Open Access DOI:10.23937/2378-3419/1410082

Radiolabeled APIs for the Conduct of Human ADME Studies of Oncology Compounds

Yuexian Li, Mihaela Plesescu and Shimoga R Prakash

Article Type: Research Article | First Published: August 30, 2017

Human ADME (Absorption, Distribution, Metabolism, and Excretion) studies of new chemical entities are an important part of the drug development process. These studies are normally performed by using a radioactive tracer (C-14 or H-3) blended with a therapeutic dose of non-radioactive drug in about four to six subjects. The radiolabeled API (Active Pharmaceutical Ingredient) is utilized to evaluate the recovery and track the metabolic fate and physiological disposition of the drug....

 Open Access DOI:10.23937/2572-4053.1510016

Valeriana Officinalis and Melissa Officinalis Extracts Normalize Brain Levels of GABA and Glutamate Altered by Chronic Stress

Francesco Scaglione and Andrea Zangara

Article Type: Research Article | First Published: September 18, 2017

Despite being traditionally used herbals to treat mild anxiety and sleep disorders, Valeriana officinalis and Melissa officinalis mechanism of action is not fully understood. While the pattern of mood modulation of both herbals suggests the involvement of the Gamma-Aminobutyric Acid (GABA) ergic system, other changes in the neurotransmitters pathways can provide an explanation for the clinical effects....

 Open Access DOI:10.23937/2377-9004/1410106

Management of Maternal Atrial Myxoma in Advanced Pregnancy: A Clinical Dilemma

Emma Wilson, Karthikeyan Gopal, Jay Iyer, Robert Tam, Ryan Schrale and Yaniv Zipori

Article Type: Case Report | First Published: October 16, 2017

In this report, we present a challenging case of pedunculated left atrial myxoma which was initially diagnosed on Transthoracic Echocardiography (TTE) at 39 weeks and 2 days gestation in a grand-multigravida woman with previous normal deliveries. She was delivered by urgent caesarean section with resection of the myxoma on the following day....

 Open Access DOI:10.23937/2377-9004/1410105

Outcome of Novasure Endometrial Ablation in Women with Heavy Menstrual Bleeding with or without Dysmenorrhoea, Including Those with Uterine Cavity Length More Than 6.5 cm

Nader Gad, Ashlee Rigby, Alia Vemuri and Mahima Singh

Article Type: Research Article | First Published: October 14, 2017

Heavy Menstrual Bleeding (HMB) is a common health problem and may be associated with iron deficiency anaemia affecting the quality of life of many women. Problems of HMB can be more complicated when it is associated with dysmenorrhea. Traditionally, medical management of HMB has been the first line therapy....

 Open Access DOI:10.23937/2377-9004/1410104

Challenges with Cervical Cancer Treatment in Cameroon

Simon Manga, Mireille Kanjo and Wilfred Ngwa

Article Type: Case Study | First Published: October 13, 2017

This is a case study of women with Invasive Cervical Cancer (ICC) and her course of treatment, showing the critical need for prevention through aggressive screening and vaccination programs. Even though cost of treatment was a barrier, she completed her radiation therapy and felt better....

 Open Access DOI:10.23937/2469-5823/1510080

Cultural Awareness: Coining and Cupping

Susan Ann Vitale and Thaleshravi Prashad

Article Type: Review Article | First Published: September 20, 2017

The theory of culture care diversity and universality, as described by the renowned anthropologist and nursing leader, Madeleine Leninger suggests that care should be both culturally competent and sensitive to its diverse populations. Within this theory, emphasis is placed on delivering respectful care for patients and their families....

 Open Access DOI:10.23937/2469-5823/1510079

Conceptual Framework for Nurses in the Use of the Neuman Systems Model on Caregivers of People Suffering by Schizophrenia

Kerime Bademli and Zekiye Çetinkaya Duman

Article Type: Review Article | First Published: September 20, 2017

Nursing knowledge is shaped by nursing conceptual models and nursing theories. Nursing theories and models explain the basic metaparadigm concepts related to nursing discipline and the correlation between these concepts, and focus on the role of nursing. Models bring a point of view on nursing and direct nursing practices. Conceptual models in nursing bring a common meaning to the basic concepts of nursing....

 Open Access DOI:10.23937/2469-5823/1510078

The Impact of Watching Movies on the Communication Skills of Nursing Students: A Pilot Study from Turkey

Ilkay Keser and Gülşah Acar

Article Type: Research Article | First Published: September 11, 2017

Communication skills can be improved in a variety of ways at any time of life. It is known in our country and in the world that watching films has a positive effect on individuals. In addition to traditional verbal lectures teaching skills to be learned by students, watching movies is thought of as contributing to the acquisition of permanent knowledge. Therefore, this study was conducted to examine the effect of watching movies on nursing students' communication skills. ...

 Open Access DOI:10.23937/2474-3658/1510038

Cytomegalovirus Infection of the Gastrointestinal Tract in Soweto, South Africa: A Look Back at the Clinical and Histological Features over 8 Years

Reena Dhansukh Mohanlal and Alan Karstaedt

Article Type: Research Article | First Published: August 26, 2017

Despite the widespread availability of antiretroviral therapy, Cytomegalovirus (CMV) infection remains an important cause of morbidity and mortality in sub-Saharan Africa. CMV gastrointestinal tract infection is poorly described. This retrospective study was undertaken to describe the clinical and histological features of biopsy confirmed CMV infection of the gastrointestinal tract in a large teaching hospital with a high prevalence of Human Immunodeficiency Virus (HIV) infection....

 Open Access DOI:10.23937/2572-3243.1510040

Intramedullary Gas not Related to Infection

Marian Vives Barquiel , Jose Roberto Ballesteros Betancourt, Raquel Garcia Tarrino, Manel LLusa, Guillem Claret, Xavier Tomas Batlle, Borja Garcia Torres, Guillem Navarro, Jose Estrada and Alex Soriano

Article Type: Case Report | First Published: August 31, 2017

The presence of gas in joints or soft tissues is usually indicative of infectious pathology or degenerative diseases. However, the presence of gas inside the medullary canal in the diaphysis of long bones is an uncommon condition, and it is often associated with fractures or previous surgeries....