Open Access DOI:10.23937/2378-3656/1410024
Metastatic Gallbladder Cancer Masquerading as Primary Colon Malignancy
Zhifei Sun, Jonathan Galeotti, Shannon McCall and Christopher R. Mantyh
Article Type: Case Report | First Published: March 28, 2015
We report a 69-year-old female with personal history of gallbladder cancer who was referred to our institution with a circumferential obstructing intra-luminal colonic mass that possessed pathological features common to both primary colorectal as well as gallbladder cancer, which posed a significant diagnostic and treatment challenge. This case reviews the method and rationale for arriving at the final diagnosis of gallbladder cancer metastasis and highlights the importance of modern molecular d...
Open Access DOI:10.23937/2474-3631/1510003
The Relationship between Psychoactive Drugs, the Brain and Psychosis
Sutapa Basu and Deeptanshu Basu
Article Type: Review Article | First Published: March 26, 2015
This paper explores the interaction between four psychoactive drugs, namely MDMA (Ecstasy), Cocaine, Methamphetamine and LSD, with neurotransmitters in the brain with the aim of understanding what links exist between these drugs and Psychosis. The paper aims to go beyond existing research on drugs and psychosis which has been primarily limited to cannabis (Marijuana) and psychosis. The findings and conclusions drawn show that all the drugs explored have the potential to induce psychosis in abuse...
Open Access DOI:10.23937/2474-3631/1510002
Logistic Regression to Assess Risk Factors in Offspring from Brazilian Families with Alcohol and Drug Problems
Roberta Paya, Luca Gomes Santoro, Denise Leite Vieira and Neliana Buzi Figlie
Article Type: Research Article | First Published: March 26, 2015
A case-control study was conducted with a convenience sample; the participants were paired by sex and age. Three hundred five families with children and adolescents (4-18 years of age) were evaluated; 60% (n=183) were in the study group, and 40% (n=122) were in the control group. In the study group, 73% (n=133) of the families had fathers with drinking problems and 27% (n=50) had fathers with illicit poly-drug addiction....
Open Access DOI:10.23937/2378-3516/1410016
Community Acquired Pneumonia
Sonia Akter
Article Type: Review Article | First Published: March 21, 2015
Community-acquired pneumonia is defined as an acute infection of the pulmonary parenchyma in a patient who has acquired the infection in the community. CAP remains a common and potentially serious illness. It is associated with considerable morbidity, mortality and treatment cost, particularly in elderly patients. CAP causes problems like difficulty in breathing, fever, chest pains, and cough....
Open Access DOI:10.23937/2378-3672/1410006
A Critical Review of Steroid Immunotherapy in Kidney Transplantation
Oluwatoyin Bamgbola
Article Type: Review Article | First Published: March 21, 2015
Steroid immunosuppression has maintained a long-lasting relevance in renal transplantation. In addition to its role in preserving allograft survival, it is often the fist line agent in the rescue treatment of acute rejection events. Its major drawbacks include metabolic adverse effects and long-term cardiovascular morbidities. Motivated by the need to avoid growth impairment, pediatric renal transplant community provided a template for steroid minimization strategy....
Open Access DOI:10.23937/2378-3419/2/2/1014
Nitric Oxide Attenuates Hypoxia-Induced 5-FU Resistance of Oral Squamous Cell Carcinoma Cells
Eri Sasabe, Ayumi Tomomura, Mayuko Hamada, Naoya Kitamura, Tomohiro Yamada and Tetsuya Yamamoto
Article Type: Original Article | First Published: March 16, 2015
Hypoxic environments in tumors induce expression of hypoxiainducible factor (HIF). HIF contributes to the development of the malignant progression through the induction of various target genes. We previously reported that treatment with chemotherapeutic drugs and γ-rays enhances expression and nuclear translocation of HIF-1α under normoxic conditions; susceptibility of oral squamous cell carcinoma (OSCC) cells to the drugs and γ-rays is negatively correlated with expression of HIF...