Kambo and its Multitude of Biological Effects: Adverse Events or Pharmacological Effects?
Jan M Keppel Hesselink
Article Type: Research Article | First Published: December 29, 2018
Kambo is the name of a secretion of a tropical frog, the Phyllomedusa bicolor or giant leaf frog from the Amazonian forest, which has been used for centuries by local tribes to enhance their hunter skills. Its first tribal use was described in 1925, and included the first effects after administration of the secretion: nausea and vomiting. Since the end of last century Kambo is introduced in Europe and the USA as a 'healing' intervention to cleanse the bodily systems, it is regarded as a 'detox' ...
Use of Dapsone for Difficult to Treat Stricturing Esophageal Crohn's Disease: A Difficult Pill to Swallow
Eran Zittan* and Mark S Silverberg
Article Type: Case Report | First Published: November 19, 2018
Crohn's disease (CD) can affect any part of the gastrointestinal tract. Although esophageal involvement is rare, it can lead to debilitating complications such as tracheobronchial fistulation. Although current guidelines recommend early, advanced therapy with acid suppression, immunosuppressants and biologics, there are a lack of specific clinical trial data demonstrating efficacy for this phenotype. Despite aggressive management, CD of the esophagus is often refractory to conventional therapy. ...
Assessment of Iron Overload and Chelation Therapy in Adult Inpatients with Sickle Cell Disease
Nicole Bohm, Brittany Toussaint, Stefanie Sarratt, Leigh Vaughan and Ashley Duckett
Article Type: Short Communication | First Published: March 24, 2018
There is no consensus for the role of iron chelation therapy in patients with sickle cell disease receiving blood transfusions while hospitalized. The primary objective of this study was to assess the frequency of iron overload in adult inpatients with sickle cell disease and characterize the use of inpatient intravenous iron chelation therapy at the time of red blood cell transfusion....