Open Access DOI:10.23937/2474-3658/1510007
Legionella's Pneumoniae: A New Outbreak in Spain and Urinary Antigen Test Review
Soraya Jodra Sanchez, Jacinto Ramos Gonzalez, Maria Teresa Santos Jimenez, Rosa Cordovilla Perez, Jose Maria Gonzalez Ruiz, Ana Maria Sanchez Hernandez, Sergio Cadenas Menendez and Miguel Barrueco Ferrero
Article Type: Short Review | First Published: February 27, 2016
Since the microorganism Legionella pneumophila (Lp) was identified during an American Legion Convention in Philadelphia in 1976, it has been recognised as a common cause of both extra- and intra-hospital pneumonia [1]. The incidence of community-associated pneumonia (CAP) due to Lp varies widely from one area to another, hovering around 1% in subjects treated on an outpatient basis and 15-28% in hospitalised patients. Of these, approximately a quarter require admission to an intensive care unit ...
Open Access DOI:10.23937/2474-3658/1510006
The Role of Procalcitonin as a Biomarker in Sepsis
Bethel Shiferaw, Ebisa Bekele, Krishan Kumar, Anthony Boutin and Marianne Frieri
Article Type: Review Article | First Published: February 11, 2016
Sepsis and its complications are one of the leading causes of mortality. Timely diagnosis and treatment is highly important in reducing the morbidity and mortality. Serum biomarkers may aid in the early diagnosis of sepsis and therapeutic intervention. Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin and its primary trigger is infection. PCT is identified as part of the complex pro-inflammatory response of the innate immune system....
Open Access DOI:10.23937/2378-3656/1410089
Aeroportia - A Rare Finding for a Frequent Disease
Marta Pereira, Luis Miguel Afonso, Sofia Patrao and Rui Araujo
Article Type: Case Report | First Published: February 13, 2016
A 69-year-old female was admitted to our hospital with complaints of abdominal pain and diarrhea for the last 2 weeks. She was obese, diabetic, and had peripheral arterial disease, but no history of bowel disease or previous gastrointestinal symptoms. Physical examination revealed severe dehydration, hypotension, and diffuse abdominal discomfort. Acute kidney injury with anuria and significant leukocytosis were documented. Furthermore, the patient had severe lactic acidosis....
Open Access DOI:10.23937/2378-3656/1410088
Stevens - Johnson Syndrome and Intestinal Perforation following regorafenib Administration for Metastatic Rectal Cancer: A Case Report
Tetsuhito Muranaka, Yoshito Komatsu, Kentaro Sawada, Hiroshi Nakatsumi, Yasuyuki Kawamoto, Satoshi Yuki, Riichiro Abe, Kanako C Hatanaka and Naoya Sakamoto
Article Type: Case Report | First Published: February 09, 2016
Regorafenib monotherapy is useful for the treatment of colorectal cancer (CRC), which is refractory to multiple anti-cancer agents. However, it is associated with a high incidence of adverse events such as hand-foot skin reactions, elevated liver enzymes, etc. Although there are few reports of Stevens-Johnson syndrome (SJS) or intestinal perforation associated with regorafenib, such events should be taken into consideration, as with various other anti-cancer therapies, including bevacizumab....
Open Access DOI:10.23937/2378-2951/1410072
Increased Corrected QT Interval (QTc) in First Nations Women of Northern British Columbia with Systemic Lupus Erythematosus (SLE)
Fritha A Munday, Sirisha Asuri, Sarah McIntosh, Heather Jackson, Anthony Tang and Laura Arbour
Article Type: Original Article | First Published: January 30, 2016
Long QT Syndrome (LQTS), a genetic predisposition to sudden cardiac death is defined by a prolonged corrected QT interval (QTc) measured on electrocardiogram (ECG). A participatory research project has been underway with the Gitxsan of Northern BC for more than ten years where the condition (LQTS1) is common, due to a founder mutation (V205M) in KCNQ1. It is effectively treated with beta blockers and avoidance of QT prolonging drugs. Some chronic conditions are also known to increase the QTc, wh...
Open Access DOI:10.23937/2378-2951/1410071
Effects of Erythropoietin Administration on Cardiomyocytes in Landrace/Large White Pigs after Ventricular Fibrillation
Armando Faa, Gavino Faa, Eliana Di Felice, Pietro Pampaloni, Daniela Fanni, Daniele Scano, Clara Gerosa, Maria Elena Pais, Panagiotis Vasileiou, Dimitrios Barouxis, Pavlos Lelovas, Theodoros Xanthos, Charalampos Pantazopoulos, Apostolos Papalois and Nicoletta Iacovidou
Article Type: Research Article | First Published: January 28, 2016
Ventricular fibrillation was induced via a pacing wire forwarded into the right ventricle in 20 female Landrace/Large-White pigs, allocated into 2 groups; the experimental group treated with a bolus dose of 5,000 U/Kg recombinant human erythropoietin and the control group which was administered saline. Cardiopulmonary resuscitation (CPR) was performed immediately after drug administration....
Open Access DOI:10.23937/2378-2951/1410070
Spontaneous Coronary Artery Dissection: Report of 6 Cases and Literature Review
Adolfo Ferrero Guadagnoli, Miguel A Ballarino, Carlos R Leonardi, Alejandro E Contreras, Eduardo J Brenna and Jonathan Miara
Article Type: Research Article | First Published: January 27, 2016
We present our recent casuistry on such an interesting issue as coronary dissections. Provide data to assist the diagnosis and treatment of this disease. Spontaneous coronary artery dissection is a non-traumatic and non-iatrogenic separation of the coronary artery walls. It is a rare cause of acute coronary syndrome, mainly affecting women with no significant cardiovascular risk factors and has varying presentations from mild chest pains to sudden cardiac death....