Open Access DOI:10.23937/iaos-2017/1710003
Analysis of Principal Stress Projection in Femur with Total Hip Arthroplasty using CT-image Based Finite Element Method
Kosei Fukuoka and Mitsugu Todo
Article Type: Original Research | First Published: September 20, 2018
The research demonstrates a novel three-dimensional finite element analysis to analyze biomechanical changes in a femur with implant. The method uses principal stress projections to determine trabeculae trajectories in the femur. Visual comparisons of the projections of the femurs show areas of cortical and cancellous changes due to changes in tensile and compressive stresses, revealing areas of stress shielding. The method also includes a bone remodeling algorithm to simulate bone adaptation. I...
Open Access DOI:10.23937/iaos-2017/1710002
Transforming Growth Factor-Beta (TGF-B) Regulates Nerve Growth Factor and Cyclooxygenase-2 Expression in Subsynovial Connective Tissue in Patients with Carpal Tunnel Syndrome
Mitsufumi Nakawaki, Kentaro Uchida, Kenji Onuma, Koji Sukegawa, Toshihide Matsumoto, Gen Inoue, Hiroyuki Sekiguchi and Masashi Takaso
Article Type: Original Article | First Published: September 19, 2018
Carpal tunnel syndrome (CTS) is a common neuropathy encountered in orthopedics. It results from compression of the distal median nerve (MN) within the carpal tunnel. Characteristic complaints of CTS are numbness, paresthesia, and pain in the hand and fingers, often exacerbated at night. This characteristic MN compression results in various degrees of disability. In recent years, elucidation of the pathological condition has progressed; however, the mechanism is still unknown....
Open Access DOI:10.23937/2469-5742/1510043
Pure Primary Small Cell Carcinoma of Urinary Bladder: An Extreme Rarity
Sanjay Kumar, Namita Bhutani, Sant Prakash Kataria and Rajeev Sen
Article Type: Case Report | First Published: September 19, 2018
Small cell carcinoma of the urinary bladder is an extremely rare tumor accounting for less than 1% of all cancers arising from the bladder. Since the tumor is very rare, pathogenesis is uncertain. The tumor shares similar histological features with the small cell carcinoma originating at the other sites in body. However, its similar clinical features like the conventional transitional cell carcinoma of the bladder, tendency to present at a advanced stage and low immunoreactivity to the conventio...
Open Access DOI:10.23937/2474-3690/1510036
Nigerian Citrullus Lanatus Fruit and Seed Juice Reduces Cardiovascular Diseases Modifiable Risk Biomarkers in Normal Experimental Rats
Aminu Ibrahim, Hadiza Babaye, Murtala Ya'u, Kamaluddeen Babagana, Salisu Maiwada Abubakar, Jamila Mashi Ahmad and Abba Babandi
Article Type: RESEARCH ARTICLE | First Published: September 12, 2018
Dyslipidemia and imbalance of electrolytes are among the modifiable risk factors for cardiovascular diseases (CVDs) which cause morbidity and mortality in hypertensive patients. Consumption of fruits and their juices has been shown to be beneficial health wise by lowering risk of coronary artery/cardiovascular diseases, stroke and other degenerative diseases. The lowering effects and protective mechanism of these fruits are probably due to numerous beneficial nutrients and extra-nutrients found ...
Open Access DOI:10.23937/2378-3648/1410037
Combination of Vitamin K2 and Phosphatidylcholine Inhibits Hepatocarcinogenesis via Mir-16 Regulating
Ruicheng Yan, Jianfei Luo, Fusheng Lin, Chao Hu, and Shiqiang Shen
Article Type: ORIGINAL RESEARCH | First Published: September 12, 2018
Vitamin K2 and phosphatidylcholine are two common drugs in clinical treatment. Studies carried out in the past several years demonstrated vitamin K2 and phosphatidylcholine could separately inhibit hepatocarcinogenesis. In this study, we sought to investigate the synergy of vitamin K2 and phosphatidylcholine and the potential mechanism. Multiple assays were performed to evaluate the effect of combination administration in vitro and in vivo. Then microRNA microarray, bioinformatics analysis and w...
Open Access DOI:10.23937/2378-346X/1410092
Giant Sebaceous Cell Carcinoma of Upper Eyelid - Case Report
Santosh Singh Patel, Reshu Malhotra, ML Garg, AK chandrakar and Dhanshree Kalway
Article Type: CASE REPORT | First Published: September 19, 2018
An eighty-year-old patient presented with right upper eyelid mass. Contrast enhanced computed tomography (CECT) showed large heterogeneously enhancing exophytic soft tissue density mass lesion with few hyperdense foci noted involving skin and subcutaneous tissue. An excisional biopsy was performed. A diagnosis of sebaceous cell carcinoma was confirmed on histopathology....