformatted from spiral CT, and panoramic images reformatted from CBCT in comparison to the measurements obtained from the cross-sectional CT. Methods: Twenty patients attending the Oral Maxillofacial Surgery Department, for placement of dental implants in both jaws (10 subjects required mandibular and the other ten required 10 maxillary). Results: A significant difference bet...

 Open Access DOI:10.23937/2377-4630/1008

Is Left Ventricular Hypertrophy Early Regression Possible?

Delgado-Baeza Emilio, Quintana-Villamandos Begona

Article Type: Editorial | First Published: September 30, 2014

It is well established that hypertension is associated with increased cardiovascular morbidity and mortality. Left Ventricular Hypertrophy (LVH) is a relevant problem in patients with hypertension because of its role in long-term severe cardiovascular diseases, including ventricular arrhythmia, congestive heart failure, myocardial infarction, stroke and sudden death. There is a relationship between the regression of LVH and a decreased morbidity and mortality. Treatment to achieve regression of ...