Open Access DOI:10.23937/2469-584X/1510040
One Size Doesn't Fit All: IBD in Arabs and Jews in Israel, Potential Environmental and Genetic Impacts
Aaron Lerner and Torsten Matthias
Article Type: Editorial | First Published: January 07, 2017
Inflammatory bowel disease (IBD) is influenced by genetic susceptibility and surrounding environmental factors. Despite unknown etiology, the environmental factors are continuously unraveled. Studying ethnical differences in a well characterized and stable region might disclose etiologies and pathophysiological mechanism. The ethnical trends in IBD in Israel disclosed incidents, epidemiological, clinical, therapeutical and morbidity differences between the Arabs and Jews dwelling in a non-migran...
Open Access DOI:10.23937/2469-584X/1510039
MMPs, ADAMs and Their Natural Inhibitors in Inflammatory Bowel Disease: Involvement of Oxidative Stress
Filippo Fontani, Vladana Domazetovic, Tommaso Marcucci, Maria Teresa Vincenzini and Teresa Iantomasi
Article Type: Review Article | First Published: January 05, 2017
Matrix metalloproteinases (MMPs) are enzymes involved in the degradation of extracellular matrix proteins and in several functions such as wound repair. The regulation of MMPs occurs at various levels including expression and inhibition by tissue specific inhibitors of MMPs (TIMPs). An alteration of intracellular redox state can modulate the activation and/or expression of MMPs. The increased expression and activity of MMPs are related to inflammatory state and pathogenesis of inflammatory bowel...
Open Access DOI:10.23937/2469-5750/1510041
A Relapsing Polychondritis and Malignancies: A Case Report and Review of Literature
Ben Salah Raida, Cherif Yosra, Frikha Faten, Snoussi Mouna, Jallouli Moez, Marzouk Sameh and Bahloul Zouhir
Article Type: Case Report | First Published: December 17, 2016
Some case reports and series presumed a link between malignancy and relapsing polychondritis. The most frequent described neoplasms have been hematological disorders especially myelodysplastic syndromes. Less commonly have also been reported solid neoplasms as colorectal cancer like our patient. We suggest that patients with RP should be monitored more carefully even in remission for early detection of cancer....
Open Access DOI:10.23937/2474-3690/1510021
Effects of Methotrexateonil-6alphar, VCAM-1 and NF Kappa B Expression in a Rat Model of Metabolic Syndrome
Nicolas F Renna, Jesica M Ramirez, Rodrigo D Garcia, Emiliano A Diez and Roberto M Miatello
Article Type: Research Article | First Published: December 17, 2016
Increasing evidence suggests that immune activation and inflammatory mediators may play a role in the development and progression of atherosclerosis. Several studies have shown that patients with some diseases characterized by inflammatory mediator activation, which rheumatoid arthritis (RA), presented accelerate atherosclerosis. RA is a systemic inflammatory disease and the most common cause of death is due to accelerated atherosclerosis, especially coronary artery disease....
Open Access DOI:10.23937/2378-3656/1410149
Isolated Limb Infusion in a Pregnant Patient with Sarcoma of the Upper Extremity: A Case Report with Literature Review
Milovanov V, Wodago FM, Sittig M and Gushchin V
Article Type: Case Report | First Published: December 19, 2016
Several scientific publications have shown Isolated Limb Infusion (ILI) as a promising treatment option for patients with soft tissue sarcomas. This minimally invasive technique has a high complete response rate (42-90%) and could serve as a neo-adjuvant treatment for limb sparing sarcoma surgical treatment to increase the likelihood of R0 resection. ILI technique has low levels of systemic leak (< 1%) and systemic toxicity rate, which makes this treatment potentially relevant in pregnant patien...
Open Access DOI:10.23937/2469-5777/1510047
Delayed-Onset Pericarditis in Non-penetrating Blunt Force Trauma: A Case Report
Andrew Mc Cague, Kerala Serio and Joanne Leibe
Article Type: Case Report | First Published: December 24, 2016
There have been rare documented instances where blunt-force trauma has been suspected to cause a delayed disease process that manifests days or weeks after the initial injury. This is a case report of a 30 year old male who suffered blunt chest trauma during a motor vehicle accident. On hospital day five the patient began to complain of significant chest pain, an increase in pain with each heartbeat, increased pain when sitting up, shortness of breath and experienced a syncopal episode in the sh...
Open Access DOI:10.23937/2469-5777/1510046
Isolated Pancreas Injury by Blunt Trauma, a Case Report
Samet Sahin, Raziye Duruk, Cengiz Ceylan, Erdinc Cetinkaya and Mesut Tez
Article Type: Case Report | First Published: December 24, 2016
We here in present our experience with the rare injury of main pancreatic duct because of the blunt trauma and managed by pancreatico-enterostomy. A 35-year-old male patient presented with a motor vehicle accident and was diagnosed isolated pancreas main duct ınjury by blunt trauma. Computerized tomography (CT) was used as a diagnostic method and were confirmed by Endoscopic retrograde cholangiopancreatography (ERCP)....
Open Access DOI:10.23937/2378-3656/1410148
An İncidental Findings of Polysplenia Syndrome in an Adult Patient with Multiple Anomalies
Mehmet Sedat Durmaz, Ali Cengiz, Serdar Arslan, Hasan Erdogan, Ismet Tolu and Arzu Cengiz
Article Type: Case Report | First Published: December 16, 2016
Polysplenia syndrome is a rare congenital subtype of heterotaxy syndrome associated with various visceral and vasculer anomalies. Polysplenia syndrome is characterized by presence of two or more spleens and anomalies of other asymetric organs. It is reported incidence of 1 per 250.000 and more common in females. Here, we report the case of a 53-year-old woman who presented with polysplenia syndrome....
Open Access DOI:10.23937/2469-5866/1510017
Headache Attributed to Obsessive Compulsive Disorder of Mastication
Mianwang He, Xiaolin Wang and Shengyuan Yu
Article Type: Editorial Letter | First Published: December 23, 2016
A 51-years-old man who had developed severe phobia, anxiety since took illicit drugs twice 10 years ago, subsequently palpitation and shortness of breath appeared, having a continuous feeling that someone would attack him and he would die soon. Only mastication can partially relieve phobia and anxiety, and continuous involuntary mastication habit with left side teeth was developed. Anxiety and depression diagnosis was made by local clinic, but he didn't take the prescribed drugs....
Open Access DOI:10.23937/2469-5866/1510016
Meta-analysis of Association between Helicobacter pylori Infection and Epilepsy
Gang Yao, Ping Wang, Xiang-Dan Luo and Ting-Min Yu
Article Type: Original Article | First Published: December 06, 2016
Despite recent research focus on the association between Helicobacter pylori (H. pylori) infection and epilepsy there is no consensus about the findings. To obtain a more comprehensive estimate of the association we conducted a meta-analysis to determine the prevalence of H. pylori infection in epilepsy patients and healthy controls. PubMed, EMBASE, Cochrane Library, Web of Science, Google Scholar and CINAHL were searched to identify eligible studies. ...