Open Access DOI:10.23937/2469-5807/1510110
Importance of Family Studies with High Performance Liquid Chromatography (HPLC) in Hemoglobin Disorders: An analysis of 37 Families
Dr. Mahesh Garje, Dr. Bharat R Sonwane, Dr. Shruti Gupta and Dr. Piyush Narkhede
Article Type: Original Article | First Published: May 22, 2020
The hemoglobin inherited disorders are one of the commonest single-gene disorders in man. Frequency of carriers of hemoglobinopathies varies from 3 to 17% in India. It is estimated that around 5.35% in India are the trait of Sickle cell, hemoglobin D, and hemoglobin E. However, the definite identification of disorders of hemoglobin synthesis can be achieved only by DNA analysis. In Indian scenario, family studies can be equally efficacious and cost-effective tool on HPLC and might be useful. Thi...
Open Access DOI:10.23937/2469-5807/1510108
α-Smooth Muscle Actin and TLR9 Expression and Correlation in Breast Cancer
Aradhana Singh, Arghya Bandyopadhyay, Narendranath Mukherjee and Anupam Basu
Article Type: Original Article | First Published: April 25, 2020
Cancer microenvironment is a complex of different kinds of cells. Ligands of different Toll-like receptors has been used in clinical trials in past decade but the mixed outcome leads to further studies. Toll-like receptor 9 expression has been observed in different type of cancer. α-Smooth muscle actin (α-SMA) is an indicator of myofibroblast. In previous studies, myofibroblasts was reported to induce angiogenesis and proliferation in cancer by providing growth factors and extracellular matrix...
Open Access DOI:10.23937/2378-3672/1410050
Corona Virus: An Immunological Perspective Review
Nimesh Singh, Bharat Suthar, Abhay Mehta, Neeti Nema and Archna Pandey
Article Type: Review Article | First Published: May 22, 2020
As the world is seeing the plague of COVID-19, an illness brought about by a novel coronavirus, SARS-CoV-2, developing hereditary qualities and clinical confirmations recommend a comparative way to those of SARS and MERS. A course of viral particles enters the body through the nose, eyes or mouth. Breathing conveys a portion of these particles to the lower respiratory tract where the spike proteins of the coronavirus, acting like a key, lock into epithelial cells that line the respiratory tract ...
Open Access DOI:10.23937/2377-3634/1410123
Renoprotective Effect of Co-Enzyme Q10 and N-Acetylcysteine on Streptozotocin-Induced Diabetic Nephropathy in Rats
Manojkumar S Mahajan, Chandrashekhar D Upasani, Aman B Upaganlawar and Vishal S Gulecha
Article Type: Original Article | First Published: May 21, 2020
Persistent chronic hyperglycemia is an important player in the development and progression of diabetic nephropathy (DN) due to generation of oxidative stress (OS) which is at the center in the pathophysiology of DN and underlying kidney damage. The present study was aimed to evaluate the effect of antioxidants like Co-enzyme Q10 (CoQ10) and N-acetylcysteine (NAC) either alone or in combination in streptozotocin (STZ) induced diabetic nephropathy (DN) in rats....
Open Access DOI:10.23937/2643-4512/1710042
Racial and Geographic Differences in Hospitalizations for Pediatric Opioid Use Disorders
Wanqing Zhang, PhD, MD, Paul R. Chelminski, MD and Dore R. LaForett, PhD
Article Type: Original Article | First Published: May 21, 2020
Opioids present unprecedented threat in the United States. Hospitalizations associated with opioid use disorders (OUD) among US children have doubled in the last decade. Important racial disparities in OUD have recently been noted. The purpose of this study is to explore the role of race in hospitalizations associated with OUD among children and adolescents across the 4 US Census Bureau-defined regions....
Open Access DOI:10.23937/2643-4512/1710041
Is India's Health Care Infrastructure Sufficient for Handling COVID 19 Pandemic?
Dr. Abhishek Singh, M.D, Dr. Preeti Deedwania, MD, Dr. Vinay K, MBBS, Dr. Apala Roy Chowdhury MD and Dr. Puneet Khanna, MD
Article Type: Commentary | First Published: May 18, 2020
In the last week of December 2019, the first case of pneumonia caused by a novel corona virus in Wuhan city, China, was diagnosed. Person to person transmission of novel coronavirus was confirmed by china on 21 January 2020 with more than 200 diagnosed cases and 4 death. On 30th January 2020, WHO declared the Chinese outbreak of COVID-19 to be a Public Health Emergency of International Concern posing a high risk to countries with the poor health care system...
Open Access DOI:10.23937/2572-3243.1510077
Validity and Reliability of the Cross-Cultural Arabic Adaptation of the Hip Disability and Osteoarthritis Outcome Score (HOOS)
Awdhah Al-Samhan, MD, BS, Owayed Al-Mutairi, MD, Abdulaziz Al-Kudair, MD and Aliaa Khaja, MD
Article Type: Original Article | First Published: May 13, 2020
110 patients participated in this survey. The internal consistency tests were performed using Cronbach’s alpha. Test-retest reliability (intra-correlation coefficient), convergent construct validity, convergent validity, floor & ceiling effects and responsiveness were also calculated. In order to measure the level of agreement, Bland & Altman Plot, forest Plots and ROC curve analysis are performed. Test reliability for the first testing situation - calculated using Cronbachs alpha - was 0.98 f...
Open Access DOI:10.23937/2643-4571/1710018
Non-biopsy Diagnosis of Hereditary Transthyretin Amyloidosis Presented with Cardiomyopathy and Peripheral Neuropathy in a Chinese Man in Hong Kong
Mei Han Ho, MBBS, MRes (Med), MRCP, Pui Lun Yip, MB, ChB, FHKAM (Med), Cheuk Bong Ho, MBBS, MRCP, Felix Chi Kin Wong, MBBS, MHKC (Path), Sammy Pak Lam Chen, FRCPA, FHKAM (Pathology) and Chi Yuen Wong, FHKCP, FHKAM (Med)
Article Type: Case Report | First Published: May 16, 2020
Amyloidosis is a rare disease characterized by deposition of misfolded amyloid protein, which commonly affects myocardium, nerves, kidneys and various organs. The clinical presentation is highly variable. We herein describe, to our knowledge, the first case of a Chinese man with hereditary transthyretin related cardiac amyloidosis (ATTR) with Ala117Ser mutation in Hong Kong who presented with peripheral neuropathy and congestive heart failure. Echocardiography showed left ventricular hypertrophy...