International Archives of

Clinical PharmacologyISSN: 2572-3987

Early Online

 Open Access DOI:10.23937/2572-3987.1510017

Kambo and its Multitude of Biological Effects: Adverse Events or Pharmacological Effects?

Jan M Keppel Hesselink

Article Type: Research Article | First Published: December 29, 2018

Kambo is the name of a secretion of a tropical frog, the Phyllomedusa bicolor or giant leaf frog from the Amazonian forest, which has been used for centuries by local tribes to enhance their hunter skills. Its first tribal use was described in 1925, and included the first effects after administration of the secretion: nausea and vomiting. Since the end of last century Kambo is introduced in Europe and the USA as a 'healing' intervention to cleanse the bodily systems, it is regarded as a 'detox' ...

 Open Access DOI:10.23937/2572-3987.1510016

Use of Dapsone for Difficult to Treat Stricturing Esophageal Crohn's Disease: A Difficult Pill to Swallow

Eran Zittan* and Mark S Silverberg

Article Type: Case Report | First Published: November 19, 2018

Crohn's disease (CD) can affect any part of the gastrointestinal tract. Although esophageal involvement is rare, it can lead to debilitating complications such as tracheobronchial fistulation. Although current guidelines recommend early, advanced therapy with acid suppression, immunosuppressants and biologics, there are a lack of specific clinical trial data demonstrating efficacy for this phenotype. Despite aggressive management, CD of the esophagus is often refractory to conventional therapy. ...

 Open Access DOI:10.23937/2572-3987.1510015

New Therapeutic Strategy for the Neurodegenerative Diseases: Pharmacological Modulation of Ca2+/Camp Signaling Interaction

Afonso Caricati-Neto and Leandro Bueno Bergantin

Article Type: Review Article | First Published: May 09, 2018

Due to the involvement of the imbalance of neuronal Ca2+ homeostasis in the pathogenesis of several neurodegenerative diseases, the use of drugs to prevent or attenuate this imbalance emerged as a new therapeutic strategy for treating these diseases....

 Open Access DOI:10.23937/2572-3987.1510014

Assessment of Iron Overload and Chelation Therapy in Adult Inpatients with Sickle Cell Disease

Nicole Bohm, Brittany Toussaint, Stefanie Sarratt, Leigh Vaughan and Ashley Duckett

Article Type: Short Communication | First Published: March 24, 2018

There is no consensus for the role of iron chelation therapy in patients with sickle cell disease receiving blood transfusions while hospitalized. The primary objective of this study was to assess the frequency of iron overload in adult inpatients with sickle cell disease and characterize the use of inpatient intravenous iron chelation therapy at the time of red blood cell transfusion....

Volume 4
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