Open Access DOI:10.23937/2378-346X/1410083
Intraocular Pressure-Lowering Effect of Ripasudil Hydrochloride Hydrate and Reasons for Discontinuation of Use in Clinical Practice
Kana Kawara, Akiyasu Kanamori, Sotaro Mori, Yukako Inoue, Takuji Kurimoto, Sentaro Kusuhara, Yuko Yamada and Makoto Nakamura
Article Type: Research Article | First Published: January 26, 2018
The median pre- and post-application IOP at 1, 3, and 6 months was 19.0, 17.5, 17.0, and 16.0 mmHg, respectively. IOP was significantly reduced after ripasudil application at all time points (P < 0.00001, the mixed effect model). The pre-application IOP and glaucoma type were associated with the IOP-lowering effect of ripasudil. Twenty-seven and 8 patients discontinued the application because of unsatisfactory IOP reduction and intolerable side effects, respectively....
Open Access DOI:10.23937/ncr-2017/1710001
Primary Central Nervous System Lymphoma: A Differential of Midline Crossing Lesions
Renu Pokharna, Miles W Reese, Souvik Sen and Tushar Trivedi
Article Type: Case Report | First Published: January 11, 2018
Primary Central Nervous System Lymphoma (PCNSL) is a rare non-Hodgkin type neoplasm, which crosses the midline. We report an unusual case of a 71-year-old Caucasian female who was shown to have PCNSL by a tissue biopsy after the brain Magnetic Resonance Imaging (MRI) showed Central Nervous System (CNS) lesions crossing the corpus callosum....
Open Access DOI:10.23937/2469-5726/1510058
The Role of Interleukin-37 in Inflammation: Suppression or Promotion?
Liping Ding, Xiaoping Hong and Dongzhou Liu
Article Type: Mini Review | First Published: January 22, 2018
IL-37 not only has anti-inflammatory effects, but also induces marked metabolic changes with higher levels of muscle AMPK, greater rates of oxygen consumption, and increased oxidative phosphorylation both in the context of inflammation- induced fatigue and in healthy mice. In addition, expression of human IL-37 in mice could protect cardiomyocytes from apoptosis and suppress the migration ability of neutrophils in myocardial ischaemia/reperfusion injury condition....
Open Access DOI:10.23937/2377-9004/1410112
Biamniotic Parasitic Conjoined Twins with Discordant Genotype
Sofie C Husen, Maarten FCM Knapen, Femke AT de Vries, Robert M Verdijk and Lutgarde CP Govaerts
Article Type: Case Report | First Published: January 20, 2018
Conjoined twin pregnancies are uncommon. The prevalence of conjoined twins in the first trimester of pregnancy is estimated as 1:50,000, with an unexplained female predominance (3:1). It is thought that at 13-14 days gestational age an incomplete fission of the germinal disc causes the development of a conjoined twin pregnancy, obligatory being associated with a monochorionic monoamniotic placentation. ...
Open Access DOI:10.23937/2377-9004/1410111
Tension Free Vaginal Tape Erosion into the Urinary Bladder: A Case Report
Priyanka Singh and Han How Chuan
Article Type: Case Report | First Published: December 28, 2017
The Tension-free Vaginal Tape (TVT) is the most commonly performed procedure for the management of Stress Urinary Incontinence (SUI). There is insufficient data on the occurrence of complications and their management. The incidence of tape erosion and infection is observed to be higher with synthetic non-absorbable slings....
Open Access DOI:10.23937/2572-4053.1510018
Corticosterone Response in Sleep Deprivation and Sleep Fragmentation
Yonglin Gao, Brandon Akers, Michael B Roberts and Rif S El-Mallakh
Article Type: Research Article | First Published: December 23, 2017
Rapid Eye Movement (REM) sleep deprivation is understood to be associated with more severe negative effects than REM fragmentation. Comparison of the corticosterone response between these patterns of sleep disruption has not been well characterized. Black Swiss mice were exposed to 1-day and 3-day periods of REM deprivation with inverted flower-pot method or REM fragmentation using the moving bar method. ...
Open Access DOI:10.23937/2572-4193.1510034
Cricoid Pressure during Rapid Sequence Induction - Time to Let Go and Grab the Ultrasound?
RA Fearnley, S Badiger, CA Oti and I Ahmad
Article Type: Research Article | First Published: January 20, 2018
Accurate localisation of the cricoid cartilage is a key step in the successful application of cricoid pressure during rapid sequence induction. Poorly localised pressure is unlikely to confer any protective benefit to our patients and may have deleterious effects on laryngoscopy. We postulated that the use of ultrasound would greatly improve the accuracy of cricoid cartilage localisation prior to the application of cricoid pressure....
Open Access DOI:10.23937/2469-584X/1510054
A Retrospective Study of Catheter-Related Thrombosis Using the Central Vein Catheters for the Ulcerative Colitis Patients
Shinichiro Koketsu, Shinichi Sameshima, Takashi Okuyama, Hiroshi Shigematsu and Masatoshi Oya
Article Type: Research Article | First Published: January 22, 2018
Leukocyte apheresis is a therapeutic option for moderate-to-severe active ulcerative colitis in Japan. It causes fewer complications, however, leukocyte apheresis requires the use of a relatively large caliber of peripheral venous line for hemodialysis. We reluctantly used a large caliber catheter with a double-lumen into the central vein. Catheter-related thrombosis and infection cases were occasionally observed during leukocyte apheresis. ...