Open Access DOI:10.23937/2469-5726/1510012

Pathogenesis of Bone Erosions in Rheumatoid Arthritis: Not Only Inflammation

Maurizio Rossini, Angelo Fassio, Luca Idolazzi, Ombretta Viapiana, Elena Fracassi, Giovanni Adami, Maria Rosaria Povino, Maria Vitiello and Davide Gatti

Article Type: Review Article | First Published: May 22, 2015

It is a matter of fact that the inflammatory pathogenesis does not explain all the skeletal manifestations of Rheumatoid Arthritis (RA), and the development of bone involvement is sometimes unconnected from the clinical scores of inflammation. On the basis of recent studies, we would like to make a point of the new available evidence about the metabolic pathogenic component of bone erosions....

 Open Access DOI:10.23937/2469-5726/1510011

Screening for Mucopolysaccharidoses in Pediatric Rheumatology Clinic

Magrini D, Lehman TJA and Moorthy LN

Article Type: Research Article | First Published: May 21, 2015

Mucopolysaccharidosis (MPS) is a rare group of inherited lysosomal storage disorders that is associated with multiple symptoms including joint stiffness, misshapen bones, reduced hand function, frequent otitis media, 'thickened' facial features, hearing problems, vision problems and heart complications. We conducted this study to determine how many (if any) children that come to pediatric rheumatology have unrecognized MPS and if routine screening for MPS is needed....

 Open Access DOI:10.23937/2469-5726/1510010

Spondyloarthropathy, Spondyloarthritis, Axial Spondyloarthritis: A Rose by any other Name?

Bruce Rothschild

Article Type: Editorial | First Published: May 13, 2015

What is a diagnosis, but recognition of a phenotype? The term spondyloarthropathy is much debated, with alternative appellation suggestions. Spondyloarthritis and spondylarthritis have been suggested, but there has also been a movement to separate peripheral and axial disease, with the latter referred to as axial spondyloarthropathy....

 Open Access DOI:10.23937/2469-5742/1510005

Repeated Intradetrusor Botulinum Toxin Type A Injections are Still Effective for Patients with Neurogenic Detrusor Overactivity Secondary to Spinal Cord Injury in China

Hui Chen, Xing Hua Yang, Jing Wen Zeng, Ma Ping Huang, Qiu Ling Liu, Jie Bing Huang, Tian Hai Huang, Ke Ji Xi and Chong He Jiang

Article Type: Research Article | First Published: May 20, 2015

Objective: To assess effective outcomes following repeated treatment with intradetrusor botulinum toxin type an in patients with neurogenic detrusor overactivity (NDO). Methods: Patients with NDO secondary to spinal cord injury (SCI) were enrolled. Botulinum toxin type A 200 U detrusor injections by a rigid cystoscope were repeated....

 Open Access DOI:10.23937/2377-9004/1410038

The Gravid Patient Presenting with Laryngeal Angioedema

Luke Maxfield Jessica R Jackson and Julie Decesare

Article Type: Case Report | First Published: May 08, 2015

Laryngeal swelling can be life threatening with etiologies including angioedema and cellulitis. While both involve swelling of subcutaneous tissues angioedema involves extravasation of fluid into interstitium while cellulitis is caused by direct extension of a spreading infection. The cause of angioedema involves multiple etiologies with response to treatment varying with underlying pathophysiology....

 Open Access DOI:10.23937/2377-9004/1410037

A Case of Arthrogryposis Multiplex Congenita in One Identical Twin Pregnancy

Ulas Fidan, Fahri Burcin Firatligil, Kazim Emre Karasahin, Mustafa Ulubay, Ugur Keskin and Ali Ergun

Article Type: Case Report | First Published: May 06, 2015

Arthrogryposis multiplex congenita, is a developmental deformation characterized with multiple joint contructures that is seen in one delivery out of 3000 in average. The limitation of fetal movements which start in early pregnancy weeks especially at the 7th or 8th gestastional week, is the most important factor in etiology....

 Open Access DOI:10.23937/2469-5734/1510008

Effectiveness of Shade Measurements Using a Scanning and Computer Software System: a Pilot Study

Gotfredsen K, Gram M, Ben Brahem E, Hosseini M, Petkov M and Sitorovic M

Article Type: Research Article | First Published: April 25, 2015

The esthetic result has become more attention and one important aspect to obtain a good esthetic result is to obtain the most optimal shade of the prosthetic reconstruction. The shade is of greatest importance when patients judge the quality of the restoration especially in the anterior region. The ideal shade is the shade from the natural, neighboring teeth....

 Open Access DOI:10.23937/2378-3656/1410028

Application of Multiple Novel Imaging Modalities for Guidance and Treatment of the Patient with Subaortic Stenosis

Xiaomei Lin, Howard Axelrod, Bruno Dantas, Patrick O'Beirne, Kenneth Khaw, Edward Wrobleski, John Saia, Gerald Ukrainski, Lannae Ewing, Chad Bousanti, Lawrence J Wehner and Jingsheng Zheng

Article Type: Case Report | First Published: April 30, 2015

Discrete Subvalvar Aortic Stenosis (DSS) is an uncommon acquired cause of left ventricular outflow tract obstruction (LVOT) and often found during Transthoracic Echocardiography (TTE). The membranes are located adjacent to the Aortic Valve (AV) or extended to the anterior leaflet of the mitral valve. The high-velocity systolic jet collides and damages the AV leaflets making the valve more likely to fail and more susceptible to clot and vegetation formation....

 Open Access DOI:10.23937/2378-2951/1410031

Anomalous Right Coronary Artery Arising from the Ascending Aorta Above the Left Sinus of Valsalva in the Setting of Acute Inferior ST-Elevation Myocardial Infarction: Unique Challenges and Literature Review

Nisharahmed Kherada, Sandeep Singla, Saqib Ali Gowani, Francesca Gallarello and Nirat Beohar

Article Type: Case Report | First Published: May 02, 2015

Anomalous origin of the right coronary artery arising from ascending aorta above the left sinus of Valsalva is an extremely rare coronary anomaly. In the setting of an acute myocardial infarction rapid identification, localization and selective cannulation of this 'culprit' anomalous right coronary artery presents a challenging scenario. Here we describe a case with this anomaly presenting as an acute inferior wall myocardial infarction along with description of its distinctive interventional ch...

 Open Access DOI:10.23937/2377-4630/2/2/1029

Early Signs and Perinatal Diagnosis of Tracheal Agenesis

Mayke E. van der Putten, Viola Christmann, Lucas E. Matthyssens, Arthur R.T. Scheffer and Chris Bleeker

Article Type: Case Report | First Published: May 11, 2015

A preterm boy of 30 weeks and fie days did not breathe spontaneously at birth and despite visualization of the vocal cords, intubation attempts did not succeed, until a tube 2.0 was placed using an Eschmann stylette, mistakenly considered endotracheal. A few hours later, suspicion of tube dislocation arose and renewed intubation attempts failed. The ENT specialist performed a tracheoscopy and found a blind ending of the trachea in the subglottic area....